JP2022058610A5 - - Google Patents
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- Publication number
- JP2022058610A5 JP2022058610A5 JP2022003838A JP2022003838A JP2022058610A5 JP 2022058610 A5 JP2022058610 A5 JP 2022058610A5 JP 2022003838 A JP2022003838 A JP 2022003838A JP 2022003838 A JP2022003838 A JP 2022003838A JP 2022058610 A5 JP2022058610 A5 JP 2022058610A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- carbothioyl
- amino
- chloro
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 125000002837 carbocyclic group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 1
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 1
- VPEOFGGTYXSDTR-UHFFFAOYSA-N 1-[3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]-4-fluorophenyl]cyclopropane-1-carboxylic acid Chemical compound CC1=C(C(=CC(=C1)OCCC1OCCCC1)C)C(=S)NC=1C=C(C=CC1F)C1(CC1)C(=O)O VPEOFGGTYXSDTR-UHFFFAOYSA-N 0.000 claims 1
- SRQXVSQNJYRWHX-UHFFFAOYSA-N 2-[3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]-4-fluorophenyl]-2-methylpropanoic acid Chemical compound CC1=C(C(=CC(=C1)OCCC1OCCCC1)C)C(=S)NC=1C=C(C=CC1F)C(C(=O)O)(C)C SRQXVSQNJYRWHX-UHFFFAOYSA-N 0.000 claims 1
- VZUOXVMAJYLIMN-UHFFFAOYSA-N 2-[3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]-4-fluorophenyl]propanoic acid Chemical compound CC1=C(C(=CC(=C1)OCCC1OCCCC1)C)C(=S)NC=1C=C(C=CC1F)C(C(=O)O)C VZUOXVMAJYLIMN-UHFFFAOYSA-N 0.000 claims 1
- LHEBDWFMNXQYHT-UHFFFAOYSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]phenyl]-2-methylpropanoic acid Chemical compound ClC1=C(C=C(C=C1)C(C(=O)O)(C)C)NC(=S)C1=C(C=C(C=C1C)OCCC1OCCCC1)C LHEBDWFMNXQYHT-UHFFFAOYSA-N 0.000 claims 1
- SUSIFHLMOQXCFJ-UHFFFAOYSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1C)OCCC1OCCCC1)C SUSIFHLMOQXCFJ-UHFFFAOYSA-N 0.000 claims 1
- LHEBDWFMNXQYHT-LJQANCHMSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-[(2R)-oxan-2-yl]ethoxy]benzenecarbothioyl]amino]phenyl]-2-methylpropanoic acid Chemical compound ClC1=C(C=C(C=C1)C(C(=O)O)(C)C)NC(=S)C1=C(C=C(C=C1C)OCC[C@@H]1OCCCC1)C LHEBDWFMNXQYHT-LJQANCHMSA-N 0.000 claims 1
- SUSIFHLMOQXCFJ-GOSISDBHSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-[(2R)-oxan-2-yl]ethoxy]benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1C)OCC[C@@H]1OCCCC1)C SUSIFHLMOQXCFJ-GOSISDBHSA-N 0.000 claims 1
- LHEBDWFMNXQYHT-IBGZPJMESA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-[(2S)-oxan-2-yl]ethoxy]benzenecarbothioyl]amino]phenyl]-2-methylpropanoic acid Chemical compound ClC1=C(C=C(C=C1)C(C(=O)O)(C)C)NC(=S)C1=C(C=C(C=C1C)OCC[C@H]1OCCCC1)C LHEBDWFMNXQYHT-IBGZPJMESA-N 0.000 claims 1
- SUSIFHLMOQXCFJ-SFHVURJKSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-[(2S)-oxan-2-yl]ethoxy]benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1C)OCC[C@H]1OCCCC1)C SUSIFHLMOQXCFJ-SFHVURJKSA-N 0.000 claims 1
