JP2022088592A5 - - Google Patents
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- Publication number
- JP2022088592A5 JP2022088592A5 JP2022058125A JP2022058125A JP2022088592A5 JP 2022088592 A5 JP2022088592 A5 JP 2022088592A5 JP 2022058125 A JP2022058125 A JP 2022058125A JP 2022058125 A JP2022058125 A JP 2022058125A JP 2022088592 A5 JP2022088592 A5 JP 2022088592A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- intranasal
- intranasal formulation
- administered
- naltrexone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 26
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 8
- 229960003086 naltrexone Drugs 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- NLEBIOOXCVAHBD-QKMCSOCLSA-N dodecyl beta-D-maltoside Chemical compound O[C@@H]1[C@@H](O)[C@H](OCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 NLEBIOOXCVAHBD-QKMCSOCLSA-N 0.000 claims 6
- 208000007848 Alcoholism Diseases 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 3
- 208000025746 alcohol use disease Diseases 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229960001716 benzalkonium Drugs 0.000 claims 1
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims 1
- 229960001484 edetic acid Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960002668 sodium chloride Drugs 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662354465P | 2016-06-24 | 2016-06-24 | |
| US62/354,465 | 2016-06-24 | ||
| US201662419736P | 2016-11-09 | 2016-11-09 | |
| US62/419,736 | 2016-11-09 | ||
| JP2018567665A JP2019520361A (ja) | 2016-06-24 | 2017-06-26 | アルコール使用障害の処置のための組成物、装置、及び、方法 |
| PCT/US2017/039300 WO2017223566A1 (en) | 2016-06-24 | 2017-06-26 | Compositions, devices, and methods for the treatment of alcohol use disorder |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567665A Division JP2019520361A (ja) | 2016-06-24 | 2017-06-26 | アルコール使用障害の処置のための組成物、装置、及び、方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022088592A JP2022088592A (ja) | 2022-06-14 |
| JP2022088592A5 true JP2022088592A5 (https=) | 2022-09-15 |
| JP7492548B2 JP7492548B2 (ja) | 2024-05-29 |
Family
ID=60784803
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567665A Pending JP2019520361A (ja) | 2016-06-24 | 2017-06-26 | アルコール使用障害の処置のための組成物、装置、及び、方法 |
| JP2022058125A Active JP7492548B2 (ja) | 2016-06-24 | 2022-03-31 | アルコール使用障害の処置のための組成物、装置、及び、方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567665A Pending JP2019520361A (ja) | 2016-06-24 | 2017-06-26 | アルコール使用障害の処置のための組成物、装置、及び、方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20190209464A1 (https=) |
| EP (1) | EP3474842A4 (https=) |
| JP (2) | JP2019520361A (https=) |
| KR (2) | KR102634829B1 (https=) |
| CN (1) | CN109789122A (https=) |
| AU (2) | AU2017281941A1 (https=) |
| CA (1) | CA3028731A1 (https=) |
| MX (2) | MX2018015985A (https=) |
| NZ (1) | NZ750067A (https=) |
| PH (1) | PH12018502738A1 (https=) |
| RU (2) | RU2767062C2 (https=) |
| SG (2) | SG11201811580SA (https=) |
| WO (1) | WO2017223566A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102634829B1 (ko) * | 2016-06-24 | 2024-02-07 | 오피언트 파마슈티컬스, 인코퍼레이티드 | 알코올 사용 장애의 치료용 조성물, 장치 및 방법 |
| US11069446B1 (en) * | 2016-09-28 | 2021-07-20 | Cerner Innovation, Inc. | Predicting addiction relapse and decision support tool |
| CA3043028A1 (en) * | 2016-11-09 | 2018-05-17 | Opiant Pharmaceuticals, Inc. | Compositions, devices, and methods for the treatment of opioid-receptor-mediated conditions |
| IL312012A (en) * | 2016-11-18 | 2024-06-01 | Opiant Pharmaceuticals Inc | Compositions and methods for the treatment of opioid overdose |
| WO2019157099A1 (en) | 2018-02-06 | 2019-08-15 | Aegis Therapeutics, Llc | Intranasal epinephrine formulations and methods for the treatment of disease |
| WO2019222408A1 (en) * | 2018-05-17 | 2019-11-21 | Aegis Therapeutics Llc | Formulations and methods for the prevention of opioid overdose |
| AU2019403368A1 (en) * | 2018-12-20 | 2021-07-29 | Aegis Therapeutics, Llc | Compositions, devices, and methods for the treatment of overdose and reward-based disorders |
| AU2020245535B2 (en) | 2019-03-26 | 2022-06-30 | Pinova Therapeutics Inc. | Devices and methods for delivering pharmaceutical compositions |
| CN113784703A (zh) * | 2019-05-16 | 2021-12-10 | 株式会社新日本科学 | 经鼻施予用粉末制剂及其制造方法 |
