JP2012509283A5 - - Google Patents
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- JP2012509283A5 JP2012509283A5 JP2011536703A JP2011536703A JP2012509283A5 JP 2012509283 A5 JP2012509283 A5 JP 2012509283A5 JP 2011536703 A JP2011536703 A JP 2011536703A JP 2011536703 A JP2011536703 A JP 2011536703A JP 2012509283 A5 JP2012509283 A5 JP 2012509283A5
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- cells
- pancreatic
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- 210000004027 cell Anatomy 0.000 claims description 79
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 30
- 230000004064 dysfunction Effects 0.000 claims description 26
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims description 24
- 210000000496 pancreas Anatomy 0.000 claims description 21
- 210000004369 blood Anatomy 0.000 claims description 20
- 239000008280 blood Substances 0.000 claims description 20
- 210000002571 pancreatic alpha cell Anatomy 0.000 claims description 16
- 102000004877 Insulin Human genes 0.000 claims description 15
- 108090001061 Insulin Proteins 0.000 claims description 15
- 229940125396 insulin Drugs 0.000 claims description 15
- 230000006698 induction Effects 0.000 claims description 12
- 210000002966 serum Anatomy 0.000 claims description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 11
- 239000008103 glucose Substances 0.000 claims description 11
- 230000014509 gene expression Effects 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 230000003247 decreasing effect Effects 0.000 claims description 9
- 230000008929 regeneration Effects 0.000 claims description 9
- 238000011069 regeneration method Methods 0.000 claims description 9
- 230000033115 angiogenesis Effects 0.000 claims description 8
- 230000027746 artery morphogenesis Effects 0.000 claims description 8
- 210000004153 islets of langerhan Anatomy 0.000 claims description 8
- 230000004203 pancreatic function Effects 0.000 claims description 8
- 230000007423 decrease Effects 0.000 claims description 7
- 102100025683 Alkaline phosphatase, tissue-nonspecific isozyme Human genes 0.000 claims description 6
- 102000051325 Glucagon Human genes 0.000 claims description 6
- 108060003199 Glucagon Proteins 0.000 claims description 6
- 101000574445 Homo sapiens Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 claims description 6
- 208000020450 carbohydrate metabolism disease Diseases 0.000 claims description 6
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims description 6
- 229960004666 glucagon Drugs 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims description 5
- 208000017745 inborn carbohydrate metabolic disease Diseases 0.000 claims description 5
- 239000004382 Amylase Substances 0.000 claims description 4
- 102000013142 Amylases Human genes 0.000 claims description 4
- 108010065511 Amylases Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 230000002159 abnormal effect Effects 0.000 claims description 4
- 235000019418 amylase Nutrition 0.000 claims description 4
- 201000001421 hyperglycemia Diseases 0.000 claims description 3
- HFDKKNHCYWNNNQ-YOGANYHLSA-N 75976-10-2 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C1=CC=C(O)C=C1 HFDKKNHCYWNNNQ-YOGANYHLSA-N 0.000 claims description 2
- 102000005367 Carboxypeptidases Human genes 0.000 claims description 2
- 108010006303 Carboxypeptidases Proteins 0.000 claims description 2
- 108010038061 Chymotrypsinogen Proteins 0.000 claims description 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 2
- 206010015150 Erythema Diseases 0.000 claims description 2
- 208000013016 Hypoglycemia Diseases 0.000 claims description 2
- 206010025476 Malabsorption Diseases 0.000 claims description 2
- 208000004155 Malabsorption Syndromes Diseases 0.000 claims description 2
- 102000018886 Pancreatic Polypeptide Human genes 0.000 claims description 2
- 108010067372 Pancreatic elastase Proteins 0.000 claims description 2
- 102000016387 Pancreatic elastase Human genes 0.000 claims description 2
- 102000019280 Pancreatic lipases Human genes 0.000 claims description 2
- 108050006759 Pancreatic lipases Proteins 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 102000005157 Somatostatin Human genes 0.000 claims description 2
