JP2022116251A5 - - Google Patents
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- Publication number
- JP2022116251A5 JP2022116251A5 JP2022089010A JP2022089010A JP2022116251A5 JP 2022116251 A5 JP2022116251 A5 JP 2022116251A5 JP 2022089010 A JP2022089010 A JP 2022089010A JP 2022089010 A JP2022089010 A JP 2022089010A JP 2022116251 A5 JP2022116251 A5 JP 2022116251A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- pharmaceutical dosage
- root extract
- valerian root
- acidifying agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 claims description 38
- 229920000642 polymer Polymers 0.000 claims description 30
- 239000002535 acidifier Substances 0.000 claims description 25
- 239000011159 matrix material Substances 0.000 claims description 15
- 235000013832 Valeriana officinalis Nutrition 0.000 claims description 6
- 244000126014 Valeriana officinalis Species 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 235000016788 valerian Nutrition 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 5
- 239000006186 oral dosage form Substances 0.000 claims description 5
- 229940038779 valerian root extract Drugs 0.000 claims 28
- 239000001192 valeriana officinalis l. rhizome/root Substances 0.000 claims 28
- 238000009472 formulation Methods 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 20
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 12
- 238000013268 sustained release Methods 0.000 claims 8
- 239000012730 sustained-release form Substances 0.000 claims 8
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 4
- 229920001661 Chitosan Polymers 0.000 claims 4
- 229920002307 Dextran Polymers 0.000 claims 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 229940072056 alginate Drugs 0.000 claims 4
- 235000010443 alginic acid Nutrition 0.000 claims 4
- 229920000615 alginic acid Polymers 0.000 claims 4
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims 4
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 4
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 4
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 4
- 229940014041 hyaluronate Drugs 0.000 claims 4
- 239000000017 hydrogel Substances 0.000 claims 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920000609 methyl cellulose Polymers 0.000 claims 4
- 239000001923 methylcellulose Substances 0.000 claims 4
- 235000010981 methylcellulose Nutrition 0.000 claims 4
- 239000001814 pectin Substances 0.000 claims 4
- 229920001277 pectin Polymers 0.000 claims 4
- 235000010987 pectin Nutrition 0.000 claims 4
- 229960000292 pectin Drugs 0.000 claims 4
- 239000008363 phosphate buffer Substances 0.000 claims 4
- 229920001983 poloxamer Polymers 0.000 claims 4
- 229960000502 poloxamer Drugs 0.000 claims 4
- 229920001987 poloxamine Polymers 0.000 claims 4
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 4
- 229920000747 poly(lactic acid) Polymers 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 239000004626 polylactic acid Substances 0.000 claims 4
- 229920002689 polyvinyl acetate Polymers 0.000 claims 4
- 239000011118 polyvinyl acetate Substances 0.000 claims 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 239000011975 tartaric acid Substances 0.000 claims 4
- 235000002906 tartaric acid Nutrition 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 238000010521 absorption reaction Methods 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000017164 Chronobiology disease Diseases 0.000 claims 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims 1
- 229960003987 melatonin Drugs 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 description 3
- 238000006114 decarboxylation reaction Methods 0.000 description 3
- 229940095602 acidifiers Drugs 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 239000007894 caplet Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- FEBNTWHYQKGEIQ-SUKRRCERSA-N valerenic acid Chemical compound C[C@@H]1CC[C@@H](\C=C(/C)C(O)=O)C2=C(C)CC[C@H]12 FEBNTWHYQKGEIQ-SUKRRCERSA-N 0.000 description 1
