JP2022076796A - Antibacterial agent against indigenous bacteria - Google Patents

Abstract

To provide a novel antibacterial polymer agent against indigenous bacteria on skin.SOLUTION: An antibacterial agent against indigenous bacteria on skin contains a copolymer. The copolymer has a constitutional unit (a) represented by general formula (1) and/or (2) and a constitutional unit (b) derived from a hydrophobic monomer with its homopolymer having a solubility parameter of 15 or less. (In the general formula (1) or (2), R1-R3 independently represent H or a C1-12 organic group, R4-R8 independently represent H or a C1-5 alkyl group, Y-is an anion).SELECTED DRAWING: None

Description

The present invention relates to an indigenous bacterial antibacterial agent. More specifically, the present invention relates to an indigenous bacterial antibacterial agent used in skin cosmetics, external skin preparations, hair cosmetics and the like.

Conventionally, paraben, phenoxyethanol, benzoic acid and its salts, salicylic acid and its salts, etc. have been used as antibacterial agents for cosmetics, but these agents have high skin irritation and sufficient antibacterial performance at low concentrations. There was a problem that it did not appear. There is an increasing demand for more effective and safer antibacterial agents. Polymer-based cosmetic antibacterial agents have been developed to solve these problems. In general, substances with a molecular weight of more than 1000 are considered to be difficult to penetrate the skin, and it is considered that a polymer-type antibacterial agent having a sufficiently large molecular weight is easy to use even for people with sensitive skin or atopic skin from the viewpoint of safety. .. For example, a polymer antibacterial agent composed of a copolymer of an amino group-containing monomer and a hydrophobic monomer has been reported to have antibacterial effects on Escherichia coli, S. aureus, Staphylococcus aureus, Candida, and Aspergillus aureus. (See Patent Document 1)

Japanese Unexamined Patent Publication No. 2018-058813

As described above, various polymer antibacterial agents have been reported, but there has been a demand for a polymer antibacterial agent having antibacterial activity against indigenous skin flora. Therefore, an object of the present invention is to provide a novel polymer antibacterial agent for indigenous bacteria.

The present inventor has made various studies in order to achieve the above object, and came up with the present invention.
That is, the indigenous bacterial antibacterial agent of the present disclosure is a skin indigenous bacterial antibacterial agent containing a copolymer, and the copolymer is a structural unit (a) derived from an amino group-containing monomer and a hydrophobic single amount. The structural unit (a) derived from the body-derived structural unit (b) and the amino group-containing monomer is represented by the following general formulas (1) and / or (2), and the hydrophobic monomer is represented by the following general formulas (1) and / or (2). It is an antibacterial agent that is indigenous to the skin and is characterized by having a solubility parameter of 15 or less for the homopolymer.

In the general formula (1) or (2), R ₁ , R ₂ , and R ₃ independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and R ₄ to R ₈ independently represent each other. It represents a hydrogen atom or an organic group having 1 to 12 carbon atoms, and Y ⁻ represents an anion. However, the asterisk represents an atom contained in another structural unit of the same type or different type to which the structural unit represented by the general formula (1) or (2) is bonded.

The indigenous bacterial antibacterial agent of the present disclosure expresses antibacterial agents such as Malassezia spp. And P. acnes by addition at a low concentration. Therefore, the indigenous bacterial antibacterial agent of the present disclosure can be preferably used as, for example, an indigenous bacterial antibacterial agent for products for scalp and scalp care.

Hereinafter, the present disclosure will be described in detail.
A combination of two or more of the preferred embodiments of the present disclosure described below is also a preferred embodiment of the present disclosure.
[Chemistry of the present disclosure]
The indigenous bacterial antibacterial agent of the present disclosure includes a copolymer containing a structural unit derived from an amino group-containing monomer and a structural unit derived from a hydrophobic monomer. The above-mentioned polymer may be referred to as a copolymer of the present disclosure.
<Structural unit derived from amino group-containing monomer>
In the present disclosure, the structural unit derived from the amino group-containing monomer is represented by the structural unit of the following general formulas (1) and / or (2).

In the general formula (1) or (2), R ₁ , R ₂ , and R ₃ independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and R ₄ to R ₈ independently represent each other. It represents a hydrogen atom or an organic group having 1 to 12 carbon atoms, and Y ⁻ represents an anion. However, the asterisk represents an atom contained in another structural unit of the same type or different type to which the structural unit represented by the general formula (1) or (2) is bonded. In the present disclosure, the "atom contained in another structural unit of the same type" is, for example, a structural unit represented by another general formula (1) if it is a structural unit represented by the general formula (1). The "atom contained in another structural unit of a different kind" is represented by the general formula (1) if it is a structural unit represented by the general formula (1), for example. Indicates that the atom is contained in a structural unit other than the structural unit.
The structure derived from the amino group-containing monomer is composed of, for example, an ethylenically unsaturated group and an acid of a primary to tertiary amino group represented by the following general formula (3) or a primary to tertiary amino group. It can be formed by radical polymerization of a Japanese product or a monomer having a quaternary ammonium base represented by the following general formula (4), but the present invention is not limited thereto.

R4 to R8 of the general formula (3) and the general formula ( ₄ ) are the _same as _R4 to R8 of the general formula ₍ 1) and the general formula (2).
The structural unit derived from the amino basic-containing monomer is a structural unit in which -X- is represented by -C (= O) -O-CH ₂ CH _2- in the general formula (1) or (2). It is preferable to include.
The structural unit derived from the amino group-containing monomer is formed, for example, by radical polymerization of the amino group-containing monomer. Specific examples of the amino group-containing monomer include N, N-dimethylaminoethyl (meth) acrylate, N, N-diethylaminoethyl (meth) acrylate, and N, N-dimethylaminopropyl (meth) acrylate. N, N-dialkylamino group-containing (meth) acrylates such as N, N-diethylaminopropyl (meth) acrylates, monomers with a quaternizing agent added to the above monomers, or neutralization with acids such as hydrochloric acid and acetic acid. Amine; N, N-dimethylaminoethyl (meth) acrylamide, N, N-diethylaminoethyl (meth) acrylamide, N, N-dimethylaminopropyl (meth) acrylamide, N, N-diethylaminopropyl (meth) acrylamide, etc. , N-dialkylamino group-containing (meth) acrylamides and monomers with a quaternizing agent added to the above monomers or neutralized products of these with acids such as hydrochloric acid and acetic acid; monomethylaminoethyl (meth) acrylate, monoethylamino Monoalkylamino group-containing (meth) acrylates such as ethyl (meth) acrylate, monomethylaminopropyl (meth) acrylate, monoethylaminopropyl (meth) acrylate, 2- (tert-butylamino) ethyl (meth) acrylate and Neutralized products of these acids such as hydrochloric acid and acetic acid; monoalkyls such as monomethylaminoethyl (meth) acrylamide, monoethylaminoethyl (meth) acrylamide, monomethylaminopropyl (meth) acrylamide, and monoethylaminopropyl (meth) acrylamide. Amino group-containing (meth) acrylamides and neutralized products of these with acids such as hydrochloric acid and acetic acid; esters of (meth) acrylic acids such as (meth) acrylic acid-2-aminoethyl and alkanolamines and their hydrochloric acid. , Neutralized with acid such as acetic acid; N, N-diallylmethylamine and monomer to which a quaternizing agent is added or its hydrochloric acid, neutralized with acid such as acetic acid; Allylamine and its hydrochloric acid, acetic acid Neutralized products with acids such as 1-allyloxy-3-dibutylamino-2-ol, 1-allyloxy-3-diethanolamino-2-ol, etc. Unsaturated monos having a cyclic ether-containing group having 2 to 8 carbon atoms. Examples thereof include an addition reaction product of a weight and an amine compound having 1 to 24 carbon atoms, a monomer having a quaternizing agent added thereto, or a neutralized product thereof with an acid such as hydrochloric acid or acetic acid.
The structural unit derived from the amino basic-containing monomer is particularly preferably the following general formula (5), which is a structural unit derived from N, N-dimethylaminoethyl (meth) acrylate.

