JP2022031662A5 - - Google Patents
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- JP2022031662A5 JP2022031662A5 JP2021177234A JP2021177234A JP2022031662A5 JP 2022031662 A5 JP2022031662 A5 JP 2022031662A5 JP 2021177234 A JP2021177234 A JP 2021177234A JP 2021177234 A JP2021177234 A JP 2021177234A JP 2022031662 A5 JP2022031662 A5 JP 2022031662A5
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- Prior art keywords
- pharmaceutical composition
- pancreatic
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- subject
- cells
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 230000004064 dysfunction Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- JLTPSDHKZGWXTD-UHFFFAOYSA-N 2-[6-(dicyanomethylidene)naphthalen-2-ylidene]propanedinitrile Chemical compound N#CC(C#N)=C1C=CC2=CC(=C(C#N)C#N)C=CC2=C1 JLTPSDHKZGWXTD-UHFFFAOYSA-N 0.000 claims 1
- HFDKKNHCYWNNNQ-YOGANYHLSA-N 75976-10-2 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C1=CC=C(O)C=C1 HFDKKNHCYWNNNQ-YOGANYHLSA-N 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 102100025683 Alkaline phosphatase, tissue-nonspecific isozyme Human genes 0.000 claims 1
- 101710161969 Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 claims 1
- 239000004382 Amylase Substances 0.000 claims 1
- 102000013142 Amylases Human genes 0.000 claims 1
- 108010065511 Amylases Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102000005367 Carboxypeptidases Human genes 0.000 claims 1
- 108010006303 Carboxypeptidases Proteins 0.000 claims 1
- 108010038061 Chymotrypsinogen Proteins 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 102400000321 Glucagon Human genes 0.000 claims 1
- 108060003199 Glucagon Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000018886 Pancreatic Polypeptide Human genes 0.000 claims 1
- 102000016387 Pancreatic elastase Human genes 0.000 claims 1
- 108010067372 Pancreatic elastase Proteins 0.000 claims 1
- 208000035467 Pancreatic insufficiency Diseases 0.000 claims 1
- 102000019280 Pancreatic lipases Human genes 0.000 claims 1
- 108050006759 Pancreatic lipases Proteins 0.000 claims 1
- 102000005157 Somatostatin Human genes 0.000 claims 1
- 108010056088 Somatostatin Proteins 0.000 claims 1
- 101000983124 Sus scrofa Pancreatic prohormone precursor Proteins 0.000 claims 1
- 102000018690 Trypsinogen Human genes 0.000 claims 1
- 108010027252 Trypsinogen Proteins 0.000 claims 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 235000019418 amylase Nutrition 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 201000000052 gastrinoma Diseases 0.000 claims 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 1
- 229960004666 glucagon Drugs 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 230000004203 pancreatic function Effects 0.000 claims 1
- 229940116369 pancreatic lipase Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 1
- 229960000553 somatostatin Drugs 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 210000005167 vascular cell Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023086994A JP7751607B2 (ja) | 2008-11-20 | 2023-05-26 | 膵機能障害の治療または予防方法 |
| JP2025099335A JP2025148353A (ja) | 2008-11-20 | 2025-06-13 | 膵機能障害の治療または予防方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19979608P | 2008-11-20 | 2008-11-20 | |
| US61/199,796 | 2008-11-20 | ||
| JP2019162845A JP7051770B2 (ja) | 2008-11-20 | 2019-09-06 | 膵機能障害の治療または予防方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019162845A Division JP7051770B2 (ja) | 2008-11-20 | 2019-09-06 | 膵機能障害の治療または予防方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023086994A Division JP7751607B2 (ja) | 2008-11-20 | 2023-05-26 | 膵機能障害の治療または予防方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022031662A JP2022031662A (ja) | 2022-02-22 |
