JP2022506687A5 - - Google Patents
Info
- Publication number
- JP2022506687A5 JP2022506687A5 JP2021524227A JP2021524227A JP2022506687A5 JP 2022506687 A5 JP2022506687 A5 JP 2022506687A5 JP 2021524227 A JP2021524227 A JP 2021524227A JP 2021524227 A JP2021524227 A JP 2021524227A JP 2022506687 A5 JP2022506687 A5 JP 2022506687A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- alkyl
- item
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022166276A JP7429750B2 (ja) | 2018-11-06 | 2022-10-17 | ピリダジノン化合物およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862756553P | 2018-11-06 | 2018-11-06 | |
| US62/756,553 | 2018-11-06 | ||
| PCT/US2019/060157 WO2020097266A1 (en) | 2018-11-06 | 2019-11-06 | Pyridazinone compounds and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022166276A Division JP7429750B2 (ja) | 2018-11-06 | 2022-10-17 | ピリダジノン化合物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022506687A JP2022506687A (ja) | 2022-01-17 |
| JP2022506687A5 true JP2022506687A5 (enExample) | 2022-05-17 |
| JP7162132B2 JP7162132B2 (ja) | 2022-10-27 |
Family
ID=69160036
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524227A Active JP7162132B2 (ja) | 2018-11-06 | 2019-11-06 | ピリダジノン化合物およびその使用 |
| JP2022166276A Active JP7429750B2 (ja) | 2018-11-06 | 2022-10-17 | ピリダジノン化合物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022166276A Active JP7429750B2 (ja) | 2018-11-06 | 2022-10-17 | ピリダジノン化合物およびその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US11091464B2 (enExample) |
| EP (2) | EP3877376B1 (enExample) |
| JP (2) | JP7162132B2 (enExample) |
| KR (2) | KR102985383B1 (enExample) |
| CN (2) | CN120737085A (enExample) |
| AU (1) | AU2019376065B2 (enExample) |
| BR (1) | BR112021008905A2 (enExample) |
| CA (1) | CA3118934A1 (enExample) |
| DK (1) | DK3877376T3 (enExample) |
| EA (1) | EA202191084A1 (enExample) |
| ES (1) | ES2958954T3 (enExample) |
| FI (1) | FI3877376T3 (enExample) |
| HR (1) | HRP20231389T1 (enExample) |
| HU (1) | HUE063586T2 (enExample) |
| IL (1) | IL282998B1 (enExample) |
| LT (1) | LT3877376T (enExample) |
| MX (2) | MX2021005350A (enExample) |
| PL (1) | PL3877376T3 (enExample) |
| PT (1) | PT3877376T (enExample) |
| RS (1) | RS64828B1 (enExample) |
| SG (1) | SG11202104713RA (enExample) |
| SI (1) | SI3877376T1 (enExample) |
| SM (1) | SMT202300355T1 (enExample) |
| WO (1) | WO2020097266A1 (enExample) |
| ZA (1) | ZA202103260B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3755352A4 (en) * | 2018-02-20 | 2021-12-22 | Edgewise Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MOTION DISORDERS |
| HU231285B1 (hu) | 2018-04-18 | 2022-08-28 | Printnet Kereskedelmi És Szolgáltató Kft. | A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek |
| SMT202300355T1 (it) | 2018-11-06 | 2024-01-10 | Edgewise Therapeutics Inc | Composti di piridazinone e loro usi |
| WO2020097258A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| KR102885525B1 (ko) | 2018-11-06 | 2025-11-13 | 엣지와이즈 테라퓨틱스, 인크. | 피리다지논 화합물 및 이의 용도 |
| WO2021231630A1 (en) * | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| EP4149467A1 (en) * | 2020-05-13 | 2023-03-22 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| WO2021231572A1 (en) * | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Pyridazinone compounds for the treatment of neuromuscular diseases |
| EP4473968A3 (en) * | 2020-05-13 | 2025-03-26 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| EP4149465A1 (en) * | 2020-05-13 | 2023-03-22 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| WO2023091606A1 (en) * | 2021-11-17 | 2023-05-25 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| WO2023220180A1 (en) * | 2022-05-11 | 2023-11-16 | Edgewise Therapeutics, Inc. | Methods of manufacturing pyridazinone compounds |
