JP2022500473A5 - - Google Patents
Info
- Publication number
- JP2022500473A5 JP2022500473A5 JP2021515046A JP2021515046A JP2022500473A5 JP 2022500473 A5 JP2022500473 A5 JP 2022500473A5 JP 2021515046 A JP2021515046 A JP 2021515046A JP 2021515046 A JP2021515046 A JP 2021515046A JP 2022500473 A5 JP2022500473 A5 JP 2022500473A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- alkyl
- haloalkyl
- cycloalkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862732588P | 2018-09-18 | 2018-09-18 | |
| US62/732,588 | 2018-09-18 | ||
| PCT/US2019/051272 WO2020060914A1 (en) | 2018-09-18 | 2019-09-16 | Oxabicyclo acids as lpa antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022500473A JP2022500473A (ja) | 2022-01-04 |
| JP2022500473A5 true JP2022500473A5 (https=) | 2023-11-08 |
| JP7412424B2 JP7412424B2 (ja) | 2024-01-12 |
Family
ID=68073221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021515046A Active JP7412424B2 (ja) | 2018-09-18 | 2019-09-16 | Ｌｐａアンタゴニストとしてのオキサビシクロ酸 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12428430B2 (https=) |
| EP (1) | EP3853232B1 (https=) |
| JP (1) | JP7412424B2 (https=) |
| KR (1) | KR102788997B1 (https=) |
| CN (1) | CN113366000A (https=) |
| ES (1) | ES2941774T3 (https=) |
| WO (1) | WO2020060914A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2948793T3 (es) * | 2018-09-18 | 2023-09-19 | Bristol Myers Squibb Co | Acidos cicloheptílicos como antagonistas de LPA |
| ES2946657T3 (es) * | 2018-09-18 | 2023-07-24 | Bristol Myers Squibb Co | Acidos ciclopentílicos como antagonistas de LPA |
| EP4058144A1 (en) | 2019-11-15 | 2022-09-21 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
| TWI843503B (zh) | 2020-06-03 | 2024-05-21 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| EP4161936A1 (en) | 2020-06-03 | 2023-04-12 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| WO2022240879A1 (en) | 2021-05-11 | 2022-11-17 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| KR20240007233A (ko) | 2021-05-13 | 2024-01-16 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
| NO346587B1 (en) * | 2021-06-02 | 2022-10-17 | Axichem Ab | Capsaicin derivatives in the treatment of idiopathic pulmonary fibrosis |
| WO2023107938A1 (en) | 2021-12-08 | 2023-06-15 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| TW202342017A (zh) | 2022-02-25 | 2023-11-01 | 美商洛子峰生物有限公司 | 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100390178C (zh) | 1999-11-12 | 2008-05-28 | 拜奥根Idec马萨诸塞公司 | 作为腺苷受体拮抗剂的多环烷基嘌呤 |
| WO2002062389A1 (en) | 2001-02-08 | 2002-08-15 | Ono Pharmaceutical Co., Ltd. | Remedies for urinary diseases comprising lpa receptor controlling agents |
| US20080186971A1 (en) | 2007-02-02 | 2008-08-07 | Tarari, Inc. | Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic |
| CN102574822A (zh) | 2009-08-04 | 2012-07-11 | 阿米拉制药公司 | 作为溶血磷脂酸受体拮抗剂的化合物 |
| GB2474748B (en) | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| TW201120016A (en) | 2009-12-08 | 2011-06-16 | Abbott Lab | Novel oxadiazole compounds |
| DK2648726T3 (da) | 2010-12-07 | 2018-07-16 | Amira Pharmaceuticals Inc | Polycyklisk lpa1-antagonist og anvendelser deraf |
