RS64828B1 - Jedinjenja piridazinona i njihove upotrebe - Google Patents

Jedinjenja piridazinona i njihove upotrebe

Info

Publication number
RS64828B1
RS64828B1 RS20231080A RSP20231080A RS64828B1 RS 64828 B1 RS64828 B1 RS 64828B1 RS 20231080 A RS20231080 A RS 20231080A RS P20231080 A RSP20231080 A RS P20231080A RS 64828 B1 RS64828 B1 RS 64828B1
Authority
RS
Serbia
Prior art keywords
pyridazinone compounds
pyridazinone
compounds
Prior art date
Application number
RS20231080A
Other languages
English (en)
Inventor
Kevin Hunt
Kevin Koch
Alan Russell
Stephen Schlachter
Paul Winship
Chris Steele
Original Assignee
Edgewise Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edgewise Therapeutics Inc filed Critical Edgewise Therapeutics Inc
Publication of RS64828B1 publication Critical patent/RS64828B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RS20231080A 2018-11-06 2019-11-06 Jedinjenja piridazinona i njihove upotrebe RS64828B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862756553P 2018-11-06 2018-11-06
PCT/US2019/060157 WO2020097266A1 (en) 2018-11-06 2019-11-06 Pyridazinone compounds and uses thereof
EP19835997.8A EP3877376B1 (en) 2018-11-06 2019-11-06 Pyridazinone compounds and uses thereof

Publications (1)

Publication Number Publication Date
RS64828B1 true RS64828B1 (sr) 2023-12-29

Family

ID=69160036

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20231080A RS64828B1 (sr) 2018-11-06 2019-11-06 Jedinjenja piridazinona i njihove upotrebe

Country Status (24)

Country Link
US (3) US11091464B2 (sr)
EP (2) EP4248973A3 (sr)
JP (2) JP7162132B2 (sr)
KR (1) KR20210100094A (sr)
CN (1) CN113272291A (sr)
AU (1) AU2019376065A1 (sr)
BR (1) BR112021008905A2 (sr)
CA (1) CA3118934A1 (sr)
DK (1) DK3877376T3 (sr)
EA (1) EA202191084A1 (sr)
ES (1) ES2958954T3 (sr)
FI (1) FI3877376T3 (sr)
HR (1) HRP20231389T1 (sr)
HU (1) HUE063586T2 (sr)
IL (1) IL282998A (sr)
LT (1) LT3877376T (sr)
MX (1) MX2021005350A (sr)
PL (1) PL3877376T3 (sr)
PT (1) PT3877376T (sr)
RS (1) RS64828B1 (sr)
SG (1) SG11202104713RA (sr)
SI (1) SI3877376T1 (sr)
WO (1) WO2020097266A1 (sr)
ZA (1) ZA202103260B (sr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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HU231285B1 (hu) 2018-04-18 2022-08-28 Printnet Kereskedelmi És Szolgáltató Kft. A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek
BR112021008905A2 (pt) 2018-11-06 2021-08-10 Edgewise Therapeutics, Inc. compostos de piridazinona e usos dos mesmos
CA3118908A1 (en) * 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
CA3118904A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
WO2021231572A1 (en) * 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Pyridazinone compounds for the treatment of neuromuscular diseases
EP4149465A1 (en) * 2020-05-13 2023-03-22 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
EP4149467A1 (en) * 2020-05-13 2023-03-22 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
WO2021231630A1 (en) * 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
WO2021231565A1 (en) * 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Pyridazinone compounds for the treatment of neuromuscular diseases
WO2023091606A1 (en) * 2021-11-17 2023-05-25 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
WO2023220180A1 (en) * 2022-05-11 2023-11-16 Edgewise Therapeutics, Inc. Methods of manufacturing pyridazinone compounds
WO2024055007A1 (en) 2022-09-09 2024-03-14 Edgewise Therapeutics, Inc. Pyridazinone compositions for the treatment of neuromuscular conditions

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BR112021008905A2 (pt) 2018-11-06 2021-08-10 Edgewise Therapeutics, Inc. compostos de piridazinona e usos dos mesmos
CA3118904A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
WO2021231630A1 (en) 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
WO2021231565A1 (en) 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Pyridazinone compounds for the treatment of neuromuscular diseases
EP4149467A1 (en) 2020-05-13 2023-03-22 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
EP4149465A1 (en) 2020-05-13 2023-03-22 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
WO2021231572A1 (en) 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Pyridazinone compounds for the treatment of neuromuscular diseases
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WO2024055007A1 (en) 2022-09-09 2024-03-14 Edgewise Therapeutics, Inc. Pyridazinone compositions for the treatment of neuromuscular conditions

Also Published As

Publication number Publication date
JP2022179796A (ja) 2022-12-02
SG11202104713RA (en) 2021-06-29
KR20210100094A (ko) 2021-08-13
HUE063586T2 (hu) 2024-01-28
IL282998A (en) 2021-06-30
EA202191084A1 (ru) 2021-10-19
PT3877376T (pt) 2023-09-21
JP7162132B2 (ja) 2022-10-27
US20210188814A1 (en) 2021-06-24
ES2958954T3 (es) 2024-02-16
AU2019376065A1 (en) 2021-05-27
JP2022506687A (ja) 2022-01-17
CN113272291A (zh) 2021-08-17
FI3877376T3 (fi) 2023-09-26
LT3877376T (lt) 2023-09-11
CA3118934A1 (en) 2020-05-14
WO2020097266A1 (en) 2020-05-14
HRP20231389T1 (hr) 2024-03-01
EP3877376B1 (en) 2023-08-23
ZA202103260B (en) 2023-01-25
PL3877376T3 (pl) 2024-02-19
EP3877376A1 (en) 2021-09-15
EP4248973A2 (en) 2023-09-27
US11091464B2 (en) 2021-08-17
US20240025879A1 (en) 2024-01-25
US12012395B2 (en) 2024-06-18
SI3877376T1 (sl) 2023-10-30
EP4248973A3 (en) 2023-12-06
JP7429750B2 (ja) 2024-02-08
DK3877376T3 (da) 2023-10-02
MX2021005350A (es) 2021-08-11
BR112021008905A2 (pt) 2021-08-10
US20220106291A1 (en) 2022-04-07

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