| JP2022031662A5 true JP2022031662A5 (enExample) | 2022-08-17 |
Family
ID=42197754
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536703A Active JP5891034B2 (ja) | 2008-11-20 | 2009-11-19 | 膵機能障害の治療または予防方法 |
| JP2015111995A Active JP6499016B2 (ja) | 2008-11-20 | 2015-06-02 | 膵機能障害の治療または予防方法 |
| JP2017112578A Withdrawn JP2017214384A (ja) | 2008-11-20 | 2017-06-07 | 膵機能障害の治療または予防方法 |
| JP2019162845A Active JP7051770B2 (ja) | 2008-11-20 | 2019-09-06 | 膵機能障害の治療または予防方法 |
| JP2021177234A Withdrawn JP2022031662A (ja) | 2008-11-20 | 2021-10-29 | 膵機能障害の治療または予防方法 |
| JP2023086994A Active JP7751607B2 (ja) | 2008-11-20 | 2023-05-26 | 膵機能障害の治療または予防方法 |
| JP2025099335A Pending JP2025148353A (ja) | 2008-11-20 | 2025-06-13 | 膵機能障害の治療または予防方法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536703A Active JP5891034B2 (ja) | 2008-11-20 | 2009-11-19 | 膵機能障害の治療または予防方法 |
| JP2015111995A Active JP6499016B2 (ja) | 2008-11-20 | 2015-06-02 | 膵機能障害の治療または予防方法 |
| JP2017112578A Withdrawn JP2017214384A (ja) | 2008-11-20 | 2017-06-07 | 膵機能障害の治療または予防方法 |
| JP2019162845A Active JP7051770B2 (ja) | 2008-11-20 | 2019-09-06 | 膵機能障害の治療または予防方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023086994A Active JP7751607B2 (ja) | 2008-11-20 | 2023-05-26 | 膵機能障害の治療または予防方法 |
| JP2025099335A Pending JP2025148353A (ja) | 2008-11-20 | 2025-06-13 | 膵機能障害の治療または予防方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8894972B2 (enExample) |
| EP (2) | EP2350266B1 (enExample) |
| JP (7) | JP5891034B2 (enExample) |
| KR (2) | KR102011609B1 (enExample) |
| CN (3) | CN104546912B (enExample) |
| AU (1) | AU2009317874B2 (enExample) |
| CA (1) | CA2744228C (enExample) |
| DK (1) | DK2350266T3 (enExample) |
| ES (2) | ES2550795T3 (enExample) |
| WO (1) | WO2010057260A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2657308C (en) * | 2006-07-12 | 2017-06-27 | Angioblast Systems, Inc. | Treatment of excessive neovascularization |
| EP2350266B1 (en) | 2008-11-20 | 2015-07-29 | Mesoblast, Inc. | Method for treating or preventing a pancreatic dysfunction |
| CN102639149A (zh) | 2009-03-05 | 2012-08-15 | 哈佛学院董事会 | 分泌的aP2及其抑制方法 |
| JP6315989B2 (ja) | 2010-07-02 | 2018-04-25 | メゾブラスト，インコーポレーテッド | Ｔ細胞性免疫不全の治療法 |
| SG194930A1 (en) * | 2011-05-19 | 2013-12-30 | Mesoblast Inc | Methods for treating obesity and/or metabolic syndrome |
| CN103841983B (zh) | 2011-06-03 | 2018-11-02 | 麦瑟布莱斯特公司 | 治疗或预防神经性疾病的方法 |
| KR101786862B1 (ko) * | 2011-07-04 | 2017-10-18 | 메소블라스트, 아이엔씨. | 류마티즘성 질환을 치료 또는 예방하는 방법 |
| MY185016A (en) | 2011-07-06 | 2021-04-30 | Cell Therapy Ltd | Progenitor cells of mesodermal lineage |
| CN104098682B (zh) * | 2013-04-03 | 2018-01-02 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
| JP6572130B2 (ja) * | 2012-12-12 | 2019-09-04 | メソブラスト、インコーポレイテッド | 内皮機能不全及び炎症の疾患の治療 |
| US20140314872A1 (en) * | 2013-04-22 | 2014-10-23 | Hans Klingemann | Methods of Use of Culture Supernatant Obtained from Mesenchymal Stem Cells from Dogs and Cats for Treatment of Organ Dysfunction |
| CN104714021B (zh) * | 2013-12-12 | 2016-05-25 | 张曼 | 尿液凝血酶原蛋白在2型糖尿病合并冠心病中的应用 |
| MX2017013807A (es) | 2015-04-30 | 2018-03-15 | Harvard College | Anticuerpos anti-proteina de union al lipido de adipocito humana (ap2) y agente de union al antigeno para tratar trastornos metabolicos. |
| WO2018005551A1 (en) * | 2016-06-27 | 2018-01-04 | President And Fellows Of Harvard College | Compounds useful to treat metabolic disorders |
| WO2018227200A1 (en) | 2017-06-09 | 2018-12-13 | President And Fellows Of Harvard College | Method to identify compounds useful to treat dysregulated lipogenesis, diabetes, and related disorders |
