JP2021534183A - 免疫応答を刺激するための方法及び組成物 - Google Patents

免疫応答を刺激するための方法及び組成物 Download PDF

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JP2021534183A
JP2021534183A JP2021507907A JP2021507907A JP2021534183A JP 2021534183 A JP2021534183 A JP 2021534183A JP 2021507907 A JP2021507907 A JP 2021507907A JP 2021507907 A JP2021507907 A JP 2021507907A JP 2021534183 A JP2021534183 A JP 2021534183A
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vaccine
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JPWO2020037285A5 (https=
JP2021534183A5 (https=
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モハンラル，ラモーン
ファン，ラン
アール． トンラ，ジェームス
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ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021507907A 2018-08-16 2019-08-16 免疫応答を刺激するための方法及び組成物 Pending JP2021534183A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862765099P 2018-08-16 2018-08-16
US62/765,099 2018-08-16
PCT/US2019/046944 WO2020037285A1 (en) 2018-08-16 2019-08-16 Method and composition for stimulating immune response

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JP2021534183A true JP2021534183A (ja) 2021-12-09
JPWO2020037285A5 JPWO2020037285A5 (https=) 2022-08-24
JP2021534183A5 JP2021534183A5 (https=) 2022-08-24

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US (1) US20210177952A1 (https=)
EP (1) EP3836930A4 (https=)
JP (1) JP2021534183A (https=)
KR (1) KR20210047309A (https=)
CN (1) CN112638388A (https=)
AU (1) AU2019320830A1 (https=)
CA (1) CA3109223A1 (https=)
MX (1) MX2021001762A (https=)
WO (1) WO2020037285A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX383691B (es) 2015-03-06 2025-03-14 Beyondspring Pharmaceuticals Inc Método de tratamiento de cáncer asociado con una mutación de ras.
US10155748B2 (en) 2015-07-13 2018-12-18 Beyondspring Pharmaceuticals, Inc. Plinabulin compositions
LT3400019T (lt) 2016-01-08 2022-12-12 Ascendis Pharma Growth Disorders A/S Cnp provaistai su prie žiedo fragmento prijungtu nešikliu
IL297375B2 (en) 2016-01-08 2024-02-01 Ascendis Pharma Growth Disorders As Controlled-release CNP agonists with low NPR–C binding
IL259827B2 (en) 2016-01-08 2025-07-01 Ascendis Pharma Growth Disorders As Controlled-release CNP agonists with low initial NPR-B activity
NZ743487A (en) 2016-01-08 2023-02-24 Ascendis Pharma Growth Disorders As Controlled-release cnp agonists with increased nep stability
WO2017118707A1 (en) 2016-01-08 2017-07-13 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with reduced side-effects
WO2017139231A1 (en) 2016-02-08 2017-08-17 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
RU2760348C2 (ru) 2016-06-06 2021-11-24 Бейондспринг Фармасьютикалс, Инк. Способ уменьшения нейтропении
HUE062117T2 (hu) 2016-09-29 2023-09-28 Ascendis Pharma Growth Disorders As Kombinációs terápia szabályozott felszabadulású CNP agonistákkal
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
KR20200112881A (ko) 2018-01-24 2020-10-05 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors
JP2024538730A (ja) * 2021-10-07 2024-10-23 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド がん及び腫瘍を治療するための方法
AU2023219702A1 (en) * 2022-02-10 2024-09-05 Beyondspring Pharmaceuticals, Inc. Stable plinabulin formulations and methods of their preparation and use
CN117860672A (zh) 2022-10-11 2024-04-12 大连万春布林医药有限公司 一种普那布林胶束组合物及其制备方法
WO2025151374A1 (en) * 2024-01-08 2025-07-17 Beyondspring Pharmaceuticals, Inc. Oncology combination therapy and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011079507A1 (zh) * 2009-12-31 2011-07-07 Hu Songhua 紫杉醇及多西紫杉醇的用途
JP2018508572A (ja) * 2015-02-12 2018-03-29 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 免疫チェックポイント阻害薬と併用するプリナブリンの使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040197312A1 (en) * 2003-04-02 2004-10-07 Marina Moskalenko Cytokine-expressing cellular vaccine combinations
US20100260677A1 (en) * 2009-03-02 2010-10-14 Massachusetts Institute Of Technology Methods and systems for treatment and/or diagnosis
WO2013124867A1 (en) * 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules
JP2020503363A (ja) * 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011079507A1 (zh) * 2009-12-31 2011-07-07 Hu Songhua 紫杉醇及多西紫杉醇的用途
JP2018508572A (ja) * 2015-02-12 2018-03-29 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 免疫チェックポイント阻害薬と併用するプリナブリンの使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. CLIN. ONCOL., vol. Vol. 36, No. 5 suppl., JPN6023026222, February 2008 (2008-02-01), pages 126, ISSN: 0005248608 *

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EP3836930A4 (en) 2022-05-11
CN112638388A (zh) 2021-04-09
EP3836930A1 (en) 2021-06-23
WO2020037285A1 (en) 2020-02-20
KR20210047309A (ko) 2021-04-29
US20210177952A1 (en) 2021-06-17
MX2021001762A (es) 2021-04-19
CA3109223A1 (en) 2020-02-20

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