JP2018503736A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018503736A5 JP2018503736A5 JP2017556786A JP2017556786A JP2018503736A5 JP 2018503736 A5 JP2018503736 A5 JP 2018503736A5 JP 2017556786 A JP2017556786 A JP 2017556786A JP 2017556786 A JP2017556786 A JP 2017556786A JP 2018503736 A5 JP2018503736 A5 JP 2018503736A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer conjugate
- polymer
- conjugate according
- kda
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000562 conjugate Substances 0.000 claims 24
- 229920000642 polymer Polymers 0.000 claims 23
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 229920001477 hydrophilic polymer Polymers 0.000 claims 4
- 229920001600 hydrophobic polymer Polymers 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 claims 3
- 229960003199 etacrynic acid Drugs 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 229920002732 Polyanhydride Polymers 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- -1 poly (alkylene glycol Chemical compound 0.000 claims 2
- 239000000580 polymer-drug conjugate Substances 0.000 claims 2
- FQJXYULOQZUKBZ-UHFFFAOYSA-N 4-[6-(4-carboxyphenoxy)hexoxy]benzoic acid Chemical group C1=CC(C(=O)O)=CC=C1OCCCCCCOC1=CC=C(C(O)=O)C=C1 FQJXYULOQZUKBZ-UHFFFAOYSA-N 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 239000004201 L-cysteine Substances 0.000 claims 1
- 229920001007 Nylon 4 Polymers 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- YOURXVGYNVXQKT-UHFFFAOYSA-N oxacycloundecane-2,11-dione Chemical compound O=C1CCCCCCCCC(=O)O1 YOURXVGYNVXQKT-UHFFFAOYSA-N 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229940116351 sebacate Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105535P | 2015-01-20 | 2015-01-20 | |
| US62/105,535 | 2015-01-20 | ||
| PCT/US2016/013914 WO2016118506A1 (en) | 2015-01-20 | 2016-01-19 | Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018503736A JP2018503736A (ja) | 2018-02-08 |
| JP2018503736A5 true JP2018503736A5 (https=) | 2019-02-28 |
Family
ID=55300792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556786A Pending JP2018503736A (ja) | 2015-01-20 | 2016-01-19 | 眼内圧を抑える抗緑内障剤の持続放出のための組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20180008718A1 (https=) |
| EP (1) | EP3247406A1 (https=) |
| JP (1) | JP2018503736A (https=) |
| CN (1) | CN107206099A (https=) |
| WO (1) | WO2016118506A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6138904B2 (ja) | 2012-03-16 | 2017-05-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート |
| WO2014124006A1 (en) | 2013-02-05 | 2014-08-14 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| CN107278151A (zh) | 2014-12-15 | 2017-10-20 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗青光眼中的使用方法 |
| US9808531B2 (en) | 2015-09-22 | 2017-11-07 | Graybug Vision, Inc. | Compounds and compositions for the treatment of ocular disorders |
| CN108367079B (zh) | 2015-11-12 | 2022-11-22 | 灰色视觉公司 | 用于治疗的聚集性微粒 |
| CA3056923A1 (en) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| US11160870B2 (en) | 2017-05-10 | 2021-11-02 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| CN115364199A (zh) * | 2021-05-19 | 2022-11-22 | 远大医药（中国）有限公司 | 包含pedf衍生的短肽的组合物及其制备方法和用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB929401A (en) | 1958-12-22 | 1963-06-19 | Upjohn Co | Encapsulated emulsions and processes for their preparation |
| GB929406A (en) | 1958-12-22 | 1963-06-19 | Upjohn Co | A process for the production of encapsulated material |
| GB969808A (en) | 1962-06-08 | 1964-09-16 | Boots Pure Drug Co Ltd | Anthelmintic compositions and compounds |
| IT1148784B (it) | 1980-04-09 | 1986-12-03 | Eurand Spa | Procedimento per la preparazione di microcapsule in un veicolo liquido |
| US4888176A (en) | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
