JP2022119843A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2022119843A5 JP2022119843A5 JP2022081328A JP2022081328A JP2022119843A5 JP 2022119843 A5 JP2022119843 A5 JP 2022119843A5 JP 2022081328 A JP2022081328 A JP 2022081328A JP 2022081328 A JP2022081328 A JP 2022081328A JP 2022119843 A5 JP2022119843 A5 JP 2022119843A5
- Authority
- JP
- Japan
- Prior art keywords
- liquid spray
- formulation
- spray formulation
- naloxone
- antioxidant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 16
- 239000007788 liquid Substances 0.000 claims 12
- 239000007921 spray Substances 0.000 claims 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims 2
- 229960004127 naloxone Drugs 0.000 claims 2
- 239000007922 nasal spray Substances 0.000 claims 2
- 229940097496 nasal spray Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 1
- 235000010378 sodium ascorbate Nutrition 0.000 claims 1
- 229960005055 sodium ascorbate Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical group [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/238,909 | 2016-08-17 | ||
| US15/238,909 US10722510B2 (en) | 2014-07-08 | 2016-08-17 | Liquid naloxone spray |
| US15/601,331 | 2017-05-22 | ||
| US15/601,331 US10617686B2 (en) | 2014-07-08 | 2017-05-22 | Liquid naloxone spray |
| JP2019508941A JP7114570B2 (ja) | 2016-08-17 | 2017-08-10 | 液体ナロキソンスプレー |
| PCT/US2017/046198 WO2018034920A1 (en) | 2016-08-17 | 2017-08-10 | Liquid naloxone spray |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508941A Division JP7114570B2 (ja) | 2016-08-17 | 2017-08-10 | 液体ナロキソンスプレー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022119843A JP2022119843A (ja) | 2022-08-17 |
| JP2022119843A5 true JP2022119843A5 (enExample) | 2022-09-22 |
| JP7455157B2 JP7455157B2 (ja) | 2024-03-25 |
Family
ID=61197156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508941A Active JP7114570B2 (ja) | 2016-08-17 | 2017-08-10 | 液体ナロキソンスプレー |
| JP2022081328A Active JP7455157B2 (ja) | 2016-08-17 | 2022-05-18 | 液体ナロキソンスプレー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508941A Active JP7114570B2 (ja) | 2016-08-17 | 2017-08-10 | 液体ナロキソンスプレー |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3500261A4 (enExample) |
| JP (2) | JP7114570B2 (enExample) |
| CN (1) | CN109922805A (enExample) |
| AU (1) | AU2017312811B2 (enExample) |
| CA (1) | CA3033897C (enExample) |
| MA (1) | MA45995A (enExample) |
| WO (1) | WO2018034920A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
| CN106233141B (zh) | 2014-02-18 | 2018-08-21 | 罗伯特·I·汉金 | 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物 |
| CA3033897C (en) * | 2016-08-17 | 2024-03-26 | Insys Development Company, Inc. | Liquid naloxone spray |
| US20180193332A1 (en) * | 2017-10-09 | 2018-07-12 | Adapt Pharma Operations Limited | Low-temperature stable opioid antagonist solutions |
| EP3897603A4 (en) * | 2018-12-19 | 2022-09-14 | Grace Therapeutics Inc. | THERAPEUTIC COMPOSITION OF INTRANASAL LIDOCAINE |
| US11129795B2 (en) | 2019-02-21 | 2021-09-28 | Pharmaceutical Productions, Inc. | Naloxone formulations for sublingual and/or buccal administration |
| CN112138250B (zh) * | 2019-06-28 | 2023-04-14 | 四川普锐特药业有限公司 | 保持给药均一度的药物流体分配器及右美托咪定鼻喷器 |
| WO2021158957A1 (en) | 2020-02-05 | 2021-08-12 | Summit Biosciences Inc. | Drug products for intranasal administration and uses thereof |
| US12569493B2 (en) | 2020-03-24 | 2026-03-10 | Cyrano Therapeutics Inc. | Treatment of chemosensory dysfunction from a coronavirus infection |
| JP2025502075A (ja) * | 2022-01-06 | 2025-01-24 | シラノ セラピューティクス， インコーポレイテッド | パーキンソン病治療剤の改善された鼻投与 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US585A (en) | 1838-01-27 | Apparatus for extinguishing sparks in the chimneys oe steam-boilers | ||
| US14730A (en) | 1856-04-22 | Improvement in corn-harvesters | ||
| CN1575795A (zh) * | 2003-06-25 | 2005-02-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 盐酸纳洛酮鼻腔喷雾剂 |
