JP7114570B2 - 液体ナロキソンスプレー - Google Patents

液体ナロキソンスプレー Download PDF

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Publication number
JP7114570B2
JP7114570B2 JP2019508941A JP2019508941A JP7114570B2 JP 7114570 B2 JP7114570 B2 JP 7114570B2 JP 2019508941 A JP2019508941 A JP 2019508941A JP 2019508941 A JP2019508941 A JP 2019508941A JP 7114570 B2 JP7114570 B2 JP 7114570B2
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formulations
formulation
naloxone
liquid spray
preferred
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JP2019508941A
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English (en)
Japanese (ja)
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JP2019528278A (ja
Inventor
アマンチャ，キラン
チラムパリ，シバーニー
ポッタ，ティモシー
イェン，ニンシン
ゴスコンダ，ベンカット・アール
ナラヤナン，エッシュワラン
Original Assignee
ヒクマ・ファーマシューティカルズ・ユー・エス・エイ・インコーポレイテッド
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Priority claimed from US15/238,909 external-priority patent/US10722510B2/en
Priority claimed from US15/601,331 external-priority patent/US10617686B2/en
Application filed by ヒクマ・ファーマシューティカルズ・ユー・エス・エイ・インコーポレイテッド filed Critical ヒクマ・ファーマシューティカルズ・ユー・エス・エイ・インコーポレイテッド
Publication of JP2019528278A publication Critical patent/JP2019528278A/ja
Priority to JP2022081328A priority Critical patent/JP7455157B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019508941A 2016-08-17 2017-08-10 液体ナロキソンスプレー Active JP7114570B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022081328A JP7455157B2 (ja) 2016-08-17 2022-05-18 液体ナロキソンスプレー

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15/238,909 US10722510B2 (en) 2014-07-08 2016-08-17 Liquid naloxone spray
US15/238,909 2016-08-17
US15/601,331 US10617686B2 (en) 2014-07-08 2017-05-22 Liquid naloxone spray
US15/601,331 2017-05-22
PCT/US2017/046198 WO2018034920A1 (en) 2016-08-17 2017-08-10 Liquid naloxone spray

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022081328A Division JP7455157B2 (ja) 2016-08-17 2022-05-18 液体ナロキソンスプレー

Publications (2)

Publication Number Publication Date
JP2019528278A JP2019528278A (ja) 2019-10-10
JP7114570B2 true JP7114570B2 (ja) 2022-08-08

Family

ID=61197156

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019508941A Active JP7114570B2 (ja) 2016-08-17 2017-08-10 液体ナロキソンスプレー
JP2022081328A Active JP7455157B2 (ja) 2016-08-17 2022-05-18 液体ナロキソンスプレー

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022081328A Active JP7455157B2 (ja) 2016-08-17 2022-05-18 液体ナロキソンスプレー

Country Status (7)

Country Link
EP (1) EP3500261A4 (enExample)
JP (2) JP7114570B2 (enExample)
CN (1) CN109922805A (enExample)
AU (1) AU2017312811B2 (enExample)
CA (1) CA3033897C (enExample)
MA (1) MA45995A (enExample)
WO (1) WO2018034920A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
EP3108245B1 (en) 2014-02-18 2020-07-22 Robert I. Henkin Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
CN109922805A (zh) * 2016-08-17 2019-06-21 因塞斯发展股份有限公司 液体纳洛酮喷雾
US20180193332A1 (en) * 2017-10-09 2018-07-12 Adapt Pharma Operations Limited Low-temperature stable opioid antagonist solutions
EA202191506A1 (ru) * 2018-12-19 2021-10-08 Нортик Холдингз Инк. Терапевтическая композиция интраназального лидокаина
US11129795B2 (en) 2019-02-21 2021-09-28 Pharmaceutical Productions, Inc. Naloxone formulations for sublingual and/or buccal administration
CN112138250B (zh) * 2019-06-28 2023-04-14 四川普锐特药业有限公司 保持给药均一度的药物流体分配器及右美托咪定鼻喷器
WO2021158957A1 (en) 2020-02-05 2021-08-12 Summit Biosciences Inc. Drug products for intranasal administration and uses thereof
KR20240134157A (ko) * 2022-01-06 2024-09-06 시라노 테라퓨틱스, 아이엔씨. 파킨슨 치료제의 개선된 코 투여

