JP2022160648A5 - - Google Patents
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- Publication number
- JP2022160648A5 JP2022160648A5 JP2022127610A JP2022127610A JP2022160648A5 JP 2022160648 A5 JP2022160648 A5 JP 2022160648A5 JP 2022127610 A JP2022127610 A JP 2022127610A JP 2022127610 A JP2022127610 A JP 2022127610A JP 2022160648 A5 JP2022160648 A5 JP 2022160648A5
- Authority
- JP
- Japan
- Prior art keywords
- topical composition
- composition
- topical
- composition according
- fenoldopam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 claims 55
- 230000000699 topical effect Effects 0.000 claims 31
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
- 229960002724 fenoldopam Drugs 0.000 claims 9
- TVURRHSHRRELCG-UHFFFAOYSA-N fenoldopam Chemical group C1=CC(O)=CC=C1C1C2=CC(O)=C(O)C(Cl)=C2CCNC1 TVURRHSHRRELCG-UHFFFAOYSA-N 0.000 claims 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 7
- 208000017520 skin disease Diseases 0.000 claims 7
- 229920001577 copolymer Polymers 0.000 claims 5
- 230000001404 mediated effect Effects 0.000 claims 5
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims 4
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000003349 gelling agent Substances 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 235000011187 glycerol Nutrition 0.000 claims 3
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims 2
- XUKUURHRXDUEBC-SXOMAYOGSA-N (3s,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-SXOMAYOGSA-N 0.000 claims 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims 2
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000006184 cosolvent Substances 0.000 claims 2
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 2
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims 2
- 239000003974 emollient agent Substances 0.000 claims 2
- 229960004009 fenoldopam mesylate Drugs 0.000 claims 2
- 229940051250 hexylene glycol Drugs 0.000 claims 2
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000003002 pH adjusting agent Substances 0.000 claims 2
- 229920002401 polyacrylamide Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000006208 topical dosage form Substances 0.000 claims 2
- ZQCIPRGNRQXXSK-UHFFFAOYSA-N 1-octadecoxypropan-2-ol Chemical group CCCCCCCCCCCCCCCCCCOCC(C)O ZQCIPRGNRQXXSK-UHFFFAOYSA-N 0.000 claims 1
- DWHIUNMOTRUVPG-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO DWHIUNMOTRUVPG-UHFFFAOYSA-N 0.000 claims 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 1
- 102000004076 Dopamine D1 Receptors Human genes 0.000 claims 1
- 108090000511 Dopamine D1 Receptors Proteins 0.000 claims 1
- CVKUMNRCIJMVAR-UHFFFAOYSA-N Fenoldopam mesylate Chemical group CS(O)(=O)=O.C1=CC(O)=CC=C1C1C2=CC(O)=C(O)C(Cl)=C2CCNC1 CVKUMNRCIJMVAR-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000007979 citrate buffer Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 229940086555 cyclomethicone Drugs 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 229940031578 diisopropyl adipate Drugs 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000004088 foaming agent Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims 1
- 229940031674 laureth-7 Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 229940078491 ppg-15 stearyl ether Drugs 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- 229960004418 trolamine Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962815893P | 2019-03-08 | 2019-03-08 | |
| US62/815,893 | 2019-03-08 | ||
| PCT/IB2020/051967 WO2020183322A1 (en) | 2019-03-08 | 2020-03-06 | Stable topical compositions of fenoldopam |
| JP2021553117A JP7124234B2 (ja) | 2019-03-08 | 2020-03-06 | フェノルドパムの安定な局所用組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021553117A Division JP7124234B2 (ja) | 2019-03-08 | 2020-03-06 | フェノルドパムの安定な局所用組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022160648A JP2022160648A (ja) | 2022-10-19 |
| JP2022160648A5 true JP2022160648A5 (https=) | 2022-11-16 |
Family
ID=69846519
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021553117A Active JP7124234B2 (ja) | 2019-03-08 | 2020-03-06 | フェノルドパムの安定な局所用組成物 |
| JP2022127610A Ceased JP2022160648A (ja) | 2019-03-08 | 2022-08-10 | フェノルドパムの安定な局所用組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021553117A Active JP7124234B2 (ja) | 2019-03-08 | 2020-03-06 | フェノルドパムの安定な局所用組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11446237B2 (https=) |
| EP (2) | EP3908255B1 (https=) |
| JP (2) | JP7124234B2 (https=) |
| CN (2) | CN116966129A (https=) |
| AU (2) | AU2020236525B2 (https=) |
| BR (1) | BR112021017140A2 (https=) |
| CA (1) | CA3131049A1 (https=) |
| ES (1) | ES2941241T3 (https=) |
| IL (1) | IL286197A (https=) |
