JP2022504036A - 大うつ病性障害を治療するためのエスケタミンの投与計画 - Google Patents

大うつ病性障害を治療するためのエスケタミンの投与計画 Download PDF

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JP2022504036A
JP2022504036A JP2021517954A JP2021517954A JP2022504036A JP 2022504036 A JP2022504036 A JP 2022504036A JP 2021517954 A JP2021517954 A JP 2021517954A JP 2021517954 A JP2021517954 A JP 2021517954A JP 2022504036 A JP2022504036 A JP 2022504036A
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administration
escutamine
treatment
dosage form
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Japanese (ja)
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JP2022504036A5 (https=
Inventor
カガン、エレナ
パスティーノ、ジーナ
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クレキシオ バイオサイエンシーズ エルティーディー．
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Priority claimed from PCT/IB2018/059107 external-priority patent/WO2020070547A1/en
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Publication of JP2022504036A publication Critical patent/JP2022504036A/ja
Publication of JP2022504036A5 publication Critical patent/JP2022504036A5/ja
Priority to JP2024078458A priority Critical patent/JP2024105527A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
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    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
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    • A61K9/2004—Excipients; Inactive ingredients
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    • A—HUMAN NECESSITIES
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021517954A 2018-10-05 2019-10-04 大うつ病性障害を治療するためのエスケタミンの投与計画 Pending JP2022504036A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024078458A JP2024105527A (ja) 2018-10-05 2024-05-14 大うつ病性障害を治療するためのエスケタミンの投与計画

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862741562P 2018-10-05 2018-10-05
US62/741,562 2018-10-05
IBPCT/IB2018/059107 2018-11-19
PCT/IB2018/059107 WO2020070547A1 (en) 2018-10-05 2018-11-19 Dosage regime of esketamine for treating major depressive disorder
US201962867354P 2019-06-27 2019-06-27
US62/867,354 2019-06-27
PCT/IB2019/058476 WO2020070706A1 (en) 2018-10-05 2019-10-04 Dosage regime of esketamine for treating major depressive disorder

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JP2022504036A true JP2022504036A (ja) 2022-01-13
JP2022504036A5 JP2022504036A5 (https=) 2023-11-10

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JP2024078458A Pending JP2024105527A (ja) 2018-10-05 2024-05-14 大うつ病性障害を治療するためのエスケタミンの投与計画

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US (9) US11865088B2 (https=)
EP (1) EP3860579A1 (https=)
JP (2) JP2022504036A (https=)
KR (1) KR20210074275A (https=)
CN (1) CN112702995A (https=)
AU (1) AU2019352028A1 (https=)
CA (1) CA3113198A1 (https=)
IL (1) IL280845A (https=)
WO (1) WO2020070706A1 (https=)

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