- FUHPCDQQVWLRRY-UHFFFAOYSA-N valerenic acid Natural products CC1CCC(C=C(/C)C(=O)O)C2C1CC=C2C FUHPCDQQVWLRRY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662332728P | 2016-05-06 | 2016-05-06 | |
| US62/332,728 | 2016-05-06 | ||
| JP2018558279A JP7576905B2 (ja) | 2016-05-06 | 2017-05-04 | バレリアン組成物及び関連方法 |
| PCT/US2017/031046 WO2017192843A1 (en) | 2016-05-06 | 2017-05-04 | Valerian composition and related methods |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558279A Division JP7576905B2 (ja) | 2016-05-06 | 2017-05-04 | バレリアン組成物及び関連方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022116251A JP2022116251A (ja) | 2022-08-09 |
| JP2022116251A5 true JP2022116251A5 (https=) | 2024-06-24 |
| JP7577090B2 JP7577090B2 (ja) | 2024-11-01 |
Family
ID=60203773
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558279A Active JP7576905B2 (ja) | 2016-05-06 | 2017-05-04 | バレリアン組成物及び関連方法 |
| JP2022089010A Active JP7577090B2 (ja) | 2016-05-06 | 2022-05-31 | バレリアン組成物及び関連方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558279A Active JP7576905B2 (ja) | 2016-05-06 | 2017-05-04 | バレリアン組成物及び関連方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10342873B2 (https=) |
| EP (1) | EP3452020A4 (https=) |
| JP (2) | JP7576905B2 (https=) |
| KR (1) | KR20190008265A (https=) |
| CN (2) | CN117482062A (https=) |
| AU (1) | AU2017260019A1 (https=) |
| CA (1) | CA3023305C (https=) |
| MX (1) | MX2018013569A (https=) |
| RU (1) | RU2018142019A (https=) |
| WO (1) | WO2017192843A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4090315A1 (en) * | 2020-01-17 | 2022-11-23 | Société des Produits Nestlé S.A. | Dosage form with sustained release melatonin pellets |
| IT202200013576A1 (it) * | 2022-06-27 | 2023-12-27 | S I I T S R L Servizio Int Imballaggi Termosaldanti | Compressa multistrato a rilascio differenziato di melatonina e principi attivi |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2699075A1 (fr) * | 1992-12-11 | 1994-06-17 | Rech Sarl Ab | Préparation médicinale à libération programmable dans le temps notamment à base de plantes. |
| FR2713636B1 (fr) | 1993-12-07 | 1996-01-05 | Adir | Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent. |
| FR2727315A1 (fr) | 1994-11-30 | 1996-05-31 | Cooperative Agricole Laitiere | Utilisation d'un decapeptide a activite de type benzodiazepine pour la preparation de medicaments et de complements alimentaires |
| US5840332A (en) | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| US6034239A (en) | 1996-03-08 | 2000-03-07 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
| RU2190609C2 (ru) | 1996-12-10 | 2002-10-10 | Бристол-Маерс Сквибб Компани | Производные бензодиоксола, бензофурана, дигидробензофурана и бензодиоксана и содержащие их композиции |
| CA2379395A1 (en) | 1999-07-21 | 2001-02-01 | Ancile Pharmaceuticals, Inc. | Process for the extraction of valerian root |
| US6419956B1 (en) * | 1999-12-30 | 2002-07-16 | Ancile Pharmaceuticals | Odor-masking coating for a pharmaceutical preparation |
| US20050129783A1 (en) | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
| EP1465600B1 (en) * | 2001-12-20 | 2007-03-07 | Alpex Pharma SA | Particulate compositions comprising a lipophilic liquid |
| EP1743633B1 (en) | 2004-04-06 | 2010-08-18 | Taiyokagaku Co., Ltd. | Use of a combination of theanine and serotonin for sleep disorders |
| DK1758557T3 (da) | 2004-05-11 | 2011-10-24 | Egalet Ltd | Kvældbar doseringsform omfattende gellangummi |
| PL1824450T3 (pl) | 2004-10-11 | 2013-04-30 | Nasaleze Patents Ltd | Kompozycje do podawania donosowego |
| JP5220408B2 (ja) | 2005-06-22 | 2013-06-26 | 武田薬品工業株式会社 | 難溶性の有効成分を含有する錠剤 |
| EP1991241A4 (en) * | 2006-02-23 | 2009-07-08 | Iomedix Sleep Internat Srl | COMPOSITIONS AND METHODS FOR INTRODUCING AND MAINTAINING HIGH-QUALITY SLEEPING |