| NZ (1) | NZ781774A (https=) |
| WO (1) | WO2020183322A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2023257375A1 (en) | 2022-04-21 | 2024-11-07 | Glaukos Corporation | Ophthalmic topical cream compositions |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| ATE210975T1 (de) | 1994-06-23 | 2002-01-15 | Procter & Gamble | Topisch anzuwendende zubereitungen enthaltend n- acetyl-l-cystein |
| US6054429A (en) | 1996-03-08 | 2000-04-25 | Elan Pharmaceuticals, Inc. | Epidural method of producing analgesia |
| AU3869399A (en) | 1998-04-27 | 1999-11-16 | Elan Pharmaceuticals, Inc. | Transdermal administration of fenoldopam |
| JPH11335236A (ja) | 1998-05-22 | 1999-12-07 | Shiseido Co Ltd | 皮膚外用剤 |
| EP1100476B1 (en) * | 1998-07-24 | 2004-06-16 | ALZA Corporation | Formulations for the transdermal administration of fenoldopam |
| US6699497B1 (en) | 1998-07-24 | 2004-03-02 | Alza Corporation | Formulations for the transdermal administration of fenoldopam |
| US7442369B1 (en) * | 2000-08-09 | 2008-10-28 | Mcneil Ab | Compositions of minoxidil |
| US7358236B1 (en) | 2002-06-21 | 2008-04-15 | Oxigene, Inc. | Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| WO2005079851A2 (en) | 2004-02-18 | 2005-09-01 | Sepracor, Inc. | Dopamine-agonist combination therapy with sedatives for improving sleep quality |
| WO2005108387A2 (en) | 2004-05-03 | 2005-11-17 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
| CN101151028A (zh) * | 2005-03-03 | 2008-03-26 | Isw集团公司 | 局部用凝胶组合物 |
| AU2006265002B2 (en) | 2005-06-30 | 2012-09-20 | Centocor, Inc. | Anti-IL-23 antibodies, compositions, methods and uses |
| JP2009502206A (ja) | 2005-08-03 | 2009-01-29 | ミニュー・セラピューティクス・リミテッド | 腫瘍壊死因子アルファ（ＴＮＦ−α）合成および分泌を調節するための、Ｔ細胞におけるＫｖ１．１電位依存性カリウムチャンネルのモデュレーション、およびＴＮＦ−αの有害な高または低レベルを介しての人の疾患または傷害の治療 |
| WO2009052491A2 (en) | 2007-10-18 | 2009-04-23 | Geraghty, Erin | Fenoldopam formulations and prodrug derivatives |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| WO2009076553A1 (en) | 2007-12-11 | 2009-06-18 | Monroe Stephen H | Composition of aqueous buffer solution for the treatment of cellular environment and ion channels and methods for using same |
| CA2732439A1 (en) | 2008-07-31 | 2010-02-04 | Case Western Reserve University | Halogen-stabilized insulin |
| JP2011144143A (ja) | 2010-01-15 | 2011-07-28 | Shiseido Co Ltd | 皮膚外用剤 |
| RU2571277C2 (ru) | 2010-10-21 | 2015-12-20 | Галдерма С.А. | Композиции геля с бримонидином и способы применения |
| HUE034480T2 (en) | 2011-04-28 | 2018-02-28 | Platform Brightworks Two Ltd | Improved parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same |
| FR2991177B1 (fr) | 2012-06-01 | 2014-12-19 | Galderma Res & Dev | Compositions topiques, contenant un retinoide, de type emulsion huile dans eau sans emulsionnant |
| AU2014227996B2 (en) * | 2013-03-15 | 2018-08-23 | Vapogenix, Inc. | Novel analgesic compositions |
| JP6893075B2 (ja) | 2014-08-04 | 2021-06-23 | 日東電工株式会社 | 液性免疫誘導促進用組成物及びワクチン医薬組成物 |
| UA121985C2 (uk) * | 2015-01-23 | 2020-08-25 | Др. Редді'З Лабораторіз Лімітед | Нефарбуюча гелева композиція для місцевого застосування, яка містить німесулід |
| EP3506906A4 (en) * | 2016-08-31 | 2020-08-12 | Taro Pharmaceutical Industries Ltd. | TOPICAL FORMULATIONS OF FENOLDOPAM FOR THE TREATMENT OF SKIN DISORDERS |
| MX2020004187A (es) * | 2017-10-24 | 2020-09-21 | Glenmark Pharmaceuticals Ltd | Composicion farmaceutica topica de adapaleno y minociclina. |
-
2020
- 2020-03-06 NZ NZ781774A patent/NZ781774A/en not_active IP Right Cessation
- 2020-03-06 US US17/430,264 patent/US11446237B2/en active Active
- 2020-03-06 EP EP20712690.5A patent/EP3908255B1/en active Active
- 2020-03-06 ES ES20712690T patent/ES2941241T3/es active Active
- 2020-03-06 CN CN202310774370.XA patent/CN116966129A/zh active Pending
- 2020-03-06 CA CA3131049A patent/CA3131049A1/en active Pending
- 2020-03-06 AU AU2020236525A patent/AU2020236525B2/en not_active Ceased
- 2020-03-06 JP JP2021553117A patent/JP7124234B2/ja active Active
- 2020-03-06 WO PCT/IB2020/051967 patent/WO2020183322A1/en not_active Ceased
- 2020-03-06 EP EP23150539.7A patent/EP4218719A3/en not_active Withdrawn
- 2020-03-06 BR BR112021017140A patent/BR112021017140A2/pt active Search and Examination
- 2020-03-06 CN CN202080019392.XA patent/CN113543773B/zh not_active Expired - Fee Related
-
2021
- 2021-09-06 IL IL286197A patent/IL286197A/en unknown
-
2022
- 2022-05-03 AU AU2022202941A patent/AU2022202941A1/en not_active Abandoned
- 2022-08-09 US US17/883,687 patent/US20230059107A1/en not_active Abandoned
- 2022-08-10 JP JP2022127610A patent/JP2022160648A/ja not_active Ceased
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