- HSWYJYRHWVMHRL-UHFFFAOYSA-N 2-[4-chloro-3-[[4-(2-cyclohexylethoxy)-2,6-dimethylbenzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1C)OCCC1CCCCC1)C HSWYJYRHWVMHRL-UHFFFAOYSA-N 0.000 claims 1
- HDOPJHZISGMQOH-UHFFFAOYSA-N 2-[4-chloro-3-[[4-(2-cyclohexylethoxy)-2-(trifluoromethyl)benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1)OCCC1CCCCC1)C(F)(F)F HDOPJHZISGMQOH-UHFFFAOYSA-N 0.000 claims 1
- MYJADEDAMLJBGK-UHFFFAOYSA-N 2-[4-chloro-3-[[4-(2-cyclopropylethoxy)-2-(trifluoromethyl)benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1)OCCC1CC1)C(F)(F)F MYJADEDAMLJBGK-UHFFFAOYSA-N 0.000 claims 1
- GXHLQNMECMHTLV-UHFFFAOYSA-N 2-[4-chloro-3-[[4-(2-phenylethoxy)-2-(trifluoromethyl)benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1)OCCC1=CC=CC=C1)C(F)(F)F GXHLQNMECMHTLV-UHFFFAOYSA-N 0.000 claims 1
- BDSTXMUAMCTJNU-UHFFFAOYSA-N 2-[4-chloro-3-[[4-[2-(oxan-2-yl)ethoxy]-2-(trifluoromethyl)benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1)OCCC1OCCCC1)C(F)(F)F BDSTXMUAMCTJNU-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018175758 | 2018-09-20 | ||
| JP2018175758 | 2018-09-20 | ||
| JP2020548589A JP7021709B2 (ja) | 2018-09-20 | 2019-09-19 | Ｄｐアンタゴニスト |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548589A Division JP7021709B2 (ja) | 2018-09-20 | 2019-09-19 | Ｄｐアンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022058610A JP2022058610A (ja) | 2022-04-12 |
| JP2022058610A5 true JP2022058610A5 (https=) | 2022-08-29 |
| JP7338711B2 JP7338711B2 (ja) | 2023-09-05 |
Family
ID=69888481
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548589A Active JP7021709B2 (ja) | 2018-09-20 | 2019-09-19 | Ｄｐアンタゴニスト |
| JP2022003838A Active JP7338711B2 (ja) | 2018-09-20 | 2022-01-13 | Ｄｐアンタゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548589A Active JP7021709B2 (ja) | 2018-09-20 | 2019-09-19 | Ｄｐアンタゴニスト |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11319296B2 (https=) |
| EP (1) | EP3854781B1 (https=) |
| JP (2) | JP7021709B2 (https=) |
| KR (2) | KR102425709B1 (https=) |
| CN (1) | CN112739680A (https=) |
| AU (1) | AU2019341082A1 (https=) |
| BR (1) | BR112021005260A2 (https=) |
| CA (1) | CA3113210A1 (https=) |
| ES (1) | ES2982217T3 (https=) |
| IL (2) | IL310383A (https=) |
| MX (1) | MX2021003131A (https=) |
| NZ (1) | NZ774113A (https=) |
| PH (1) | PH12021550549A1 (https=) |
| SG (1) | SG11202102566YA (https=) |
| TW (2) | TWI822457B (https=) |
| WO (1) | WO2020059790A1 (https=) |
| ZA (1) | ZA202101887B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019341082A1 (en) * | 2018-09-20 | 2021-04-15 | Ono Pharmaceutical Co., Ltd. | DP antagonist |
| TW202146394A (zh) * | 2020-03-19 | 2021-12-16 | 日商小野藥品工業股份有限公司 | 苯乙酸化合物之結晶 |
| JP2024016311A (ja) * | 2020-12-24 | 2024-02-07 | 小野薬品工業株式会社 | Ｅｐ２アンタゴニスト |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986005779A1 (en) * | 1985-04-03 | 1986-10-09 | Yamanouchi Pharmaceutical Co., Ltd. | Phenylene derivatives |
| JPS63159342A (ja) | 1985-04-03 | 1988-07-02 | Yamanouchi Pharmaceut Co Ltd | 新規カルボン酸化合物 |