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1575795A (zh) 2003-06-25 2005-02-09 中国人民解放军军事医学科学院毒物药物研究所 盐酸纳洛酮鼻腔喷雾剂
CN103637987A (zh) 2013-12-09 2014-03-19 韩彬 羟考酮的液体药物组合物
JP2014513683A (ja) 2011-05-13 2014-06-05 ユーロ−セルティーク エス．エイ． ナロキソンを含む鼻腔内医薬剤形
WO2015038327A1 (en) 2013-09-10 2015-03-19 Insys Pharma, Inc. Sublingual buprenorphine spray
WO2015136373A1 (en) 2014-03-14 2015-09-17 Lightlake Therapeutics Inc. Nasal drug products and methods of their use
WO2016007245A1 (en) 2014-07-08 2016-01-14 Insys Pharma, Inc. Sublingual naloxone spray

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US585A (en) 1838-01-27 Apparatus for extinguishing sparks in the chimneys oe steam-boilers
US14730A (en) 1856-04-22 Improvement in corn-harvesters
US8627816B2 (en) * 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
EP2915525B1 (en) * 2011-09-19 2021-08-11 Orexo AB Sublingual abuse-resistant tablets comprising buprenorphine and naloxone
US8940052B2 (en) 2012-07-26 2015-01-27 DePuy Synthes Products, LLC Expandable implant
CA2795324C (en) * 2012-11-09 2015-07-14 Purdue Pharma Pharmaceutical compositions comprising hydromorphone and naloxone
CA2875384A1 (en) 2013-12-20 2015-06-20 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
US9480644B2 (en) 2014-03-14 2016-11-01 Opiant Pharmaceuticals, Inc. Nasal drug products and methods of their use
US20160199294A1 (en) * 2014-07-08 2016-07-14 Insys Development Company, Inc. Sublingual naloxone spray
CN109922805A (zh) 2016-08-17 2019-06-21 因塞斯发展股份有限公司 液体纳洛酮喷雾

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1575795A (zh) 2003-06-25 2005-02-09 中国人民解放军军事医学科学院毒物药物研究所 盐酸纳洛酮鼻腔喷雾剂
JP2014513683A (ja) 2011-05-13 2014-06-05 ユーロ−セルティーク エス．エイ． ナロキソンを含む鼻腔内医薬剤形
WO2015038327A1 (en) 2013-09-10 2015-03-19 Insys Pharma, Inc. Sublingual buprenorphine spray
CN103637987A (zh) 2013-12-09 2014-03-19 韩彬 羟考酮的液体药物组合物
WO2015136373A1 (en) 2014-03-14 2015-09-17 Lightlake Therapeutics Inc. Nasal drug products and methods of their use
WO2016007245A1 (en) 2014-07-08 2016-01-14 Insys Pharma, Inc. Sublingual naloxone spray

Also Published As

Publication number Publication date
CA3033897C (en) 2024-03-26
JP7455157B2 (ja) 2024-03-25
AU2017312811A1 (en) 2019-03-07
MA45995A (fr) 2019-06-26
AU2017312811B2 (en) 2023-03-16
JP2019528278A (ja) 2019-10-10
EP3500261A1 (en) 2019-06-26
CA3033897A1 (en) 2018-02-22
CN109922805A (zh) 2019-06-21
JP2022119843A (ja) 2022-08-17
EP3500261A4 (en) 2020-05-06
AU2017312811A8 (en) 2019-03-14
WO2018034920A1 (en) 2018-02-22

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