JP2022119843A5 - - Google Patents
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- Publication number
- JP2022119843A5 JP2022119843A5 JP2022081328A JP2022081328A JP2022119843A5 JP 2022119843 A5 JP2022119843 A5 JP 2022119843A5 JP 2022081328 A JP2022081328 A JP 2022081328A JP 2022081328 A JP2022081328 A JP 2022081328A JP 2022119843 A5 JP2022119843 A5 JP 2022119843A5
- Authority
- JP
- Japan
- Prior art keywords
- liquid spray
- formulation
- spray formulation
- naloxone
- antioxidant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 16
- 239000007788 liquid Substances 0.000 claims 12
- 239000007921 spray Substances 0.000 claims 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims 2
- 229960004127 naloxone Drugs 0.000 claims 2
- 239000007922 nasal spray Substances 0.000 claims 2
- 229940097496 nasal spray Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 1
- 235000010378 sodium ascorbate Nutrition 0.000 claims 1
- 229960005055 sodium ascorbate Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical group [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/238,909 US10722510B2 (en) | 2014-07-08 | 2016-08-17 | Liquid naloxone spray |
| US15/238,909 | 2016-08-17 | ||
| US15/601,331 US10617686B2 (en) | 2014-07-08 | 2017-05-22 | Liquid naloxone spray |
| US15/601,331 | 2017-05-22 | ||
| JP2019508941A JP7114570B2 (ja) | 2016-08-17 | 2017-08-10 | 液体ナロキソンスプレー |
| PCT/US2017/046198 WO2018034920A1 (en) | 2016-08-17 | 2017-08-10 | Liquid naloxone spray |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508941A Division JP7114570B2 (ja) | 2016-08-17 | 2017-08-10 | 液体ナロキソンスプレー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022119843A JP2022119843A (ja) | 2022-08-17 |
| JP2022119843A5 true JP2022119843A5 (enrdf_load_stackoverflow) | 2022-09-22 |
| JP7455157B2 JP7455157B2 (ja) | 2024-03-25 |
Family
ID=61197156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508941A Active JP7114570B2 (ja) | 2016-08-17 | 2017-08-10 | 液体ナロキソンスプレー |
| JP2022081328A Active JP7455157B2 (ja) | 2016-08-17 | 2022-05-18 | 液体ナロキソンスプレー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508941A Active JP7114570B2 (ja) | 2016-08-17 | 2017-08-10 | 液体ナロキソンスプレー |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3500261A4 (enrdf_load_stackoverflow) |
| JP (2) | JP7114570B2 (enrdf_load_stackoverflow) |
| CN (1) | CN109922805A (enrdf_load_stackoverflow) |
| AU (1) | AU2017312811B2 (enrdf_load_stackoverflow) |
| CA (1) | CA3033897C (enrdf_load_stackoverflow) |
| MA (1) | MA45995A (enrdf_load_stackoverflow) |
| WO (1) | WO2018034920A1 (enrdf_load_stackoverflow) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
| WO2015126944A1 (en) | 2014-02-18 | 2015-08-27 | Henkin Robert I | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
| WO2018034920A1 (en) * | 2016-08-17 | 2018-02-22 | Insys Development Company, Inc. | Liquid naloxone spray |
| US20180193332A1 (en) * | 2017-10-09 | 2018-07-12 | Adapt Pharma Operations Limited | Low-temperature stable opioid antagonist solutions |
| MX2021007213A (es) * | 2018-12-19 | 2021-09-23 | Grace therapeutics Inc | Composicion terapeutica de lidocaina intranasal. |
| WO2020172498A1 (en) * | 2019-02-21 | 2020-08-27 | Pharmaceutical Productions, Inc. | Naloxone formulations for sublingual and/or buccal administration |
| CN116474218A (zh) * | 2019-06-28 | 2023-07-25 | 四川普锐特药业有限公司 | 保持给药均一度的药物流体分配器及右美托咪定鼻喷器 |
| AU2021217164A1 (en) * | 2020-02-05 | 2022-08-25 | Summit Biosciences Inc. | Drug products for intranasal administration and uses thereof |
| EP4460291A1 (en) * | 2022-01-06 | 2024-11-13 | Cyrano Therapeutics, Inc. | Improved nasal administration of parkinson's therapeutics |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US14730A (en) | 1856-04-22 | Improvement in corn-harvesters | ||
| US585A (en) | 1838-01-27 | Apparatus for extinguishing sparks in the chimneys oe steam-boilers | ||
| CN1575795A (zh) | 2003-06-25 | 2005-02-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 盐酸纳洛酮鼻腔喷雾剂 |
| US8627816B2 (en) * | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| RU2657441C1 (ru) * | 2011-05-13 | 2018-06-13 | Эро-Селтик С.А. | Интраназальные фармацевтические дозированные формы, содержащие налоксон |
| PT2706986E (pt) * | 2011-09-19 | 2015-07-07 | Orexo Ab | Nova composição farmacêutica resistente ao abuso para o tratamento da dependência de opiáceos |
| WO2014018098A1 (en) | 2012-07-26 | 2014-01-30 | DePuy Synthes Products, LLC | Expandable implant |
| CA2795324C (en) * | 2012-11-09 | 2015-07-14 | Purdue Pharma | Pharmaceutical compositions comprising hydromorphone and naloxone |
| JP2016529328A (ja) | 2013-09-10 | 2016-09-23 | インシス・ファーマ・インコーポレーテッド | 舌下ブプレノルフィンスプレー |
| CN103637987B (zh) | 2013-12-09 | 2015-12-02 | 韩彬 | 羟考酮的液体药物组合物 |
| EP3082816B1 (en) | 2013-12-20 | 2019-03-20 | Indivior UK Limited | Intranasal naloxone compositions and methods of making and using same |
| US9211253B2 (en) | 2014-03-14 | 2015-12-15 | Lightlake Therapeutics Inc. | Nasal drug products and methods of their use |
| US9480644B2 (en) | 2014-03-14 | 2016-11-01 | Opiant Pharmaceuticals, Inc. | Nasal drug products and methods of their use |
| CA2954370A1 (en) | 2014-07-08 | 2016-01-14 | Insys Pharma, Inc. | Sublingual naloxone spray |
| US20160199294A1 (en) * | 2014-07-08 | 2016-07-14 | Insys Development Company, Inc. | Sublingual naloxone spray |
| WO2018034920A1 (en) | 2016-08-17 | 2018-02-22 | Insys Development Company, Inc. | Liquid naloxone spray |
-
2017
- 2017-08-10 WO PCT/US2017/046198 patent/WO2018034920A1/en unknown
- 2017-08-10 CN CN201780063967.6A patent/CN109922805A/zh active Pending
- 2017-08-10 MA MA045995A patent/MA45995A/fr unknown
- 2017-08-10 AU AU2017312811A patent/AU2017312811B2/en active Active
- 2017-08-10 JP JP2019508941A patent/JP7114570B2/ja active Active
- 2017-08-10 CA CA3033897A patent/CA3033897C/en active Active
- 2017-08-10 EP EP17841883.6A patent/EP3500261A4/en active Pending
-
2022
- 2022-05-18 JP JP2022081328A patent/JP7455157B2/ja active Active
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