| CN110959579A (zh) * | 2019-11-14 | 2020-04-07 | 顾隽 | 患者来源的淋巴瘤免疫缺陷小鼠移植瘤模型的构建方法及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| WO1992001070A1 (en) | 1990-07-09 | 1992-01-23 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| CA2115742A1 (en) | 1991-08-20 | 1993-03-04 | Ronald G. Crystal | Adenovirus mediated transfer of genes to the gastrointestinal tract |
| AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| AU2003901668A0 (en) | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| DE19939781C2 (de) | 1999-08-21 | 2003-06-18 | Schott Glas | Skulltiegel für das Erschmelzen oder das Läutern von anorganischen Substanzen, insbesondere von Gläsern und Glaskeramiken |
| WO2004016747A2 (en) * | 2002-08-14 | 2004-02-26 | University Of Florida | Bone marrow cell differentiation |
| ATE493492T1 (de) * | 2003-11-04 | 2011-01-15 | Biomaster Inc | Verfahren und system zur herstellung von stammzellen aus fettgewebe |
| KR101441026B1 (ko) | 2004-09-24 | 2014-10-01 | 메소블라스트, 아이엔씨. | 증폭된 다능성 간엽 전구세포 자손 및 이의 용도 |
| KR101446634B1 (ko) * | 2005-04-12 | 2014-10-16 | 메소블라스트, 아이엔씨. | 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체세포의 분리 |
| GB0514785D0 (en) * | 2005-07-19 | 2005-08-24 | Innovia Films Ltd | Sealed ream wrap package and films suitable for forming such packages |
| CA2650638A1 (en) * | 2006-04-28 | 2007-11-08 | Tulane University Health Sciences Center | Methods for treating diabetes |
| WO2008094689A2 (en) * | 2007-02-01 | 2008-08-07 | Nephrogen, Llc | Potentiation of stem cell homing and treatment of organ dysfunction or organ failure |
| EP2350266B1 (en) * | 2008-11-20 | 2015-07-29 | Mesoblast, Inc. | Method for treating or preventing a pancreatic dysfunction |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
-
2009
- 2009-11-19 EP EP09827049.9A patent/EP2350266B1/en active Active
- 2009-11-19 CN CN201410727242.0A patent/CN104546912B/zh active Active
- 2009-11-19 DK DK09827049.9T patent/DK2350266T3/en active
- 2009-11-19 KR KR1020187004814A patent/KR102011609B1/ko active Active
- 2009-11-19 AU AU2009317874A patent/AU2009317874B2/en active Active
- 2009-11-19 CN CN200980155054.2A patent/CN102307992B/zh active Active
- 2009-11-19 ES ES09827049.9T patent/ES2550795T3/es active Active
- 2009-11-19 WO PCT/AU2009/001511 patent/WO2010057260A1/en not_active Ceased
- 2009-11-19 KR KR1020117012519A patent/KR101832497B1/ko active Active
- 2009-11-19 ES ES15178550.8T patent/ES2651503T3/es active Active
- 2009-11-19 JP JP2011536703A patent/JP5891034B2/ja active Active
- 2009-11-19 CA CA2744228A patent/CA2744228C/en active Active
- 2009-11-19 CN CN201310652234.XA patent/CN103800370B/zh active Active
- 2009-11-19 EP EP15178550.8A patent/EP3002329B1/en active Active
- 2009-11-19 US US13/129,180 patent/US8894972B2/en active Active
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2014
- 2014-11-07 US US14/535,827 patent/US9480713B2/en active Active
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2015
- 2015-06-02 JP JP2015111995A patent/JP6499016B2/ja active Active
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2016
- 2016-10-27 US US15/336,234 patent/US9968640B2/en active Active
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2017
- 2017-06-07 JP JP2017112578A patent/JP2017214384A/ja not_active Withdrawn
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2019
- 2019-09-06 JP JP2019162845A patent/JP7051770B2/ja active Active
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2021
- 2021-10-29 JP JP2021177234A patent/JP2022031662A/ja not_active Withdrawn
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2023
- 2023-05-26 JP JP2023086994A patent/JP7751607B2/ja active Active
-
2025
- 2025-06-13 JP JP2025099335A patent/JP2025148353A/ja active Pending
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