JP2022501341A5 - - Google Patents
Info
- Publication number
- JP2022501341A5 JP2022501341A5 JP2021514531A JP2021514531A JP2022501341A5 JP 2022501341 A5 JP2022501341 A5 JP 2022501341A5 JP 2021514531 A JP2021514531 A JP 2021514531A JP 2021514531 A JP2021514531 A JP 2021514531A JP 2022501341 A5 JP2022501341 A5 JP 2022501341A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- ligand
- camptothecin
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862732199P | 2018-09-17 | 2018-09-17 | |
| US62/732,199 | 2018-09-17 | ||
| PCT/US2019/051457 WO2020061007A1 (en) | 2018-09-17 | 2019-09-17 | Polymer-based macromolecular prodrugs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022501341A JP2022501341A (ja) | 2022-01-06 |
| JP2022501341A5 true JP2022501341A5 (https=) | 2022-09-26 |
| JP7546552B2 JP7546552B2 (ja) | 2024-09-06 |
Family
ID=69887739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021514531A Active JP7546552B2 (ja) | 2018-09-17 | 2019-09-17 | ポリマーベースの高分子プロドラッグ |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US11253603B2 (https=) |
| EP (1) | EP3852793B1 (https=) |
| JP (1) | JP7546552B2 (https=) |
| KR (1) | KR20210072002A (https=) |
| CN (2) | CN112996533B (https=) |
| AU (1) | AU2019344783B2 (https=) |
| CA (1) | CA3112778A1 (https=) |
| EA (1) | EA202190799A1 (https=) |
| MX (1) | MX2021003116A (https=) |
| WO (1) | WO2020061007A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3112778A1 (en) * | 2018-09-17 | 2020-03-26 | The Children's Hospital Of Philadelphia | Polymer-based macromolecular prodrugs |
| CN115443947B (zh) * | 2022-10-12 | 2023-11-21 | 江苏省人民医院（南京医科大学第一附属医院） | 高血压动物模型的制备方法 |
| WO2025101904A1 (en) * | 2023-11-08 | 2025-05-15 | The Children's Hospital Of Philadelphia | Norepinephrine transporter-targeted prodrugs for cancer therapy |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999052861A1 (de) | 1998-04-09 | 1999-10-21 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Neue benzylguanidinderivate für die therapie, in-vivo- und in-vitro-diagnostik |
| JP2002255821A (ja) | 2001-03-06 | 2002-09-11 | Yakult Honsha Co Ltd | 抗癌剤耐性癌に対する治療剤 |
| US7591994B2 (en) | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| US20040258754A1 (en) * | 2003-06-18 | 2004-12-23 | Valery Alakhov | Compositions for oral administration of camptothecin and its analogs |
| CA2537336C (en) | 2003-09-17 | 2013-02-26 | Nektar Therapeutics Al, Corporation | Multi-arm polymer prodrugs |
| US8394365B2 (en) | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
| WO2005042539A1 (en) * | 2003-10-29 | 2005-05-12 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| WO2007106549A2 (en) * | 2006-03-15 | 2007-09-20 | Alza Corporation | Method for treating brain cancer |
| BRPI0716808A2 (pt) * | 2006-09-15 | 2013-11-05 | Enzon Pharmaceuticals Inc | Ligantes poliméricos baseados em lisina |
| US20090074074A1 (en) | 2007-06-29 | 2009-03-19 | The Hong Kong University Of Science And Technology | Multiple description encoder and decoder for transmitting multiple descriptions |
| AU2009282413B2 (en) * | 2008-08-11 | 2014-07-17 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
| LT2349346T (lt) | 2008-09-23 | 2019-09-25 | Nektar Therapeutics | Kamptotecino provaistų (pvz., peg-irinotekano) metronominio dozavimo būdas |
| KR20110075029A (ko) | 2008-10-21 | 2011-07-05 | 엔즌 파마슈티칼스, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료 |
| CN101385860B (zh) * | 2008-10-31 | 2011-11-02 | 美国草药泉有限责任公司 | 喜树碱及其衍生物的非线性聚乙二醇前药 |
