JP2022172244A - E1e2 hcvワクチン及び使用方法 - Google Patents
E1e2 hcvワクチン及び使用方法 Download PDFInfo
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Abstract
Description
本願は、2013年5月15日出願の米国仮特許出願第61/823,712号および2013年10月4日出願の同第61/887,229号の利益を主張するものであり、これらの出願は、参照によりそれら全体が本明細書に組み込まれる。
配列表は、2014年5月9日に作成され、339KBのサイズを有するテキストファイル、「UALB-017WO SeqList_ST25.txt」として本明細書に提供される。テキストファイルの内容全体が本明細書に参照により組み込まれる。
C型肝炎ウイルス(HCV)は、世界中で1.5~2億人が感染すると推定されている血液由来病原体である。HCVによる感染は、無症候性である場合があり、時には医学的介入なしで患者により治すことができる。しかしながら、大多数の患者は、慢性HCV感染を発症し、肝炎、瘢痕、さらには肝不全もしくは肝癌を引き起こすことがある。米国のみでも、300万を超える人が慢性感染を有している。
本開示は、2つ以上の異なるHCV遺伝子型からのHCV E1、E2、またはE1/E2ポリペプチドを含む免疫原性組成物を提供する。本開示は、2つ以上の異なるHCV遺伝子型からのHCV E2またはE1/E2ポリペプチドを含む免疫原性組成物を提供する。免疫原性組成物は、HCVに対して免疫応答を誘導する方法を実施するのに有用である。本開示はさらに、個体におけるHCVに対して免疫応答を刺激する方法を提供する。
(i)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ポリペプチド;
(ii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド;
(iii)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(iv)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;
(v)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型2型のE2ポリペプチド;
(vi)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;
(vii)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(viii)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ix)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;
(x)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xi)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型2型のE2ポリペプチド;
(xii)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xiii)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1ポリペプチド;または
(xiv)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体。
(i)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド;
(iii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(iv)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(v)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(vi)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド;
(vii)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(viii)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ix)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(x)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1ポリペプチド;
(xi)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xii)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xiii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;
(xiv)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(xv)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(xvi)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;または
(xvii)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド。
[本発明1001]
(a)第1のC型肝炎ウイルス(HCV)遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1E2ポリペプチドと;
(b)第2のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1E2ポリペプチドと;
(c)薬学的に許容される賦形剤と
を含み、
但し、少なくとも1つのE1ポリペプチドと少なくとも1つのE2ポリペプチドとを含む、免疫原性組成物。
[本発明1002]
前記第1のHCV遺伝子型が、遺伝子型1型であり;前記第2のHCV遺伝子型が、遺伝子型2型である、本発明1001の組成物。
[本発明1003]
前記第1のHCV遺伝子型が、遺伝子型1型であり;前記第2のHCV遺伝子型が、遺伝子型3型である、本発明1001の組成物。
[本発明1004]
(i)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ポリペプチド;
(ii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド;
(iii)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(iv)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;
(v)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型2型のE2ポリペプチド;
(vi)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;
(vii)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(viii)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ix)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;
(x)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xi)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型2型のE2ポリペプチド;
(xii)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xiii)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1ポリペプチド;または
(xiv)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体
を含む、本発明1001の組成物。
[本発明1005]
第3のHCV遺伝子型のHCV E1、E2、またはE1/E2ポリペプチドをさらに含む、本発明1004の組成物。
[本発明1006]
前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、本発明1001の組成物。
[本発明1007]
前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含む、本発明1001の組成物。
[本発明1008]
前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含み、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、本発明1001の組成物。
[本発明1009]
前記薬学的に許容される賦形剤がアジュバントを含む、本発明1001の組成物。
[本発明1010]
前記アジュバントが、MF59、ミョウバン、ポリ(DL-ラクチド-コ-グリコリド)、またはCpGオリゴヌクレオチドである、本発明1001の組成物。
[本発明1011]
(a)第1のHCV遺伝子型からのC型肝炎ウイルス(HCV)E1ポリペプチド、E2ポリペプチド、またはE1/E2ポリペプチドと;
(b)第2のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1/E2ポリペプチドと;
(c)第3のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1/E2ポリペプチドと;
(d)薬学的に許容される賦形剤と
を含み、
但し、少なくとも1つのE1ポリペプチドと少なくとも1つのE2ポリペプチドとを含む、免疫原性組成物。
[本発明1012]
前記第1のHCV遺伝子型が、遺伝子型1型であり、前記第2のHCV遺伝子型が、遺伝子型2型であり、かつ前記第3のHCV遺伝子型が、遺伝子型3型である、本発明1011の免疫原性組成物。
[本発明1013]
(i)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド;
(iii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(iv)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(v)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(vi)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド;
(vii)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(viii)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ix)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(x)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1ポリペプチド;
(xi)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xii)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xiii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;
(xiv)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(xv)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(xvi)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;または
(xvii)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド
を含む、本発明1011の免疫原性組成物。
[本発明1014]
前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型であり、かつ前記第3のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、本発明1011の組成物。
[本発明1015]
前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型であり、かつ前記第3のHCV遺伝子型からの前記HCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含む、本発明1011の組成物。
[本発明1016]
前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含み、かつ前記第3のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、本発明1011の組成物。
[本発明1017]
前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含み、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型であり、かつ前記第3のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、本発明1011の組成物。
[本発明1018]
前記薬学的に許容される賦形剤がアジュバントを含む、本発明1011の組成物。
[本発明1019]
前記アジュバントが、MF59、ミョウバン、ポリ(DL-ラクチド-コ-グリコリド)、またはCpGオリゴヌクレオチドである、本発明1011の組成物。
[本発明1020]
個体における免疫応答の誘導方法であって、
本発明1001~1019のいずれかの組成物の有効量を前記個体に投与することを含む、前記方法。
[本発明1021]
(a)HCV遺伝子型1a型のC型肝炎ウイルス(HCV)E2ポリペプチドと;
(b)HCV遺伝子型3a型のHCV E1/E2ヘテロ二量体ポリペプチドと;
(c)薬学的に許容される賦形剤と
を含む、組成物。
[本発明1022]
前記ポリペプチドの全てが野生型である、本発明1021の組成物。
[本発明1023]
前記E2ポリペプチドが全長である、本発明1021の組成物。
[本発明1024]
前記E2ポリペプチドが可溶性E2ポリペプチドである、本発明1021の組成物。
[本発明1025]
(a)HCV遺伝子型3a型のC型肝炎ウイルス(HCV)E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(b)HCV遺伝子型1a型のHCV E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(c)薬学的に許容される賦形剤と
を含む、組成物。
[本発明1026]
前記ポリペプチドの全てが野生型である、本発明1025の組成物。
[本発明1027]
前記E2ポリペプチドが全長である、本発明1025の組成物。
[本発明1028]
前記E2ポリペプチドが可溶性E2ポリペプチドである、本発明1025の組成物。
[本発明1029]
個体における免疫応答の誘導方法であって、
本発明1021~1028のいずれかの組成物の有効量を前記個体に投与することを含み、
前記組成物を、少なくともHCV遺伝子型1a型及び3a型に対して中和抗体を誘導するのに有効な量で投与する、前記方法。
[本発明1030]
個体における免疫応答の誘導方法であって、
本発明1021~1028のいずれかの組成物の有効量を前記個体に投与することを含み、
前記組成物を、少なくともHCV遺伝子型1a型及び3a型に対して細胞傷害性Tリンパ球応答を誘導するのに有効な量で投与する、前記方法。
[本発明1031]
個体における免疫応答の誘導方法であって、
本発明1021~1028のいずれかの組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型及び3a型の50%以上の中和を達成するのに有効な量で投与する、前記方法。
[本発明1032]
(a)HCV遺伝子型2a型のC型肝炎ウイルス(HCV)E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(b)HCV遺伝子型1a型のHCV E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(c)薬学的に許容される賦形剤と
を含む、組成物。
[本発明1033]
前記ポリペプチドの全てが野生型である、本発明1032の組成物。
[本発明1034]
前記E2ポリペプチドが全長である、本発明1032の組成物。
[本発明1035]
前記E2ポリペプチドが可溶性E2ポリペプチドである、本発明1032の組成物。
[本発明1036]
個体における免疫応答の誘導方法であって、
本発明1032~1035のいずれかの組成物の有効量を前記個体に投与することを含み、
前記組成物を、少なくともHCV遺伝子型1a型及び2a型に対して中和抗体を誘導するのに有効な量で投与する、前記方法。
[本発明1037]
個体における免疫応答の誘導方法であって、
本発明1032~1035のいずれかの組成物の有効量を前記個体に投与することを含み、
前記組成物を、少なくともHCV遺伝子型1a型及び2a型に対して細胞傷害性Tリンパ球応答を誘導するのに有効な量で投与する、前記方法。
[本発明1038]
個体における免疫応答の誘導方法であって、
本発明1032~1035のいずれかの組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型及び2a型の50%以上の中和を達成するのに有効な量で投与する、前記方法。
[本発明1039]
(a)HCV遺伝子型1a型のC型肝炎ウイルス(HCV)E2またはHCV E1/E2ヘテロ二量体ポリペプチドと;
(b)HCV遺伝子型2a型のHCV E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(c)HCV遺伝子型3a型のE2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(d)薬学的に許容される賦形剤と
を含む、組成物。
[本発明1040]
前記ポリペプチドの全てが野生型である、本発明1039の組成物。
[本発明1041]
前記E2ポリペプチドの少なくとも1つが全長である、本発明1039の組成物。
[本発明1042]
前記E2ポリペプチドの少なくとも1つが可溶性E2ポリペプチドである、本発明1039の組成物。
[本発明1043]
HCV遺伝子型7a型のE1/E2ポリペプチドを含む、本発明1039~1042のいずれかの組成物。
[本発明1044]
HCV遺伝子型7a型のE2ポリペプチドを含む、本発明1039~1042のいずれかの組成物。
[本発明1045]
個体における免疫応答の誘導方法であって、
本発明1039~1044のいずれかの組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型、1b型、2a型、2b型、3a型、4a型、5a型、6a型、及び7a型に対して中和抗体を誘導するのに有効な量で投与する、前記方法。
[本発明1046]
個体における免疫応答の誘導方法であって、
本発明1039~1044のいずれかの組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型、1b型、2a型、2b型、3a型、4a型、5a型、6a型、及び7a型に対して細胞傷害性Tリンパ球応答を誘導するのに有効な量で投与する、前記方法。
[本発明1047]
個体における免疫応答の誘導方法であって、
本発明1039~1044のいずれかの組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型、1b型、2a型、2b型、3a型、4a型、5a型、6a型、及び7a型の50%以上の中和を達成するのに有効な量で投与する、前記方法。
本明細書で使用される場合、用語「C型肝炎ウイルス」(「HCV」)とは、C型肝炎ウイルスの多数の異なる遺伝子型及び単離体のいずれか1つのことを指す。従って、「HCV」は、例えば、遺伝子型1型、2型、3型、4型、6型、7型など、亜型(例えば、1a、1b、2a、2b、3a、4a、4cなど)、及び準種を含む、HCVの多数の遺伝子型、亜型、または準種のいずれかを包含する。代表的なHCV遺伝子型及び単離体としては、「カイロン」単離体HCV-1、H77、J6、Con1、単離体1、BK、EC1、EC10、HC-J2、HC-J5;HC-J6、HC-J7、HC-J8、HC-JT、HCT18、HCT27、HCV-476、HCV-KF、「湖南」、「日本」、「台湾」、TH、1型、1a型、H77 1b型、1c型、1d型、1e型、1f型、10型、2型、2a型、2b型、2c型、2d型、2f型、3型、3a型、3b型、3g型、4型、4a型、4c型、4d型、4f型、4h型、4k型、5型、5a型、6型、及び6a型が挙げられる。
本開示は、2つ以上の異なるHCV遺伝子型からのHCV E1、E2、またはE1/E2ポリペプチドを含む免疫原性組成物を提供する。本開示は、2つ以上の異なるHCV遺伝子型からのHCV E2またはE1/E2ポリペプチドを含む免疫原性組成物を提供する。免疫原性組成物は、HCVに対して免疫応答を誘導する方法を実施するのに有用である。本開示はさらに、個体におけるHCVに対して免疫応答を刺激する方法を提供する。
本開示は、HCV構造ポリペプチド、例えば、E1、E2、及び/またはE1/E2を含む免疫原性組成物を提供し、ここで、組成物は、少なくとも2つの異なるHCV遺伝子型からのHCV構造ポリペプチドを含む。本開示は、2つ以上の異なるHCV遺伝子型からのHCV E2またはE1/E2ポリペプチドを含む免疫原性組成物を提供する。
本開示の免疫原性組成物で使用するのに適したHCV E1ポリペプチドは、約150アミノ酸(aa)~約175aa、約175aa~約195aa、約131aa~約175aa、または約175aa~約193aaの長さを有してもよい。
本免疫原性組成物で使用するのに適したE2ポリペプチドは、約200アミノ酸(aa)~約250aa、約250aa~約275aa、約275aa~約300aa、約300aa~約325aa、約325aa~約350aa、または約350aa~約365aaの長さを有してもよい。
場合によっては、本免疫原性組成物に存在するE2ポリペプチドは、野生型E2ポリペプチドと比べてE2ポリペプチドのグリコシル化が減少しているように修飾される。野生型HCV E2は、E2N1及び/またはE2N6でグリコシル化され、参考株H77は、残基Asn-417及び/またはAsn-532をそれぞれ含む。「E2N1」及び「E2N6」とは、天然に存在するHCV E2ポリペプチドをN結合グリコシル化することができるアミノ酸配列モチーフのことを指し、該モチーフは、図1A~1C、図2A~2E、及び図5の配列に示すようにE2ポリペプチドに位置する。例えば、図1A~1Cに示すように、遺伝子型1型の参照株H77において、E2N1部位は、Asn-417を含み、E2N6部位は、Asn-532を含む。別の例として、図2A及び2Bに示すように、E2N1部位は、Asn-418を含み、E2N6部位は、Asn-534を含む。別の例として、図8A及び8Bに示すように、E2N1部位は、Asn-417を含み、E2N6部位は、Asn-533を含む。
本開示は、HCV遺伝子型1型のE1/E2を含む免疫原性組成物を提供する。場合によっては、免疫原性組成物は、HCV遺伝子型1型のE1/E2のみを含み、例えば、免疫原性組成物は、他の任意のHCV遺伝子型のE1ポリペプチド、E2ポリペプチド、またはE1/E2ヘテロ二量体を含まない。
本開示の組成物は、(a)第1のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1/E2ヘテロ二量体ポリペプチド複合体と;(b)第2のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1/E2ヘテロ二量体ポリペプチド複合体と;(c)薬学的に許容される賦形剤とを含み、但し、組成物は、少なくとも1つのE1ポリペプチドと少なくとも1つのE2ポリペプチドとを含む。E2ポリペプチドは、E1ポリペプチドとのヘテロ二量体複合体中の組成物に存在していてもよいし、あるいはE1ポリペプチドと複合化していない組成物に存在していてもよい。
(a)第1のHCV遺伝子型のE1/E2ヘテロ二量体ポリペプチド複合体;及び第2のHCV遺伝子型のE1/E2ヘテロ二量体ポリペプチド複合体;
(b)第1のHCV遺伝子型のE1/E2ヘテロ二量体ポリペプチド複合体;及び第2のHCV遺伝子型のE2ポリペプチド;
(c)第1のHCV遺伝子型のE2ポリペプチド;及び第2のHCV遺伝子型のE1/E2ヘテロ二量体ポリペプチド複合体;
(d)第1のHCV遺伝子型のE1ポリペプチド;及び第2のHCV遺伝子型のE2ポリペプチド;
(e)第1のHCV遺伝子型のE1ポリペプチド;及び第2のHCV遺伝子型のE1/E2ヘテロ二量体ポリペプチド複合体;
(f)第1のHCV遺伝子型のE2ポリペプチド;及び第2のHCV遺伝子型のE1ポリペプチド;または
(g)第1のHCV遺伝子型のE2ポリペプチド;及び第2のHCV遺伝子型のE1/E2ヘテロ二量体ポリペプチド複合体。
(1)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(2)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド、例えば、ここで、全てのポリペプチドは、野生型である;
(3)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(4)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(5)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型2型のE2ポリペプチド、例えば、ここで、全てのポリペプチドは、野生型である;
(6)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(7)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド、例えば、ここで、全てのポリペプチドは、野生型である;
(8)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(9)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド、例えば、ここで、全てのポリペプチドは、野生型である;
(10)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(11)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型2型のE2ポリペプチド、例えば、ここで、全てのポリペプチドは、野生型である;
(12)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(13)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1ポリペプチド、例えば、ここで、全てのポリペプチドは、野生型である;
(14)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である、が挙げられる。
15)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、野生型である;
16)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、野生型である;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;
17)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;及びHCV遺伝子型3型のE2ポリペプチド、ここで、E2ポリペプチドは、野生型である;
18)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、野生型である;及びHCV遺伝子型3型のE2ポリペプチド、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;
19)HCV遺伝子型1型のE2ポリペプチド、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、野生型である;
20)HCV遺伝子型1型のE2ポリペプチド、ここで、E2ポリペプチドは、野生型である;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;
21)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、野生型である;
22)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、野生型である;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;
23)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;及びHCV遺伝子型2型のE2ポリペプチド、ここで、E2ポリペプチドは、野生型である;
24)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、野生型である;及びHCV遺伝子型2型のE2ポリペプチド、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;
25)HCV遺伝子型1型のE2ポリペプチド、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、野生型である;
26)HCV遺伝子型1型のE2ポリペプチド、ここで、E2ポリペプチドは、野生型である;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体、ここで、E2ポリペプチドは、上述のようなE2N1部位及び/またはE2N6部位におけるアスパラギンの修飾(例えば、置換)を含む。
本開示の組成物は、(a)第1のHCV遺伝子型からのHCV E2ポリペプチドまたはE1/E2ヘテロ二量体ポリペプチド複合体と;(b)第2のHCV遺伝子型からのHCV E2ポリペプチドまたはE1/E2ヘテロ二量体ポリペプチド複合体と;(c)薬学的に許容される賦形剤とを含む。E2ポリペプチドは、E1ポリペプチドとのヘテロ二量体複合体中の組成物に存在していてもよいし、あるいはE1ポリペプチドと複合化していない組成物に存在していてもよい。E2ポリペプチドは、可溶性であってもよい。
本開示の組成物は、(a)第1のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1/E2ヘテロ二量体ポリペプチド複合体と;(b)第2のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1/E2ヘテロ二量体ポリペプチド複合体と;(c)第3のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1/E2ヘテロ二量体ポリペプチド複合体と;(d)薬学的に許容される賦形剤とを含み、但し、組成物は、少なくとも1つのE1ポリペプチドと少なくとも1つのE2ポリペプチドとを含む。E2ポリペプチドは、E1ポリペプチドとのヘテロ二量体複合体中の組成物に存在していてもよいし、あるいはE1ポリペプチドと複合化していない組成物に存在していてもよい。以下に記載の組成物において、「E2」は、E1ポリペプチドと複合化していないE2ポリペプチドを指すが、「E1/E2」は、ヘテロ二量体ポリペプチド複合体中に一緒に存在するE1及びE2を指す。同様に、E1ポリペプチドは、E2ポリペプチドとのヘテロ二量体複合体中の組成物に存在していてもよいし、あるいはE2ポリペプチドと複合化していない組成物に存在していてもよい。以下に記載の組成物において、「E1」は、E2ポリペプチドと複合化していないE1ポリペプチドを指すが、「E1/E2」は、ヘテロ二量体ポリペプチド複合体中に一緒に存在するE1及びE2を指す。
(i)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(ii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド、例えば、ここで、全てのポリペプチドは、野生型である;
(iii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(iv)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である;
(v)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド、例えば、ここで、全てのポリペプチドは、野生型である;
(vi)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド、例えば、ここで、全てのポリペプチドは、野生型である;
(vii)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体、例えば、ここで、全てのポリペプチドは、野生型である.
(viii)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ix)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(x)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1ポリペプチド;
(xi)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xii)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xiii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;
(xiv)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(xv)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(xvi)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;
(xvii)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド。
本開示の組成物は、(a)第1のHCV遺伝子型からのHCV E2ポリペプチドまたはE1/E2ヘテロ二量体ポリペプチド複合体と;(b)第2のHCV遺伝子型からのHCV E2ポリペプチドまたはE1/E2ヘテロ二量体ポリペプチド複合体と;(c)第3のHCV遺伝子型からのHCV E2ポリペプチドまたはE1/E2ヘテロ二量体ポリペプチド複合体と;(d)薬学的に許容される賦形剤とを含む。E2ポリペプチドは、E1ポリペプチドとのヘテロ二量体複合体中の組成物に存在していてもよいし、あるいはE1ポリペプチドと複合化していない組成物に存在していてもよい。E2ポリペプチドは、可溶性であってもよい。