R ₉ in the above general formula (5) represents a hydrogen atom or a methyl group. However, the asterisk represents an atom contained in another structural unit of the same type or different type to which the structural unit represented by the general formula (1) or (2) is bonded. Most preferably, it is a structural unit derived from N, N-dimethylaminoethyl (meth) acrylate.
The content of the structural unit derived from the amino group monomer in the copolymer of the present disclosure is 1% by mass with respect to 100% by mass of the structural unit derived from all the monomers constituting the copolymer of the present disclosure. As mentioned above, it is 99% by mass or less, preferably 10% by mass or more, 97% by mass or less, more preferably 36% by mass or more, 96% by mass or less, and most preferably 60% by mass or more and 95% by mass or less. Within the above range, the proportion of cationic sites that can act on the microbial membrane becomes appropriate, and the antibacterial performance of the antibacterial agent of the present disclosure tends to be improved.
<Structural unit derived from hydrophobic monomer>
In the present disclosure, the structural unit derived from the hydrophobic monomer is a structural unit derived from a monomer having a solubility parameter of 15 or less of the homopolymer obtained by homopolymerizing the hydrophobic monomer. Is.
The structure derived from the hydrophobic monomer represents, for example, a structural unit in which a carbon-carbon double bond portion of a monomer having an ethylenically unsaturated group and a hydrophobic group is replaced with a carbon-carbon single bond. These structural units can be formed, for example, by radical polymerization of the monomer. The structural unit derived from the hydrophobic group-containing monomer may have the same structure as the structural unit in which the carbon-carbon double bond portion is replaced with the carbon-carbon single bond, and is, for example, a structure formed by a post-reaction after polymerization. It may be a unit. Even if the solubility parameter is 15 or less, those having an amino group are included in the amino group-containing monomer and are not included in the hydrophobic monomer.
The solubility parameter is a value calculated by the method described on pages 147 to 154 of "POLYMERENGINEERINGANDSCIENCE" (1974, Vol. 14, No. 2).
The method is outlined below. The solubility parameter (δ) (cal / cm3) 1/2 of the homopolymer is described below based on the evaporation energy (Δei) and molar volume (Δvi) of the constituent units forming the polymer. It is calculated by the calculation method.
δ = (Δei / Δvi) 1/2 (cal / cm3) 1/2.
The hydrophobic monomer (B) is not particularly limited as long as the solubility parameter in the homopolymer is 15 or less, but it is an ester of (meth) acrylic acid and an alcohol which may have a substituent. ((Meta) acrylates that may have substituents); unsaturated monocarboxylic acids such as (meth) acrylic acid, crotonic acid, α-allyloxyacrylic acid and salts thereof; aromatic vinyl such as styrene System monomers; Olefin-based monomers such as propylene; Esters of unsaturated alcohols such as vinyl acetate and carboxylic acids; Vinyl halides such as vinyl chloride; Alkyl vinyl ethers such as methyl vinyl ethers and ethyl vinyl ethers; 1-allyloxy Addition reaction product of unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms such as -3-butoxypropane-2-ol and alcohol having 1 to 20 carbon atoms; ethylene oxide adduct of allyl alcohol, polymer. Ester adducts of unsaturated alcohols having 2 to 20 carbon atoms such as ethylene oxide adducts of lyl alcohols and ethylene oxide adducts of isoprenol and their terminal hydrophobic modified products; cyclic vinyl monomers such as N-vinylpyrrolidone can be mentioned. Be done. Among the hydrophobic monomers having a solubility parameter of 15 or less, those having an alkyl group having 2 or more carbon atoms are preferable. When the hydrophobic monomer has an alkyl group having 2 or more carbon atoms, the affinity with the cell membrane of the microorganism is increased, and the antibacterial property is further improved.
The hydrophobic monomer (B) preferably contains at least one (meth) acrylic acid ester. The (meth) acrylic acid ester is preferably an ester of (meth) acrylic acid and a monoalcohol, and is preferably a compound having 1 to 20 carbon atoms in the hydrocarbon group of the monoalcohol. The hydrocarbon group of the monoalcohol has more preferably 1 to 16 carbon atoms, still more preferably 1 to 12 carbon atoms, particularly preferably 1 to 8 carbon atoms, and most preferably 2 to 8 carbon atoms. When the number of carbon atoms of the hydrocarbon group is 1 to 20, the water solubility and viscosity of the polymer can be in a suitable range, and the handling is excellent. When the hydrocarbon group has 1 to 12 carbon atoms, the polymer can be easily produced, and the safety is excellent in addition to the antibacterial property.
Further, when the hydrocarbon group has 2 to 8 carbon atoms, not only the polymer can be easily produced, but also the safety is excellent, the affinity with the cell membrane of the microorganism is increased, and the antibacterial property is further improved. It becomes a thing. The hydrocarbon group is preferably an alkyl group or an alkenyl group, and more preferably an alkyl group. That is, the (meth) acrylic acid ester is preferably a (meth) acrylic acid alkyl ester (alkyl (meth) acrylate), and the hydrophobic monomer (B) is at least one (meth) acrylic acid alkyl ester. It is preferable to include it.
Among these, it is particularly preferable that the structural unit is represented by the following general formula (6), which is a structural unit derived from ethyl (meth) acrylate.

In the above general formula (6), R ₁₀ represents a hydrogen atom or a methyl group. However, the asterisk represents an atom contained in another structural unit of the same type or different type to which the structural unit represented by the general formula (1) or (2) is bonded. Most preferably, it is a structural unit derived from ethyl methacrylate.
The content of the structural unit derived from the hydrophobic monomer in the copolymer of the present disclosure is 1% by mass with respect to 100% by mass of the structural unit derived from all the monomers constituting the copolymer of the present disclosure. As mentioned above, it is 99% by mass or less, preferably 3% by mass or more, 90% by mass or less, more preferably 4% by mass or more, 64% by mass or less, and most preferably 5% by mass or more and 40% by mass or less. When the content ratio is within such a range, the above-mentioned copolymer has appropriate hydrophobicity and the ability to disturb the membrane of microorganisms is enhanced, so that the antibacterial performance is improved, and in particular, Escherichia coli and Gram-positive bacteria having an outer membrane. It tends to show high antibacterial performance against gram-negative bacteria such as.

<Structural units derived from other monomers>
The copolymer of the present disclosure may be a structural unit derived from a monomer other than the structural unit derived from an amino group-containing monomer and the structural unit derived from a hydrophobic monomer (to other monomers, if desired. It may also have a structural unit from which it is derived. The other monomer is not particularly limited as long as it does not have an amino group and can be copolymerized with the amino group-containing monomer and the hydrophobic monomer. As long as the hydrophobic monomer is polymerized at a preferable ratio, the hydrophobicity as a copolymer is sufficiently maintained.
In the present disclosure, the structural unit derived from another single amount refers to a structural unit in which at least one carbon-carbon double bond of another single amount is replaced with a carbon-carbon single bond. The structural unit derived from the other monomer may have the same structure as the structure in which at least one carbon-carbon double bond of the other monomer is replaced with the carbon-carbon single bond, and the other monomer may be used. The structural unit is not limited to the structural unit formed by polymerization, and may be, for example, a structural unit formed by a post-reaction after polymerization. The content of the structural unit derived from other monomers in the copolymer of the present disclosure is 0 mass with respect to 100% by mass of the structural unit derived from all the monomers constituting the copolymer of the present disclosure. % Or more, 15% by mass or less, preferably 0% by mass or more, 10% by mass or less, more preferably 0% by mass or more and 5% by mass or less. These other monomers may be used alone or in combination of two or more.

<Physical characteristics of the co-heavy bodies disclosed in this disclosure>
The copolymer of the present disclosure preferably has a weight average molecular weight (Mw) of 4000 or more and 800,000 or less, more preferably 6000 or more and 400,000 or less, and further preferably 7,000 or more and 80,000 or less. Within the above range, the antibacterial performance of the antibacterial agent of the present disclosure is further improved, and the product tends to be handled with excellent water solubility and dispersibility.