| US8627816B2 (en) * | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| SG194927A1 (en) * | 2011-05-13 | 2013-12-30 | Euro Celtique Sa | Intranasal pharmaceutical dosage forms comprising naloxone |
| MY185284A (en) * | 2011-09-19 | 2021-04-30 | Orexo Ab | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
| US8940052B2 (en) | 2012-07-26 | 2015-01-27 | DePuy Synthes Products, LLC | Expandable implant |
| CA2795324C (en) * | 2012-11-09 | 2015-07-14 | Purdue Pharma | Pharmaceutical compositions comprising hydromorphone and naloxone |
| ES2802976T3 (es) * | 2013-09-10 | 2021-01-22 | Fresh Cut Dev Llc | Pulverizador de buprenorfina sublingual |
| CN103637987B (zh) * | 2013-12-09 | 2015-12-02 | 韩彬 | 羟考酮的液体药物组合物 |
| EP3082816B1 (en) | 2013-12-20 | 2019-03-20 | Indivior UK Limited | Intranasal naloxone compositions and methods of making and using same |
| US9480644B2 (en) | 2014-03-14 | 2016-11-01 | Opiant Pharmaceuticals, Inc. | Nasal drug products and methods of their use |
| EP3777838A1 (en) | 2014-03-14 | 2021-02-17 | Opiant Pharmaceuticals, Inc. | Nasal drug products and methods of their use |
| US20160199294A1 (en) * | 2014-07-08 | 2016-07-14 | Insys Development Company, Inc. | Sublingual naloxone spray |
| CA2954370A1 (en) * | 2014-07-08 | 2016-01-14 | Insys Pharma, Inc. | Sublingual naloxone spray |
| CA3033897C (en) * | 2016-08-17 | 2024-03-26 | Insys Development Company, Inc. | Liquid naloxone spray |
-
2017
- 2017-08-10 CA CA3033897A patent/CA3033897C/en active Active
- 2017-08-10 MA MA045995A patent/MA45995A/fr unknown
- 2017-08-10 JP JP2019508941A patent/JP7114570B2/ja active Active
- 2017-08-10 AU AU2017312811A patent/AU2017312811B2/en active Active
- 2017-08-10 CN CN201780063967.6A patent/CN109922805A/zh active Pending
- 2017-08-10 EP EP17841883.6A patent/EP3500261A4/en active Pending
- 2017-08-10 WO PCT/US2017/046198 patent/WO2018034920A1/en not_active Ceased
-
2022
- 2022-05-18 JP JP2022081328A patent/JP7455157B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022119843A5 (enExample) | ||
| CA2870158C (en) | Xylitol-based anti-mucosal compositions and related methods and compositions | |
| ES2236189T3 (es) | Nueva combinacion de antihistaminicos no sedativos que contienen sustancias que influyen en la accion del leucotrieno, para el tratamiento de la rinitis/conjuntivitis. | |
| US7115275B2 (en) | System for delivering a composition to the nasal membrane and method of using same | |
| US6333044B1 (en) | Therapeutic compositions for intranasal administration which include KETOROLAC® | |
| CA2456356C (en) | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection | |
| CA2489427A1 (en) | Combination of azelastine and steroids | |
| JPH0161086B2 (enExample) | ||
| JP2014040481A (ja) | 座瘡病変の治療のためのアダパレンと過酸化ベンゾイルとの組合せ | |
| JP2011529038A5 (enExample) | ||
| LT4677B (lt) | Vandeninė suspensija, vartotina per nosį | |
| US20110237547A1 (en) | Pharmaceutical compositions for the treatment of fungal infections | |
| HUP0303877A2 (hu) | Imidazotriazinon-tartalmú készítmények nazális alkalmazásra | |
| WO2001035926A2 (en) | An improved pharmaceutical composition for treating male erectile dysfunction | |
| EP1006969A1 (en) | Intranasal formulations for promoting sleep and method of using the same | |
| JP5695580B2 (ja) | ラタノプロストのバイオアベイラビリティを向上させる方法 | |
| CA1197783A (en) | Nasal pharmaceutical compositions | |
| US12311004B2 (en) | Ophthalmic formulations and methods of use | |
| JP2005053907A (ja) | エピナスチンと１種以上のさらなる抗−ｈ１−ヒスタミン類との組合せを含む皮膚疾患治療用製薬組成物 | |
| JPH10259132A (ja) | 点鼻用水性懸濁液 | |
| WO2022272083A1 (en) | Dexmecamylamine and uses thereof | |
| US20250255915A1 (en) | Ophthalmic formulations and methods of use | |
| IT202000014350A1 (it) | NUOVO APPROCCIO FARMACOLOGICO PER IL TRATTAMENTO DI SARS-CoV2 E VIRUS INFLUENZALI TRAMITE L’USO DI SPRAY NASALI | |
| JPWO2023102363A5 (enExample) | ||
| MXPA99007597A (en) | Topical nasal antiinflammatory compositions |