E1及びE2ポリペプチドは、組換え方法及び非組換え方法(例えば、化学合成)を含む任意の適当な方法によって作製することができる。
HCV E1、E2、及びE1/E2ポリペプチドは、薬学的に許容される賦形剤(単数または複数)と製剤化し、本免疫原性組成物を生成することができる。多種多様な薬学的に許容される賦形剤が、当該技術分野では公知であり、本明細書で詳細に論じる必要はない。薬学的に許容される賦形剤は、例えば、A.Gennaro(2000年)「Remington:The Science and Practice of Pharmacy」、第20版、Lippincott,Williams,& Wilkins;Pharmaceutical Dosage Forms and Drug Delivery Systems(1999年)H.C.Ansel他編、第7版、Lippincott,Williams,& Wilkins;及びHandbook of Pharmaceutical Excipients(2000年)A.H.Kibbe他編、第3版 Amer.Pharmaceutical Assocを含めた様々な出版物に十分に記載されている。
本開示の免疫原性組成物は、アジュバントを含み得る。ヒトにおいて使用され得る公知の適当なアジュバントの例としては、ミョウバン、リン酸アルミニウム、水酸化アルミニウム、MF59(4.3% w/vスクアレン、0.5% w/v Tween80(商標)、0.5% w/v Span85)、CpG含有核酸(シトシンがメチル化されていない)、QS21、MPL、3DMPL、Aquillaからの抽出物、ISCOMS、LT/CT変異体、ポリ(D,L-ラクチド-コ-グリコリド)(PLG)ミクロ粒子、Quil A、インターロイキンなどが挙げられるが、必ずしもそれらに限定されない。実験用動物には、フロイント、N-アセチル-ムラミル-L-スレオニル-D-イソグルタミン(thr-MDP)、N-アセチル-ノル-ムラミル-L-アラニル-D-イソグルタミン(CGP11637、ノル-MDPと呼ばれる)、N-アセチルムラミル-L-アラニル-D-イソグルタミニル-L-アラニン-2-(1'-2'-ジパルミトイル-sn-グリセロ-3-ヒドロキシホスホリルオキシ)-エチルアミン(CGP19835A、MTP-PEと呼ばれる)、ならびに、2%スクアレン/Tween80乳濁液中に細菌から抽出された3種類の成分、モノホスホリル脂質A、トレハロースジミコレート、及び細胞壁骨格(MPL+TDM+CWS)を含有するRIBIを使用することができる。アジュバントの有効性は、免疫原性抗原またはその抗原エピトープに対する抗体の量を測定すること、抗原に対する細胞傷害性Tリンパ球応答を測定すること、及び抗原に対するヘルパーT細胞応答を測定することの1つ以上によって判定してもよい。
本開示は、哺乳動物対象において少なくとも1つのHCV遺伝子型に対する免疫応答の誘導方法を提供する。本方法は、一般に、本免疫原性組成物の有効量を、それを必要とする個体に投与することを含む。
本開示のHCV組成物の投与に適する個体には、免疫学的にナイーブな個体(例えば、HCVに感染していない個体及び/またはHCVワクチンを投与されていない個体)が含まれる。
材料及び方法
ヤギ免疫化
ヤギ(G714及びG757)及びヤギ(G766及びG773)をHCV1(遺伝子型1a型)由来のE1E2及びJ6(遺伝子型2a型)由来のE2でそれぞれ免疫化した。組換えE1E2及び可溶性E2タンパク質は、HCV遺伝子型1a型株及びHCV遺伝子型2a型株の配列からそれぞれ誘導された。組換えE1E2タンパク質は、糖タンパク質を構成的に発現するチャイニーズハムスター卵巣細胞株から精製し;E2タンパク質は、E2糖タンパク質を発現する293T細胞の培地から精製した。スクアレンベースのAddavaxまたはフロイントアジュバントのいずれかと共に10μgの精製タンパク質抗原(E2E1またはE2)からなる、0.5mlの実験ワクチンを、ヤギに投与した。このデータで用いたワクチン接種後の血清は、4回ワクチン接種して免疫化した後の129日目に収集した。ワクチン接種前に収集した血清は、陰性対照として用いた。
in vitroの細胞培養で産生されたキメラ遺伝子型1a型H77c/JFH1または遺伝子型2a型J6/JFH1 HCV(HCVcc)に対するワクチン接種後のヤギ血清の中和活性について試験した。
組織培養由来のキメラ遺伝子型1a型(H77c/JFH1)または2a型(J6/JFH1)に対するワクチン接種後のヤギ血清の中和活性についてin vitro中和アッセイを用いて試験した。ヤギ(G714及びG757)は、遺伝子型1a型(G1a)の配列から誘導された組換えE1E2で免疫化したが、ヤギ(G766及びG773)は、遺伝子型2a型(G2a)の配列から誘導されたE2で免疫化した。G1a抗原は、G1aキメラウイルスH77/JFHに対して強い中和活性を誘発したが、G2aウイルスJ6/JFHに対する効果は弱かった(図4)。一方、G2aから誘導されたE2抗原は、G1aウイルスよりもG2aウイルスに対してより有効な中和抗体を誘導した。同時に、汎用ワクチンでは抗原カクテルが交差遺伝子型の防御をもたらす必要があることを、データは示している。
材料及び方法
ヤギ免疫化
ヤギ(G757、G714)をHCV1(遺伝子型1a型)由来のE1E2で免疫化し;ヤギ(G004、G752)をHCV1(遺伝子型1a型)由来のE1細胞外ドメインで免疫化し;ヤギ(G786、G799)をHCV1(遺伝子型1a型)由来のE2細胞外ドメインで免疫化し;ヤギ(G766、G733)をJ6(遺伝子型2a型)由来のE2細胞外ドメインで免疫化した。E1E2タンパク質、E1及びE2細胞外ドメインは、HCV遺伝子型1a型(H77)株及びHCV遺伝子型2a型(J6)株の配列からそれぞれ誘導された。組換え抗原は、糖タンパク質を構成的に発現するチャイニーズハムスター卵巣細胞株から精製した。スクアレンベースのAddaVaxまたはフロイント不完全アジュバント(IFA)のいずれかと共に10μgの精製タンパク質抗原(E1E2)またはモル等量のE1またはE2からなる、0.5mlの実験ワクチンを、ヤギに投与した。このデータで用いたワクチン接種後の血清は、4回ワクチン接種して免疫化した後の129日目に収集した。ワクチン接種前に収集した血清は、陰性対照として用いた。E1細胞外ドメイン及びE2細胞外ドメインは、C末端膜貫通領域が除去された可溶性E1及びE2ポリペプチドである。
in vitroの細胞培養で産生されたキメラ遺伝子型1a型H77c/JFH1または遺伝子型2a型J6/JFH1 HCV(HCVcc)に対するワクチン接種後のヤギ血清の中和活性について試験した。
ワクチンで誘導された抗体の交差中和について試験した。1:50に希釈した血清をH77/JFH1(G1a)またはJ6/JFH(G2a)のいずれかの組織培養由来のHCVでプレインキュベートした後、Huh-7.5細胞への感染に用いた。感染レベルは、フローサイトメトリーを用いてNS5a染色でモニタリングした。中和活性レベルは、ワクチン接種前のある対照セットを0%にして正規化した。ワクチン接種前の第2の血清セットを用いて、アッセイの変動を示した。
ヤギは、HCV株HCV1(遺伝子型1a型)からのE1/E2ヘテロ二量体複合体、またはHCV株J6(遺伝子型2a型)からの可溶性E2(sE2)で免疫化した。ワクチン接種後のヤギ血清を、HCV遺伝子型1a型、1b型、2a型、2b型、3a型、4a型、5a型、及び6a型に対する中和活性について試験した。データを図7A及び7Bに示す。図7aに示すデータは、HCV遺伝子型1a型からのE1/E2による免疫化により、2a型、2b型、及び3a型以外の試験した全ての遺伝子型のHCVに対する中和抗体が惹起されたことを示しており;図7bに示すデータは、HCV遺伝子型2a型からのsE2による免疫化により、遺伝子型1b型、2a型、4a型、及び6a型のHCVに対する中和抗体が惹起されたことを示している。
SEQUENCE LISTING
<110> THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
<120> E1E2 HCV VACCINES AND METHODS OF USE
<150> US 61/823,712
<151> 2013-05-15
<150> US 61/887,229
<151> 2013-10-04
<160> 53
<170> PatentIn version 3.5
<210> 1
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 1
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val
225 230 235 240
Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu
370 375 380
Thr His Val Thr Gly Gly Ser Ala Gly Arg Thr Thr Ala Gly Leu Val
385 390 395 400
Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser
420 425 430
Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Leu
465 470 475 480
Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser
515 520 525
Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr
610 615 620
Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 2
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 2
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Val Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val
225 230 235 240
Ala Leu Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu
370 375 380
Thr Tyr Thr Thr Gly Gly Ser Val Ala Gln Ala Ala Phe Gly Leu Thr
385 390 395 400
Ser Leu Phe Arg Pro Gly Pro Lys Gln Asp Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Val Pro Thr Tyr Ser
515 520 525
Trp Gly Ser Asn Glu Thr Asp Val Leu Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Ala Gly Asn
565 570 575
Arg Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Met Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 3
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 3
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Phe
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Asp Asn Thr Ser Arg Cys Trp Val
225 230 235 240
Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser Val Asp Ala Glu
370 375 380
Thr Tyr Thr Ser Gly Gly Ser Val Ala Arg Ala Thr Ala Gly Phe Ala
385 390 395 400
Gly Ile Phe Asn Pro Gly Ala Lys Gln Asp Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ala His
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro
465 470 475 480
Asp His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Ala Pro Thr Tyr Asn
515 520 525
Trp Gly Ser Asn Asp Thr Asp Val Phe Ile Leu Asn Asn Thr Arg Pro
530 535 540
Pro Gly Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Thr Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Val Thr Pro Arg Phe Leu
595 600 605
Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Leu Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 4
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 4
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Lys Cys Trp Val
225 230 235 240
Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Thr Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Ala Gly Asn Trp
355 360 365
Ala Lys Val Leu Leu Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu
370 375 380
Thr Tyr Thr Thr Gly Gly Ser Val Ala Arg Thr Thr Arg Gly Leu Ala
385 390 395 400
Ser Leu Leu Gln Val Gly Pro Lys Gln Asp Ile Arg Leu Ile His Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser
420 425 430
Leu Asp Thr Gly Trp Leu Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Gln Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Val Pro Thr Tyr Thr
515 520 525
Trp Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Gln Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 5
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 5
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Asp Asn Ala Ser Arg Cys Trp Val
225 230 235 240
Pro Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Val Ala Leu Val Met Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gln
370 375 380
Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Gly Ala Ser Gly Leu Ala
385 390 395 400
Asn Leu Phe Thr Pro Gly Ala Lys Gln Asp Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Arg His Ala Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Ser Ala Gln Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asn Arg Leu Gly Val Pro Thr Tyr Ser
515 520 525
Trp Gly Thr Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 6
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 6
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Glu Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Lys Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Val Ser Lys Cys Trp Val
225 230 235 240
Pro Val Ala Leu Thr Val Ala Thr Arg Asp Gly Asn Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Met Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ser Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser Val Asp Ala Gly
370 375 380
Thr His Val Thr Gly Gly Ser Ala Ala His Asp Val Ser Ala Leu Ala
385 390 395 400
Gly Phe Phe Arg Arg Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Val Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Arg Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Thr Asn Val Asp Gly Gly Gly Ser
465 470 475 480
Glu Tyr Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Glu Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Lys Val Gly Val Pro Thr Tyr Asn
515 520 525
Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Val Lys Val Cys Gly Ala Pro Pro Cys Ile Ile Gly Gly Ala Gly Asn
565 570 575
Lys Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Val Ala Ala Cys Asn Trp Thr Tyr Gly Glu Arg Cys Asn Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 7
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 7
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val
225 230 235 240
Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Thr Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Gly Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Ile Val Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu
370 375 380
Thr His Val Thr Gly Gly Ser Ala Ala Gln Val Thr Ser Arg Val Ala
385 390 395 400
Gly Phe Phe Asn Pro Gly Pro Lys Gln Asn Val Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr His Tyr Asn Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asn Arg Leu Gly Val Pro Thr Tyr Asn
515 520 525
Trp Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 8
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 8
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val
225 230 235 240
Ala Leu Ala Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala His
370 375 380
Thr Arg Val Thr Gly Gly Ser Ala Ala Arg Ala Thr Ala Arg Leu Thr
385 390 395 400
Thr Leu Phe Ser Pro Gly Ala Lys Gln Asp Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Ile Pro Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Phe Asn
515 520 525
Trp Gly Asp Asn Asp Thr Asp Val Leu Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Tyr
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Ile Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Val Glu Ala
740 745
<210> 9
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 9
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val
225 230 235 240
Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Ala Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gly
370 375 380
Thr His Val Thr Gly Gly Ser Ala Ala Lys Asp Thr Ser Gly Phe Thr
385 390 395 400
Ser Leu Phe Arg Ile Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Ser
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn
515 520 525
Trp Gly Cys Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Asp Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 10
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 10
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val
225 230 235 240
Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Ala Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gly
370 375 380
Thr His Val Thr Gly Gly Ser Ala Ala Lys Asp Thr Ser Gly Phe Thr
385 390 395 400
Ser Leu Phe Arg Ile Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Ser
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn
515 520 525
Trp Gly Cys Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Asp Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 11
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 11
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val
225 230 235 240
Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Ala Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gly
370 375 380
Thr His Val Thr Gly Gly Ser Ala Ala Lys Asp Thr Ser Gly Phe Thr
385 390 395 400
Ser Leu Phe Arg Ile Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Ser
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn
515 520 525
Trp Gly Cys Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Asp Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 12
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 12
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Ser Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val
225 230 235 240
Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Ala Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu
370 375 380
Thr His Thr Thr Gly Gly Ser Ala Ala Tyr Ala Thr Ser Gly Phe Val
385 390 395 400
Gly Leu Phe Arg Gln Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Val Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser
420 425 430
Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Lys Pro Leu Ala Asn
450 455 460
Phe Asp Gln Gly Trp Gly Ser Ile Ser Tyr Thr Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr Phe Asn
515 520 525
Trp Gly Glu Asn Glu Ser Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Ser Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Asn Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Val Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Leu Asn Tyr
610 615 620
Ser Leu Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu
625 630 635 640
Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Thr Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Val Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 13
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 13
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val
225 230 235 240
Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg His His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr
370 375 380
Thr His Thr Thr Gly Gly Ala Val Ala His Asn Thr Arg Met Phe Thr
385 390 395 400
Ser Ile Phe Ser Leu Gly Pro Arg Gln Glu Ile Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser
420 425 430
Leu Glu Thr Gly Trp Ile Ala Gly Leu Leu Tyr Ala Asn Arg Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro
465 470 475 480
Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Thr Pro Thr Tyr Asp
515 520 525
Trp Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Ala Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Tyr
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Ser Asn
565 570 575
Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Val Lys Trp Glu Tyr Val Ile
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 14
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 14
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ala Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr
245 250 255
Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Leu Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ala
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly
370 375 380
Thr Tyr Val Thr Gly Gly Thr Met Ala Lys Asn Thr Leu Gly Ile Thr
385 390 395 400
Ser Leu Phe Ser Pro Gly Ser Ser Gln Lys Ile Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Val His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Ser Pro Ile Asp Ala
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Asn Glu Ser His Ser Ser
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Ala Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser
515 520 525
Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Ile Gly Asn
565 570 575
Lys Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe
610 615 620
Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Val Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val Leu
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 15
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 15
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Val Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr
245 250 255
Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Ile Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Glu
370 375 380
Thr Arg Val Thr Gly Gly Gln Ile Ala Arg Asn Ala Tyr Ser Leu Thr
385 390 395 400
Thr Leu Phe Ser Ser Gly Ser Ala Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr His Lys Phe Asn
435 440 445
Ala Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Ile Asp Lys
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Gln Gly Gly Gln
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Lys Pro Cys Gly Ile
485 490 495