[Method for producing the copolymer of the present disclosure]
The method for producing the copolymer of the present disclosure is not particularly limited, but usually polymerizes a structural unit derived from an amino group-containing monomer, a hydrophobic group-containing monomer, and if necessary, other monomers. It is preferable to manufacture by The method for producing the copolymer can be, for example, solution polymerization, bulk polymerization, suspension polymerization, emulsion polymerization, living polymerization, graft polymerization, or the like, and is not particularly limited, but solution polymerization. Is preferable. The solvent used at this time is not particularly limited, but is water; monohydric alcohols such as methyl alcohol, ethyl alcohol, isopropyl alcohol, butanol, THF (tetratetra); glycerin, (poly) ethylene glycol, propylene glycol, 1, Polyhydric alcohols such as 3-butylene glycol and dipropylene glycol; aromatic or aliphatic hydrocarbons such as benzene, toluene, xylene, cyclohexane and n-heptane; esters such as ethyl acetate; ketones such as acetone and methyl ethyl ketone Amids such as dimethylformamide; ethers such as diethyl ether and dioxane are suitable. These may be used alone or in combination of two or more. Among these, one or more solvents selected from the group consisting of water and lower alcohols having 1 to 4 carbon atoms may be used from the viewpoint of the solubility of the monomer component and the obtained copolymer. preferable. Polyhydric alcohol solvent such as propylene glycol or ethylene glycol may be added to water for polymerization. When the polyhydric alcohol solvent is used in combination with water, the solubility of the polymer can be enhanced and soap-free polymerization can be suppressed more sufficiently. As a result, the formation of a polymer having poor water solubility can be more sufficiently suppressed, and the transparency of the solution can be further improved. Further, if the solvent is water, ethyl alcohol, glycerin, 1,3-butanediol or a combination thereof, it can be directly used as a raw material for a skin external preparation without performing a solvent removal step. Suitable.

[Indigenous bacteria of this disclosure]
Indigenous bacteria are microorganisms that exist in the body such as human skin, scalp, and mucous membranes and are possessed by many people. In the present disclosure, among them, in general, bad bacteria such as Malassezia spp., Which is a lipophilic fungus that is greatly involved in the development of dandruff, and P. acnes, which proliferates excessively and causes inflammation in the sebum of human skin. What is called is called indigenous bacteria. By reducing these bacteria, effects such as reduction of dandruff and improvement of inflammatory skin can be obtained. The genus Malassezia means a fungus belonging to the genus Malassezia, and specific examples thereof include Malassezia furfur, Malassezia globosa, and Malassezia restricta. P. acnes means Cutibacterium acnes, a bacterium belonging to the genus Cutibacterium.

[Indigenous bacteria antibacterial agent of the present disclosure]
The indigenous bacterial antibacterial agents of the present disclosure essentially include the copolymers of the present disclosure. The content of the copolymer of the present disclosure in the indigenous bacterial antibacterial agent of the present disclosure may be 100% by mass at the upper limit and is not particularly limited at the lower limit, but is 30% by mass from the viewpoint of making the viscosity easy to handle. % Or less is preferable. The indigenous bacterial antibacterial agent of the present disclosure may contain a solvent such as water, other antibacterial agents, preservatives and the like.
The above-mentioned other components are not particularly limited as long as they do not inhibit the antibacterial performance of the indigenous bacteria antibacterial agent, and are, for example, an alkali adjusting agent, an anionic surfactant, a compatibilizer, a stabilizer, other antibacterial agents and the like. Additives and the like. Further, the indigenous bacterial antibacterial agent of the present invention may further contain a metal salt, a metal oxide, a metal hydroxide, or the like from the viewpoint of improving the antibacterial property. The content of the other components is not particularly limited as long as it does not inhibit the antibacterial performance of the indigenous bacterial antibacterial agent, but is preferably 0 to 20% by mass with respect to 100% by mass of the copolymer.
In addition, the indigenous bacterial antibacterial agent of the present invention includes additive components such as oil-based bases, moisturizers, feel-improving agents, surfactants, which are generally added to water and cosmetics and external skin preparations as needed. Molecules, thickening / gelling agents, solvents, propellants, antioxidants, reducing agents, oxidizing agents, preservatives / antibacterial agents other than the antiseptic / antibacterial agents of the present invention, chelating agents, pH adjusters, acids, alkalis, powders Body, inorganic salt, UV absorber, whitening agent, vitamins and their derivatives, anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, tightening Agents, cooling agents, warming agents, wound healing promoters, stimulants, painkillers, cell activators, plant / animal / microbial extracts, antipruritic agents, keratin exfoliating / dissolving agents, antiperspirants, refreshing agents, astringent Agents, enzymes, nucleic acids, fragrances, pigments, colorants, dyes, pigments, water and the like can be blended.

To exemplify these additive components, examples of the oily base include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, araquil alcohol, behenyl alcohol, jojoba alcohol, kimil alcohol, seraquil alcohol, and bacillus. Higher alcohols such as alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimerdiol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylene Acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eikosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long chain branched fatty acid, dimer acid , Higher fatty acids such as hydrogenated dimer acid and metal soaps such as aluminum salt, calcium salt, magnesium salt, zinc salt and potassium salt, and nitrogen-containing derivatives such as amide; liquid paraffin (mineral oil), heavy Carbides such as liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalane, vaseline, solid paraffin, hydrogenated polydecene; candelilla wax, carnauba wax. , Rice wax, wood wax, mitsuro, montan wax, ozokelite, ceresin, paraffin wax, microcrystallin wax, petrolatum, fisher tropsh wax, polyethylene wax, ethylene / propylene copolymer and other waxes; palm oil, palm oil, palm kernel oil , Saflower oil, olive oil, castor oil, avocado oil, sesame oil, brown oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rose hip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil , Corn oil, rapeseed oil, sunflower oil, wheat germ oil, flaxseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated hojoba Vegetable oils and fats such as oils; animal oils and fats such as beef oil, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; animal products such as whale wax, lanolin, and orange raffy oil. Rows;

Lanolins such as liquid lanolin, reduced lanolin, adsorption purified lanolin, acetate lanolin, acetate liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, acetate lanolin alcohol, acetic acid (cetyl lanolyl) ester Sphingophospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phosphatidic acid, phospholipids such as lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogen Phospholipid derivatives such as added egg yolk phospholipids and partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid and other sterols; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, Cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (cholesteryl / octyldodecyl), N-lauroyl-L- Acylsarcosine alkyl esters such as diglutamate (phytosteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl / octyldodecyl), N-lauroyl sarcosin isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, Phospholipid / cholesterol complex, phospholipid / phytosterol complex, sterol esters such as macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; Phospholipid complex such as body;

Octyldodecyl myristite, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanate, hexyldecyl octanoate, isotrideyl isononanoate, isononyl isononanoate, octyl isononanoate, isononenate Isodecyl acid, isotridecyl neopentate, isostearyl neopentate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, hexyldecyl dimethyloctanoate, octyldodecyl erucate, cured isostearate. Himasi oil, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, diethyl sebatate, diisopropyl sebatate, dioctyl sebatate, diisopropyl adipate, sebatic acid Monoalcohol carboxylic acid esters such as dibutyloctyl, diisobutyl adipate, dioctyl succinate, triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate;

Triethylhexanoin, glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (capric acid / capric acid) glyceryl, tri (capric acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated Rozine triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl dicosanate behenate, trimethylol propane trioctanoate, trimethylol propane triisostearate, neopentylglycol dioctanoate, neopentyl glycol dicaprate, dioctanoic acid 2-Butyl-2-ethyl-1,3-propanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylol (isostearic acid / sebacic acid) Propane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / logonic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) Polyhydric alcohol fatty acid esters such as polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate);

Diisopropyl dimergilinoleate, diisostearyl dimergilinolate, dimersielyl dimergylinolate (isostearyl / phytosteryl), dimerjilinol acid (phytosteryl / behenyl), dimerserinol acid (phytosteryl / isostearyl / cetyl / stearyl /) Dimeric acid or dimer such as behenyl), dimerging linoleic acid dimerging linoleil, diisostearate dimerging linoleyl, dimerging linoleyl hydrogenated rosin condensate, dimerging linoleic acid hardened castor oil, hydroxyalkyl dymerging linoleyl ether, etc. Derivatives of diols; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramic acid monoisopropanolamide). Lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidemethyl MEA) and other fatty acid alkanolamides; dimethicone (dimethylpolysiloxane), highly polymerized dimethicone. (Highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol , Dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, polyether-modified silicone such as cation-modified silicone and dimethicone copolypoly, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone. , Phosphate-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cationic-modified and polyether-modified silicone, amino-modified and polyether-modified silicone. , Alkyl-modified and polyether-modified silicones, silicones such as polysiloxane / oxyalkylene copolymer; perfluorodecane, pa -Fluorine-based oils such as fluorooctane and perfluoropolyether are preferable.

