JP2022130527A5 - - Google Patents

Info

Publication number

JP2022130527A5

JP2022130527A5 JP2022100650A JP2022100650A JP2022130527A5 JP 2022130527 A5 JP2022130527 A5 JP 2022130527A5 JP 2022100650 A JP2022100650 A JP 2022100650A JP 2022100650 A JP2022100650 A JP 2022100650A JP 2022130527 A5 JP2022130527 A5 JP 2022130527A5

Authority

JP

Japan

Prior art keywords

peptide

inhibitor

seq

thrombin

amino acid

Prior art date

2022-06-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 150000001413 amino acids Chemical group 0.000 claims description 18
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
• 239000003112 inhibitor Substances 0.000 claims 19
• 108090000190 Thrombin Proteins 0.000 claims 8
• 229960004072 thrombin Drugs 0.000 claims 8
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 8
• 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 claims 7
• 229940122388 Thrombin inhibitor Drugs 0.000 claims 7
• 108010091748 peptide A Proteins 0.000 claims 7
• 239000003868 thrombin inhibitor Substances 0.000 claims 7
• 235000001014 amino acid Nutrition 0.000 claims 6
• 235000002374 tyrosine Nutrition 0.000 claims 6
• 102000007625 Hirudins Human genes 0.000 claims 4
• 108010007267 Hirudins Proteins 0.000 claims 4
• WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 claims 4
• 229940006607 hirudin Drugs 0.000 claims 4
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 238000002560 therapeutic procedure Methods 0.000 claims 3
• 239000003146 anticoagulant agent Substances 0.000 claims 2
• 108020001507 fusion proteins Proteins 0.000 claims 2
• 102000037865 fusion proteins Human genes 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 230000002537 thrombolytic effect Effects 0.000 claims 2
• 206010053567 Coagulopathies Diseases 0.000 claims 1
• 102000009123 Fibrin Human genes 0.000 claims 1
• 108010073385 Fibrin Proteins 0.000 claims 1
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
• 108010049003 Fibrinogen Proteins 0.000 claims 1
• 102000008946 Fibrinogen Human genes 0.000 claims 1
• 101800005149 Peptide B Proteins 0.000 claims 1
• 230000000740 bleeding effect Effects 0.000 claims 1
• 230000035602 clotting Effects 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 229950003499 fibrin Drugs 0.000 claims 1
• 229940012952 fibrinogen Drugs 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 108010005636 polypeptide C Proteins 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1