Val Ser Ala Ser Lys Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser
515 520 525
Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Gly Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Gly Gly Asn
565 570 575
Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Ala Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ala Asn Phe
610 615 620
Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp
645 650 655
Arg Asp Arg Leu Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Asp Tyr Ile Val
705 710 715 720
Ile Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 16
<211> 747
<212> PRT
<213> Hepatitis C virus
<400> 16
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Ile Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Leu Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Gly Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala His
180 185 190
Glu Val Arg Asn Ala Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Leu Ile Met His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Thr Ile Pro Thr Thr
245 250 255
Thr Ile Arg His His Val Asp Leu Leu Val Gly Ala Ala Ala Leu Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Ala Thr Leu Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ala Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Val Ile Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Ala Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly His
370 375 380
Thr Leu Thr Thr Gly Gly His Ala Ala Arg Leu Thr Ser Gly Phe Ala
385 390 395 400
Gly Leu Phe Thr Pro Gly Pro Ser Gln Arg Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Ala His Arg Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Ile Asp Lys
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Thr Lys Asp
465 470 475 480
Pro Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Gln Gln Cys Gly
485 490 495
Ile Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Asn Pro Thr Tyr
515 520 525
Ser Trp Gly Glu Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr Arg
530 535 540
Pro Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Gly Gly Val Gly
565 570 575
Asn Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu
580 585 590
Ala Thr Tyr Ser Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys
595 600 605
Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn
610 615 620
Phe Ser Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg
625 630 635 640
Leu Asn Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp
645 650 655
Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu
660 665 670
Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr
675 680 685
Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr
690 695 700
Gly Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val
705 710 715 720
Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu
725 730 735
Trp Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 17
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 17
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg His Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Val Ile Met His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Val Thr
245 250 255
Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Pro Val Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Gln Thr Val Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Met Ile Val Leu Leu Leu Phe Ala Gly Val Asp Gly Thr
370 375 380
Thr His Thr Thr Gly Gly Ala Ala Ala Arg Ala Thr Gln Gly Phe Thr
385 390 395 400
Ser Phe Phe Ser Leu Gly Pro Ser Gln Lys Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr Tyr Arg Phe Asn
435 440 445
Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Asp Ser Ser
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Thr
515 520 525
Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Ala Gly Asn
565 570 575
Thr Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Ala Val Asn Phe
610 615 620
Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Asn Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Ile Gly Ser Ala Val Ile Pro Phe Ala Ile Lys Trp Glu Tyr Val Leu
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 18
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 18
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ile Ile Met His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Lys Asn Ile Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ile Ser Val Pro Thr Ala
245 250 255
Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Trp His Glu Thr Val Gln Asp Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Ile Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Ala Asp Gly Thr
370 375 380
Thr His Val Thr Gly Gly Val Gln Ala His Gly Ala Tyr Gly Leu Ala
385 390 395 400
Ser Leu Phe Asn Val Gly Pro His Gln Lys Ile Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Thr
420 425 430
Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Lys His Arg Phe Asn
435 440 445
Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Asp Arg Leu
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Leu Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser
515 520 525
Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Tyr
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu
595 600 605
Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe
610 615 620
Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu
625 630 635 640
Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Arg Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val Leu
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 19
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 19
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Val Ile Met His Ala Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr
245 250 255
Thr Leu Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Ile Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Val Met Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly His
370 375 380
Thr Arg Val Thr Gly Gly Val Gln Gly His Val Thr Ser Thr Leu Thr
385 390 395 400
Ser Leu Phe Arg Pro Gly Ala Ser Gln Lys Ile Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Lys Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr His Lys Phe Asn
435 440 445
Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Ile Asp Lys
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Gln Pro Asp Asn Ser
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Gln Cys Gly Ile
485 490 495
Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Ala Pro Thr Tyr Asn
515 520 525
Trp Gly Asp Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro His Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Arg Gly Val Gly Asn
565 570 575
Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe
610 615 620
Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp
645 650 655
Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Ile Leu Pro Cys Ser Tyr Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Ile Gln Tyr Leu Tyr Gly
690 695 700
Ile Gly Ser Ala Val Val Ser Ile Ala Ile Lys Trp Glu Tyr Val Val
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 20
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 20
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asp Glu Gly Met Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ile Ile Met His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Lys Asn Thr Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ile Ser Val Pro Thr Thr
245 250 255
Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Ala Asp Gly Thr
370 375 380
Thr His Val Thr Gly Gly Val Gln Ala His Gly Ala Tyr Gly Leu Ala
385 390 395 400
Ser Leu Phe Asn Val Gly Pro His Gln Lys Ile Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Thr
420 425 430
Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Lys His Arg Phe Asn
435 440 445
Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Asp Arg Leu
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Leu Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser
515 520 525
Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Asn Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe
610 615 620
Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu
625 630 635 640
Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Arg Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Ile Leu
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 21
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 21
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Asp Asn Ser Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ser Ser Val Pro Thr Thr
245 250 255
Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Ile Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Arg Tyr Glu Thr Val Gln Asp Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Asn
370 375 380
Thr Arg Val Ser Gly Gly Glu Ala Ala Lys Asn Thr Met Gly Phe Ala
385 390 395 400
Ser Leu Phe Val Ser Gly Pro Ser Gln Lys Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asp Asp Ser
420 425 430
Leu His Thr Gly Phe Leu Ala Ala Leu Phe Tyr Ala His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Ser Gly Arg Met Ala Ser Cys Arg Pro Ile Asp Glu
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Thr His Gly Val Pro Asp Asn Leu
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Ala Pro Thr Tyr Ser
515 520 525
Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Met
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe
610 615 620
Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Val Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Val Val Val Ser Val Val Ile Arg Trp Glu Tyr Val Val
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 22
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 22
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Met Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Leu His Ala Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr
245 250 255
Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Leu Leu Val Ser
275 280 285
Gln Ile Phe Thr Phe Ser Pro Arg Arg His Glu Thr Met Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly
370 375 380
Thr Tyr Val Thr Gly Gly Glu Ala Gly Arg Arg Thr Ser Gly Phe Ala
385 390 395 400
Ser Ile Phe Thr Pro Gly Ala Ser Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu His Thr Gly Phe Ile Ala Ala Leu Phe Tyr His His Lys Phe Asn
435 440 445
Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Gly Glu
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Thr Glu Pro Pro Ser Ser
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr Tyr Asn
515 520 525
Trp Gly Asp Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Gly Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Ile
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe
610 615 620
Thr Ile Thr Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Ile Met Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Ile Gln Tyr Leu Tyr Gly
690 695 700
Ile Gly Ser Ala Ala Val Ser Phe Ala Ile Arg Trp Glu Tyr Val Leu
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 23
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 23
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Met Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Leu His Ala Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr
245 250 255
Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Leu Leu Val Ser
275 280 285
Gln Ile Phe Thr Phe Ser Pro Arg Arg His Glu Thr Met Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly
370 375 380
Thr Tyr Val Thr Gly Gly Glu Ala Gly Arg Arg Thr Ser Gly Phe Ala
385 390 395 400
Ser Ile Phe Thr Pro Gly Ala Ser Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu His Thr Gly Phe Ile Ala Ala Leu Phe Tyr His His Lys Phe Asn
435 440 445
Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Gly Glu
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Thr Glu Pro Pro Ser Ser
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr Tyr Asn
515 520 525
Trp Gly Asp Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Gly Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Ile
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe
610 615 620
Thr Ile Thr Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Ile Met Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Ile Gln Tyr Leu Tyr Gly
690 695 700
Ile Gly Ser Ala Ala Val Ser Phe Ala Ile Arg Trp Glu Tyr Val Leu
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 24
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 24
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Thr Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Met Ile Met His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Asp Asn Phe Thr Arg Cys Trp Val
225 230 235 240
Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Gly Ser Val Pro Thr Thr
245 250 255
Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Trp His Glu Thr Val Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Ile Val Thr Leu Leu Phe Ala Gly Val Asp Gly Asn
370 375 380
Thr His Thr Ile Gly Gly Lys Gln Ala Gln Ala Thr Gly Gly Phe Val
385 390 395 400
Ala Trp Leu Ala Arg Gly Pro Ser Gln Glu Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Lys Thr Gly Phe Ile Ala Ala Leu Phe Tyr Ala His Arg Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Lys Pro Asp Ser Leu
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Gln Pro Cys Gly Ile
485 490 495
Val Pro Ala Ser Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Val Pro Thr Tyr Arg
515 520 525
Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro
530 535 540
Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ala Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Gly Gly Leu Gly Asn
565 570 575
Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Ile
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe
610 615 620
Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu
625 630 635 640
Ser Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp
660 665 670
Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Thr Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Val Leu Val Ser Phe Ala Ile Lys Trp Glu Tyr Ile Leu
705 710 715 720
Leu Phe Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ala Gln Ala Glu Ala
740 745
<210> 25
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 25
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Cys Leu Leu Pro Arg Arg Gly Pro Arg Val Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Arg Gly Pro Ser Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val
180 185 190
Glu Val Arg Asn Ser Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ala Ser Val Val Tyr Glu Thr Asp Ser Leu Ile Ile His Leu Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val
225 230 235 240
Ser Leu Ser Pro Thr Val Ala Ala Lys Asp Pro Gly Val Pro Val Asn
245 250 255
Glu Ile Arg Arg His Val Asp Leu Ile Val Gly Ala Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Leu Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Gly Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Val Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Pro Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr
370 375 380
Thr Gln Val Thr Gly Gly Thr Ala Gly Arg Asn Ala Tyr Arg Leu Ala
385 390 395 400
Ser Leu Phe Ser Thr Gly Pro Ser Gln Asn Ile Gln Leu Ile Asn Ser
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu His Thr Gly Trp Val Ala Ala Leu Phe Tyr Ser His Lys Phe Asn
435 440 445
Ser Ser Gly Arg Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Thr Ala
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Gly Gly Lys Ala Ser Asn
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Lys Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Lys Tyr Gly Val Pro Thr Tyr Thr
515 520 525
Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Ser Arg Pro
530 535 540
Pro Ile Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Ala Pro Ala Cys Asn Val Gly Gly Ser Glu Thr
565 570 575
Asn Thr Leu Ser Cys Pro Thr Asp Cys Phe Arg Arg His Pro Asp Ala
580 585 590
Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Leu Asn Pro Arg Cys Met
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Ile Phe Lys Ile Arg Met Phe Val Gly Gly Ile Glu His Arg Leu
625 630 635 640
Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp
645 650 655
Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Leu Ser Ser Val Val Thr Ser Trp Ala Ile Arg Trp Glu Tyr Val Val
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Val Glu Ala
