EP3500261A4 - Liquid naloxone spray - Google Patents
Liquid naloxone spray Download PDFInfo
- Publication number
- EP3500261A4 EP3500261A4 EP17841883.6A EP17841883A EP3500261A4 EP 3500261 A4 EP3500261 A4 EP 3500261A4 EP 17841883 A EP17841883 A EP 17841883A EP 3500261 A4 EP3500261 A4 EP 3500261A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- naloxone spray
- liquid
- liquid naloxone
- spray
- naloxone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 title 1
- 229960004127 naloxone Drugs 0.000 title 1
- 239000007921 spray Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/238,909 US10722510B2 (en) | 2014-07-08 | 2016-08-17 | Liquid naloxone spray |
| US15/601,331 US10617686B2 (en) | 2014-07-08 | 2017-05-22 | Liquid naloxone spray |
| PCT/US2017/046198 WO2018034920A1 (en) | 2016-08-17 | 2017-08-10 | Liquid naloxone spray |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3500261A1 EP3500261A1 (en) | 2019-06-26 |
| EP3500261A4 true EP3500261A4 (en) | 2020-05-06 |
Family
ID=61197156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP17841883.6A Pending EP3500261A4 (en) | 2016-08-17 | 2017-08-10 | Liquid naloxone spray |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3500261A4 (en) |
| JP (2) | JP7114570B2 (en) |
| CN (1) | CN109922805A (en) |
| AU (1) | AU2017312811B2 (en) |
| CA (1) | CA3033897C (en) |
| MA (1) | MA45995A (en) |
| WO (1) | WO2018034920A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10598672B2 (en) | 2014-02-18 | 2020-03-24 | Cyrano Therapeutics, Inc. | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
| EP3500261A4 (en) | 2016-08-17 | 2020-05-06 | Hikma Pharmaceuticals USA Inc. | Liquid naloxone spray |
| US20180193332A1 (en) * | 2017-10-09 | 2018-07-12 | Adapt Pharma Operations Limited | Low-temperature stable opioid antagonist solutions |
| US11129795B2 (en) | 2019-02-21 | 2021-09-28 | Pharmaceutical Productions, Inc. | Naloxone formulations for sublingual and/or buccal administration |
| CN112138250B (en) * | 2019-06-28 | 2023-04-14 | 四川普锐特药业有限公司 | Medicament fluid dispenser and dexmedetomidine nasal spray device for maintaining uniform administration |
| WO2021158957A1 (en) * | 2020-02-05 | 2021-08-12 | Summit Biosciences Inc. | Drug products for intranasal administration and uses thereof |
| WO2023133463A1 (en) * | 2022-01-06 | 2023-07-13 | Cyrano Therapeutics, Inc. | Improved nasal administration of parkinson's therapeutics |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1575795A (en) * | 2003-06-25 | 2005-02-09 | 中国人民解放军军事医学科学院毒物药物研究所 | Naloxone hydrochloride nasal spray |
| US20160199294A1 (en) * | 2014-07-08 | 2016-07-14 | Insys Development Company, Inc. | Sublingual naloxone spray |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US585A (en) | 1838-01-27 | Apparatus for extinguishing sparks in the chimneys oe steam-boilers | ||
| US14730A (en) | 1856-04-22 | Improvement in corn-harvesters | ||
| US8627816B2 (en) * | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| DK2706982T4 (en) | 2011-05-13 | 2021-05-10 | Euro Celtique Sa | INTRANASAL PHARMACEUTICAL DOSAGE FORMS INCLUDING NALOXON |
| CA2834327C (en) * | 2011-09-19 | 2017-05-30 | Orexo Ab | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
| US8940052B2 (en) | 2012-07-26 | 2015-01-27 | DePuy Synthes Products, LLC | Expandable implant |
| CA2881144A1 (en) * | 2012-11-09 | 2014-05-09 | Purdue Pharma | Pharmaceutical compositions comprising hydromorphone and naloxone |
| EP3043777B1 (en) | 2013-09-10 | 2020-04-22 | Fresh Cut Development, LLC | Sublingual buprenorphine spray |
| CN103637987B (en) | 2013-12-09 | 2015-12-02 | 韩彬 | The composition of liquid medicine of oxycodone |
| CA2875384A1 (en) | 2013-12-20 | 2015-06-20 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
| US9480644B2 (en) | 2014-03-14 | 2016-11-01 | Opiant Pharmaceuticals, Inc. | Nasal drug products and methods of their use |
| CN110755372A (en) | 2014-03-14 | 2020-02-07 | 欧皮安特制药有限公司 | Pharmaceutical product suitable for nasal delivery, pharmaceutical composition for intranasal administration and use thereof |
| WO2016007245A1 (en) | 2014-07-08 | 2016-01-14 | Insys Pharma, Inc. | Sublingual naloxone spray |
| EP3500261A4 (en) | 2016-08-17 | 2020-05-06 | Hikma Pharmaceuticals USA Inc. | Liquid naloxone spray |
-
2017
- 2017-08-10 EP EP17841883.6A patent/EP3500261A4/en active Pending
- 2017-08-10 CN CN201780063967.6A patent/CN109922805A/en active Pending
- 2017-08-10 CA CA3033897A patent/CA3033897C/en active Active
- 2017-08-10 JP JP2019508941A patent/JP7114570B2/en active Active
- 2017-08-10 WO PCT/US2017/046198 patent/WO2018034920A1/en unknown
- 2017-08-10 MA MA045995A patent/MA45995A/en unknown
- 2017-08-10 AU AU2017312811A patent/AU2017312811B2/en active Active
-
2022
- 2022-05-18 JP JP2022081328A patent/JP7455157B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1575795A (en) * | 2003-06-25 | 2005-02-09 | 中国人民解放军军事医学科学院毒物药物研究所 | Naloxone hydrochloride nasal spray |
| US20160199294A1 (en) * | 2014-07-08 | 2016-07-14 | Insys Development Company, Inc. | Sublingual naloxone spray |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019528278A (en) | 2019-10-10 |
| AU2017312811B2 (en) | 2023-03-16 |
| WO2018034920A1 (en) | 2018-02-22 |
| MA45995A (en) | 2019-06-26 |
| CN109922805A (en) | 2019-06-21 |
| EP3500261A1 (en) | 2019-06-26 |
| CA3033897C (en) | 2024-03-26 |
| AU2017312811A1 (en) | 2019-03-07 |
| JP7455157B2 (en) | 2024-03-25 |
| JP2022119843A (en) | 2022-08-17 |
| JP7114570B2 (en) | 2022-08-08 |
| CA3033897A1 (en) | 2018-02-22 |
| AU2017312811A8 (en) | 2019-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20190315 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| AX | Request for extension of the european patent |
Extension state: BA ME |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: HIKMA PHARMACEUTICALS USA INC. |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20200402 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 9/00 20060101ALI20200328BHEP Ipc: A61K 47/18 20170101ALI20200328BHEP Ipc: A61K 31/485 20060101AFI20200328BHEP |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40011159 Country of ref document: HK |
|
| P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230513 |
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| RAP3 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: HIKMA PHARMACEUTICALS USA INC. |