- 108010056088 Somatostatin Proteins 0.000 claims description 2
- 101000983124 Sus scrofa Pancreatic prohormone precursor Proteins 0.000 claims description 2
- 102000018690 Trypsinogen Human genes 0.000 claims description 2
- 108010027252 Trypsinogen Proteins 0.000 claims description 2
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 230000001363 autoimmune Effects 0.000 claims description 2
- 210000004204 blood vessel Anatomy 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000003111 delayed effect Effects 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 230000004069 differentiation Effects 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 231100000321 erythema Toxicity 0.000 claims description 2
- 230000006870 function Effects 0.000 claims description 2
- 201000000052 gastrinoma Diseases 0.000 claims description 2
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 235000016709 nutrition Nutrition 0.000 claims description 2
- 229940116369 pancreatic lipase Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 201000001474 proteinuria Diseases 0.000 claims description 2
- 230000003248 secreting effect Effects 0.000 claims description 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims description 2
- 229960000553 somatostatin Drugs 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 210000005167 vascular cell Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 230000002956 necrotizing effect Effects 0.000 claims 1
- 230000009996 pancreatic endocrine effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 23
- 230000002459 sustained effect Effects 0.000 description 3
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 description 2
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 description 1
- 208000035197 Disorder of carbohydrate metabolism Diseases 0.000 description 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 description 1
- 101000684208 Homo sapiens Prolyl endopeptidase FAP Proteins 0.000 description 1
- 102100040918 Pro-glucagon Human genes 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007368 endocrine function Effects 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000003282 necrolytic effect Effects 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19979608P | 2008-11-20 | 2008-11-20 | |
| US61/199,796 | 2008-11-20 | ||
| PCT/AU2009/001511 WO2010057260A1 (en) | 2008-11-20 | 2009-11-19 | Method for treating or preventing a pancreatic dysfunction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015111995A Division JP6499016B2 (ja) | 2008-11-20 | 2015-06-02 | 膵機能障害の治療または予防方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509283A JP2012509283A (ja) | 2012-04-19 |
| JP2012509283A5 true JP2012509283A5 (enExample) | 2012-12-20 |
| JP5891034B2 JP5891034B2 (ja) | 2016-03-22 |
Family
ID=42197754
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536703A Active JP5891034B2 (ja) | 2008-11-20 | 2009-11-19 | 膵機能障害の治療または予防方法 |
| JP2015111995A Active JP6499016B2 (ja) | 2008-11-20 | 2015-06-02 | 膵機能障害の治療または予防方法 |
| JP2017112578A Withdrawn JP2017214384A (ja) | 2008-11-20 | 2017-06-07 | 膵機能障害の治療または予防方法 |
| JP2019162845A Active JP7051770B2 (ja) | 2008-11-20 | 2019-09-06 | 膵機能障害の治療または予防方法 |
| JP2021177234A Withdrawn JP2022031662A (ja) | 2008-11-20 | 2021-10-29 | 膵機能障害の治療または予防方法 |
| JP2023086994A Active JP7751607B2 (ja) | 2008-11-20 | 2023-05-26 | 膵機能障害の治療または予防方法 |
| JP2025099335A Pending JP2025148353A (ja) | 2008-11-20 | 2025-06-13 | 膵機能障害の治療または予防方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015111995A Active JP6499016B2 (ja) | 2008-11-20 | 2015-06-02 | 膵機能障害の治療または予防方法 |
| JP2017112578A Withdrawn JP2017214384A (ja) | 2008-11-20 | 2017-06-07 | 膵機能障害の治療または予防方法 |
| JP2019162845A Active JP7051770B2 (ja) | 2008-11-20 | 2019-09-06 | 膵機能障害の治療または予防方法 |
| JP2021177234A Withdrawn JP2022031662A (ja) | 2008-11-20 | 2021-10-29 | 膵機能障害の治療または予防方法 |
| JP2023086994A Active JP7751607B2 (ja) | 2008-11-20 | 2023-05-26 | 膵機能障害の治療または予防方法 |
| JP2025099335A Pending JP2025148353A (ja) | 2008-11-20 | 2025-06-13 | 膵機能障害の治療または予防方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8894972B2 (enExample) |
| EP (2) | EP2350266B1 (enExample) |
| JP (7) | JP5891034B2 (enExample) |
