JP2022017260A5 - - Google Patents

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Publication number
JP2022017260A5
JP2022017260A5 JP2021164372A JP2021164372A JP2022017260A5 JP 2022017260 A5 JP2022017260 A5 JP 2022017260A5 JP 2021164372 A JP2021164372 A JP 2021164372A JP 2021164372 A JP2021164372 A JP 2021164372A JP 2022017260 A5 JP2022017260 A5 JP 2022017260A5
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Japan
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formulation
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compound
salt
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JP2021164372A
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English (en)
Japanese (ja)
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JP2022017260A (ja
JP7465453B2 (ja
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Priority claimed from JP2020021093A external-priority patent/JP6994061B2/ja
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Priority to JP2023206043A priority Critical patent/JP2024037806A/ja
Priority to JP2024039978A priority patent/JP2024095674A/ja
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Publication of JP7465453B2 publication Critical patent/JP7465453B2/ja
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JP2021164372A 2019-02-15 2021-10-06 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤 Active JP7465453B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023206043A JP2024037806A (ja) 2019-02-15 2023-12-06 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP2024039978A JP2024095674A (ja) 2019-02-15 2024-03-14 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962806705P 2019-02-15 2019-02-15
US62/806,705 2019-02-15
JP2020021093A JP6994061B2 (ja) 2019-02-15 2020-02-12 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2020021093A Division JP6994061B2 (ja) 2019-02-15 2020-02-12 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2023206043A Division JP2024037806A (ja) 2019-02-15 2023-12-06 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP2024039978A Division JP2024095674A (ja) 2019-02-15 2024-03-14 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤

Publications (3)

Publication Number Publication Date
JP2022017260A JP2022017260A (ja) 2022-01-25
JP2022017260A5 true JP2022017260A5 (enExample) 2023-05-09
JP7465453B2 JP7465453B2 (ja) 2024-04-11

Family

ID=69740424

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2020021093A Active JP6994061B2 (ja) 2019-02-15 2020-02-12 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP2021547131A Pending JP2022520795A (ja) 2019-02-15 2020-02-13 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP2021164372A Active JP7465453B2 (ja) 2019-02-15 2021-10-06 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP2023206043A Pending JP2024037806A (ja) 2019-02-15 2023-12-06 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP2024039978A Pending JP2024095674A (ja) 2019-02-15 2024-03-14 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2020021093A Active JP6994061B2 (ja) 2019-02-15 2020-02-12 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP2021547131A Pending JP2022520795A (ja) 2019-02-15 2020-02-13 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023206043A Pending JP2024037806A (ja) 2019-02-15 2023-12-06 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP2024039978A Pending JP2024095674A (ja) 2019-02-15 2024-03-14 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤

Country Status (23)

Country Link
US (3) US11478480B2 (enExample)
EP (1) EP3923912A1 (enExample)
JP (5) JP6994061B2 (enExample)
KR (1) KR20210127197A (enExample)
CN (2) CN111568906B (enExample)
AU (2) AU2020220957B2 (enExample)
BR (1) BR112021015737A2 (enExample)
CA (1) CA3130237A1 (enExample)
CL (1) CL2021002153A1 (enExample)
CO (1) CO2021010689A2 (enExample)
CR (1) CR20210428A (enExample)
EC (1) ECSP21059628A (enExample)
IL (1) IL284628A (enExample)
JO (1) JOP20210224A1 (enExample)
MX (2) MX2021009704A (enExample)
MY (1) MY206327A (enExample)
PE (1) PE20212106A1 (enExample)
PH (1) PH12021551967A1 (enExample)
SA (1) SA521430043B1 (enExample)
SG (1) SG11202107259QA (enExample)
TW (1) TWI827800B (enExample)
WO (1) WO2020165839A1 (enExample)
ZA (1) ZA202104594B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI878266B (zh) 2019-02-15 2025-04-01 愛爾蘭商博士倫愛爾蘭有限公司 治療眼表痛之方法
JP6994061B2 (ja) * 2019-02-15 2022-01-14 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
WO2021191273A1 (en) * 2020-03-24 2021-09-30 Hovione Scientia Limited Compositions for use in treating meibomian gland dysfunction
JP2023536938A (ja) * 2020-08-06 2023-08-30 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの結晶形態及びその製剤
TW202222298A (zh) * 2020-10-07 2022-06-16 瑞士商諾華公司 含有可溶解的眼部插入物之藥物及其使用方法
US20230159202A1 (en) * 2021-11-23 2023-05-25 Bausch + Lomb Ireland Limited Method for making a preservative-free packaged ophthalmic device product
US20240197691A1 (en) * 2022-12-15 2024-06-20 Cn2 Therapeutics, Inc. Tacrolimus compositions and methods of use
CN118340775A (zh) * 2023-01-09 2024-07-16 维眸生物科技(浙江)有限公司 一种含vvn539的眼用组合物及其用途
EP4454639A1 (en) * 2023-04-14 2024-10-30 Omnivision GmbH Ophthalmic composition comprising carbomer and taurine