| KR20130126659A (ko) | 2010-12-07 | 2013-11-20 | 아미라 파마슈티칼스 인코포레이티드 | 리소포스파티드산 수용체 길항제 및 섬유증 치료에서의 그의 용도 |
| WO2012138648A1 (en) | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
| WO2013070879A1 (en) | 2011-11-10 | 2013-05-16 | Bristol-Myers Squibb Company | Methods for treating spinal cord injury with lpa receptor antagonists |
| CA2870336A1 (en) | 2012-04-27 | 2013-10-31 | Novartis Ag | Cyclic bridgehead ether dgat1 inhibitors |
| JP2015520202A (ja) | 2012-06-20 | 2015-07-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｌｐａｒ拮抗薬としてのｎ−アルキルトリアゾール化合物 |
| IN2014DN09352A (https=) | 2012-06-20 | 2015-07-17 | Hoffmann La Roche | |
| US20140213538A1 (en) * | 2013-01-15 | 2014-07-31 | Intermune, Inc. | Lysophosphatidic acid receptor antagonists |
| US8962660B2 (en) | 2013-03-14 | 2015-02-24 | Bristol-Myers Squibb Company | Oxabicyclo [2.2.2] acid GPR120 modulators |
| WO2014145873A2 (en) | 2013-03-15 | 2014-09-18 | Epigen Biosciences, Inc. | Heterocyclic compounds useful in the treatment of disease |
| AR108838A1 (es) | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa |
| US11261180B2 (en) | 2017-12-19 | 2022-03-01 | Bristol-Myers Squibb Company | Cyclohexyl acid isoxazole azoles as LPA antagonists |
| JP7299892B2 (ja) | 2017-12-19 | 2023-06-28 | ブリストル－マイヤーズ スクイブ カンパニー | Ｌｐａアンタゴニストとしてのシクロヘキシル酸ピラゾールアジン |
| EP3728209B1 (en) | 2017-12-19 | 2025-12-24 | Bristol-Myers Squibb Company | Cyclohexyl acid isoxazole azines as lpa antagonists |
| ES2898364T3 (es) | 2017-12-19 | 2022-03-07 | Bristol Myers Squibb Co | Acidos carbamoilciclohexílicos ligados a N triazol como antagonistas de LPA |
| CN112041302B (zh) | 2017-12-19 | 2024-11-19 | 百时美施贵宝公司 | 作为lpa拮抗剂的吡唑o-连接的氨基甲酰基环己基酸 |
| US11447475B2 (en) | 2017-12-19 | 2022-09-20 | Bristol-Myers Squibb Company | Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists |
| JP7212047B2 (ja) | 2017-12-19 | 2023-01-24 | ブリストル－マイヤーズ スクイブ カンパニー | Ｌｐａアンタゴニストとしてのシクロヘキシル酸ピラゾールアゾール |
| WO2019126084A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Isoxazole o-linked carbamoyl cyclohexyl acids as lpa antagonists |
| EP3728216B1 (en) * | 2017-12-19 | 2023-09-06 | Bristol-Myers Squibb Company | Pyrazole n-linked carbamoyl cyclohexyl acids as lpa antagonists |
| ES2948793T3 (es) | 2018-09-18 | 2023-09-19 | Bristol Myers Squibb Co | Acidos cicloheptílicos como antagonistas de LPA |
| ES2946657T3 (es) | 2018-09-18 | 2023-07-24 | Bristol Myers Squibb Co | Acidos ciclopentílicos como antagonistas de LPA |
-
2019
- 2019-09-16 EP EP19779297.1A patent/EP3853232B1/en active Active
- 2019-09-16 US US17/276,173 patent/US12428430B2/en active Active
- 2019-09-16 KR KR1020217011085A patent/KR102788997B1/ko active Active
- 2019-09-16 CN CN201980074322.1A patent/CN113366000A/zh active Pending
- 2019-09-16 WO PCT/US2019/051272 patent/WO2020060914A1/en not_active Ceased
- 2019-09-16 JP JP2021515046A patent/JP7412424B2/ja active Active
- 2019-09-16 ES ES19779297T patent/ES2941774T3/es active Active
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