| US10729687B1 (en) | 2019-07-09 | 2020-08-04 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| US10653690B1 (en) * | 2019-07-09 | 2020-05-19 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| CA3166250A1 (en) | 2020-02-05 | 2021-08-12 | Gregory G. Plucinski | Drug products for intranasal administration and uses thereof |
| US11278709B1 (en) | 2021-03-12 | 2022-03-22 | Pocket Naloxone Corp. | Drug delivery device and methods for using same |
| MX2024001659A (es) | 2021-08-04 | 2024-06-26 | Indivior Inc | Composiciones y métodos para el tratamiento de la sobredosis por opioides. |
| US20250134883A1 (en) * | 2022-01-26 | 2025-05-01 | Tulex Pharmaceuticals Inc. | Novel compositions |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4882335A (en) * | 1988-06-13 | 1989-11-21 | Alko Limited | Method for treating alcohol-drinking response |
| US5069895A (en) * | 1989-11-09 | 1991-12-03 | Diamond Ivan F | Methods for the treatment of alcohol intoxication and dependence |
| EP0444778A1 (en) * | 1990-02-14 | 1991-09-04 | Alcon Laboratories, Inc. | Use of alkyl saccharides to enhance the penetration of drugs |
| EP1423116A1 (en) * | 2001-08-14 | 2004-06-02 | Biotie Therapies Corp. | Method of treating alcoholism or alcohol abuse |
| US9895444B2 (en) * | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
| US8268791B2 (en) * | 2004-08-25 | 2012-09-18 | Aegis Therapeutics, Llc. | Alkylglycoside compositions for drug administration |
| US20070212307A1 (en) * | 2006-02-10 | 2007-09-13 | Daniel Wermeling | Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same |
| US20100076006A1 (en) * | 2007-01-31 | 2010-03-25 | University Of Virginia Patent Foundation | Topiramate Plus Naltrexone for the Treatment of Addictive Disorders |
| WO2009029308A1 (en) * | 2007-08-27 | 2009-03-05 | University Of Virginia Patent Foundation | Medication combinations for the treatment of alcoholism and drug addiction |
| JP5437236B2 (ja) * | 2008-04-16 | 2014-03-12 | 一般財団法人化学及血清療法研究所 | トロンビン固定化生体吸収性シート製剤の製造方法 |
| PE20131137A1 (es) * | 2010-10-29 | 2013-10-03 | Troikaa Pharmaceuticals Ltd | Composiciones nasales de vitamina b12 |
| MY194947A (en) * | 2011-05-13 | 2022-12-27 | Euro Celtique Sa | Intranasal pharmaceutical dosage forms comprising naloxone |
| US10485798B2 (en) * | 2012-08-22 | 2019-11-26 | Aptapharma Inc. | Methylnaltrexone nasal formulations, methods of making, and use thereof |
| US20140171458A1 (en) * | 2012-12-13 | 2014-06-19 | 3B Pharmaceuticals, Inc. | Intranasal naltrexone |
| DE202013105715U1 (de) * | 2013-08-22 | 2014-02-19 | Sipnose Ltd. | Vorrichtung zur Abgabe einer vorbestimmten Menge einer Substanz an eine natürliche Öffnung des Körpers |
| WO2015095389A1 (en) * | 2013-12-18 | 2015-06-25 | Aegis Therapeutics, Llc | Compositions for drug administration |
| US9480644B2 (en) * | 2014-03-14 | 2016-11-01 | Opiant Pharmaceuticals, Inc. | Nasal drug products and methods of their use |
| KR102634829B1 (ko) * | 2016-06-24 | 2024-02-07 | 오피언트 파마슈티컬스, 인코퍼레이티드 | 알코올 사용 장애의 치료용 조성물, 장치 및 방법 |
-
2017
- 2017-06-26 KR KR1020227034876A patent/KR102634829B1/ko active Active
- 2017-06-26 RU RU2019101810A patent/RU2767062C2/ru active
- 2017-06-26 CA CA3028731A patent/CA3028731A1/en active Pending
- 2017-06-26 EP EP17816377.0A patent/EP3474842A4/en not_active Withdrawn
- 2017-06-26 JP JP2018567665A patent/JP2019520361A/ja active Pending
- 2017-06-26 WO PCT/US2017/039300 patent/WO2017223566A1/en not_active Ceased
- 2017-06-26 SG SG11201811580SA patent/SG11201811580SA/en unknown
- 2017-06-26 RU RU2022103366A patent/RU2022103366A/ru unknown
- 2017-06-26 NZ NZ750067A patent/NZ750067A/en unknown
- 2017-06-26 MX MX2018015985A patent/MX2018015985A/es unknown
- 2017-06-26 SG SG10202013034QA patent/SG10202013034QA/en unknown
- 2017-06-26 AU AU2017281941A patent/AU2017281941A1/en not_active Abandoned
- 2017-06-26 US US16/311,944 patent/US20190209464A1/en not_active Abandoned
- 2017-06-26 KR KR1020197001264A patent/KR102453781B1/ko active Active
- 2017-06-26 CN CN201780044057.3A patent/CN109789122A/zh active Pending
-
2018
- 2018-12-18 MX MX2022013671A patent/MX2022013671A/es unknown
- 2018-12-21 PH PH12018502738A patent/PH12018502738A1/en unknown
-
2022
- 2022-03-31 JP JP2022058125A patent/JP7492548B2/ja active Active
-
2023
- 2023-04-20 AU AU2023202420A patent/AU2023202420A1/en not_active Abandoned
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