| JP2025530218A (ja) | 2022-09-09 | 2025-09-11 | エッジワイズ セラピューティクス， インコーポレイテッド | 神経筋の状態の処置のためのピリダジノン組成物 |
| EP4647429A1 (en) * | 2023-01-04 | 2025-11-12 | Xizang Haisco Pharmaceutical Co., Ltd. | Pyridazinone heterocyclic compound myosin ii inhibitor and use thereof |
| WO2025167826A1 (zh) * | 2024-02-06 | 2025-08-14 | 西藏海思科制药有限公司 | 三环化合物作为Myosin II抑制剂及其用途 |
| WO2025242154A1 (zh) * | 2024-05-23 | 2025-11-27 | 西藏海思科制药有限公司 | 哒嗪酮衍生物及其用途 |
| WO2026102326A1 (en) * | 2024-11-08 | 2026-05-15 | Edgewise Therapeutics, Inc. | Pyridazinone compositions and methods for the treatment of muscular conditions |
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| JPS6140270A (ja) | 1984-08-01 | 1986-02-26 | Morishita Seiyaku Kk | ピリダジノン誘導体 |
| DD286354A5 (de) | 1989-08-08 | 1991-01-24 | Karl-Marx-Universitaet Leipzig,De | Verfahren zur herstellung substituierter 2-carbamoyl-methyl-4-phenyl-1,2,5,6-tetrahydro- und 1,2-dihydro-1-oxo-pyridazine |
| ATE180475T1 (de) | 1990-09-21 | 1999-06-15 | Rohm & Haas | Dihydropyridazinone und pyridazinone als fungizide |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| KR100477070B1 (ko) | 1994-03-25 | 2006-04-21 | 이소테크니카 인코포레이티드 | 중수소화작용에의한의약품의효능강화법 |
| IL118631A (en) | 1995-06-27 | 2002-05-23 | Tanabe Seiyaku Co | History of pyridazinone and processes for their preparation |
| DE19629817A1 (de) | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| CN1471515A (zh) | 2000-06-05 | 2004-01-28 | ��̹��ҽҩ��˾ | 作为β2-肾上腺素受体激动剂及PDE-4抑制剂的有效的化合物 |
| WO2004022540A2 (en) | 2002-09-06 | 2004-03-18 | Fujisawa Pharmaceutical Co., Ltd. | Pyridazinone and pyridone derivatives as adenosine antagonists |
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| GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| DE102007038957A1 (de) | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
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| EP2328586A2 (en) | 2008-05-20 | 2011-06-08 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
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| AR081626A1 (es) * | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
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| WO2012021707A2 (en) | 2010-08-11 | 2012-02-16 | The Regents Of The University Of California | Premature-termination-codons readthrough compounds |
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| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| EP2768826A1 (de) | 2011-10-17 | 2014-08-27 | Bayer Intellectual Property GmbH | Substituierte oxadiazolylpyridinone und - pyridazinone als hif - hemmer |
| CN103570730A (zh) | 2012-08-01 | 2014-02-12 | 中国科学院上海药物研究所 | 具有桥环结构的稠环哒嗪酮类化合物及其制备方法和用途 |
| WO2014031928A2 (en) | 2012-08-24 | 2014-02-27 | Philip Jones | Heterocyclic modulators of hif activity for treatment of disease |
| US9566310B2 (en) * | 2012-09-10 | 2017-02-14 | Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno | Methods of treating muscular dystrophy |
| WO2014055644A2 (en) | 2012-10-02 | 2014-04-10 | New York University | Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated rna decay |
| JP2016507496A (ja) | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． | ブロモドメイン阻害剤としての新規複素環式化合物 |
| JP6483624B2 (ja) | 2013-02-07 | 2019-03-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ピリダジノン−アミド誘導体 |
| EP2968323A4 (en) | 2013-03-13 | 2016-12-14 | Flatley Discovery Lab | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS |
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| BE1025518B1 (fr) | 2017-08-30 | 2019-04-03 | E2 Drives Sa | Groupe motopropulseur |
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| MX2020012243A (es) | 2018-05-17 | 2021-01-29 | Bolt Threads Inc | Cepas modificadas con sec para una mejor secrecion de proteinas recombinantes. |