740 745
<210> 26
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 26
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Tyr
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val
180 185 190
Gly Val Arg Asn Ser Ser Gly Val Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ala Ser Val Val Tyr Glu Thr Asp Ser Leu Ile Ile His Leu Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Gly Ser Arg Cys Trp Val
225 230 235 240
Ser Leu Ser Pro Thr Val Ala Ala Lys Asp Pro Gly Val Pro Val Asn
245 250 255
Glu Ile Arg Arg His Val Asp Leu Ile Ala Gly Ala Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly His Leu Cys Gly Ser Ile Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Leu Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Thr Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr
370 375 380
Thr Ile Val Ser Gly Gly Ser Ala Gly Arg Ser Thr Ala Gly Leu Val
385 390 395 400
Gly Leu Phe Ser Pro Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Thr
420 425 430
Leu Gln Thr Gly Trp Val Ala Gly Leu Phe Tyr Thr Asn Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Leu Ala Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Thr Asn Gly Ser Gly Pro
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile
485 490 495
Val Pro Ala Glu Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Asn
515 520 525
Trp Gly Glu Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Arg Leu Gly Asn Trp Phe Gly Gly Thr Trp Met Asn Ser Thr Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Ala Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu Tyr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Ile His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr
610 615 620
Thr Ile Phe Lys Ile Arg Met Phe Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp
645 650 655
Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Leu Ser Ser Ala Val Thr Ser Trp Val Ile Lys Trp Glu Tyr Val Val
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Val Glu Ala
740 745
<210> 27
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 27
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Val Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Ser Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val
180 185 190
Gly Val Arg Asn Ser Ser Gly Val Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ala Ser Val Val Tyr Glu Thr Glu Asn Leu Ile Met His Leu Pro
210 215 220
Gly Cys Val Pro Tyr Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val
225 230 235 240
Ser Leu Ser Pro Thr Val Ala Ala Arg Asp Ser Arg Val Pro Val Ser
245 250 255
Glu Val Arg Arg Arg Val Asp Ser Ile Val Gly Ala Ala Ala Phe Cys
260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly
275 280 285
Gln Ile Phe Thr Phe Ser Pro Arg His His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Gly Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Val Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu
370 375 380
Thr Arg Val Thr Gly Gly Ala Ala Gly His Thr Ala Phe Gly Phe Ala
385 390 395 400
Ser Phe Leu Ala Pro Gly Ala Lys Gln Lys Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser
420 425 430
Leu Asp Thr Gly Trp Leu Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Gln Pro Leu Thr Ala
450 455 460
Phe Asp Gln Gly Trp Gly Pro Ile Thr His Glu Gly Asn Ala Ser Asp
465 470 475 480
Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Leu Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Lys Lys Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Ala Gly Val Pro Thr Tyr Arg
515 520 525
Trp Gly Ala Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Ser Arg Pro
530 535 540
Pro Met Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe
545 550 555 560
Thr Lys Thr Cys Gly Ala Pro Ala Cys Asn Ile Gly Gly Ser Gly Asn
565 570 575
Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr
610 615 620
Thr Ile Phe Lys Ile Arg Met Phe Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp
645 650 655
Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Leu Ser Ser Ala Val Thr Ser Trp Val Ile Lys Trp Glu Tyr Val Val
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Val Glu Ala
740 745
<210> 28
<211> 752
<212> PRT
<213> Hepatitis C virus
<400> 28
Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu
180 185 190
Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr
225 230 235 240
Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala
245 250 255
Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly
275 280 285
Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His
325 330 335
Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Met Ala Gly Ala His
340 345 350
Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp
355 360 365
Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala His
370 375 380
Thr Tyr Thr Thr Gly Gly Thr Ala Ser Arg His Thr Gln Ala Phe Ala
385 390 395 400
Gly Leu Phe Asp Ile Gly Pro Gln Gln Lys Leu Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser
420 425 430
Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe
450 455 460
Phe Arg Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro
465 470 475 480
Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp
485 490 495
Ile Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Ala Arg Gly Val Pro Thr Tyr
515 520 525
Thr Trp Gly Glu Asn Glu Lys Asp Val Phe Leu Leu Lys Ser Gln Arg
530 535 540
Pro Pro Ser Gly Arg Trp Phe Gly Cys Ser Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Glu
565 570 575
Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe
580 585 590
Arg Lys His Pro Glu Thr Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp
595 600 605
Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
610 615 620
Pro Cys Thr Val Asp Phe Arg Leu Phe Lys Val Arg Met Phe Val Gly
625 630 635 640
Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu
645 650 655
Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu
660 665 670
His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met
675 680 685
Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp
690 695 700
Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu
705 710 715 720
Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg
725 730 735
Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Thr Glu Ala
740 745 750
<210> 29
<211> 752
<212> PRT
<213> Hepatitis C virus
<400> 29
Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Gln Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu
180 185 190
Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr
225 230 235 240
Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala
245 250 255
Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly
275 280 285
Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ser His
325 330 335
Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His
340 345 350
Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp
355 360 365
Ala Lys Val Ala Val Ile Met Val Met Phe Ser Gly Val Asp Ala Glu
370 375 380
Thr Tyr Ile Thr Gly Gly Ser Ala Ala His Gly Val Ser Thr Leu Thr
385 390 395 400
Ser Leu Phe Ser Ser Gly Pro Gln Gln Lys Leu Gln Leu Val Lys Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser
420 425 430
Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe
450 455 460
Phe Arg Gln Gly Trp Gly Ser Leu Thr Asp Ala Asn Val Thr Gly Ala
465 470 475 480
Ser Ala Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp
485 490 495
Val Val Pro Ala Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Arg Lys Gly Val Pro Thr Tyr
515 520 525
Asn Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Glu Ser Leu Arg
530 535 540
Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly
565 570 575
Gly Asn Pro Asn Asn Glu Ser His Leu Phe Cys Pro Thr Asp Cys Phe
580 585 590
Arg Lys His Pro Asp Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp
595 600 605
Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
610 615 620
Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly
625 630 635 640
Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu
645 650 655
Arg Cys Asn Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu
660 665 670
His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met
675 680 685
Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp
690 695 700
Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu
705 710 715 720
Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Ala Arg
725 730 735
Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala
740 745 750
<210> 30
<211> 752
<212> PRT
<213> Hepatitis C virus
<400> 30
Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Cys Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Arg Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Gln Ser Gly Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu
180 185 190
Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Gln Asn Asp Asn Ile Ser Thr Cys Trp Thr
225 230 235 240
Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala
245 250 255
Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly
275 280 285
Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Phe Pro Ala Leu Gly Met Ala Val Ala His
325 330 335
Val Leu Arg Val Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His
340 345 350
Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp
355 360 365
Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Val
370 375 380
Thr Tyr Thr Thr Gly Gly Ser Ala Ala His Ala Thr Arg Gly Leu Thr
385 390 395 400
Ser Leu Phe Ser Val Gly Ala Gln Gln Lys Leu Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser
420 425 430
Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Arg Phe Asn
435 440 445
Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe
450 455 460
Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Ser Gly Pro
465 470 475 480
Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Lys
485 490 495
Val Val Pro Ala Ser Gly Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr
515 520 525
Thr Trp Gly Ala Asn Asp Thr Asp Val Phe Leu Leu Glu Ser Leu Arg
530 535 540
Pro Pro Gly Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Val Lys Thr Cys Gly Ala Ser Pro Cys Asp Ile Tyr Gly Gly Gly
565 570 575
Gly Asn Ser Gly Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe
580 585 590
Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp
595 600 605
Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
610 615 620
Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly
625 630 635 640
Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu
645 650 655
Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu
660 665 670
His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met
675 680 685
Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp
690 695 700
Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu
705 710 715 720
Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Arg Arg
725 730 735
Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Thr Gln Ala Glu Ala
740 745 750
<210> 31
<211> 752
<212> PRT
<213> Hepatitis C virus
<400> 31
Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Val
1 5 10 15
Cys Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu
180 185 190
Glu Trp Arg Asn Val Ser Gly Leu Tyr Ile Leu Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro
210 215 220
Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr
225 230 235 240
Ala Leu Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala
245 250 255
Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly
275 280 285
Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Leu Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His
325 330 335
Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His
340 345 350
Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp
355 360 365
Ala Lys Val Ile Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr
370 375 380
Thr His Val Thr Gly Gly Thr Ala Gly Leu Thr Ala Phe Arg Leu Thr
385 390 395 400
Gly Leu Phe Thr Val Gly Pro Gln Gln Lys Leu Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Asn Thr Gly Phe Ile Ala Gly Leu Phe Arg Phe His Lys Phe Asn
435 440 445
Ser Thr Gly Cys Pro Glu Met Leu Ser Ser Cys Lys Pro Ile Thr Ser
450 455 460
Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Ile Pro
465 470 475 480
Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Ser Cys Glu
485 490 495
Val Val Pro Ala Leu Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr
515 520 525
Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Lys Ser Leu Arg
530 535 540
Pro Pro Gly Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Val Gln Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly
565 570 575
Gly Asp Leu Lys Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe
580 585 590
Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp
595 600 605
Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
610 615 620
Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly
625 630 635 640
Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu
645 650 655
Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Leu His Pro Leu Leu
660 665 670
His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met
675 680 685
Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp
690 695 700
Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Val
705 710 715 720
Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg
725 730 735
Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala
740 745 750
<210> 32
<211> 752
<212> PRT
<213> Hepatitis C virus
<400> 32
Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu
180 185 190
Gln Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr
225 230 235 240
Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala
245 250 255
Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly
275 280 285
Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Ala Ala Gly Met Val Val Ala His
325 330 335
Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His
340 345 350
Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp
355 360 365
Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr
370 375 380
Thr Tyr Thr Ser Gly Gly Ser Val Ala Gln Gln Ala Arg Gly Leu Ala
385 390 395 400
Asp Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asp Asp Ser
420 425 430
Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Thr Gly Cys Pro Gln Arg Leu Ser Asp Cys Lys Pro Ile Thr Phe
450 455 460
Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro
465 470 475 480
Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Arg Cys Gly
485 490 495
Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr
515 520 525
Thr Trp Gly Ala Asn Glu Thr Asp Val Phe Leu Leu Glu Ser Leu Arg
530 535 540
Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly
565 570 575
Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe
580 585 590
Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp
595 600 605
Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
610 615 620
Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Met Arg Thr Phe Val Gly
625 630 635 640
Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu
645 650 655
Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu
660 665 670
His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met
675 680 685
Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp
690 695 700
Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu
705 710 715 720
Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg
725 730 735
Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala
740 745 750
<210> 33
<211> 752
<212> PRT
<213> Hepatitis C virus
<400> 33
Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu
180 185 190
Gln Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro
210 215 220
Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr
225 230 235 240
Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala
245 250 255
Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly
275 280 285
Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Ala Ala Gly Met Val Val Ala His
325 330 335
Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His
340 345 350
Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp
355 360 365
Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr
370 375 380
Thr Tyr Thr Ser Gly Gly Ser Val Ala Gln Gln Ala Arg Gly Leu Ala
385 390 395 400
Asp Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asp Asp Ser
420 425 430
Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Thr Gly Cys Pro Gln Arg Leu Ser Asp Cys Lys Pro Ile Thr Phe
450 455 460
Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro
465 470 475 480
Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Arg Cys Gly
485 490 495
Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr
515 520 525
Thr Trp Gly Ala Asn Glu Thr Asp Val Phe Leu Leu Glu Ser Leu Arg
530 535 540
Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly
565 570 575
Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe
580 585 590
Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp
595 600 605
Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
610 615 620
Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Met Arg Thr Phe Val Gly
625 630 635 640
Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu
645 650 655
Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu
660 665 670
His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met
675 680 685
Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp
690 695 700
Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu
705 710 715 720
Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg
725 730 735
Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala
740 745 750
<210> 34
<211> 752
<212> PRT
<213> Hepatitis C virus
<400> 34
Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Cys Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Phe Ser Cys Leu Val His Pro Ala Ala Ser Leu
180 185 190
Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro
210 215 220
Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Lys Ser Thr Cys Trp Thr
225 230 235 240
Ser Val Thr Pro Thr Val Ala Val Lys Tyr Val Gly Ala Thr Thr Ala
245 250 255
Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly
275 280 285
Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His
325 330 335
Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His
340 345 350
Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp
355 360 365
Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr
370 375 380
Thr Tyr Thr Thr Gly Gly Asn Ala Ala Arg Gly Ala Ser Gly Ile Val
385 390 395 400
Ser Leu Phe Thr Pro Gly Ala Lys Gln Asn Leu Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Ile Asn Thr Gly Phe Ile Ala Gly Leu Ile Tyr Tyr His Lys Phe Asn
435 440 445
Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe
450 455 460
Phe Arg Gln Gly Trp Gly Ser Leu Thr Asp Ala Asn Ile Thr Gly Pro
465 470 475 480
Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Asp
485 490 495
Thr Ile Arg Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Ala Pro Thr Tyr
515 520 525
Asn Trp Gly Ala Asn Glu Thr Asp Met Phe Leu Leu Gln Ser Leu Arg
530 535 540
Pro Pro Ser Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly
565 570 575
Gly Asn Leu Asn Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe
580 585 590
Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp
595 600 605
Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
610 615 620
Pro Cys Thr Val Asn Phe Thr Leu Phe Arg Met Arg Thr Phe Val Gly
625 630 635 640
Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu
645 650 655
Arg Cys Asn Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu
660 665 670
His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met
675 680 685
Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp
690 695 700
Val Gln Tyr Leu Tyr Gly Ile Gly Ser Gly Val Val Gly Trp Ala Leu
705 710 715 720
Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg
725 730 735
Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala
740 745 750
<210> 35
<211> 752
<212> PRT
<213> Hepatitis C virus
<400> 35
Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Val Ile Tyr Val
20 25 30
Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Lys Pro
50 55 60
Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Ala Pro Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu
180 185 190
Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro
210 215 220
Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr
225 230 235 240
Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala
245 250 255
Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Gly Thr Met Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Pro Val Phe Leu Val Gly
275 280 285
Gln Ala Phe Thr Phe Arg Pro Arg Arg His Arg Thr Val Gln Thr Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly Gln Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His
325 330 335
Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Val Val Ala Gly Ala His
340 345 350
Trp Gly Ile Ile Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp
355 360 365
Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Ser
370 375 380
Thr His Val Thr Ala Gly Gln Ala Ala Arg Asn Ala Tyr Gly Ile Thr
385 390 395 400
Ser Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser
420 425 430
Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn
435 440 445
Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe
450 455 460
Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro
465 470 475 480
Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly
485 490 495
Ile Val Pro Ala Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Ala Pro Thr Tyr
515 520 525
Thr Trp Gly Ala Asn Lys Thr Asp Val Phe Leu Leu Glu Ser Leu Arg
530 535 540
Pro Pro Ser Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Asp Gly
565 570 575
Arg Asp Ala Gln Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe
580 585 590
Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp
595 600 605
Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
610 615 620
Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly
625 630 635 640
Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu
645 650 655
Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu
660 665 670
His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met
675 680 685
Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp
690 695 700
Val Gln Tyr Leu Tyr Gly Ile Gly Ser Gly Met Val Gly Trp Ala Leu
705 710 715 720
Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Ala Arg
725 730 735
Val Cys Val Ala Leu Trp Leu Ile Leu Thr Ile Ser Gln Ala Glu Ala
740 745 750
<210> 36
<211> 754
<212> PRT
<213> Hepatitis C virus
<400> 36
Met Ser Thr Leu Pro Lys Pro Lys Arg Gln Thr Lys Arg Asn Thr Leu
1 5 10 15
Arg Arg Pro Lys Asn Val Lys Phe Pro Ala Gly Gly Gln Ile Val Gly
20 25 30
Glu Val Tyr Val Leu Pro Arg Arg Gly Pro Gln Leu Gly Val Arg Glu
35 40 45
Val Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Thr Pro Lys Ala Arg Pro Arg Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Pro Pro Arg Gly Ser Arg Pro Ser Trp Gly Gln Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Ile Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Phe Ser Cys Leu Thr Cys Pro Ala Ser Ser Leu
180 185 190
Glu Tyr Arg Asn Ala Ser Gly Leu Tyr Leu Leu Thr Asn Asp Cys Ser
195 200 205
Asn Arg Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Leu Pro
210 215 220
Gly Cys Val Pro Cys Val Glu Thr Asp Asn Asn Asn Thr Ser Cys Trp
225 230 235 240
Thr Pro Ile Ser Pro Thr Val Ala Val Lys His Pro Gly Val Thr Thr
245 250 255
Ala Ser Ile Arg Asn His Val Asn Met Leu Val Ala Pro Pro Thr Leu
260 265 270
Cys Ser Ala Leu Tyr Val Glu Asp Ala Phe Gly Ala Val Ser Leu Val
275 280 285
Gly Gln Ala Phe Thr Phe Arg Pro Arg Gln His Lys Thr Val Gln Thr
290 295 300
Cys Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala
305 310 315 320
Trp Asp Met Met Met Asn Trp Ser Pro Ala Ile Gly Leu Val Ile Ser
325 330 335
His Leu Met Arg Leu Pro Gln Thr Phe Phe Asp Leu Val Val Gly Ala
340 345 350
His Trp Gly Val Met Ala Gly Leu Ala Tyr Phe Ser Met Gln Gly Asn
355 360 365
Trp Ala Lys Val Val Ile Val Leu Ile Met Phe Ser Gly Val Asp Ala
370 375 380
Thr Thr His Thr Thr Gly Gly Ser Ala Ala Gln Ala Thr Ala Gly Phe
385 390 395 400
Thr Ser Phe Phe Thr Arg Gly Pro Ser Gln Asn Leu Gln Leu Val Asn
405 410 415
Ser Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp
420 425 430
Ser Leu Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe
435 440 445
Asn Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Lys Pro Ile Thr
450 455 460
Tyr Phe Asn Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Asn Gly
465 470 475 480
Pro Ser Glu Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys
485 490 495
Asn Ile Thr Lys Pro Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asp Ile Lys Gly Leu Pro Thr
515 520 525
Tyr Arg Phe Gly Val Asn Glu Ser Asp Val Phe Leu Leu Thr Ser Leu
530 535 540
Arg Pro Pro Gln Gly Arg Trp Phe Gly Cys Val Trp Met Asn Ser Thr
545 550 555 560
Gly Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly
565 570 575
Met Lys Asp Ile Glu Ala Asn Gln Thr His Leu Lys Cys Pro Thr Asp
580 585 590
Cys Phe Arg Lys His His Asp Ala Thr Phe Thr Arg Cys Gly Ser Gly
595 600 605
Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp
610 615 620
His Tyr Pro Cys Thr Val Asn Phe Ser Ile Phe Lys Val Arg Met Phe
625 630 635 640
Val Gly Gly His Glu His Arg Phe Ser Ala Ala Cys Asn Trp Thr Arg
645 650 655
Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Gln Gln Pro
660 665 670
Leu Leu His Ser Thr Thr Asp Ser Leu Ile Leu Pro Cys Ser Phe Thr
675 680 685
Pro Met Arg Arg Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile
690 695 700
Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Gly Trp
705 710 715 720
Ala Leu Lys Trp Glu Phe Val Val Leu Val Phe Leu Leu Leu Ala Asp
725 730 735
Ala Arg Val Cys Val Ala Leu Trp Met Met Leu Leu Ile Ser Gln Ala
740 745 750
Glu Ala
<210> 37
<211> 751
<212> PRT
<213> Hepatitis C virus
<400> 37
Met Ser Thr Leu Pro Lys Pro Gln Arg Ile Thr Lys Arg Asn Ile Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Lys Leu Gly Val Arg Ala
35 40 45
Val Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Ser Arg Arg Gln Pro
50 55 60
Ile Pro Arg Ala Arg Arg Thr Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp
145 150 155 160
Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Leu Thr Pro Thr Ala Gly Leu
180 185 190
Glu Tyr Arg Asn Ala Ser Gly Leu Tyr Thr Val Thr Asn Asp Cys Ser
195 200 205
Asn Gly Ser Ile Val Tyr Glu Ala Gly Asp Val Ile Leu His Leu Pro
210 215 220
Gly Cys Ile Pro Cys Val Arg Leu Asn Asn Ala Ser Lys Cys Trp Thr
225 230 235 240
Pro Val Ser Pro Thr Val Ala Val Ser Arg Pro Gly Ala Ala Thr Ala
245 250 255
Ser Leu Arg Thr His Val Asp Met Met Val Gly Ala Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ala Leu Phe Leu Val Gly
275 280 285
Gln Gly Phe Ser Trp Arg His Arg Gln His Trp Thr Val Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Leu Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Ala Met Thr Leu Ile Val Ser Gln
325 330 335
Val Leu Arg Leu Pro Gln Thr Met Phe Asp Leu Val Ile Gly Ala His
340 345 350
Trp Gly Val Met Ala Gly Val Ala Tyr Tyr Ser Met Gln Gly Asn Trp
355 360 365
Ala Lys Val Phe Leu Val Leu Cys Leu Phe Ser Gly Val Asp Ala Ser
370 375 380
Thr Thr Ile Thr Gly Gly Val Ala Ala Ser Gly Ala Phe Thr Ile Thr
385 390 395 400
Ser Leu Phe Ser Thr Gly Ala Lys Gln Pro Leu His Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Asn Thr Gly Phe Ile Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Val Glu Arg Met Ser Ala Cys Ser Pro Leu Asp Arg
450 455 460
Phe Ala Gln Gly Trp Gly Pro Leu Gly Pro Ala Asn Ile Ser Gly Pro
465 470 475 480
Ser Ser Glu Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp
485 490 495
Thr Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Ala Thr Asp Lys Arg Gly Ala Pro Thr Tyr
515 520 525
Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Glu Ser Ala Arg
530 535 540
Pro Pro Thr Glu Pro Trp Phe Gly Cys Thr Trp Met Asn Gly Ser Gly
545 550 555 560
Tyr Val Lys Thr Cys Gly Ala Pro Pro Cys His Ile Tyr Gly Gly Arg
565 570 575
Glu Gly Lys Ser Asn Asn Ser Leu Val Cys Pro Thr Asp Cys Phe Arg
580 585 590
Lys His Pro Asp Ala Thr Tyr Asn Arg Cys Gly Ala Gly Pro Trp Leu
595 600 605
Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro
610 615 620
Cys Thr Val Asn Tyr Thr Ile Phe Lys Val Arg Met Phe Val Gly Gly
625 630 635 640
Leu Glu His Arg Phe Asn Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg
645 650 655
Cys Asn Leu Glu Asp Arg Asp Arg Ser Glu Met Tyr Pro Leu Leu His
660 665 670
Ser Thr Thr Glu Gln Ala Ile Leu Pro Cys Ser Phe Val Pro Ile Pro
675 680 685
Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val
690 695 700
Gln Tyr Leu Tyr Gly Ile Ser Ser Gly Leu Val Gly Trp Ala Ile Lys
705 710 715 720
Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Ala Arg Val
725 730 735
Cys Val Val Leu Trp Met Met Met Leu Ile Ser Gln Ala Glu Ala
740 745 750
<210> 38
<211> 745
<212> PRT
<213> Hepatitis C virus
<220>
<221> misc_feature
<222> (198)..(198)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (217)..(217)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (223)..(223)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (235)..(235)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (242)..(242)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (268)..(268)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (297)..(297)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (313)..(313)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (329)..(329)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (344)..(344)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (379)..(379)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (390)..(390)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (392)..(392)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (394)..(394)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (396)..(396)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (402)..(404)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (406)..(406)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (411)..(411)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (423)..(423)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (430)..(430)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (441)..(441)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (443)..(445)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (473)..(474)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (479)..(479)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (527)..(527)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (530)..(530)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (569)..(569)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (579)..(579)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (590)..(590)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (607)..(607)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (625)..(625)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (709)..(709)
<223> Xaa can be any naturally occurring amino acid
<400> 38
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Xaa Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Xaa Asp Ala Ile Leu His Xaa Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Xaa Ser Arg Cys Trp Val
225 230 235 240
Ala Xaa Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Xaa Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Xaa His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Tyr Pro Gly His Ile Xaa Gly His Arg Met Ala Trp Asp
305 310 315 320
Met Met Met Asn Trp Ser Pro Thr Xaa Ala Leu Val Val Ala Gln Leu
325 330 335
Leu Arg Ile Pro Gln Ala Ile Xaa Asp Met Ile Ala Gly Ala His Trp
340 345 350
Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp Ala
355 360 365
Lys Val Leu Val Val Leu Leu Leu Phe Ala Xaa Val Asp Ala Glu Thr
370 375 380
His Val Thr Gly Gly Xaa Ala Xaa Arg Xaa Thr Xaa Gly Leu Val Gly
385 390 395 400
Leu Xaa Xaa Xaa Gly Xaa Lys Gln Asx Ile Xaa Leu Ile Asn Thr Asn
405 410 415
Gly Ser Trp His Ile Asn Xaa Thr Ala Leu Asn Cys Asn Xaa Ser Leu
420 425 430
Asn Thr Gly Trp Leu Ala Gly Leu Xaa Tyr Xaa Xaa Xaa Phe Asn Ser
435 440 445
Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp Phe
450 455 460
Ala Gln Gly Trp Gly Pro Ile Ser Xaa Xaa Asn Gly Ser Gly Xaa Asp
465 470 475 480
Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile Val
485 490 495
Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro
500 505 510
Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Xaa Trp
515 520 525
Gly Xaa Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro Pro
530 535 540
Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe Thr