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1280874B (de) 1963-10-09 1968-10-24 Boehringer Sohn Ingelheim 2-Methyl-3-(2-dimethylaminophenyl)-8-amino-3H-chinazolon-(4)
US3931319A (en) 1974-10-29 1976-01-06 Millmaster Onyx Corporation Capped polymers
US4027020A (en) 1974-10-29 1977-05-31 Millmaster Onyx Corporation Randomly terminated capped polymers
US4525346A (en) 1981-09-28 1985-06-25 Alcon Laboratories, Inc. Aqueous antimicrobial ophthalmic solutions
US4407791A (en) 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
US4836986A (en) 1984-09-28 1989-06-06 Bausch & Lomb Incorporated Disinfecting and preserving systems and methods of use
US5037647A (en) 1988-09-15 1991-08-06 Alcon Laboratories, Inc. Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride
US5145643A (en) 1990-01-05 1992-09-08 Allergan, Inc. Nonoxidative ophthalmic compositions and methods for preserving and using same
US5300287A (en) 1992-11-04 1994-04-05 Alcon Laboratories, Inc. Polymeric antimicrobials and their use in pharmaceutical compositions
MXPA02003130A (es) * 1999-09-24 2004-04-21 Alcon Inc Formulaciones topicas en suspension que contienen ciprofloxacino y dexametasona.
GB0412769D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
TWI358290B (en) * 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations
US20100152209A1 (en) 2005-11-04 2010-06-17 Hydra Biosciences Inc. Compounds for Modulating TRPV3 Function
GB0525069D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
GB0525068D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
EP1999116A2 (en) 2005-12-22 2008-12-10 Prolexys Pharmaceuticals, Inc. 3-aryl-substituted quinazolones, and uses thereof
TW200738232A (en) 2006-01-31 2007-10-16 Alcon Mfg Ltd Use of vanilloid receptor-1 antagonists for the prevention and treatment of glaucoma
EP1964548A1 (en) 2007-03-02 2008-09-03 Novartis AG Pharmaceutical compositions comprising a calcilytic agent
WO2008140750A1 (en) 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
WO2009010529A1 (en) 2007-07-18 2009-01-22 Novartis Ag Synergistic combinations of vr-1 antagonists and cox-2 inhibitors
TW200927192A (en) * 2007-11-19 2009-07-01 Alcon Res Ltd Use of TRPV1 receptor antagonists for treating dry eye and ocular pain
WO2009081222A1 (en) 2007-12-21 2009-07-02 Glenmark Pharmaceuticals, S.A. Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands
CA2707441A1 (en) 2008-01-09 2009-07-16 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2009090548A2 (en) 2008-01-17 2009-07-23 Glenmark Pharmaceuticals, S.A. 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands
WO2009149239A1 (en) 2008-06-04 2009-12-10 Children's Medical Center Corporation Methods of modulating angiogenesis via trpv4
WO2010023512A1 (en) 2008-08-28 2010-03-04 Matrix Laboratories Ltd. Novel vanilloid receptor modulators, process for their preparation and pharmaceutical compositions containing them
US8349852B2 (en) * 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
EP2316420B1 (en) 2009-10-22 2014-02-26 Consorzio Universitario Unifarm Topical ophthalmic composition to reduce pain
EP2377850A1 (en) 2010-03-30 2011-10-19 Pharmeste S.r.l. TRPV1 vanilloid receptor antagonists with a bicyclic portion
US8927559B2 (en) 2010-10-11 2015-01-06 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as CRTH2 antagonists
CN102659629B (zh) * 2012-02-14 2014-03-19 杭州华东医药集团新药研究院有限公司 化合物及其在制备埃罗替尼中的用途
CN102875480A (zh) 2012-04-23 2013-01-16 中国药科大学 喹唑啉酮类血管抑制剂、其制备方法及其医药用途
GB201215857D0 (en) 2012-09-05 2012-10-24 Sylentis Sau siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
JP2016513706A (ja) * 2013-03-15 2016-05-16 イノテック ファーマシューティカルズ コーポレイション 点眼用製剤
US20150352176A1 (en) * 2014-06-06 2015-12-10 Newport Research, Inc. Oil-free and fat-free aqueous suspensions of cyclosporin
US10172852B2 (en) 2014-07-28 2019-01-08 Sun Pharma Advanced Research Company Ltd. Method of increasing bioavailability and/or prolonging ophthalmic action of a drug
DK3494962T3 (da) * 2014-09-15 2021-06-21 Verona Pharma Plc Flydende inhalationsformulering omfattende RPL554
HUE048564T2 (hu) 2015-01-26 2020-08-28 Bausch & Lomb Szemészeti szuszpenzió készítmény
JP7106528B2 (ja) 2016-09-20 2022-07-26 グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッド Trpv4拮抗薬
EP3515889A1 (en) 2016-09-20 2019-07-31 GlaxoSmithKline Intellectual Property (No. 2) Limited Trpv4 antagonists
TW201825458A (zh) 2016-09-20 2018-07-16 英商葛蘭素史克智慧財產(第二)有限公司 Trpv4拮抗劑
TWI878266B (zh) 2019-02-15 2025-04-01 愛爾蘭商博士倫愛爾蘭有限公司 治療眼表痛之方法
JP6994061B2 (ja) 2019-02-15 2022-01-14 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤

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