| ES3041367T3 (en) | 2018-06-04 | 2025-11-11 | Ohio State Innovation Foundation | Eaat2 activators and methods of using thereof |
| EP3828174A4 (en) | 2018-07-19 | 2022-08-17 | Sumitomo Pharma Co., Ltd. | PYRIDAZINONE DERIVATIVE |
| CN108947912B (zh) | 2018-07-31 | 2021-10-01 | 中国人民解放军总医院 | 一种靶向Neddylation通路的抗肿瘤化合物 |
| SMT202300355T1 (it) * | 2018-11-06 | 2024-01-10 | Edgewise Therapeutics Inc | Composti di piridazinone e loro usi |
| KR102885525B1 (ko) | 2018-11-06 | 2025-11-13 | 엣지와이즈 테라퓨틱스, 인크. | 피리다지논 화합물 및 이의 용도 |
| WO2020097258A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| WO2021231630A1 (en) | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| EP4149465A1 (en) | 2020-05-13 | 2023-03-22 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| EP4473968A3 (en) | 2020-05-13 | 2025-03-26 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| EP4149467A1 (en) | 2020-05-13 | 2023-03-22 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| WO2021231572A1 (en) | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Pyridazinone compounds for the treatment of neuromuscular diseases |
| WO2023091606A1 (en) | 2021-11-17 | 2023-05-25 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| WO2023220180A1 (en) | 2022-05-11 | 2023-11-16 | Edgewise Therapeutics, Inc. | Methods of manufacturing pyridazinone compounds |
| JP2025530218A (ja) | 2022-09-09 | 2025-09-11 | エッジワイズ セラピューティクス， インコーポレイテッド | 神経筋の状態の処置のためのピリダジノン組成物 |
-
2019
- 2019-11-06 SM SM20230355T patent/SMT202300355T1/it unknown
- 2019-11-06 SI SI201930610T patent/SI3877376T1/sl unknown
- 2019-11-06 KR KR1020217016684A patent/KR102985383B1/ko active Active
- 2019-11-06 KR KR1020267020785A patent/KR20260112244A/ko active Pending
- 2019-11-06 MX MX2021005350A patent/MX2021005350A/es unknown
- 2019-11-06 HU HUE19835997A patent/HUE063586T2/hu unknown
- 2019-11-06 CN CN202510831147.3A patent/CN120737085A/zh active Pending
- 2019-11-06 EP EP19835997.8A patent/EP3877376B1/en active Active
- 2019-11-06 HR HRP20231389TT patent/HRP20231389T1/hr unknown
- 2019-11-06 JP JP2021524227A patent/JP7162132B2/ja active Active
- 2019-11-06 PT PT198359978T patent/PT3877376T/pt unknown
- 2019-11-06 IL IL282998A patent/IL282998B1/en unknown
- 2019-11-06 AU AU2019376065A patent/AU2019376065B2/en active Active
- 2019-11-06 SG SG11202104713RA patent/SG11202104713RA/en unknown
- 2019-11-06 LT LTEPPCT/US2019/060157T patent/LT3877376T/lt unknown
- 2019-11-06 WO PCT/US2019/060157 patent/WO2020097266A1/en not_active Ceased
- 2019-11-06 BR BR112021008905-5A patent/BR112021008905A2/pt unknown
- 2019-11-06 FI FIEP19835997.8T patent/FI3877376T3/fi active
- 2019-11-06 ES ES19835997T patent/ES2958954T3/es active Active
- 2019-11-06 CA CA3118934A patent/CA3118934A1/en active Pending
- 2019-11-06 CN CN201980088114.7A patent/CN113272291B/zh active Active
- 2019-11-06 EP EP23189000.5A patent/EP4248973A3/en active Pending
- 2019-11-06 RS RS20231080A patent/RS64828B1/sr unknown
- 2019-11-06 PL PL19835997.8T patent/PL3877376T3/pl unknown
- 2019-11-06 EA EA202191084A patent/EA202191084A1/ru unknown
- 2019-11-06 DK DK19835997.8T patent/DK3877376T3/da active
-
2020
- 2020-11-03 US US17/088,469 patent/US11091464B2/en active Active
-
2021
- 2021-05-06 MX MX2024004531A patent/MX2024004531A/es unknown
- 2021-05-13 ZA ZA2021/03260A patent/ZA202103260B/en unknown
- 2021-06-11 US US17/345,909 patent/US12012395B2/en active Active
-
2022
- 2022-10-17 JP JP2022166276A patent/JP7429750B2/ja active Active
-
2023
- 2023-09-01 US US18/460,464 patent/US12240831B2/en active Active
-
2024
- 2024-12-13 US US18/981,327 patent/US20250223278A1/en active Pending
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