As moisturizing agents / feeling improvers, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polypolymers such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymers and their polymers; diethylene glycol monoethyl ether Glycol alkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, martitol; glucose, fructose, galactose, mannose , Treose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and maltosylated, hydroxyalkyl. Modifications such as cyclodextrin), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer and other saccharides thereof. Derivatives; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronine sulfate, keratosulfate, dermatane sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; citric acid, tartrate, Organic acids such as lactic acid and salts thereof; urea; salts such as 2-pyrrolidone-5-carboxylic acid and sodium thereof;

Betain (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamate, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, Amino acids such as valine, tryptophan, histidine, taurine and salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptide, keratin-degrading peptide , Hydrolyzed keratin, conchiolin-degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl-hydrolyzed silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein-degrading peptide, acylated peptide Protein peptides and derivatives thereof; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mutin, etc. Hippotaurin, sesame lignan glycoside, glutathione, albumin, lactose; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract, hamamelis water, hechima water, chamomile extract, kanzo extract, confree extract, silk extract, Animal / plant extracts such as Izayoibara extract, Seiyo-no-kogiri-sou extract, Eucalyptus extract, Merilot extract, natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, sphingoglycolipids, ceramides and Ceramides such as sugar ceramide-containing extracts are preferred.

Preferred examples of the surfactant include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymer surfactants. The HLB of the surfactant is not particularly limited and can be used from a low HLB of about 1 to a high HLB of about 20, and it is also preferable to combine a low HLB and a high HLB. Examples of preferred surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulphates such as sodium lauryl sulphate, triethanolamine lauryl sulphate and ammonium lauryl sulphate; laureth. Polyoxyethylene alkyl sulfates such as sodium sulphate, triethanolamine laures sulphate; sodium cocoylmethyl taurine, potassium cocoyl methyl taurine, sodium lauroyl methyl taurine, sodium myristylmethyl taurine, sodium lauroyl methyl alanine, sodium lauroyl sulcocin, sodium lauroyl sulcocin triethanol. Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine. Acylamino acid salts such as; polyoxyethylene alkyl ether acetates such as sodium laures acetate; succinic acid ester salts such as lauroyl monoethanolamide sodium succinate; fatty acid alkanolamide ether carboxylates; acyl lates; polyoxyethylene fatty amines. Sulfate; fatty acid alkanolamide sulfate; hardened coconut oil fatty acid fatty acid glyceride sulfate such as sodium glycerin sulfate; alkylbenzenepolyoxyethylene sulfate; olefin sulfonate such as α-olefin sulfonate sodium; lauryl lauryl sulfosuccinate disodium, sulfokohaku Alkyl sulfosuccinates such as sodium dioctyl sulphonate; alkyl ether sulfosuccinates such as laures disodium sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate sodium, sodium lauryl polypropylene glycol sulfosuccinate; sodium tetradecylbenzene sulfonate, tetra Alkylbenzene sulfonates such as decylbenzenesulfonic acid triethanolamine; Alkylnaphthalene sulfonates; Alcan sulfonates; Alkyl ether phosphate esters such as sodium acid, sodium dilaures phosphate, sodium trilaures phosphate, sodium monoolesphosphate; alkyl phosphates such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphate; fatty acid amide ether phosphorus Acid salt; Phosphatidylglycerol, phosphatidylinositol, phosphatidic acid and other phospholipids; carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfate-modified silicone and other silicone-based anionic surfactants;

Non-ionic surfactants include laures (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steares (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), and isosteares (poly). Polyoxyethylene alkyl ethers with various polyoxyethylene additions such as oxyethylene isostearyl ethers), octyldodeces (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkylphenyl ethers; polyoxyethylene hydrogenated castor oil, poly Oxyethylene castor oil, polyoxyethylene cured castor oil monoisostearate, polyoxyethylene cured castor oil triisostearate, polyoxyethylene cured castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene cured castor oil maleic acid, etc. Himashima oil and hardened Himashima oil derivative; Polyoxyethylene phytosterol; Polyoxyethylene cholesterol; Polyoxyethylene cholestanol; Polyoxyethylene lanolin; Polyoxyethylene reduced lanolin; Polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / Polyoxyethylene / polyoxypropylene alkyl such as polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether, etc. Ether; polyoxyethylene / polyoxypropylene glycol; (poly) glycerin such as PPG-9 diglyceryl Polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid Glyceryl fatty acid partial esters such as glyceryl, monocotton oil fatty acid glycerin, glycerin monoerlate, glycerin sesquioleate, α, α'-glycerin pyroglutamate oleate, glycerin monostearate and malic acid; polyglyceryl-2 stearate, 3, 4, 5, 6, 8, 10, distearate polyglyceryl-6, 10, tristearate polyglyceryl-2, decastarate polyglyceryl-10, isostearate polyglyce Lil-2, 3, 4, 5, 5, 6, Polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, Polyglyceryl triisostearate-2, Tetraisostearic acid. Polyglyceryl-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 6, 8, polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, decaurenic acid Polyglycerin fatty acid ester such as polyglyceryl-10; ethylene glycol monofatty acid ester such as ethylene glycol monostearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid ester; martitol moiety Acid ester;

Multitoll ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, penta-2-ethylhexyl diglycerol sorbitan, tetra Sorbitan fatty acid ester such as -2-ethylhexyl diglycerol sorbitan; sugar derivative partial ester such as sucrose fatty acid ester, methyl glucoside fatty acid ester, undosilenic acid trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; lanolin alcohol; reduction Lanolin; Polyoxyethylene fatty acid mono and diesters such as polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxyethylene / propylene glycol fatty acid ester; poly Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as oxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, poly Polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol Polyoxyethylene sorbitol fatty acid esters such as pentaoleate and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol honeybees; Alkyl glyceryl ethers such as isostearyl glyceryl ether, kimil alcohol, seraquil alcohol, batyl alcohol; polyhydric alcohol alkyl ether; polyoxyethylene alkylamine; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensate; saponin , Sophorolipid and other natural surfactants; polyoxyethylene fat Acid amide; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide) MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA) and other fatty acid alkanolamides;
Alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxides; polyoxyethylene alkyl mercaptans; polyether-modified silicones such as dimethicone copolyol, polysiloxanes and oxyalkylenes. Silicone-based nonionic surfactants such as copolymers, polyglycerin-modified silicones, and sugar-modified silicones; among cationic surfactants, behentrimonium chloride, stealtrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride. Alkyltrimethylammonium chlorides such as; alkyltrimethylammonium bromides such as stearyltrimonium bromides; dialkyldimethylammonium chlorides such as distearyldimonium chlorides and dicocodimonium chlorides; fatty acid amide amines such as stealamidopropyldimethylamine and stearamideethyldiethylamine and The salt; an alkyl ether amine such as stearoxypropyl dimethylamine and a salt thereof or a quaternary salt; a long chain branched fatty acid ethyl sulfate (12-31) aminopropyl ethyl dimethyl ammonium, a lanolin fatty acid ethyl sulfate, a fatty acid such as amino propyl ethyl dimethyl ammonium. Amido-type quaternary ammonium salt; polyoxyethylene alkylamine and its salt or quaternary salt; alkylamine salt; fatty acid amide guanidium salt; alkyl etheraminemonium salt; alkyltrialkylene glycol ammonium salt; benzalconium salt; benzethonium Salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmoriphonium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyldimethicone and amodimethicone, cation-modified silicones, cation-modified And silicone-based cationic surfactants such as polyether-modified silicones, amino-modified and polyether-modified silicones; for amphoteric surfactants, N-alkyl-N, N- such as lauryl betaine (lauryl dimethylaminoacetic acid betaine). Dimethyl amino acid betaine; fatty acid amide alkyl-N, N-dimethylamino acid betaine such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaine such as sodium cocoamphoacetate and sodium lauroamphoacetate; Alkyl sulfobetaine such as ledimethyltaurin; Sulfate-type betaine such as alkyldimethylaminoethanol sulfate ester; Phospholipid-type betaine such as alkyldimethylaminoethanol phosphate ester; Sphingoline such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin Lipids, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as lecithin hydroxide; silicone-based amphoteric surfactants, etc .; Examples of the activator include polyvinyl alcohol, sodium alginate, starch derivative, tragant gum, acrylic acid / alkyl methacrylic acid copolymer; and various silicone-based surfactants are preferable.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, farcerelan, karaya gum, trolley aoi, cara gum, tragant gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potatoes, wheat; xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid and its salts, zansan gum, purulan, gellan gum, chitin , Chitosan, agar, casso extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts such as sodium thereof, methyl hydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethyl. Ammium sulfate cellulose, crystalline cellulose, cellulose such as cellulose powder and derivatives thereof; starch-based polymers such as soluble starch, carboxymethyl starch, methyl hydroxypropyl starch, methyl starch, hydroxypropyltrimonium chloride starch, octenyl succinate corn starch aluminum, etc. Alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpidridone / vinyl alcohol copolymer, polyvinylmethyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene. Polyoxypropylene copolymer; (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (Acrylate / stearyl acrylate / ethylamine methacrylate) copolymer and other amphoteric methacrylic acid ester copolymers; (dimethicone / vinyldimethicone) cloth Polymers, (alkyl acrylate / diacetone acrylamide) copolymers, (alkyl acrylate / diacetone acrylamide) copolymers AMP; partially saponified polyvinyl acetate, maleic acid copolymers; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymers; Acrylic resin alkanolamine; polyester, water-dispersible polyester; polya Crylamide; polyacrylic acid ester copolymer such as ethyl polyacrylic acid, carboxyvinyl polymer, salt such as polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer;