| US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
| US4794000A (en) | 1987-01-08 | 1988-12-27 | Synthetic Blood Corporation | Coacervate-based oral delivery system for medically useful compositions |
| US4789724A (en) | 1986-10-17 | 1988-12-06 | Massachusetts Institute Of Technology | Preparation of anhydride copolymers |
| US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| KR20110096566A (ko) * | 2008-12-05 | 2011-08-30 | 인터메드 디스커버리 게엠베하 | Ｈｉｆ-1 단백질 축적의 억제제 |
| JP6138904B2 (ja) * | 2012-03-16 | 2017-05-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート |
| US8962577B2 (en) * | 2012-03-16 | 2015-02-24 | The Johns Hopkins University | Controlled release formulations for the delivery of HIF-1 inhibitors |
| AU2013240247A1 (en) * | 2012-03-27 | 2014-10-16 | Duke University | Ophthalmic drug delivery device and methods of use |
| CN103833998B (zh) * | 2012-11-26 | 2017-10-27 | 杨子剑 | 含有利尿酸结构的新化合物以及制备方法和用途 |
| CN103897174A (zh) * | 2012-12-26 | 2014-07-02 | 杨子剑 | 含有利尿酸结构的新聚合物以及制备方法和用途 |
-
2016
- 2016-01-19 WO PCT/US2016/013914 patent/WO2016118506A1/en not_active Ceased
- 2016-01-19 CN CN201680006433.5A patent/CN107206099A/zh active Pending
- 2016-01-19 US US15/545,020 patent/US20180008718A1/en not_active Abandoned
- 2016-01-19 JP JP2017556786A patent/JP2018503736A/ja active Pending
- 2016-01-19 EP EP16703016.2A patent/EP3247406A1/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018503736A5 (https=) | ||
| Tang et al. | Ocular nanomedicine | |
| Zamboulis et al. | Chitosan and its derivatives for ocular delivery formulations: Recent advances and developments | |
| Tortorella et al. | Zein as a versatile biopolymer: different shapes for different biomedical applications | |
| Budiarso et al. | Chitosan-based smart biomaterials for biomedical applications: Progress and perspectives | |
| Gopi et al. | Effective drug delivery system of biopolymers based on nanomaterials and hydrogels-a review | |
| Manjappa et al. | Polymeric mixed micelles: improving the anticancer efficacy of single-copolymer micelles | |
| Hathout et al. | Gelatin-based particulate systems in ocular drug delivery | |
| Akagi et al. | Biodegradable nanoparticles as vaccine adjuvants and delivery systems: regulation of immune responses by nanoparticle-based vaccine | |
| Wu et al. | Injectable and pH-responsive silk nanofiber hydrogels for sustained anticancer drug delivery | |
| Sultana et al. | An overview of nanogel drug delivery system | |
| Tiyaboonchai | Chitosan nanoparticles: a promising system for drug delivery | |
| Luten et al. | Biodegradable polymers as non-viral carriers for plasmid DNA delivery | |
| Tang et al. | Physical hydrogels with self-assembled nanostructures as drug delivery systems | |
| Jain et al. | An overview of nanogel–novel drug delivery system | |
| JP2018500394A5 (https=) | ||
| Hamidi et al. | Copolymers: efficient carriers for intelligent nanoparticulate drug targeting and gene therapy | |
| Phanse et al. | Functionalization of polyanhydride microparticles with di-mannose influences uptake by and intracellular fate within dendritic cells | |
| JP2019504027A (ja) | 可溶性の生物製剤、治療薬、および造影剤を封入するためのプロセス | |
| JP2015520197A5 (https=) | ||
| Chen et al. | Biomimetic nucleation of Metal–Organic frameworks on silk fibroin nanoparticles for designing Core–Shell-Structured pH-Responsive anticancer drug carriers | |
| Michalak et al. | Polymeric nanoparticles–a novel solution for delivery of antimicrobial agents | |
| CN108697810A (zh) | 用于剂的控制释放的聚合物复合材料 | |
| Osmani et al. | Cyclodextrin nanosponges in drug delivery and nanotherapeutics | |
| Thalhauser et al. | Silica particles incorporated into PLGA-based in situ-forming implants exploit the dual advantage of sustained release and particulate delivery |