JP2022507265A5 - - Google Patents
Info
- Publication number
- JP2022507265A5 JP2022507265A5 JP2021525753A JP2021525753A JP2022507265A5 JP 2022507265 A5 JP2022507265 A5 JP 2022507265A5 JP 2021525753 A JP2021525753 A JP 2021525753A JP 2021525753 A JP2021525753 A JP 2021525753A JP 2022507265 A5 JP2022507265 A5 JP 2022507265A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- composition
- compound
- alkyl
- electron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862767424P | 2018-11-14 | 2018-11-14 | |
| US62/767,424 | 2018-11-14 | ||
| PCT/US2019/061474 WO2020102529A1 (en) | 2018-11-14 | 2019-11-14 | Electrophiles and electrophile pro-drugs as rad51 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022507265A JP2022507265A (ja) | 2022-01-18 |
| JP2022507265A5 true JP2022507265A5 (https=) | 2022-11-18 |
| JP7656922B2 JP7656922B2 (ja) | 2025-04-04 |
Family
ID=70732197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021525753A Active JP7656922B2 (ja) | 2018-11-14 | 2019-11-14 | Ｒａｄ５１阻害薬としての求電子剤および求電子剤プロドラッグ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12390435B2 (https=) |
| EP (1) | EP3880188A4 (https=) |
| JP (1) | JP7656922B2 (https=) |
| CN (1) | CN112996493A (https=) |
| CA (1) | CA3114406A1 (https=) |
| WO (1) | WO2020102529A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12390435B2 (en) | 2018-11-14 | 2025-08-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Electrophiles and electrophile pro-drugs as RAD51 inhibitors |
| WO2023025263A1 (en) * | 2021-08-25 | 2023-03-02 | Ensem Therapeutics Holding (Singapore) Pte. Ltd. | Systems and methods for post-translational modification-inspired drug design and screening |
| KR20230102353A (ko) * | 2021-12-30 | 2023-07-07 | 주식회사 대웅제약 | 삼중음성유방암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776916B2 (en) | 2004-04-28 | 2010-08-17 | The Uab Research Foundation | Nitrated lipids and methods of making and using thereof |
| WO2009017802A1 (en) | 2007-08-01 | 2009-02-05 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Nitro-fattyacid modulation of type ii diabetes |
| JP2011519373A (ja) | 2008-05-01 | 2011-07-07 | コンプレクザ インコーポレイテッド | ビニル置換脂肪酸 |
| EP2299997A4 (en) | 2008-06-19 | 2012-01-11 | Univ Utah Res Found | USE OF NITRATED LIPIDS FOR THE TREATMENT OF SIDE EFFECTS OF TOXIC MEDICAL THERAPIES |
| EP3045167A1 (en) | 2009-07-31 | 2016-07-20 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Keto fatty acids as anti-inflammatory agents |
| EP2483233A4 (en) | 2009-10-02 | 2013-08-14 | Complexa Inc | HETEROATOMA CONTAINING SUBSTITUTED FATTY ACIDS |
| WO2013116753A1 (en) | 2012-02-03 | 2013-08-08 | University Of Pittsburgh-Of The Commonwelth System Of Higher Education | Fatty acids as anti-inflammatory agents |
| AU2016247674A1 (en) | 2015-04-14 | 2017-10-19 | Atossa Genetics Inc. | Compositions and methods of treatment of breast disorders and estrogen-related disorders |
| CA3016180A1 (en) | 2016-03-04 | 2017-09-08 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Prevention, treatment and reversal of disease using therapeutically effective amounts of dicarboxylic acid compounds |
| CN109803648A (zh) | 2016-10-05 | 2019-05-24 | 高等教育联邦系统-匹兹堡大学 | 可逆保护的硫醇化亲电脂肪酸作为前药 |
| US10765652B2 (en) | 2016-10-05 | 2020-09-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions |
| US12390435B2 (en) | 2018-11-14 | 2025-08-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Electrophiles and electrophile pro-drugs as RAD51 inhibitors |
-
2019
- 2019-11-14 US US17/290,963 patent/US12390435B2/en active Active
- 2019-11-14 EP EP19885442.4A patent/EP3880188A4/en active Pending
- 2019-11-14 JP JP2021525753A patent/JP7656922B2/ja active Active
- 2019-11-14 CA CA3114406A patent/CA3114406A1/en active Pending
- 2019-11-14 CN CN201980074600.3A patent/CN112996493A/zh active Pending
- 2019-11-14 WO PCT/US2019/061474 patent/WO2020102529A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7407880B2 (ja) | 前立腺癌の併用療法 | |
| JP2022507265A5 (https=) | ||
| Vis et al. | Key targets of hormonal treatment of prostate cancer. Part 1: the androgen receptor and steroidogenic pathways | |
| JP7129095B2 (ja) | スプライシング異常に起因する遺伝性疾病のための医薬組成物及び治療方法 | |
| De Velasco et al. | Targeting castration-resistant prostate cancer with androgen receptor antisense oligonucleotide therapy | |
| Devulapally et al. | Formulation of anti-miR-21 and 4-hydroxytamoxifen co-loaded biodegradable polymer nanoparticles and their antiproliferative effect on breast cancer cells | |
| US20220000824A1 (en) | Treatment of pulmonary arterial hypertension using therapeutically effective oral doses of 10-nitro-9(e)-octadec-9-enoic acid | |
| EP3791897A1 (en) | Hsp90 inhibitor drug conjugates | |
| Hassan et al. | MicroRNA-122 mimic/microRNA-221 inhibitor combination as a novel therapeutic tool against hepatocellular carcinoma | |
| Blazek et al. | Novel therapies on the horizon of hypertension management | |
| JP7197370B2 (ja) | がんの予防および／または治療のための化合物、組成物および方法 | |
| IL272095B2 (en) | Cortaxolone 17alpha-valerate for use in the treatment of diseases associated with epithelial tumors | |
| JP2016515630A5 (https=) | ||
| Markowski et al. | Early use of chemotherapy in metastatic prostate cancer | |
| US20200108089A1 (en) | Gemcitabine Derivatives for Cancer Therapy | |
| US20250248999A1 (en) | Bavdegalutamide and combinations thereof for use in treating prostate cancer | |
| Tong et al. | ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acid resistance in acute promyelocytic leukemia | |
| CN110352058A (zh) | 相伴给予糖皮质激素受体调节剂和cyp3a抑制剂 | |
| Dong et al. | Synthesis of bisethylnorspermine lipid prodrug as gene delivery vector targeting polyamine metabolism in breast cancer | |
| CN109125313B (zh) | 一种复合制剂及其在制备肿瘤治疗药物中的用途 | |
| WO2012109527A2 (en) | Class of hdac inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury | |
| Tsang et al. | U1 adaptors suppress the KRAS-MYC oncogenic axis in human pancreatic cancer xenografts | |
| WO2006003013B1 (de) | NEUE 2-SUBSTITUIERTE ESTRA-1,3,5(10)-TRIEN-17-ONE ALS INHIBITOREN DER 17β-HYDROXYSTEROIDDEHYDROGENASE TYP 1 | |
| EP3861119A1 (en) | Splicing-dependent transcriptional gene silencing or activation | |
| WO2014159774A1 (en) | Custirsen treatment with reduced toxicity |