Acrylic acid / alkyl methacrylic acid copolymer; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaterium-22. , Polyquaternium-39 and other acrylic acid / diallyldimethylammonium chloride / acrylamide copolymers, acrylic acid / cationized methacrylic acid ester copolymers, acrylic acid / cationized methacrylic acid amide copolymers, polyquaterium-47 and the like. Acrylic acid / methyl acrylate / methacrylate propyltrimethylammonium chloride copolymer, choline chloride ester polymer; cationized oligosaccharides, cationized dextran, cationized polysaccharides such as guarhydroxypropyltrimonium chloride; polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and polymer with butyl methacrylate copolymer; acrylic resin emulsion, ethyl polyacrylate emulsion, polyacrylic alkyl ester emulsion, vinyl acetate Polymer emulsions such as resin emulsions, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; Polymers; 12-hydroxystearic acid and salts thereof; dextrin fatty acid esters such as dextrin palmitate and dextrin myristinate; silicic acid anhydride, fumigant silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal. Preferred examples include soap, dialkyl phosphate metal salt, bentonite, hectrite, organically modified clay mineral, sucrose fatty acid ester, and fructo-oligosaccharide fatty acid ester.

Examples of solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol and isopentyldiol. Kind: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate, ethylene glycol dissuccinate; benzyl Preferred examples include propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation freon; LPG, dimethyl ether, carbon dioxide gas and the like.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; asbestosic acid derivatives such as propyl bisulfate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; Sodium bisulfite and other sulfites; Sodium bisulfite and other sulfite hydrogen salts; Sodium bisulfite and other thiosulfates; Metahydrosulfite hydrogen salts; Thiotaurine, hypotaurine; Thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferred. Is mentioned as. As the reducing agent, thioglycolic acid, cysteine, cysteamine and the like are preferable. As the oxidizing agent, hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like are preferable.

Examples of the preservative / antibacterial agent other than the indigenous bacterial antibacterial agent of the present invention include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben and butylparaben and salts thereof or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1, 1,2-diols such as 2-pentanediol and 1,2-hexanediol; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; triclosan Halogenated bisphenols such as, acid amides, quaternary ammonium salts; trichlorocarbanide, zincpyrythion, benzalconium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophenol, hinokithiol; phenol, isopropyl. Other phenols such as phenol, cresol, timol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion are preferred. Examples of the chelating agent include edetates (ethylenediamine tetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediamine triacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; ethidronic acid and the like. Phosphonic acid and salts such as sodium salts thereof; Sodium oxalate; Polypolyamino acids such as polyaspartic acid and polyglutamic acid; Sodium polyphosphate, sodium metaphosphate, phosphate; sodium citrate, citric acid, alanine, dihydroxyethylglycine , Gluconic acid, ascorbic acid, succinic acid, tartrate acid are preferred.

pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol. Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Preferred are sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate and ammonium carbonate.
Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, white mica, gold mica, synthetic mica, red mica, black mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, cay. Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal salt of tungsten acid, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (eg zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, dark blue, carbon black, titanium oxide, fine powder and ultrafine titanium oxide, zinc oxide , Fine particles and ultrafine zinc oxide, alumina, silica, fumigant silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine gold mica, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with silicones such as hydrogen silicone and cyclic hydrogen silicone or other surface treatment agents such as silane or titanium coupling agents to make them hydrophobic. Inorganic powder such as hydrophilized powder; starch, cellulose, nylon powder, polyethylene powder, polymethylmethacrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate -Polymethylmethacrylate laminated powder, polyethylene terephthalate, aluminum, epoxy laminated powder, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders and surface-treated powders of various sizes and shapes, organic and inorganic Composite powders are preferred. Examples of inorganic salts include sodium chloride-containing salts such as salt, normal salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, ginger, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, etc. Aluminum / potassium sulfate (myoban), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphoric acid Potassiums, calcium phosphates and magnesium phosphates are preferred.

Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoate ethyl. Anthranic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl esters, N, N-dimethylparaaminobenzoic acid ethyl esters; anthranilic acid-based ultraviolet absorbers such as homomentyl-N-acetylanthranilate; salicylic acid. And salicylic acid-based ultraviolet absorbers such as sodium salt, amilsalicylate, mentylsalicylate, homomentylsalicylate, octylsalicylate, phenylsalicylate, benzylsalicylate, p-isopropanol phenylsalicylate; -2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy Synnamate, 2-Ethylhexyl p-methoxysinamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxysinamate (synoxate), cyclohexyl-p-methoxysinamate, ethyl-α-cyano-β-phenyl Ceramic acid-based ultraviolet absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrine), glycerylmono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and its derivatives; 2, 4-Dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-Methoxybenzophenone (oxybenzon-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' Benzopheno such as -phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Derivatives of UV absorbers; 3- (4'-methylbenziliden) -d, l-camfer, 3-benziliden-d, l-camper; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy- 5-Methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole;dibenzalazine;dianisoilmethane; 5- (3,3-Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octylriazone; urocanic acid such as urocanic acid and ethyl urocanate Derivatives; 2- (2'-hydroxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, dimethoxybenzilidendioxoimidazolidinepropion Hydantin derivatives such as 2-ethylhexyl acid, phenylbenzimidazole sulfonic acid, terephthalylidenedicanfursulfonic acid, drometrizoletrisiloxane, methyl anthranilate, rutin and its derivatives, orizanol and its derivatives are preferred. ..

Examples of the whitening agent include hydroquinone glycosides such as albutin and α-albutin and their esters; ascorbic acid, ascorbic acid phosphate ester salts such as ascorbic acid, ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, and ascorbic acid. Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid sulfate esters, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as: kodiic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, orizanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble kanzo extract, Nishikawayanagi extract, yukinoshita extract. Esters are preferred.

Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxin hydrochloride, pyridoxin dioctanoate, pyridoxin dipalmitate, and the like. Flavin adenine dinucleotide, cyanocobalamine, folic acid, nicotinic acids such as nicotinic acid amide and benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin E such as β, γ, δ-tocopherol; Other vitamins such as pantothenic acid and biotin; Ascorbic acid phosphate ester salt such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, ascorbic acid tetra Ascorbic acid fatty acid ester such as isopalmitic acid ester, ascorbic stearate, ascorbic palmitate, ascorbic dipalmitate, ascorbic acid alkyl ether such as ethyl ascorbic acid ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid ester. , Ascorbic acid derivatives such as tocopheryl phosphate ascorbic; vitamin derivatives such as tocopherol derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleic acid, tocopherol ferulate, tocopherol phosphate ester, tocotrienol, and other various vitamin derivatives are preferable. Is mentioned as.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokithiol, guaiazulene, allantin, indomethacin, zinc oxide, hydrocortisone acetate, prednison, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract. , Plant extracts such as Honoha extract are preferred.

As hair growth agents, blood circulation promoters and stimulants, plant extracts and tinctures such as senburi extract, sugar cane tincture, ginger tincture, ginger extract, cantalis tincture; , Borneol, cyclanderate, cinnaridine, trazoline, acetylcholine, verapamil, cepharanthin, γ-orizanol, cepharanthin, vitamin E and derivatives such as tocopherol nicotinate / tocopherol acetate, γ-orizanol, nicotinic acid and nicotinic acid amide / benzyl nicotinate. Derivatives such as ester inositol hexanicotinate and nicotine alcohol, allantin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivative, stigmasterol or stigmasterol and its glycosyl, minoxidyl are preferable. Is mentioned as. As the hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like are preferable.

Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cold sensitizers, warming agents, wound healing promoters, stimulants, painkillers, cell activators, etc. include retinols, retinoic acids, retinoins. Tocopheryl acid; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, hydroxycapric acid, long-chain α-hydroxy fatty acid, long-chain α-hydroxy fatty acid cholesteryl and the like α-or β-Hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; creatin; ceramides, sphingosines; caffeine, xanthin and its derivatives; coenzyme Q10, carotene, lycopene, astaxanthin Antioxidants and active oxygen scavengers such as α-lipoic acid; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamine, protoanthocyanidin, chlorogenic acid and apple polyphenols. Derivatives such as rutin and glycosides; Derivatives such as hesperidin and glycosides; Lignan glycosides; Perfume substances and derivatives thereof; capsaicin, vanillin and the like and derivatives; insect repellents such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred.

Plant / animal / microbial extracts include iris extract, asitaba extract, asnalo extract, asparagus extract, avocado extract, flaxseed extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract. , Inchkou extract, Uikyo extract, Ukon extract, Woolong tea extract, Uwaurushi extract, Agetsu extract, Echinashi leaf extract, Enmeisou extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otaneninjin extract, Otogirisou extract, Odorikosou extract, Ononis extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cucumber extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi Extract, crow wheat extract, karukade extract, kanzo extract, oil-soluble kanzo extract, kiwi extract, kiou extract, kikurage extract, kina extract, cucumber extract, kiri leaf extract, guanosine, guava extract, kujin extract, kuchinashi extract, kumazasa extract, clara extract, walnut Extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, quail extract, gentiana extract, gennoshoco extract, tea extract, yeast extract, koboku extract, coffee extract, gobo extract, rice extract, rice Fermented extract, fermented rice bran extract, rice germ oil, confree extract, collagen, kokemomo extract, saishin extract, psycho extract, saitai extract, saffron extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract, sansha extract, sansho Extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Jatoba extract, Shakuyaku extract, Shokyu extract, Shobu root extract, Shirakaba extract, White chrysanthemum extract, Sugina extract, Stevia extract, Stevia fermented product, Nishikawayanagi extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract, Seiyouhakka extract, Sage extract, Zeniaoi extract, Senkyu extract, Senburi extract, Souhakuhi extract, Daiou extract, Die Zu extract, Taisou extract, Thyme extract, Dandelion extract, Local clothing extract, Tea extract, Chouji extract, Chigaya extract, Chinpi extract, Tea tree oil, Jincha extract, Togarashi extract, Touki extract, Tokinsenka extract, Tounin extract, Tohi extract, Dokudami extract, Tomato Extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Hass extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietaria extract, Hikiokoshi extract, Bisabolol, Hinoki extract, Bifizus bacterium extract, Biwa extract, Fukitanpopo extract, Fukinotou extract, Bukuryo extract, Butcher bloom extract, Grape extract, Grape seed extract, Propolis, Hechima extract, Benibana extract, Peppermint extract, Bodaiju extract, Button extract, Hop extract, Maikaika extract, Pine extract, Maronie extract , Mizubasho extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Yuri extract, Yokuinin extract, Yomogi extract, Lavender extract, Green tea extract, Eggshell membrane extract, Apple extract, Louis Boss tea extract , Reishi extract, lettuce extract, lemon extract, lotus extract, lotus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, crackle extract and the like are preferable.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenolsulfonate and the like. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like. Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like. Preferred examples of nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and disodium adenosine triphosphate.

As fragrances, acetylsedrene, amilcinnamaldehyde, allylamylglycolate, β-ionone, isoe super, isobutylquinoline, iris oil, iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragor, Eugenol, Oak Moss, Opoponax Resinoid, Orange Oil, Eugenol, Oranthiol, Galaxolid, Carbachlor, L-Carbon, Kamfer, Cannon, Carrot Seed Oil, Clove Oil, Methyl Caynate, Geraniol, Geranylnitrile , Isobornyl acetate, Geranyl acetate, Dimethylbenzylcarbyl acetate, Styralyl acetate, Sedrill acetate, Telepinel acetate, pt-butylcyclohexyl acetate, Vetiberyl acetate, benzyl acetate, Linaryl acetate, Isopentyl salicylate, benzyl salicylate, Sandalwood oil, Santa Roll, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citroneral, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, Stilax resinoid, cedarwood oil, sedren, sedrol, celery seed oil, thyme oil, damascon, damasenon, timol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinen, triplar, nerol, nonanar, 2,6-nonadienol, nonalactone , Pacholi alcohol, vanilla absolute, vanillin, basil oil, pachori oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil , Vetiberol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, millresinoid, muskketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthon, eucalyptus oil, β-yonon, Synthetic fragrances such as lime oil, lavender oil, D-lymonen, linalol, lylar, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils and natural Fragrances and various blended fragrances are preferred.

Dyes / colorants / dyes / pigments include brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, and blue 204. , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213. , Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1. , Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505. , Red 506, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1 , Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow Legal dyes such as No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14;

Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow5, HC Red 3, 4-hydoxypolythrinth (4-hydoxypoly- Pigment-2-it. Nitro dyes such as 2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (Bengala) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and ocher; Inorganic black pigments such as black iron oxide and lower titanium oxide; Inorganic purple pigments such as mango violet and cobalt violet; Inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; Inorganic blue pigments such as ultramarine and dark blue; Titanium oxide coated mica, Titanium oxide coated bismuth oxide, Titanium oxide coated talc, Colored titanium oxide coated mica, Pearl pigments such as bismuth oxychloride and fish scale foil; metal powder pigments such as aluminum powder, copper powder and gold; surface-treated inorganic and metal powder pigments; red 201, red 202, red 204, red 205, red 220 No., Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Organics such as zirconium, barium or aluminum lake such as red 230, red 401, red 505, orange 205, yellow 4, yellow 5, yellow 202, yellow 203, green 3 and blue 1. Pigments; Surface-treated organic pigments; Anthracinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsantine, chalcone, calsamine, quercetin, closin, chlorophyll, curcumin, cochineal, siconin and other naphthoquinones, bixins, flavones, etc. Natural pigments and dyes such as betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediami Oxidation dye intermediates and couplers such as amine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and salts thereof; autoxidation dyes such as indoline; dihydroxyacetone is preferred. Can be mentioned.

As the water, in addition to normal water and purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytically acidic ionized water, ionized water, and cluster water are preferable. In addition to these, cosmetic raw material standards, compounding ingredient standards by cosmetic type, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Handbook), non-pharmaceutical raw material standards, Japanese Pharmacy, pharmaceutical additives Ingredients described in standards, official standards for food additives, etc., and the international patent classification IPC is described in Japanese and foreign patent gazettes and patent publication gazettes (including published gazettes and republished gazettes) that belong to the A61K7 classification. It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc. in known combinations, blending ratios, and blending amounts.

[Use of the indigenous bacteria antibacterial agent of the present disclosure]
The indigenous bacteria antibacterial agent of the present disclosure can exhibit high antibacterial properties in cosmetic applications, and can be preferably applied as an indigenous bacteria antibacterial agent used in skin cosmetics, external skin preparations, hair cosmetics and the like.
The cosmetics in the present disclosure mean cosmetics, quasi-drugs, and pharmaceuticals that are applied directly to the skin of the human body, and the cosmetics include skin cosmetics, external skin preparations, skin cleaning agents, hair cosmetics, external hair preparations, and hair. Contains cleaning agents and the like. The indigenous bacteria antibacterial agent in the present disclosure is an agent having antibacterial properties, which is used for the above-mentioned uses and the like. Antibacterial properties are performances such as sterilization (killing microorganisms), bacteriostatic (suppressing the growth of microorganisms), sterilization, disinfection, sterilization, sterilization, antifungal, etc. It is indigenous. The indigenous bacteria are various bacteria listed in the above-mentioned indigenous bacteria of the present disclosure.
In particular, since the indigenous bacteria antibacterial agent of the present disclosure exhibits antibacterial performance at a low concentration against indigenous skin bacteria, the following basic lotions, makeup lotions, body lotions, hair lotions, and external skin lotions are used. Basic cosmetics include soft lotion, astringent lotion, cleaning lotion, multi-layer lotion, etc .; emollient lotion, moisturizing lotion, milky lotion, nourishing lotion, nourishing milk, skin moisturizer, moisturizer. Emollient cream, nourishing cream, emulsions such as jar emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sun screen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion, etc. Lotion cream, vanishing cream, moisturizing cream, night cream, massage cream, cleansing cream, make-up cream, base cream, pre-make-up cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc. Cream; Moisture gel and other gels; Moisturizing essence, whitening essence, UV protection essence and other essences; Lipstick beauty liquid, liposome lotion and other liposome cosmetics; Peel-off pack, powder pack, washing pack, oil pack, cleansing mask, etc. Packs and masks; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, washing powder, face washing powder, etc.; cosmetic soap, clear soap, medicated soap, liquid soap, shaving soap , Synthetic lotion and the like are preferred.