545 550 555 560
Lys Val Cys Gly Ala Pro Pro Cys Xaa Ile Gly Gly Val Gly Asn Asn
565 570 575
Thr Leu Xaa Cys Pro Thr Asp Cys Phe Arg Lys His Pro Xaa Ala Thr
580 585 590
Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Xaa Val
595 600 605
Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr Thr
610 615 620
Xaa Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Glu
625 630 635 640
Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asx Leu Glu Asp Arg
645 650 655
Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp Gln
660 665 670
Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly Leu
675 680 685
Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val
690 695 700
Gly Ser Ser Ile Xaa Ser Trp Ala Ile Lys Trp Glu Tyr Val Val Leu
705 710 715 720
Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp Met
725 730 735
Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 39
<211> 746
<212> PRT
<213> Hepatitis C virus
<400> 39
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Ala Ile Leu His Ala Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ile Ser Arg Cys Trp Val
225 230 235 240
Ala Met Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr
245 250 255
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Gly Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285
Gln Leu Phe Thr Phe Ser Pro Arg Leu His Trp Thr Thr Gln Asp Cys
290 295 300
Asn Cys Ser Leu Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln
325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His
340 345 350
Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp
355 360 365
Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser Val Asp Ala Glu
370 375 380
Thr His Val Thr Gly Gly Asn Ala Ala Arg Ser Thr Ser Gly Leu Val
385 390 395 400
Gly Leu Phe Ser Ala Gly Pro Lys Gln Asp Ile Arg Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Asn Thr Gly Trp Leu Ala Gly Leu Leu Tyr Arg Tyr Asn Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp
450 455 460
Phe Ala Gln Gly Trp Gly Pro Ile Ser His Val Asn Gly Ser Gly Pro
465 470 475 480
Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile
485 490 495
Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser
500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Asn
515 520 525
Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro
530 535 540
Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe
545 550 555 560
Thr Lys Val Cys Gly Ala Pro Pro Cys Ala Ile Gly Gly Val Gly Asn
565 570 575
Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala
580 585 590
Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu
595 600 605
Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr
610 615 620
Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu
625 630 635 640
Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp
645 650 655
Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp
660 665 670
Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly
675 680 685
Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly
690 695 700
Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Val
705 710 715 720
Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp
725 730 735
Met Met Leu Leu Ile Ser Gln Ala Glu Ala
740 745
<210> 40
<211> 750
<212> PRT
<213> Hepatitis C virus
<400> 40
Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val
1 5 10 15
Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly
35 40 45
Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg
50 55 60
Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
180 185 190
Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro
195 200 205
Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro
210 215 220
Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu
225 230 235 240
Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp
245 250 255
Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser
275 280 285
Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr
325 330 335
Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His
340 345 350
Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp
355 360 365
Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu
370 375 380
Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val
385 390 395 400
Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp
450 455 460
Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro
465 470 475 480
Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly
485 490 495
Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr
515 520 525
Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg
530 535 540
Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly
545 550 555 560
Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly
565 570 575
Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr
595 600 605
Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val
625 630 635 640
Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys
645 650 655
Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln
690 695 700
Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp
705 710 715 720
Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys
725 730 735
Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala
740 745 750
<210> 41
<211> 750
<212> PRT
<213> Hepatitis C virus
<400> 41
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Glu Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ala Trp Gly Lys Pro Gly
65 70 75 80
Arg Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu
130 135 140
Ser Gly Ala Ala Arg Ala Val Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Phe Pro Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Ala Ala
180 185 190
Gln Val Lys Asn Thr Ser Ser Ser Tyr Met Val Thr Asn Asp Cys Ser
195 200 205
Asn Asp Ser Ile Thr Trp Gln Leu Glu Ala Ala Val Leu His Val Pro
210 215 220
Gly Cys Val Pro Cys Glu Arg Val Gly Asn Thr Ser Arg Cys Trp Val
225 230 235 240
Pro Val Ser Pro Asn Met Ala Val Arg Gln Pro Gly Ala Leu Thr Gln
245 250 255
Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Phe Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala
275 280 285
Gln Val Phe Ile Val Ser Pro Gln Tyr His Trp Phe Val Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr
325 330 335
Val Met Arg Val Pro Glu Val Ile Ile Asp Ile Val Ser Gly Ala His
340 345 350
Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Ile Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Gly
370 375 380
Thr Thr Thr Val Gly Gly Ala Val Ala Arg Ser Thr Asn Val Ile Ala
385 390 395 400
Gly Val Phe Ser His Gly Pro Gln Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr Asn Arg Phe Asn
435 440 445
Ser Ser Gly Cys Pro Gly Arg Leu Ser Ala Cys Arg Asn Ile Glu Ala
450 455 460
Phe Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn
465 470 475 480
Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys
485 490 495
Gly Val Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr
515 520 525
Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr
530 535 540
Arg Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr
545 550 555 560
Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp
565 570 575
Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Asp Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr
595 600 605
Pro Lys Cys Leu Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Val Asn Phe Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val
625 630 635 640
Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys
645 650 655
Asp Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Tyr Met Tyr Gly Leu Ser Pro Ala Ile Thr Lys Tyr Val Val Arg Trp
705 710 715 720
Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala
740 745 750
<210> 42
<211> 749
<212> PRT
<213> Hepatitis C virus
<400> 42
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala
180 185 190
Gln Val Lys Asn Thr Ser Asp Ile Tyr Met Val Thr Asn Asp Cys Ser
195 200 205
Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Ala Leu His Val Pro
210 215 220
Gly Cys Val Pro Cys Glu Arg Val Gly Asn Thr Ser Arg Cys Trp Ile
225 230 235 240
Pro Val Ser Pro Asn Val Ala Val Arg Gln Pro Gly Ala Leu Thr Gln
245 250 255
Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala
275 280 285
Gln Met Phe Ile Ile Ser Pro Gln His His Trp Phe Val Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Thr Met Ile Leu Ala Tyr
325 330 335
Val Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala His
340 345 350
Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala His
370 375 380
Thr Arg Thr Gly Ser Ser Val Gly Tyr Ala Thr Ser Gly Ile Val Gly
385 390 395 400
Leu Phe Thr Ser Gly Pro Lys Gln Asn Ile Gln Leu Ile Asn Thr Asn
405 410 415
Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu
420 425 430
Asn Thr Gly Phe Ile Val Ser Leu Phe Tyr Ala Arg Asn Phe Asn Ser
435 440 445
Thr Gly Cys Pro Glu Arg Leu Ser Ala Cys Arg Gly Ile Glu Gly Phe
450 455 460
Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn Pro
465 470 475 480
Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln Cys Gly
485 490 495
Ile Val Pro Ala Gly Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val Pro Thr Tyr
515 520 525
Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr Arg
530 535 540
Pro Pro Val Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp Phe
565 570 575
Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His
580 585 590
Pro Glu Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro
595 600 605
Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr
610 615 620
Val Asn Tyr Ser Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu
625 630 635 640
His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys Asn
645 650 655
Leu Glu Asp Arg Asp Arg Ser Gln Leu Thr Pro Leu Leu His Ser Thr
660 665 670
Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala Leu
675 680 685
Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln Tyr
690 695 700
Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Val Val Arg Trp Glu
705 710 715 720
Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala
725 730 735
Cys Val Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala
740 745
<210> 43
<211> 749
<212> PRT
<213> Hepatitis C virus
<220>
<221> misc_feature
<222> (386)..(386)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (392)..(394)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (398)..(399)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (444)..(444)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (496)..(496)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (525)..(525)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (538)..(538)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (712)..(712)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (722)..(722)
<223> Xaa can be any naturally occurring amino acid
<400> 43
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys His Arg Arg Ser Thr Gly Lys Ser Trp Gly Thr Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Ile Pro Val Ser Ala Ala
180 185 190
Gln Val Lys Asn Thr Ser Ser Gly Tyr Met Val Thr Asn Asp Cys Ser
195 200 205
Asn Asp Ser Ile Thr Trp Gln Leu Glu Ala Ala Val Leu His Val Pro
210 215 220
Gly Cys Val Pro Cys Glu Lys Val Gly Asn Thr Ser Arg Cys Trp Ile
225 230 235 240
Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln
245 250 255
Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Phe Cys Gly Gly Val Met Leu Ala Ala
275 280 285
Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly Thr Ile Ser Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Met Ala Tyr
325 330 335
Val Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ala Gly Ala His
340 345 350
Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Val Val Ile Leu Leu Leu Thr Ala Gly Val Asp Ala His
370 375 380
Thr Xaa Ile Gly Ser Ala Val Xaa Xaa Xaa Thr Ser Gly Xaa Xaa Gly
385 390 395 400
Leu Phe Tyr Arg Gly Ala Gln Gln Asn Ile Gln Leu Ile Asn Thr Asn
405 410 415
Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu
420 425 430
Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Ala Xaa Arg Phe Asn Ser
435 440 445
Ser Gly Cys Pro Glu Arg Leu Ser Val Cys Arg Asn Ile Glu Ala Phe
450 455 460
Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn Pro
465 470 475 480
Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Xaa
485 490 495
Ile Val Pro Ala Gly Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro
500 505 510
Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Xaa Pro Thr Tyr
515 520 525
Thr Trp Gly Glu Asn Glu Thr Asp Val Xaa Leu Leu Asn Ser Thr Arg
530 535 540
Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly
545 550 555 560
Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp Phe
565 570 575
Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His
580 585 590
Pro Glu Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro
595 600 605
Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr
610 615 620
Val Asn Tyr Ser Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu
625 630 635 640
His Arg Leu Met Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys Asp
645 650 655
Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser Thr
660 665 670
Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala Leu
675 680 685
Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln Tyr
690 695 700
Met Tyr Gly Leu Ser Pro Ala Xaa Thr Lys Tyr Val Val Arg Trp Glu
705 710 715 720
Trp Xaa Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala
725 730 735
Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala
740 745
<210> 44
<211> 750
<212> PRT
<213> Hepatitis C virus
<400> 44
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ser
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Ala Val
180 185 190
Gln Val Lys Asn Ile Ser Asp Ser Tyr Met Val Thr Asn Asp Cys Ser
195 200 205
Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro
210 215 220
Gly Cys Val Pro Cys Glu Lys Met Gly Asn Ile Ser Arg Cys Trp Ile
225 230 235 240
Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln
245 250 255
Gly Leu Arg Ala His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala
275 280 285
Gln Met Phe Ile Val Ser Pro Gln His His His Phe Val Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly Ala Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr
325 330 335
Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His
340 345 350
Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Val Val Ile Leu Leu Leu Thr Ala Gly Val Asp Ala His
370 375 380
Thr Arg Ser Ile Ala Gly Ser Val Ala His Ala Thr Ser Gly Leu Ala
385 390 395 400
Gly Leu Phe Thr Ser Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Asn Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr Tyr Arg Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Leu Ser Ala Cys Arg Gly Ile Gln Ala
450 455 460
Phe Arg Ile Gly Trp Gly Thr Leu Arg Tyr Glu Asp Asn Val Thr Asn
465 470 475 480
Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln Cys
485 490 495
Gly Ile Val Ser Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val Pro Thr
515 520 525
Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Ile Leu Asn Ser Thr
530 535 540
Arg Pro Pro Gly Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr
545 550 555 560
Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp
565 570 575
Phe Asn Ala Ser Met Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Asp Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr
595 600 605
Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Ile Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val
625 630 635 640
Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Pro Cys
645 650 655
Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Tyr Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp
705 710 715 720
Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala
740 745 750
<210> 45
<211> 750
<212> PRT
<213> Hepatitis C virus
<220>
<221> misc_feature
<222> (458)..(458)
<223> Xaa can be any naturally occurring amino acid
<400> 45
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val
180 185 190
Gln Val Lys Asn Thr Ser Glu Thr Tyr Met Val Thr Asn Asp Cys Ser
195 200 205
Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro
210 215 220
Gly Cys Val Pro Cys Glu Arg Thr Gly Asn Thr Ser Arg Cys Trp Ile
225 230 235 240
Pro Val Ser Pro Asn Val Ala Val Gln Gln Pro Gly Ala Leu Thr Gln
245 250 255
Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Val Leu Ala Ala