| ATE516277T1 (de) * | 2002-03-19 | 2011-07-15 | Ono Pharmaceutical Co | Carbonsäureverbindungen und arzneimittel, die diese verbindungen als wirkstoffe enthalten |
| DK1666473T3 (da) * | 2003-09-17 | 2013-03-25 | Ono Pharmaceutical Co | Carboxylsyreforbindelser og medicinske sammensætninger indeholdende samme som aktiv ingrediens |
| WO2005080367A1 (en) * | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
| WO2006007448A2 (en) | 2004-06-17 | 2006-01-19 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions and related methods of use |
| TWI410410B (zh) | 2007-08-10 | 2013-10-01 | Ono Pharmaceutical Co | Phenylacetic acid compounds |
| US8765733B2 (en) | 2011-09-26 | 2014-07-01 | Gruenenthal Gmbh | Amine substituted methanesulfonamide derivatives as vanilloid receptor ligands |
| WO2018116107A1 (en) | 2016-12-20 | 2018-06-28 | Glaxosmithkline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
| JP6533249B2 (ja) | 2017-04-21 | 2019-06-19 | 山佐株式会社 | 遊技機用基板ケースの取り付け構造及び遊技機 |
| US20210139467A1 (en) | 2017-06-28 | 2021-05-13 | Glaxosmithkline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
| AU2019341082A1 (en) * | 2018-09-20 | 2021-04-15 | Ono Pharmaceutical Co., Ltd. | DP antagonist |
-
2019
- 2019-09-19 AU AU2019341082A patent/AU2019341082A1/en not_active Abandoned
- 2019-09-19 ES ES19862361T patent/ES2982217T3/es active Active
- 2019-09-19 TW TW111143026A patent/TWI822457B/zh active
- 2019-09-19 TW TW108133822A patent/TWI784199B/zh not_active IP Right Cessation
- 2019-09-19 WO PCT/JP2019/036725 patent/WO2020059790A1/ja not_active Ceased
- 2019-09-19 KR KR1020217008017A patent/KR102425709B1/ko active Active
- 2019-09-19 EP EP19862361.3A patent/EP3854781B1/en active Active
- 2019-09-19 KR KR1020227025551A patent/KR20220107330A/ko not_active Withdrawn
- 2019-09-19 CN CN201980061636.8A patent/CN112739680A/zh active Pending
- 2019-09-19 JP JP2020548589A patent/JP7021709B2/ja active Active
- 2019-09-19 US US17/276,284 patent/US11319296B2/en active Active
- 2019-09-19 BR BR112021005260-7A patent/BR112021005260A2/pt not_active Application Discontinuation
- 2019-09-19 NZ NZ774113A patent/NZ774113A/en unknown
- 2019-09-19 IL IL310383A patent/IL310383A/en unknown
- 2019-09-19 MX MX2021003131A patent/MX2021003131A/es unknown
- 2019-09-19 SG SG11202102566YA patent/SG11202102566YA/en unknown
- 2019-09-19 CA CA3113210A patent/CA3113210A1/en active Pending
-
2021
- 2021-03-11 IL IL281433A patent/IL281433A/en unknown
- 2021-03-12 PH PH12021550549A patent/PH12021550549A1/en unknown
- 2021-03-19 ZA ZA2021/01887A patent/ZA202101887B/en unknown
-
2022
- 2022-01-13 JP JP2022003838A patent/JP7338711B2/ja active Active
- 2022-03-15 US US17/695,796 patent/US20220204468A1/en not_active Abandoned
-
2024
- 2024-10-14 US US18/915,276 patent/US20250042870A1/en active Pending
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