Preferred makeup cosmetics include white powder / dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment. Preferred fragrance cosmetics include perfumes, perfumes, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powders, perfume soaps, body lotions and bath oils.
Body cosmetics include body cleaning agents such as body shampoo; deodorant cosmetics such as deodorant lotion, deodorant powder, deodorant spray, and deodorant stick; depigmenting agents, depilatory / depilatory agents; bathing agents; insect repellent sprays, etc. Repellers are preferred.

Hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, indulgence shampoos, hair color shampoos, rinse-integrated shampoos, and other shampoos; for rinses, treatments, hair packs, color lotions, split hair coats, and permanent waves. Agents, straight perm agents, oxidative hair dyes, hair bleach, hair color pretreatment, hair color aftertreatment, perm pretreatment, perm aftertreatment, hair manicure, hair tonic, and hair restorer are preferred.

As the external skin preparation, it can also be used as a dosage form such as an ointment, a patch, a lotion, a liniment, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

Examples of the dosage form of the indigenous bacterial antibacterial agent of the present disclosure include oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type and other emulsified types. Cosmetics, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste-like cosmetics, stick-like cosmetics, volatile oil-type cosmetics, powder-like cosmetics, jelly-like cosmetics, gel-like cosmetics, paste-like makeup Pharmaceuticals, emulsified polymer type cosmetics, sheet-like cosmetics, mist-like cosmetics, spray-type cosmetics and the like are preferable.
The indigenous bacterial antibacterial agent of the present disclosure is particularly preferably applicable to cosmetic applications used by directly applying it to the skin, shampoos, washing pigments and the like used by directly applying it to the skin.

[Method of using the copolymer of the present disclosure]
Since the copolymer of the present disclosure is excellent in antibacterial properties of indigenous bacteria, for example, it can be preferably used as an antibacterial agent for indigenous bacteria. The copolymer of the present disclosure can be preferably blended in cosmetics and the like. The copolymer of the present disclosure or the indigenous bacterial antibacterial agent of the present disclosure is not particularly limited, but the copolymer of the present disclosure should be blended with cosmetics so as to be, for example, 0.01 ppm or more and 5% or less. It is more preferable to mix it so as to be 0.1 ppm or more and 1% or less, and it is most preferable to mix it so as to be 1 ppm or more and 1000 ppm or less.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. Unless otherwise specified, "part" means "part by mass" and "%" means "% by mass".
[Manufacturing Example 1]
29.4 g of pure water and 100.0 g of 1,3-butanediol (manufactured by KH Neochem Co., Ltd.) are charged in a glass separable flask equipped with a thermometer, a reflux condenser, and a stirrer, and the temperature is adjusted to 90 ° C. under stirring. The temperature was raised. Then, under stirring, in a polymerization reaction system at a constant state of 80 ° C., from 65.0 g of 2- (dimethylamino) ethyl methacrylate (N, N-dimethylaminoethyl methacrylate) (manufactured by Kyoeisha Chemical Co., Ltd., hereinafter referred to as DAM). Polymer solution 1, a monomer solution 2 consisting of 35.0 g of ethyl methacrylate (manufactured by Kyoeisha Chemical Co., Ltd., hereinafter referred to as EMA), and 2,2'-azobis (2-methylpropionamidine) dihydrochloride (Fujifilm). A starting agent aqueous solution consisting of 18.3 g of a 10% aqueous solution (hereinafter referred to as V-50) manufactured by Wako Pure Chemical Co., Ltd. was added dropwise from separate dropping nozzles. Regarding the dropping start time, the monomer solutions 1 and 2 and the initiator aqueous solution started dropping at the same time, the monomer solution 1 was dropped for 180 minutes, the monomer solution 2 was dropped for 170 minutes, and the initiator aqueous solution was dropped for 210 minutes. After the completion of all dropping, the reaction solution was kept at 80 ° C. for another 30 minutes for aging to complete the polymerization, and then 55.2 g of pure water and 205.5 g of 1,3-butanediol were added to the copolymer 1. Got The solid content of the obtained copolymer was 19.7%, the pH was 9.0, and the weight average molecular weight was 34000.
[Manufacturing Example 2]
90.0 g of 1,3-butanediol and 22.6 g of water were placed in a glass separable flask equipped with a thermometer, a reflux condenser and a stirrer, and the temperature was raised to 80 ° C. under stirring. Next, under stirring, in a polymerization reaction system at a constant state of 80 ° C., a monomer solution 1 consisting of 117.5 g of DAM, a monomer solution 2 consisting of 13.5 g of EMA, and an 18% aqueous acrylic acid solution (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) ) 23.2 g of the monomer solution 3 and 22.6 g of the V-50, 10% aqueous solution of the initiator were added dropwise from separate dropping nozzles.
Regarding the dropping start time, the monomer solutions 1 and 2 and the initiator aqueous solution started dropping at the same time, the monomer solution was dropped for 150 minutes, and the initiator aqueous solution was dropped for 180 minutes. After the completion of all dropping, the reaction solution was kept at 80 ° C. for another 60 minutes for aging to complete the polymerization, and then 53.9 g of pure water was added to obtain a copolymer 1. The solid content of the obtained copolymer was 39.3%, the pH was 9.0, and the weight average molecular weight was 38,000.

[Example 1]
<Antibacterial test (Malassezia furfurin)>
35 The cells were cultured at ° C for 4 days. The grown colonies were suspended in butterfield buffer to prepare 5 ml of OD660 = 1 solution. Next, 10 ml each of the aqueous solution containing the copolymer 1 obtained in Production Example 1 and the aqueous solution containing the antibacterial agent obtained in Production Example 2 were prepared by diluting them to a specified concentration. To each of these aqueous solutions, 0.1 ml of the Malassezia bacterium solution prepared above was added. This was inverted and mixed and incubated at 25 ° C. After 4 hours and 4 days, a diluted series was prepared by partially sampling from each aqueous solution, streaked into a Clomore garmalassezia medium, cultured at 35 ° C. for 4 days, and the number of residual bacteria was counted. As comparison targets, zinc pyrithione (Comparative Example 1) and methylparaben (Comparative Example 2), which are often used as preservatives, were used and carried out in the same manner. The results are shown in Table 1.

表１の結果から、本開示における重合体はマラセチア菌に対して顕著な効果を有することがわかる。

From the results in Table 1, it can be seen that the polymers in the present disclosure have a remarkable effect on Malassezia furfurin.

[Example 2]
<Antibacterial test (P. acnes)>
P. acnes (Cutibacterium acnesNBRC-107605) sold by NBRC (Biotechnology Center, Product Evaluation Technology Infrastructure) was leaked to GAM broth agar medium (manufactured by Nissui Pharmaceutical Co., Ltd.), and Aneropack Kenki (Mitsubishi Gas Chemical Co., Ltd.) (Manufactured by the company) was placed in the enclosed anaerobic chamber and cultured at 37 ° C. for 4 days under anaerobic conditions. The formed colonies were suspended in butterfield buffer to prepare a bacterial solution of about 10 × 10 ⁸ cells / mL. Next, the prepared bacterial solution was diluted with GAM broth medium to about 10 × 10 ⁶ cells / mL. Next, the test aqueous solution was sequentially diluted 2-fold in GAM broth medium to prepare a medium containing the copolymer 1 obtained in Production Example 1 and the copolymer 2 obtained in Production Example 2, respectively. A dilution series was prepared. Then, 50 μL of a medium containing each concentration of antibacterial agent was added to a polystyrene 96-well plate. Next, 50 μL of the diluted bacterial solution prepared above was added to the diluted series of the medium. Subsequently, a 96-well polystyrene plate was placed in an anaerobic chamber containing Aneropack Kenki, and after standing still culturing at 37 ° C. under anaerobic conditions for 3 days, the minimum antibacterial agent concentration in the medium in which bacteria did not grow ( Mass ppm) was determined as the minimum inhibitory concentration (MIC). The presence or absence of bacterial growth was visually determined by whether the turbidity had increased. As comparison targets, zinc pyrithione (Comparative Example 1) and methylparaben (Comparative Example 2), which are often used as preservatives for cosmetics, were used. The results are shown in Table 2.