275 280 285
Gln Leu Phe Ile Val Ser Pro Arg Arg His Trp Phe Val Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly Ala Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Thr Thr Met Val Leu Ala Tyr
325 330 335
Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His
340 345 350
Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Ala Val Ile Leu Leu Leu Thr Ala Gly Val Glu Ala Arg
370 375 380
Thr His Thr Thr Gly Ser Val Ala Gly Arg Thr Thr Ser Gly Phe Ala
385 390 395 400
Gly Ile Phe Thr Ser Gly Pro Lys Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Asn Thr Gly Phe Met Ala Ala Leu Phe Tyr Thr Lys Asn Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Leu Ser Xaa Cys Arg Asn Ile Glu Ala
450 455 460
Phe Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asp Val Thr Asn
465 470 475 480
Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln Cys
485 490 495
Gly Ile Phe Pro Ala Gly Ser Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Val Pro Thr
515 520 525
Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Ile Leu Asn Ser Thr
530 535 540
Arg Pro Pro Arg Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr
545 550 555 560
Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp
565 570 575
Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Glu Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr
595 600 605
Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Val Asn Tyr Ser Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val
625 630 635 640
Glu His Arg Leu Thr Ala Ala Cys Asn Phe Ser Arg Gly Asp Arg Cys
645 650 655
Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Thr Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Tyr Met Tyr Gly Leu Thr Pro Ala Leu Thr Lys Tyr Val Val Arg Trp
705 710 715 720
Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala
740 745 750
<210> 46
<211> 751
<212> PRT
<213> Hepatitis C virus
<400> 46
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Gln Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr
35 40 45
Ala Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Arg Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Ile Pro Ala Ser Ala Val
180 185 190
Glu Val Lys Asn Thr Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Ala
195 200 205
Asn Ser Ser Ile Thr Trp Gln Leu His Ala Ala Val Leu His Val Pro
210 215 220
Gly Cys Val Pro Cys Glu Arg Val Asp Asn Asn Thr Ser Arg Cys Trp
225 230 235 240
Ile Pro Val Ser Pro Asn Ile Ala Val Gln Arg Pro Gly Ala Leu Thr
245 250 255
Gln Gly Leu Arg Ser His Ile Asp Ile Val Val Met Ser Ala Thr Leu
260 265 270
Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala
275 280 285
Ala Gln Met Phe Val Val Ser Pro Glu His His Trp Phe Val Gln Glu
290 295 300
Cys Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala
305 310 315 320
Trp Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala
325 330 335
Tyr Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala
340 345 350
His Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala
355 360 365
Trp Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala
370 375 380
Tyr Thr His Thr Val Gly Gly Ala Ala Ala Ser Thr Ala Asn Ser Ile
385 390 395 400
Ala Gly Leu Leu Ser Arg Gly Pro Arg Gln Asn Leu Gln Leu Ile Asn
405 410 415
Ser Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys His Asp
420 425 430
Ser Leu Gln Thr Gly Phe Ile Thr Ala Leu Phe Tyr Ala Arg His Phe
435 440 445
Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ala Cys Arg Asn Ile Glu
450 455 460
Ala Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr
465 470 475 480
Asn Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln
485 490 495
Cys Gly Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe
500 505 510
Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Leu Gly Val Pro
515 520 525
Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser
530 535 540
Thr Arg Pro Pro Gln Gly Pro Trp Phe Gly Cys Thr Trp Met Asn Ser
545 550 555 560
Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala
565 570 575
Asp Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg
580 585 590
Lys His Pro Asp Ala Thr Tyr Asn Lys Cys Gly Ser Gly Pro Trp Leu
595 600 605
Thr Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro
610 615 620
Cys Thr Val Asn Tyr Thr Thr Phe Lys Ile Arg Met Tyr Val Gly Gly
625 630 635 640
Val Glu His Arg Leu Met Ala Ala Cys Asn Phe Thr Arg Gly Asp Ser
645 650 655
Cys Asp Leu Ser Gln Arg Asp Arg Gly Gln Leu Ser Pro Leu Leu His
660 665 670
Ser Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Phe Ser Asp Leu Pro
675 680 685
Ala Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val
690 695 700
Gln Tyr Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg
705 710 715 720
Trp Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val
725 730 735
Cys Ala Cys Ile Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala
740 745 750
<210> 47
<211> 750
<212> PRT
<213> Hepatitis C virus
<400> 47
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala
180 185 190
Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr
195 200 205
Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro
210 215 220
Gly Cys Val Pro Cys Glu Lys Val Gly Asn Thr Ser Arg Cys Trp Ile
225 230 235 240
Pro Val Ser Pro Asn Val Ala Val Gln Gln Pro Gly Ala Leu Thr Gln
245 250 255
Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala
275 280 285
Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr
325 330 335
Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala His
340 345 350
Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Gln
370 375 380
Thr His Thr Val Gly Gly Ser Thr Ala His Asn Ala Arg Thr Leu Thr
385 390 395 400
Gly Met Phe Ser Leu Gly Ala Arg Gln Lys Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu His Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Ser Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala
450 455 460
Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn
465 470 475 480
Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys
485 490 495
Gly Val Val Ser Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr
515 520 525
Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr
530 535 540
Arg Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr
545 550 555 560
Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp
565 570 575
Phe Asn Ala Ser Met Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Asp Thr Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr
595 600 605
Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val
625 630 635 640
Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys
645 650 655
Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp
705 710 715 720
Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala
740 745 750
<210> 48
<211> 750
<212> PRT
<213> Hepatitis C virus
<400> 48
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala
180 185 190
Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr
195 200 205
Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro
210 215 220
Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile
225 230 235 240
Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln
245 250 255
Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala
275 280 285
Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys
290 295 300
Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr
325 330 335
Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His
340 345 350
Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg
370 375 380
Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr
385 390 395 400
Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala
450 455 460
Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn
465 470 475 480
Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys
485 490 495
Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr
515 520 525
Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr
530 535 540
Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser
545 550 555 560
Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp
565 570 575
Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr
595 600 605
Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val
625 630 635 640
Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys
645 650 655
Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp
705 710 715 720
Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala
740 745 750
<210> 49
<211> 750
<212> PRT
<213> Hepatitis C virus
<400> 49
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val
180 185 190
Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser
195 200 205
Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro
210 215 220
Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile
225 230 235 240
Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg
245 250 255
Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser
275 280 285
Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Leu Ser Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr
325 330 335
Ala Ala Arg Val Pro Glu Leu Val Leu Glu Ile Ile Phe Gly Gly His
340 345 350
Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr
370 375 380
Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Ala Gly Phe Ala
385 390 395 400
Gly Leu Phe Thr Thr Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Gln Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp
450 455 460
Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn
465 470 475 480
Asp Gly Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys
485 490 495
Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr
515 520 525
Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr
530 535 540
Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr
545 550 555 560
Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp
565 570 575
Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr
595 600 605
Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val
625 630 635 640
Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys
645 650 655
Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp
705 710 715 720
Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala
740 745 750
<210> 50
<211> 750
<212> PRT
<213> Hepatitis C virus
<400> 50
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Ser Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Ile Asn Tyr Ala Thr Arg Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ser Val
180 185 190
Glu Ile Arg Asn Ile Ser Thr Ser Tyr Tyr Ala Thr Asn Asp Cys Ser
195 200 205
Asn Asn Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro
210 215 220
Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile
225 230 235 240
Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr His
245 250 255
Asn Leu Arg Ala His Val Asp Val Ile Val Met Ala Ala Thr Val Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Val Ser
275 280 285
Gln Ala Leu Ile Val Ser Pro Glu Arg His Asn Phe Thr Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly Gln Arg Met Ala Trp
305 310 315 320
Asp Met Met Leu Asn Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr
325 330 335
Ala Ala Arg Val Pro Glu Leu Val Leu Glu Ile Val Phe Gly Gly His
340 345 350
Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr
370 375 380
Thr Tyr Ser Thr Gly Ala Thr Val Gly Arg Thr Val Gly Ser Phe Ala
385 390 395 400
Gly Leu Phe Lys Leu Gly Ala Gln Gln Asn Val Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu His Thr Gly Phe Met Ala Ala Leu Phe Tyr Ala Asn Lys Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp
450 455 460
Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn
465 470 475 480
Val Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys
485 490 495
Gly Ile Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Gln Gly Val Pro Thr
515 520 525
Tyr Asn Trp Gly Asp Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr
530 535 540
Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr
545 550 555 560
Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp
565 570 575
Phe Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Asp Ala Thr Tyr Val Lys Cys Gly Ala Gly Pro Trp Leu Thr
595 600 605
Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val
625 630 635 640
Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys
645 650 655
Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Tyr Leu Tyr Gly Leu Ser Pro Ala Val Thr Lys Tyr Ile Val Lys Trp
705 710 715 720
Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala
740 745 750
<210> 51
<211> 750
<212> PRT
<213> Hepatitis C virus
<400> 51
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro His Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Ile Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Ile Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val
180 185 190
Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser
195 200 205
Asn Asn Ser Ile Thr Trp Gln Leu Glu Asn Ala Val Leu His Leu Pro
210 215 220
Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Thr
225 230 235 240
Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Gln
245 250 255
Asn Leu Arg Thr His Val Asp Val Ile Val Val Ala Ala Thr Val Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Ala Ser
275 280 285
Gln Ala Leu Ile Val Ser Pro Ala Arg His Asn Phe Thr Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Gln Gly Arg Ile Thr Gly His His Met Ala Trp
305 310 315 320
Asp Met Met Leu Asn Trp Ser Pro Thr Ile Thr Met Ile Leu Ala Tyr
325 330 335
Ala Ala Arg Ile Pro Glu Leu Val Leu Glu Val Ile Phe Gly Gly His
340 345 350
Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Ile Val Ile Leu Leu Leu Val Ala Gly Val Asp Ala Arg
370 375 380
His His Thr Thr Gly Leu Gln Ala Gly Lys Thr Leu Ala Arg Val Thr
385 390 395 400
Ser Leu Phe Ser Ile Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Gln Thr Gly Phe Ile Ala Ser Leu Phe Tyr Val Asn Asn Ile Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Arg Glu Leu Asp Asp
450 455 460
Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn
465 470 475 480
Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys
485 490 495
Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Ile Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr
515 520 525
Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr
530 535 540
Arg Pro Pro Arg Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Gly Thr
545 550 555 560
Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp
565 570 575
Tyr Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr
595 600 605
Pro Lys Cys Leu Val Glu Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Ala Val
625 630 635 640
Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys
645 650 655
Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Arg Tyr Ile Val Lys Trp
705 710 715 720
Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala
740 745 750
<210> 52
<211> 750
<212> PRT
<213> Hepatitis C virus
<400> 52
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Cys Thr Val Pro Val Ser Ala Val
180 185 190
Glu Val Arg Asn Ile Ser Thr Ser Tyr Tyr Ala Thr Asn Asp Cys Ser
195 200 205
Asn Thr Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro
210 215 220
Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile
225 230 235 240
Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr His
245 250 255
Asn Leu Arg Thr His Val Asp Val Ile Val Met Ala Ala Thr Val Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Val Met Ile Val Ser
275 280 285
Gln Ala Phe Ile Ile Ser Pro Glu Arg His Asn Phe Thr Gln Glu Cys
290 295 300
Asn Cys Ser Met Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Leu Asn Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr
325 330 335
Ala Ala Arg Val Pro Glu Leu Val Leu Glu Val Ile Phe Gly Gly His
340 345 350
Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Asn
370 375 380
Thr Tyr Ser Ser Gly Val Thr Val Gly His Thr Thr Ser Thr Phe Ala
385 390 395 400
Asn Ile Phe Ser Val Gly Pro Ser Gln Lys Ile Asn Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser
420 425 430
Leu Gln Thr Gly Phe Leu Ala Ser Leu Phe Tyr Val Arg Asn Phe Asn
435 440 445
Ser Ser Gly Cys Arg Glu Arg Leu Ser Ser Cys Arg Arg Leu Asp Asp
450 455 460
Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn
465 470 475 480
Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys
485 490 495
Gly Ile Val Ser Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Gln Gly Val Pro Thr