| CN1850212A (zh) * | 2006-02-28 | 2006-10-25 | 潮州市强基制药厂 | 一种缬草油液体硬胶囊及其制备方法 |
| BRPI0719442A2 (pt) | 2006-09-27 | 2013-12-03 | Finzelberg Gmbh & Co Kg | Processo para a preparação de um extrato de valeriana |
| US20080248106A1 (en) | 2007-04-05 | 2008-10-09 | Marvin Heuer | Melatonin-based composition for improved sleep |
| US20090197974A1 (en) * | 2008-02-05 | 2009-08-06 | Khaleeq Ahmed | Natural dietary supplement tablet |
| EP2389350A1 (en) | 2009-01-23 | 2011-11-30 | Valericon GmbH | Methods for making valerenic acid derivatives and their use |
| US20110064720A1 (en) | 2009-09-16 | 2011-03-17 | Daniel Moses Amato | Dietary Supplement Compositions and Methods of Making and Using the Same |
| CN102370833B (zh) * | 2010-08-17 | 2014-03-26 | 北京亚东生物制药有限公司 | 一种解表祛暑的泡腾剂及其制备方法和用途 |
| CN102058630B (zh) * | 2010-12-16 | 2014-03-19 | 苏州大学 | 一种镇静安神的缬草制剂及其制备方法 |
| CN102247443A (zh) * | 2010-12-23 | 2011-11-23 | 祝凤仪 | 治疗神经衰弱中药外洗粉、泡腾片的配方及其制备方法 |
| CN103429223A (zh) | 2011-01-17 | 2013-12-04 | 武田药品工业株式会社 | 口腔分散片 |
| WO2012103411A2 (en) * | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
| CN102114060B (zh) * | 2011-02-22 | 2012-12-12 | 都晓伟 | 黑水缬草提取物及其制备方法和应用 |
| JP2013053144A (ja) * | 2011-08-09 | 2013-03-21 | Daiichi Sankyo Healthcare Co Ltd | 鎮静剤組成物 |
| WO2013061161A2 (en) * | 2011-10-28 | 2013-05-02 | Green Bcn Consulting Services Sl | New combination therapies for treating neurological disorders |
| US20150250203A1 (en) | 2012-01-26 | 2015-09-10 | Wikifoods, Inc. | Enclosing materials in natural transport systems |
| KR102593047B1 (ko) | 2012-01-26 | 2023-10-24 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
| WO2014083438A2 (en) | 2012-11-09 | 2014-06-05 | Abattis Bioceuticals Corp | Nitric oxide increasing nutritional supplements and methods |
| US20140271890A1 (en) | 2013-03-14 | 2014-09-18 | Thaer Ahmad | Controlled-release pharmaceutical composition |
| CA2909591C (en) * | 2013-04-23 | 2017-03-28 | Zx Pharma, Llc | Enteric coated multiparticulate composition with proteinaceous subcoat |
| PL231923B1 (pl) | 2013-10-28 | 2019-04-30 | Proteon Pharmaceuticals Spolka Akcyjna | Sposób enkapsulacji materiału zawierającego bakteriofagi, otrzymywana nim mikrokapsułka oraz jej zastosowania |
| RU2535020C1 (ru) | 2014-01-23 | 2014-12-10 | Карпов Алексей Николаевич | Фармацевтическая композиция седативного и спазмолитического действия |
| CA2934595C (en) * | 2014-02-06 | 2022-06-21 | Sequential Medicine Limited | Composition and method for aiding sleep |
| CA2948070C (en) * | 2014-05-05 | 2024-02-13 | Boehringer Ingelheim International Gmbh | Fast dissolving granulate |
| ES2597784T3 (es) | 2014-07-14 | 2017-01-23 | Dr. Willmar Schwabe Gmbh & Co. Kg | Combinación de extracto de raíz de valeriana y aceite de lavanda para utilizar en el tratamiento de trastornos del sueño |
-
2017
- 2017-05-04 WO PCT/US2017/031046 patent/WO2017192843A1/en not_active Ceased
- 2017-05-04 CA CA3023305A patent/CA3023305C/en active Active
- 2017-05-04 CN CN202311459688.5A patent/CN117482062A/zh active Pending
- 2017-05-04 JP JP2018558279A patent/JP7576905B2/ja active Active
- 2017-05-04 RU RU2018142019A patent/RU2018142019A/ru not_active Application Discontinuation
- 2017-05-04 EP EP17793336.3A patent/EP3452020A4/en active Pending
- 2017-05-04 CN CN201780027996.7A patent/CN109310638A/zh active Pending
- 2017-05-04 MX MX2018013569A patent/MX2018013569A/es unknown
- 2017-05-04 US US15/586,709 patent/US10342873B2/en active Active
- 2017-05-04 AU AU2017260019A patent/AU2017260019A1/en not_active Abandoned
- 2017-05-04 KR KR1020187035039A patent/KR20190008265A/ko not_active Ceased
-
2019
- 2019-07-03 US US16/502,976 patent/US11141484B2/en active Active
- 2019-07-09 US US16/506,443 patent/US11141485B2/en active Active
-
2021
- 2021-09-08 US US17/469,458 patent/US11701425B2/en active Active
-
2022
- 2022-05-31 JP JP2022089010A patent/JP7577090B2/ja active Active
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