| KR (2) | KR102011609B1 (enExample) |
| CN (3) | CN104546912B (enExample) |
| AU (1) | AU2009317874B2 (enExample) |
| CA (1) | CA2744228C (enExample) |
| DK (1) | DK2350266T3 (enExample) |
| ES (2) | ES2550795T3 (enExample) |
| WO (1) | WO2010057260A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100111910A1 (en) * | 2006-07-12 | 2010-05-06 | Angioblast Systems, Inc. | Treatment of excessive neovascularization |
| KR102011609B1 (ko) * | 2008-11-20 | 2019-08-16 | 메소블라스트, 아이엔씨. | 췌장 기능장애를 치료 또는 예방하는 방법 |
| EP2898898B1 (en) | 2009-03-05 | 2025-09-10 | President and Fellows of Harvard College | Secreted AP2 and methods of inhibiting same |
| KR101871472B1 (ko) * | 2010-07-02 | 2018-06-27 | 메소블라스트, 아이엔씨. | 이식편대숙주 질환의 치료 방법 |
| SG194930A1 (en) | 2011-05-19 | 2013-12-30 | Mesoblast Inc | Methods for treating obesity and/or metabolic syndrome |
| CN109276706A (zh) * | 2011-06-03 | 2019-01-29 | 麦瑟布莱斯特公司 | 治疗或预防神经性疾病的方法 |
| WO2013003899A1 (en) * | 2011-07-04 | 2013-01-10 | Mesoblast, Inc | Methods of treating or preventing rheumatic disease |
| EP2729562B1 (en) | 2011-07-06 | 2018-04-18 | Cell Therapy Limited | Progenitor cells of mesodermal lineage |
| CN104098682B (zh) * | 2013-04-03 | 2018-01-02 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
| KR102506612B1 (ko) * | 2012-12-12 | 2023-03-06 | 메소블라스트, 아이엔씨. | 내피 기능장애 및 염증 질환의 치료 |
| US20140314872A1 (en) * | 2013-04-22 | 2014-10-23 | Hans Klingemann | Methods of Use of Culture Supernatant Obtained from Mesenchymal Stem Cells from Dogs and Cats for Treatment of Organ Dysfunction |
| CN104714021B (zh) * | 2013-12-12 | 2016-05-25 | 张曼 | 尿液凝血酶原蛋白在2型糖尿病合并冠心病中的应用 |
| BR112017023158A2 (pt) | 2015-04-30 | 2018-07-24 | Harvard College | anticorpos anti-ap2 e agentes de ligação de antígeno para tratar distúrbios metabólicos |
| EP3475299A4 (en) * | 2016-06-27 | 2020-03-18 | President and Fellows of Harvard College | CONNECTIONS FOR TREATING METABOLISM DISORDERS |
| CA3066733A1 (en) | 2017-06-09 | 2018-12-13 | President And Fellows Of Harvard College | Method to identify compounds useful to treat dysregulated lipogenesis, diabetes, and related disorders |
| CN110959579A (zh) * | 2019-11-14 | 2020-04-07 | 顾隽 | 患者来源的淋巴瘤免疫缺陷小鼠移植瘤模型的构建方法及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| WO1992001070A1 (en) | 1990-07-09 | 1992-01-23 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| DE69233013T2 (de) | 1991-08-20 | 2004-03-04 | The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer | Adenovirus vermittelter gentransfer in den gastrointestinaltrakt |
| AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| AU2003901668A0 (en) | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| DE19939781C2 (de) | 1999-08-21 | 2003-06-18 | Schott Glas | Skulltiegel für das Erschmelzen oder das Läutern von anorganischen Substanzen, insbesondere von Gläsern und Glaskeramiken |
| WO2004016747A2 (en) * | 2002-08-14 | 2004-02-26 | University Of Florida | Bone marrow cell differentiation |
| DE602004030823D1 (de) * | 2003-11-04 | 2011-02-10 | Biomaster Inc | Verfahren und system zur herstellung von stammzellen aus fettgewebe |
| US20080260694A1 (en) | 2004-09-24 | 2008-10-23 | Angioblast Systems, Inc. | Multipotential Expanded Mesenchymal Precursor Cell Progeny (Memp) and Uses Thereof |
| KR101617319B1 (ko) * | 2005-04-12 | 2016-05-02 | 메소블라스트, 아이엔씨. | 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체 세포의 분리 |
| GB0514785D0 (en) * | 2005-07-19 | 2005-08-24 | Innovia Films Ltd | Sealed ream wrap package and films suitable for forming such packages |
| US20120027729A1 (en) * | 2006-04-28 | 2012-02-02 | Tulane University Health Sciences Center | Methods for treating diabetes |
| EP2117543A4 (en) * | 2007-02-01 | 2011-09-28 | Nephrogen Llc | POTENTIALIZATION OF THE IMPLANTATION OF STEM CELLS AND TREATMENT OF ORGAN DYSFUNCTION OR BODY INSUFFICIENCY |
| KR102011609B1 (ko) | 2008-11-20 | 2019-08-16 | 메소블라스트, 아이엔씨. | 췌장 기능장애를 치료 또는 예방하는 방법 |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
-
2009
- 2009-11-19 KR KR1020187004814A patent/KR102011609B1/ko active Active
- 2009-11-19 WO PCT/AU2009/001511 patent/WO2010057260A1/en not_active Ceased
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