515 520 525
Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr
530 535 540
Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr
545 550 555 560
Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp
565 570 575
Tyr Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr
595 600 605
Pro Lys Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val
625 630 635 640
Glu His Arg Leu Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys
645 650 655
Gly Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Arg Tyr Ile Val Lys Trp
705 710 715 720
Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala
740 745 750
<210> 53
<211> 750
<212> PRT
<213> Hepatitis C virus
<220>
<221> misc_feature
<222> (203)..(203)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (295)..(295)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (343)..(343)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (401)..(401)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (426)..(426)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (626)..(626)
<223> Xaa can be any naturally occurring amino acid
<400> 53
Met Ser Thr Asp Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45
Ala Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro
50 55 60
Ile Pro Lys Asp Arg Arg Ser Pro Gly Lys Ser Trp Gly Lys Pro Gly
65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp
85 90 95
Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro
100 105 110
Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Ile Thr Cys
115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val
130 135 140
Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160
Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val
180 185 190
Glu Val Arg Asn Ile Ser Ser Gly Tyr Tyr Xaa Thr Asn Asp Cys Ser
195 200 205
Asn Ser Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro
210 215 220
Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile
225 230 235 240
Gln Val Thr Pro Asn Val Ala Val Lys Tyr Arg Gly Ala Leu Thr His
245 250 255
Asn Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Val Cys
260 265 270
Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Val Ser
275 280 285
Gln Ala Phe Ile Met Ser Xaa Glu Arg His Asn Phe Thr Gln Glu Cys
290 295 300
Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp
305 310 315 320
Asp Met Met Leu Gly Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr
325 330 335
Ala Ala Arg Val Pro Glu Xaa Val Leu Glu Val Val Phe Gly Gly His
340 345 350
Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp
355 360 365
Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Gly
370 375 380
Thr Tyr Ser Ser Gly Ala Thr Ile Gly Gln Gly Thr Arg Gly Leu Val
385 390 395 400
Xaa Leu Phe Ser Ala Gly Pro Ser Gln Lys Ile Ser Leu Ile Asn Thr
405 410 415
Asn Gly Ser Trp His Ile Asn Arg Thr Xaa Leu Asn Cys Asn Asp Ser
420 425 430
Leu Gln Thr Gly Phe Ile Ala Ser Leu Phe Tyr Ala Lys Ser Phe Asn
435 440 445
Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp
450 455 460
Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Asn Asn Val Thr Asn
465 470 475 480
Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys
485 490 495
Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr
500 505 510
Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr
515 520 525
Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr
530 535 540
Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr
545 550 555 560
Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp
565 570 575
His Thr Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys
580 585 590
His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr
595 600 605
Pro Lys Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys
610 615 620
Thr Xaa Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val
625 630 635 640
Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys
645 650 655
Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser
660 665 670
Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala
675 680 685
Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln
690 695 700
Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Lys Tyr Ile Val Lys Trp
705 710 715 720
Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys
725 730 735
Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala
740 745 750
Claims (47)
- (a)第1のC型肝炎ウイルス(HCV)遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1E2ポリペプチドと;
(b)第2のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1E2ポリペプチドと;
(c)薬学的に許容される賦形剤と
を含み、
但し、少なくとも1つのE1ポリペプチドと少なくとも1つのE2ポリペプチドとを含む、免疫原性組成物。 - 前記第1のHCV遺伝子型が、遺伝子型1型であり;前記第2のHCV遺伝子型が、遺伝子型2型である、請求項1に記載の組成物。
- 前記第1のHCV遺伝子型が、遺伝子型1型であり;前記第2のHCV遺伝子型が、遺伝子型3型である、請求項1に記載の組成物。
- (i)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ポリペプチド;
(ii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド;
(iii)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(iv)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;
(v)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型2型のE2ポリペプチド;
(vi)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;
(vii)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(viii)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ix)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;
(x)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xi)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型2型のE2ポリペプチド;
(xii)HCV遺伝子型1型のE1ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xiii)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1ポリペプチド;または
(xiv)HCV遺伝子型1型のE2ポリペプチド;及びHCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体
を含む、請求項1に記載の組成物。 - 第3のHCV遺伝子型のHCV E1、E2、またはE1/E2ポリペプチドをさらに含む、請求項4に記載の組成物。
- 前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、請求項1に記載の組成物。
- 前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含む、請求項1に記載の組成物。
- 前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含み、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、請求項1に記載の組成物。
- 前記薬学的に許容される賦形剤がアジュバントを含む、請求項1に記載の組成物。
- 前記アジュバントが、MF59、ミョウバン、ポリ(DL-ラクチド-コ-グリコリド)、またはCpGオリゴヌクレオチドである、請求項1に記載の組成物。
- (a)第1のHCV遺伝子型からのC型肝炎ウイルス(HCV)E1ポリペプチド、E2ポリペプチド、またはE1/E2ポリペプチドと;
(b)第2のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1/E2ポリペプチドと;
(c)第3のHCV遺伝子型からのHCV E1ポリペプチド、E2ポリペプチド、またはE1/E2ポリペプチドと;
(d)薬学的に許容される賦形剤と
を含み、
但し、少なくとも1つのE1ポリペプチドと少なくとも1つのE2ポリペプチドとを含む、免疫原性組成物。 - 前記第1のHCV遺伝子型が、遺伝子型1型であり、前記第2のHCV遺伝子型が、遺伝子型2型であり、かつ前記第3のHCV遺伝子型が、遺伝子型3型である、請求項11に記載の免疫原性組成物。
- (i)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド;
(iii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(iv)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(v)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(vi)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド;
(vii)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(viii)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(ix)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(x)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE1ポリペプチド;
(xi)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xii)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE1/E2ヘテロ二量体ポリペプチド複合体;
(xiii)HCV遺伝子型1型のE1/E2ヘテロ二量体ポリペプチド複合体;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;
(xiv)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(xv)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE1ポリペプチド;及びHCV遺伝子型3型のE2ポリペプチド;
(xvi)HCV遺伝子型1型のE2ポリペプチド;HCV遺伝子型2型のE2ポリペプチド;及びHCV遺伝子型3型のE1ポリペプチド;または
(xvii)HCV遺伝子型1型のE1ポリペプチド;HCV遺伝子型2型のE1/E2ヘテロ二量体ポリペプチド複合体;及びHCV遺伝子型3型のE2ポリペプチド
を含む、請求項11に記載の免疫原性組成物。 - 前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型であり、かつ前記第3のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、請求項11に記載の組成物。
- 前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型であり、かつ前記第3のHCV遺伝子型からの前記HCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含む、請求項11に記載の組成物。
- 前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、野生型であり、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含み、かつ前記第3のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、請求項11に記載の組成物。
- 前記第1のHCV遺伝子型からのHCV E2ポリペプチドが、E2N1部位及び/またはE2N6部位におけるアスパラギンのアミノ酸置換を含み、前記第2のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型であり、かつ前記第3のHCV遺伝子型からの前記HCV E2ポリペプチドが、野生型である、請求項11に記載の組成物。
- 前記薬学的に許容される賦形剤がアジュバントを含む、請求項11に記載の組成物。
- 前記アジュバントが、MF59、ミョウバン、ポリ(DL-ラクチド-コ-グリコリド)、またはCpGオリゴヌクレオチドである、請求項11に記載の組成物。
- 個体における免疫応答の誘導方法であって、
請求項1~19のいずれか1項に記載の組成物の有効量を前記個体に投与することを含む、前記方法。 - (a)HCV遺伝子型1a型のC型肝炎ウイルス(HCV)E2ポリペプチドと;
(b)HCV遺伝子型3a型のHCV E1/E2ヘテロ二量体ポリペプチドと;
(c)薬学的に許容される賦形剤と
を含む、組成物。 - 前記ポリペプチドの全てが野生型である、請求項21に記載の組成物。
- 前記E2ポリペプチドが全長である、請求項21に記載の組成物。
- 前記E2ポリペプチドが可溶性E2ポリペプチドである、請求項21に記載の組成物。
- (a)HCV遺伝子型3a型のC型肝炎ウイルス(HCV)E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(b)HCV遺伝子型1a型のHCV E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(c)薬学的に許容される賦形剤と
を含む、組成物。 - 前記ポリペプチドの全てが野生型である、請求項25に記載の組成物。
- 前記E2ポリペプチドが全長である、請求項25に記載の組成物。
- 前記E2ポリペプチドが可溶性E2ポリペプチドである、請求項25に記載の組成物。
- 個体における免疫応答の誘導方法であって、
請求項21~28のいずれか1項に記載の組成物の有効量を前記個体に投与することを含み、
前記組成物を、少なくともHCV遺伝子型1a型及び3a型に対して中和抗体を誘導するのに有効な量で投与する、前記方法。 - 個体における免疫応答の誘導方法であって、
請求項21~28のいずれか1項に記載の組成物の有効量を前記個体に投与することを含み、
前記組成物を、少なくともHCV遺伝子型1a型及び3a型に対して細胞傷害性Tリンパ球応答を誘導するのに有効な量で投与する、前記方法。 - 個体における免疫応答の誘導方法であって、
請求項21~28のいずれか1項に記載の組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型及び3a型の50%以上の中和を達成するのに有効な量で投与する、前記方法。 - (a)HCV遺伝子型2a型のC型肝炎ウイルス(HCV)E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(b)HCV遺伝子型1a型のHCV E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(c)薬学的に許容される賦形剤と
を含む、組成物。 - 前記ポリペプチドの全てが野生型である、請求項32に記載の組成物。
- 前記E2ポリペプチドが全長である、請求項32に記載の組成物。
- 前記E2ポリペプチドが可溶性E2ポリペプチドである、請求項32に記載の組成物。
- 個体における免疫応答の誘導方法であって、
請求項32~35のいずれか1項に記載の組成物の有効量を前記個体に投与することを含み、
前記組成物を、少なくともHCV遺伝子型1a型及び2a型に対して中和抗体を誘導するのに有効な量で投与する、前記方法。 - 個体における免疫応答の誘導方法であって、
請求項32~35のいずれか1項に記載の組成物の有効量を前記個体に投与することを含み、
前記組成物を、少なくともHCV遺伝子型1a型及び2a型に対して細胞傷害性Tリンパ球応答を誘導するのに有効な量で投与する、前記方法。 - 個体における免疫応答の誘導方法であって、
請求項32~35のいずれか1項に記載の組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型及び2a型の50%以上の中和を達成するのに有効な量で投与する、前記方法。 - (a)HCV遺伝子型1a型のC型肝炎ウイルス(HCV)E2またはHCV E1/E2ヘテロ二量体ポリペプチドと;
(b)HCV遺伝子型2a型のHCV E2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(c)HCV遺伝子型3a型のE2ポリペプチドまたはHCV E1/E2ヘテロ二量体ポリペプチドと;
(d)薬学的に許容される賦形剤と
を含む、組成物。 - 前記ポリペプチドの全てが野生型である、請求項39に記載の組成物。
- 前記E2ポリペプチドの少なくとも1つが全長である、請求項39に記載の組成物。
- 前記E2ポリペプチドの少なくとも1つが可溶性E2ポリペプチドである、請求項39に記載の組成物。
- HCV遺伝子型7a型のE1/E2ポリペプチドを含む、請求項39~42のいずれか1項に記載の組成物。
- HCV遺伝子型7a型のE2ポリペプチドを含む、請求項39~42のいずれか1項に記載の組成物。
- 個体における免疫応答の誘導方法であって、
請求項39~44のいずれか1項に記載の組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型、1b型、2a型、2b型、3a型、4a型、5a型、6a型、及び7a型に対して中和抗体を誘導するのに有効な量で投与する、前記方法。 - 個体における免疫応答の誘導方法であって、
請求項39~44のいずれか1項に記載の組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型、1b型、2a型、2b型、3a型、4a型、5a型、6a型、及び7a型に対して細胞傷害性Tリンパ球応答を誘導するのに有効な量で投与する、前記方法。 - 個体における免疫応答の誘導方法であって、
請求項39~44のいずれか1項に記載の組成物の有効量を前記個体に投与することを含み、
前記組成物を、HCV遺伝子型1a型、1b型、2a型、2b型、3a型、4a型、5a型、6a型、及び7a型の50%以上の中和を達成するのに有効な量で投与する、前記方法。
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Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
GB8815795D0 (en) | 1988-07-02 | 1988-08-10 | Bkl Extrusions Ltd | Glazing bead |
WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
KR100278157B1 (ko) | 1992-06-25 | 2001-01-15 | 장 스테판느 | 보조약을 함유하는 백신 조성물 |
DK0812593T4 (da) | 1993-03-23 | 2008-05-13 | Smithkline Beecham Biolog | Vaccinepræparater indeholdende 3-O-deacyleret monophosphoryllipid-A |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
EP0772619B2 (en) | 1994-07-15 | 2010-12-08 | The University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
WO1996004301A2 (en) | 1994-07-29 | 1996-02-15 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
JP2001513776A (ja) | 1997-02-28 | 2001-09-04 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | LPS関連障害の処置における非メチル化CpGジヌクレオチドを含む核酸の使用 |
WO1998040100A1 (en) | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT |
ES2328536T3 (es) | 1997-05-06 | 2009-11-13 | Novartis Vaccines And Diagnostics, Inc. | Produccion intracelular de polipeptido e2 truncado de la hepatitis c. |
AU7690898A (en) | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
CA2291483C (en) | 1997-06-06 | 2012-09-18 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
WO1999011241A1 (en) | 1997-09-05 | 1999-03-11 | Smithkline Beecham Biologicals S.A. | Oil in water emulsions containing saponins |
US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
WO1999052549A1 (en) | 1998-04-09 | 1999-10-21 | Smithkline Beecham Biologicals S.A. | Adjuvant compositions |
GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
ATE357252T1 (de) | 1998-10-16 | 2007-04-15 | Glaxosmithkline Biolog Sa | Adjuvanzsysteme und impfstoffe |
PL203917B1 (pl) | 1999-03-19 | 2009-11-30 | Glaxosmithkline Biolog Sa | Kompozycja immunogenna, sposób jej wytwarzania oraz zastosowanie |
CZ303515B6 (cs) | 1999-04-19 | 2012-11-07 | Smithkline Beecham Biologicals S. A. | Adjuvantní prostredek |
TR200200777T2 (tr) | 1999-09-24 | 2002-09-23 | Smithkline Beecham Biologicals S.A. | Polioksietilen alkil eteri veya esteriyle en az bir iyonik olmayan yüzey aktif maddeli adjuvant. |
EP1221971A2 (en) | 1999-09-24 | 2002-07-17 | SmithKline Beecham Biologics SA | Use of the combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines |
WO2003002065A2 (en) * | 2001-06-29 | 2003-01-09 | Chiron Corporation | Hcv e1e2 vaccine compositions |
US7348011B2 (en) * | 2005-06-10 | 2008-03-25 | Sudershan Biotech Ltd. | Hepatitis C virus vaccine |
WO2007041432A2 (en) * | 2005-09-30 | 2007-04-12 | Novartis Vaccines And Diagnostics, Inc. | Cross-neutralization of hcv with recombinant proteins |
US8603468B2 (en) * | 2007-11-06 | 2013-12-10 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Neutralization of HCV |
WO2014060851A2 (en) * | 2012-10-05 | 2014-04-24 | The Governors Of The University Of Alberta | Hepatitis c virus immunogenic compositions and methods of use thereof |
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2014
- 2014-05-15 WO PCT/IB2014/001972 patent/WO2015132619A1/en active Application Filing
- 2014-05-15 US US14/783,699 patent/US20210145963A9/en not_active Abandoned
- 2014-05-15 CN CN201480027001.3A patent/CN105263517B/zh active Active
- 2014-05-15 CA CA2909586A patent/CA2909586C/en active Active
- 2014-05-15 JP JP2016513459A patent/JP2016520077A/ja not_active Withdrawn
- 2014-05-15 EP EP14884476.4A patent/EP2996718B1/en active Active
- 2014-05-15 EP EP19215826.9A patent/EP3689375A1/en not_active Withdrawn
- 2014-05-15 CN CN202110252076.3A patent/CN112999344A/zh active Pending
- 2014-05-15 AU AU2014385320A patent/AU2014385320B2/en active Active
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2015
- 2015-11-13 CL CL2015003333A patent/CL2015003333A1/es unknown
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2016
- 2016-04-18 HK HK16104408.0A patent/HK1216395A1/zh unknown
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2019
- 2019-05-08 JP JP2019087976A patent/JP2019142962A/ja not_active Withdrawn
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2020
- 2020-01-10 AU AU2020200216A patent/AU2020200216A1/en not_active Abandoned
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2021
- 2021-01-08 JP JP2021001926A patent/JP2021059596A/ja active Pending
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2022
- 2022-02-04 AU AU2022200747A patent/AU2022200747A1/en active Pending
- 2022-03-23 US US17/702,231 patent/US20230098265A1/en not_active Abandoned
- 2022-08-31 JP JP2022137454A patent/JP2022172244A/ja active Pending
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US20160067332A1 (en) | 2016-03-10 |
EP2996718B1 (en) | 2020-01-15 |
CN105263517A (zh) | 2016-01-20 |
CA2909586C (en) | 2021-08-31 |
CA2909586A1 (en) | 2015-09-11 |
US20210145963A9 (en) | 2021-05-20 |
JP2019142962A (ja) | 2019-08-29 |
CL2015003333A1 (es) | 2016-09-30 |
JP2016520077A (ja) | 2016-07-11 |
CN105263517B (zh) | 2021-03-26 |
JP2021059596A (ja) | 2021-04-15 |
EP2996718A1 (en) | 2016-03-23 |
AU2022200747A1 (en) | 2022-02-24 |
WO2015132619A1 (en) | 2015-09-11 |
EP2996718A4 (en) | 2017-06-21 |
AU2014385320A1 (en) | 2015-11-12 |
US20230098265A1 (en) | 2023-03-30 |
EP3689375A1 (en) | 2020-08-05 |
AU2014385320B2 (en) | 2019-10-10 |
HK1216395A1 (zh) | 2016-11-11 |
AU2020200216A1 (en) | 2020-02-06 |
CN112999344A (zh) | 2021-06-22 |
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