JP2022506761A - ＩｇＡ抗体構築物を含む組成物および方法 - Google Patents

ＩｇＡ抗体構築物を含む組成物および方法 Download PDF

Info

Publication number
JP2022506761A
JP2022506761A JP2021524345A JP2021524345A JP2022506761A JP 2022506761 A JP2022506761 A JP 2022506761A JP 2021524345 A JP2021524345 A JP 2021524345A JP 2021524345 A JP2021524345 A JP 2021524345A JP 2022506761 A JP2022506761 A JP 2022506761A
Authority
JP
Japan
Prior art keywords
antibody construct
heavy chain
domain
amino acid
iga
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021524345A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020092427A5 (enExample
Inventor
デ・ブール，マーク
ロイゼン，ジャネット・ヘンリカ・ウィルヘルミナ
ファン・テザリング，ゲールツ・ヤン
Original Assignee
ティガティーエックス，インコーポレーテッド
ユーエムセー・ユトレヒト・ホールディング・ベー・フェー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ティガティーエックス，インコーポレーテッド, ユーエムセー・ユトレヒト・ホールディング・ベー・フェー filed Critical ティガティーエックス，インコーポレーテッド
Publication of JP2022506761A publication Critical patent/JP2022506761A/ja
Publication of JPWO2020092427A5 publication Critical patent/JPWO2020092427A5/ja
Priority to JP2024144789A priority Critical patent/JP2024170456A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021524345A 2018-10-29 2019-10-29 ＩｇＡ抗体構築物を含む組成物および方法 Pending JP2022506761A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024144789A JP2024170456A (ja) 2018-10-29 2024-08-26 ＩｇＡ抗体構築物を含む組成物および方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP18203183 2018-10-29
US201862752641P 2018-10-30 2018-10-30
US62/752,641 2018-10-30
EP18203183.1 2019-10-29
PCT/US2019/058648 WO2020092427A1 (en) 2018-10-29 2019-10-29 COMPOSITIONS AND METHODS COMPRISING IgA ANTIBODY CONSTRUCTS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024144789A Division JP2024170456A (ja) 2018-10-29 2024-08-26 ＩｇＡ抗体構築物を含む組成物および方法

Publications (2)

Publication Number Publication Date
JP2022506761A true JP2022506761A (ja) 2022-01-17
JPWO2020092427A5 JPWO2020092427A5 (enExample) 2022-10-31

Family

ID=70462698

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021524345A Pending JP2022506761A (ja) 2018-10-29 2019-10-29 ＩｇＡ抗体構築物を含む組成物および方法
JP2024144789A Pending JP2024170456A (ja) 2018-10-29 2024-08-26 ＩｇＡ抗体構築物を含む組成物および方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024144789A Pending JP2024170456A (ja) 2018-10-29 2024-08-26 ＩｇＡ抗体構築物を含む組成物および方法

Country Status (9)

Country Link
US (1) US20210332131A1 (enExample)
EP (1) EP3873942A4 (enExample)
JP (2) JP2022506761A (enExample)
KR (1) KR20210096612A (enExample)
CN (1) CN113260632A (enExample)
AU (1) AU2019369397A1 (enExample)
CA (1) CA3118312A1 (enExample)
GB (1) GB2596411B (enExample)
WO (1) WO2020092427A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114096559A (zh) * 2019-03-27 2022-02-25 蒂嘉特克斯公司 工程化iga抗体及其使用方法
JP2023546679A (ja) * 2020-10-22 2023-11-07 アクティニウム ファーマシューティカルズ インコーポレイテッド がん治療における放射免疫療法とｃｄ４７遮断の併用
CN116829698A (zh) * 2020-12-07 2023-09-29 加利福尼亚大学董事会 通过SIRP-α衔接体的先天免疫细胞沉默
WO2023154730A2 (en) * 2022-02-09 2023-08-17 Exelixis, Inc. Multispecific binding agents and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008500017A (ja) * 2003-11-05 2008-01-10 グリクアート バイオテクノロジー アクチェンゲゼルシャフト 高められたＦｃレセプター結合親和性及びエフェクター機能をもつＣＤ２０抗体
JP2015536351A (ja) * 2012-12-03 2015-12-21 ノビミューン エスアー 抗ｃｄ４７抗体およびその使用方法
JP2017525698A (ja) * 2014-08-15 2017-09-07 メルク パテント ゲーエムベーハー Ｓｉｒｐ−アルファ免疫グロブリン融合タンパク質