| US20120171201A1 (en) | 2009-07-22 | 2012-07-05 | Enzon Pharmaceuticals, Inc. | Methods of treating her2 positive cancer with her2 receptor antagonist in combination with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| PT2501413T (pt) | 2009-11-18 | 2019-07-10 | Nektar Therapeutics | Formas de sal de ácido de conjugados de polímero-fármaco |
| US20140371258A1 (en) | 2010-12-17 | 2014-12-18 | Nektar Therapeutics | Water-Soluble Polymer Conjugates of Topotecan |
| CN102626518B (zh) * | 2012-05-09 | 2014-05-28 | 中国药科大学 | 一种包载难溶性药物的泊洛沙姆/两亲性多糖混合胶束的制备和应用 |
| WO2014085571A1 (en) | 2012-11-28 | 2014-06-05 | Nektar Therapeutics | Method for assessing and predicting efficacy of breast cancer treatment with a long-acting topoisomerase i inhibitor |
| WO2014194289A1 (en) | 2013-05-31 | 2014-12-04 | Nektar Therapeutics | Method for predicting and evaluating responsiveness to cancer treatment with dna-damaging chemotherapeutic agents |
| MX371201B (es) | 2013-10-04 | 2020-01-22 | Prolynx Llc | Conjugados de liberación lenta de sn-38. |
| WO2015191583A2 (en) | 2014-06-09 | 2015-12-17 | Biomed Valley Discoveries, Inc. | Combination therapies targeting tumor-associated stroma or tumor cells and topoisomerase |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| US11324827B2 (en) | 2014-10-01 | 2022-05-10 | Xiamen Sinopeg Biotech Co., Ltd. | Multifunctionalized polyethylene glycol derivative and preparation method therefor |
| CN104877127B (zh) | 2015-06-23 | 2017-11-10 | 厦门赛诺邦格生物科技股份有限公司 | 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质 |
| CN107375288B (zh) | 2016-05-16 | 2019-08-23 | 博瑞生物医药（苏州）股份有限公司 | 多臂的聚合靶向抗癌偶联物 |
| US20200163956A1 (en) | 2016-09-06 | 2020-05-28 | Cerebral Therapeutics LLC | Direct brain administration of chemotherapeutics to the csf for patients with primary and secondary brain tumors |
| KR102279429B1 (ko) | 2017-04-21 | 2021-07-20 | 브라이트제네 바이오-메디컬 테크놀로지 코., 엘티디. | 멀티 암 표적 항암 콘쥬게이트 |
| JP7381083B2 (ja) | 2017-09-08 | 2023-11-15 | フォスプラティン テラピューティクス インコーポレイテッド | 免疫調節剤としてのホスファプラチン化合物およびその治療的使用 |
| WO2019090141A1 (en) | 2017-11-02 | 2019-05-09 | Vicus Therapeutics, Llc | Combination drug therapies for cancer and methods of making and using them |
| CA3099155A1 (en) | 2018-05-14 | 2019-11-21 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| CA3112778A1 (en) | 2018-09-17 | 2020-03-26 | The Children's Hospital Of Philadelphia | Polymer-based macromolecular prodrugs |
| CN111603567B (zh) | 2019-02-22 | 2024-12-27 | 赣江新区博瑞创新医药有限公司 | Cd44靶向多臂偶联物 |
| CA3138197A1 (en) | 2019-05-14 | 2020-11-19 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
-
2019
- 2019-09-17 CA CA3112778A patent/CA3112778A1/en active Pending
- 2019-09-17 MX MX2021003116A patent/MX2021003116A/es unknown
- 2019-09-17 WO PCT/US2019/051457 patent/WO2020061007A1/en not_active Ceased
- 2019-09-17 CN CN201980060783.3A patent/CN112996533B/zh active Active
- 2019-09-17 US US16/969,790 patent/US11253603B2/en active Active
- 2019-09-17 JP JP2021514531A patent/JP7546552B2/ja active Active
- 2019-09-17 EP EP19863240.8A patent/EP3852793B1/en active Active
- 2019-09-17 CN CN202510008384.XA patent/CN119950749A/zh active Pending
- 2019-09-17 KR KR1020217011264A patent/KR20210072002A/ko active Pending
- 2019-09-17 EA EA202190799A patent/EA202190799A1/ru unknown
- 2019-09-17 AU AU2019344783A patent/AU2019344783B2/en active Active
-
2022
- 2022-02-11 US US17/670,218 patent/US11642414B2/en active Active
-
2023
- 2023-04-27 US US18/140,289 patent/US12311028B2/en active Active
-
2025
- 2025-05-13 US US19/206,574 patent/US20250387496A1/en active Pending
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