CN113195502A - 大环流感内切核酸酶抑制剂 - Google Patents

大环流感内切核酸酶抑制剂 Download PDF

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Publication number
CN113195502A
CN113195502A CN201980082149.XA CN201980082149A CN113195502A CN 113195502 A CN113195502 A CN 113195502A CN 201980082149 A CN201980082149 A CN 201980082149A CN 113195502 A CN113195502 A CN 113195502A
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CN
China
Prior art keywords
compound
synthesis
dione
phenyl
pyrido
Prior art date
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Pending
Application number
CN201980082149.XA
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English (en)
Chinese (zh)
Inventor
R·T·亨德里克斯
A·D·斯托切瓦
J-F·邦凡蒂
P·J-M·B·拉布瓦松
J·M·C·福丁
G·J·M·梅西
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Jensen Biopharmaceutical Co ltd
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Jensen Biopharmaceutical Co ltd
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Filing date
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Application filed by Jensen Biopharmaceutical Co ltd filed Critical Jensen Biopharmaceutical Co ltd
Publication of CN113195502A publication Critical patent/CN113195502A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201980082149.XA 2018-10-10 2019-10-09 大环流感内切核酸酶抑制剂 Pending CN113195502A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862744060P 2018-10-10 2018-10-10
US62/744060 2018-10-10
PCT/IB2019/058591 WO2020075080A1 (en) 2018-10-10 2019-10-09 Macrocyclic flu endonuclease inhibitors

Publications (1)

Publication Number Publication Date
CN113195502A true CN113195502A (zh) 2021-07-30

Family

ID=68242803

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980082149.XA Pending CN113195502A (zh) 2018-10-10 2019-10-09 大环流感内切核酸酶抑制剂

Country Status (10)

Country Link
US (2) US11312727B1 (https=)
EP (1) EP3864020A1 (https=)
JP (1) JP2022512676A (https=)
KR (1) KR20210074329A (https=)
CN (1) CN113195502A (https=)
AU (1) AU2019359539A1 (https=)
CA (1) CA3115792A1 (https=)
MX (1) MX2021004182A (https=)
TW (1) TW202035424A (https=)
WO (1) WO2020075080A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020197991A1 (en) 2019-03-22 2020-10-01 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
WO2021191872A1 (en) * 2020-03-26 2021-09-30 Janssen Biopharma, Inc. Heteroaryl-substituted macrocyclic flu endonuclease inhibitors
CN113444010B (zh) * 2020-03-28 2023-09-05 南京正大天晴制药有限公司 一种沙芬酰胺有关物质的制备方法
US12516070B2 (en) 2020-05-21 2026-01-06 Cisen Pharmaceutical Co., Ltd Fused ring derivatives and use thereof in pharmacy
TW202146413A (zh) * 2020-06-12 2021-12-16 大陸商上海翰森生物醫藥科技有限公司 含吡啶酮稠環類衍生物抑制劑、其製備方法和應用
CA3192145A1 (en) 2020-09-30 2022-04-07 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
WO2022105669A1 (zh) * 2020-11-17 2022-05-27 南京明德新药研发有限公司 含Se大环类化合物
FI4196479T3 (fi) * 2021-01-19 2024-01-17 Gilead Sciences Inc Substituoituja pyridotriatsiiniyhdisteitä ja niiden käyttöjä
EP4384178A4 (en) * 2021-08-11 2025-07-02 Merck Sharp & Dohme Llc POLYCYCLIC CAP-DEPENDENT ENDONUCLEASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF INFLUENZA
CN118317964A (zh) * 2021-11-17 2024-07-09 辰欣药业股份有限公司 一种稠环衍生物的晶型及其制备方法
WO2025015300A2 (en) * 2023-07-12 2025-01-16 Apac Pharma, Llc Hepoxilin analogs, methods, uses, and processes for preparation thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102803260A (zh) * 2009-06-15 2012-11-28 盐野义制药株式会社 被取代的多环性氨基甲酰基吡啶酮衍生物
CN103228653A (zh) * 2010-09-24 2013-07-31 盐野义制药株式会社 被取代的多环性氨基甲酰基吡啶酮衍生物的前药
CN105722831A (zh) * 2013-09-12 2016-06-29 艾丽奥斯生物制药有限公司 哒嗪酮化合物及其用途
US20180057501A1 (en) * 2016-08-29 2018-03-01 Novartis Ag Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102803260A (zh) * 2009-06-15 2012-11-28 盐野义制药株式会社 被取代的多环性氨基甲酰基吡啶酮衍生物
CN103228653A (zh) * 2010-09-24 2013-07-31 盐野义制药株式会社 被取代的多环性氨基甲酰基吡啶酮衍生物的前药
CN105722831A (zh) * 2013-09-12 2016-06-29 艾丽奥斯生物制药有限公司 哒嗪酮化合物及其用途
US20180057501A1 (en) * 2016-08-29 2018-03-01 Novartis Ag Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections

Also Published As

Publication number Publication date
CA3115792A1 (en) 2020-04-16
US20230002409A1 (en) 2023-01-05
KR20210074329A (ko) 2021-06-21
MX2021004182A (es) 2021-09-08
EP3864020A1 (en) 2021-08-18
WO2020075080A1 (en) 2020-04-16
AU2019359539A1 (en) 2021-04-29
US11312727B1 (en) 2022-04-26
TW202035424A (zh) 2020-10-01
JP2022512676A (ja) 2022-02-07

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