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0226878D0 (en) * 2002-11-18 2002-12-24 Univ Warwick Antibodies
CA2737241C (en) * 2008-09-26 2017-08-29 Ucb Pharma S.A. Multivalent antibody fusion proteins
AU2010295661B2 (en) * 2009-09-15 2015-04-30 The Board Of Trustees Of The Leland Stanford Junior University Synergistic anti-CD47 therapy for hematologic cancers
EP2791169B1 (en) * 2011-12-16 2017-07-19 Synthon Biopharmaceuticals B.V. Compounds and methods for treating inflammatory diseases
US20140213771A1 (en) * 2012-12-28 2014-07-31 Abbvie, Inc. Multi-specific binding proteins
HK1217958A1 (zh) * 2013-03-15 2017-01-27 默克专利有限公司 四价双特异性抗体
DK3089994T3 (da) * 2013-12-30 2022-07-04 Epimab Biotherapeutics Inc Fabs-in-tandem-immunglobulin og anvendelser deraf
EP3188758B1 (en) * 2014-08-08 2023-10-04 The Board of Trustees of the Leland Stanford Junior University Sirp alpha-antibody fusion proteins
EP3353209B1 (en) * 2015-09-21 2022-03-16 Erasmus University Medical Center Rotterdam Anti-cd47 antibodies and methods of use
CN107459579B (zh) * 2016-06-01 2021-09-24 泰州迈博太科药业有限公司 一种靶向egfr和cd47双特异性融合蛋白、制备方法及应用
US11414495B2 (en) * 2016-09-01 2022-08-16 Tiga Tx, Inc. CD20 antibodies
US11267885B2 (en) * 2017-01-26 2022-03-08 Zlip Holding Limited CD47 antigen binding unit and uses thereof
DK3658141T3 (da) * 2017-07-24 2023-02-06 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Behandling af patologiske tilstande ved direkte og indirekte målretning af Sirpalpha-CD47-interaktion
EP3665196B1 (en) * 2017-08-08 2022-10-19 F. Hoffmann-La Roche AG Obinutuzumab treatment of a dlbcl patient subgroup

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008500017A (ja) * 2003-11-05 2008-01-10 グリクアート バイオテクノロジー アクチェンゲゼルシャフト 高められたＦｃレセプター結合親和性及びエフェクター機能をもつＣＤ２０抗体
JP2015536351A (ja) * 2012-12-03 2015-12-21 ノビミューン エスアー 抗ｃｄ４７抗体およびその使用方法
JP2017525698A (ja) * 2014-08-15 2017-09-07 メルク パテント ゲーエムベーハー Ｓｉｒｐ−アルファ免疫グロブリン融合タンパク質

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MABS, vol. 8, no. 1, JPN6023039808, 2016, pages 87 - 98, ISSN: 0005162233 *
MOL. IMMUNOL., vol. 68, no. 1, JPN6023039806, 2015, pages 35 - 39, ISSN: 0005311311 *

Also Published As

Publication number Publication date
AU2019369397A1 (en) 2021-05-27
EP3873942A1 (en) 2021-09-08
WO2020092427A1 (en) 2020-05-07
JP2024170456A (ja) 2024-12-10
GB2596411A (en) 2021-12-29
GB2596411B (en) 2023-09-20
CN113260632A (zh) 2021-08-13
KR20210096612A (ko) 2021-08-05
CA3118312A1 (en) 2020-05-07
GB202107478D0 (en) 2021-07-07
EP3873942A4 (en) 2022-12-28
US20210332131A1 (en) 2021-10-28

Similar Documents

Publication Publication Date Title
CN112513085B (zh) Psma结合剂及其用途
JP7019423B2 (ja) 前立腺特異的膜抗原（ｐｓｍａ）二重特異性結合剤及びその使用
JP2018161141A (ja) ヘテロ多量体分子を作製するための方法
US20210332131A1 (en) COMPOSITIONS AND METHODS COMPRISING IgA ANTIBODY CONSTRUCTS
US20240059789A1 (en) Psma binding proteins and uses thereof
KR102885855B1 (ko) 항-pd-1 항체 및 이의 용도
TWI833742B (zh) Ｃ３結合劑及其使用方法
TW201600527A (zh) 結合人類大麻素１（ｃｂ１）受體之抗體
WO2021008523A1 (zh) 抗tigit抗体及其应用
JP2021517807A (ja) 抗ｐｄ−１抗体及びその用途
TWI784932B (zh) 結合人類大麻素1(cb1)受體之抗體
TW202003584A (zh) 單特異性及多特異性抗ｔｍｅｆｆ２抗體及其用途
RU2770620C1 (ru) Связывающие молекулы, вызывающие клеточную активацию
TW202237187A (zh) 組合療法
TW202216789A (zh) 預靶向抗體及使用方法
KR20240156628A (ko) 항-cd36 항체 및 이의 이용
TW202246324A (zh) 用於治療癌症的經掩蔽之ｃｔｌａ４及ｐｄ１／ｐｄｌ１抗體之組合
HK40059443A (en) Compositions and methods comprising iga antibody constructs
CN115698066A (zh) 抗cd47抗体及其用途
JP7789368B2 (ja) 炎症性腸疾患に対する治療用抗体
CN117580867A (zh) Psma结合蛋白及其用途
TW202517683A (zh) 可活化之ror結合劑及其用途
BR112016022381B1 (pt) Anticorpo humanizado isolado ou fragmento de ligação ao antígeno deste que se liga ao receptor canabinóide 1 (cb1), uso do mesmo, composição farmacêutica e método in vitro de agonizar ou antagonizar cb1

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221021

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20221021

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230915

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230928

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231208

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240328

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240424