表２の結果から、本開示における重合体はアクネ菌に対して顕著な効果を有することがわかる。

From the results in Table 2, it can be seen that the polymer in the present disclosure has a remarkable effect on P. acnes.

[Examples 3 and 4]
<Adjustment of shampoo prescription>
For the copolymer 1 obtained in Production Example 1 and the copolymer 2 obtained in Production Example 2, the pH was adjusted to around 6 using a 10 wt% aqueous solution of citric acid (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd.). Diluting with water while maintaining, a 2% aqueous solution was prepared (Tables 8 and 9). The shampoo composition of the present disclosure was produced by blending as shown in Table 3 below.

調整方法を以下に示す。
１）１～４を均一溶解後、さらに５を添加して均一混合した。（８０℃、１０分）
２）１）に６を添加して均一溶解した。（８０℃、５分）
３）２）を４０℃まで冷却した。
４）３）に予め均一混合した７～９を添加し、均一混合した。
５）４）に１０、１１、１２、１３をこの順に添加し、均一混合した。
表３に示す品名については、下記に示す商品を用いた。
ＥＤＴＡ－Ｎａ：キレスト２Ｂ－ＳＤ（中部キレスト株式会社製）
安息香酸Ｎａ：安息香酸ナトリウム（富士フイルム和光純薬株式会社製）
グリセリン：化粧品用濃グリセリン（阪本薬品工業株式会社製）
ヒドロキシエチルセルロースヒドロキシプロピルトリメチルアンモニウムクロリドエーテル：ポイズＣ－６０Ｈ（花王株式会社製）
ヤシ油脂肪酸モノエタノールアミド：アミゾールＣＭＥ（川研ファインケミカル株式会社製）
ヤシ油脂肪酸アミドプロピルカルボベタイン：アンヒトール５５ＡＢ（花王株式会社製）
アルキル(８～１６)グルコシド：マイドール１０（花王株式会社製）
ポリオキシエチレンラウリルエーテル酢酸ナトリウム：ビューライトＬＣＡ－２５Ｆ（三洋化成工業株式会社製）
塩化ジメチルジアリルアンモニウム・アクリルアミド共重合体：ＭＥＲＱＵＡＴ５５０ＲＲ（日本ルーブリゾール株式会社製）
クエン酸１０％水溶液：（扶桑化学工業株式会社製）
実施例３、４のシャンプー用組成物は、常温で１か月間静置後も分離、析出がなく安定であった。

The adjustment method is shown below.
1) After 1 to 4 were uniformly dissolved, 5 was further added and uniformly mixed. (80 ° C, 10 minutes)
2) 6 was added to 1) and uniformly dissolved. (80 ° C, 5 minutes)
3) 2) was cooled to 40 ° C.
4) 7 to 9 which had been uniformly mixed in advance were added to 3) and uniformly mixed.
5) 10, 11, 12, and 13 were added to 4) in this order and mixed uniformly.
As for the product names shown in Table 3, the products shown below were used.
EDTA-Na: Kirest 2B-SD (manufactured by Chubu Kirest Co., Ltd.)
Na benzoate: Sodium benzoate (manufactured by Wako Pure Chemical Industries, Ltd.)
Glycerin: Concentrated glycerin for cosmetics (manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.)
Hydroxyethyl Cellulose Hydroxypropyltrimethylammonium Chloride Ether: Poise C-60H (manufactured by Kao Corporation)
Coconut oil fatty acid monoethanolamide: Amizole CME (manufactured by Kawaken Fine Chemical Co., Ltd.)
Coconut oil fatty acid amide propylcarbobetaine: Anchtor 55AB (manufactured by Kao Corporation)
Alkyl (8-16) Glucoside: Mydor 10 (manufactured by Kao Corporation)
Polyoxyethylene lauryl ether sodium acetate: Beaulite LCA-25F (manufactured by Sanyo Chemical Industries, Ltd.)
Dimethyldiallyl ammonium chloride / acrylamide copolymer: MERQUAT550RR (manufactured by Japan Lubrizol Co., Ltd.)
10% aqueous solution of citric acid: (manufactured by Fuso Chemical Industry Co., Ltd.)
The shampoo compositions of Examples 3 and 4 were stable without separation or precipitation even after being allowed to stand at room temperature for 1 month.

[Examples 5 and 6]
<Adjustment of face wash foam prescription>
The copolymer 1 obtained in Production Example 1 and the copolymer 2 obtained in Production Example 2 were blended as shown in Table 4 below to produce the composition for facial cleansing foam of the present disclosure.

調整方法を以下に示す。
１）１～９を８０℃に加温して均一溶解する。
２）１０、１１を８０℃に加温して均一溶解する。
３）１）に２）をゆっくり添加して、均一混合する。（８０℃、３０分）
４）３）に１２、１３をこの順に添加後、４０℃までゆっくり冷却する。
５）４）に１４を添加し、均一混合する。
表４に示す品名については、下記に示す商品を用いた。
ラウリン酸：ルナックＬ－９８（花王株式会社製）
ミリスチン酸：ルナックＭＹ－９８（花王株式会社製）
ステアリン酸：ルナックＳ－９８（花王株式会社製）
パルミチン酸：ルナックＰ－９５（花王株式会社製）
ステアリン酸グリセリル：レオドールＭＳ－５０（花王株式会社製）
ジステアリン酸グリコール：ＮＩＫＫＯＬエステパール１０Ｖ（日光ケミカルズ株式会社製）
ＰＥＧ－８：ＰＥＧ＃４００（日油株式会社製）
水酸化カリウム（８５％）：富士フイルム和光純薬株式会社製
実施例５、６の洗顔フォーム用組成物は、常温で1か月間静置後も分離、析出がなく安定であった。

The adjustment method is shown below.
1) Heat 1 to 9 to 80 ° C. to uniformly dissolve.
2) Heat 10 and 11 to 80 ° C. to uniformly dissolve them.
3) Add 2) slowly to 1) and mix uniformly. (80 ° C, 30 minutes)
4) Add 12 and 13 to 3) in this order, and then slowly cool to 40 ° C.
5) Add 14 to 4) and mix uniformly.
As for the product names shown in Table 4, the products shown below were used.
Lauric acid: Lunac L-98 (manufactured by Kao Corporation)
Myristic acid: Lunac MY-98 (manufactured by Kao Corporation)
Stearic acid: Lunac S-98 (manufactured by Kao Corporation)
Palmitic acid: Lunac P-95 (manufactured by Kao Corporation)
Glyceryl stearate: Leodor MS-50 (manufactured by Kao Corporation)
Glycol distearate: NIKKOL Estepearl 10V (manufactured by Nikko Chemicals Co., Ltd.)
PEG-8: PEG # 400 (manufactured by NOF CORPORATION)
Potassium hydroxide (85%): The facial cleansing foam compositions of Examples 5 and 6 manufactured by Wako Pure Chemical Industries, Ltd. were stable without separation or precipitation even after being allowed to stand at room temperature for 1 month.

Claims (5)

An antibacterial agent for indigenous skin flora containing a copolymer
The copolymer has a structural unit (a) derived from an amino group-containing monomer and a structural unit (b) derived from a hydrophobic monomer, and the structural unit (a) derived from the amino group-containing monomer. ) Is represented by the following general formulas (1) and / or (2), and the hydrophobic monomer is an antibacterial agent for indigenous skin bacteria having a solubility parameter of a homopolymer of 15 or less.

(In the general formula (1) or (2), R ₁ , R ₂ , and R ₃ independently represent a hydrogen atom or an organic group having 1 to 12 carbon atoms, and R ₄ to R ₈ independently represent each. , A hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and Y ⁻ represents an anion. However, asterisk is the same kind or the same type to which the structural unit represented by the general formula (1) or (2) is bonded. Represents an atom contained in another different structural unit.) The antibacterial agent for indigenous skin flora according to claim 1, wherein the copolymer contains at least one kind of (meth) acrylic acid alkyl ester. The copolymer comprises a structural unit in which -X- is represented by -C (= O) -O-CH ₂ CH _2- in the general formula (1) or (2), according to claim 1 or The antibacterial agent for indigenous skin bacteria according to 2. The copolymer is a skin flora antibacterial agent containing a structural unit derived from ethyl (meth) acrylate. A scalp or scalp care product containing the copolymer according to any one of claims 1 to 4.