JP2021533134A - チェックポイント阻害抗体と相乗効果を示し、疾患を排除するｔｌｒ１／２アゴニストジプロボッシムのアジュバント効果 - Google Patents

チェックポイント阻害抗体と相乗効果を示し、疾患を排除するｔｌｒ１／２アゴニストジプロボッシムのアジュバント効果 Download PDF

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JP2021533134A
JP2021533134A JP2021505847A JP2021505847A JP2021533134A JP 2021533134 A JP2021533134 A JP 2021533134A JP 2021505847 A JP2021505847 A JP 2021505847A JP 2021505847 A JP2021505847 A JP 2021505847A JP 2021533134 A JP2021533134 A JP 2021533134A
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diprobossim
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conhch
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ブルース ボイトラー
イン ワン
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ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ テキサス システム
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JP2021505847A 2018-08-02 2019-07-31 チェックポイント阻害抗体と相乗効果を示し、疾患を排除するｔｌｒ１／２アゴニストジプロボッシムのアジュバント効果 Pending JP2021533134A (ja)

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US201862713823P 2018-08-02 2018-08-02
US62/713,823 2018-08-02
PCT/US2019/044421 WO2020028532A1 (en) 2018-08-02 2019-07-31 Adjuvant effect of the tlr1/2 agonist diprovocim synergizes with checkpoint-inhibiting antibodies to eliminate disease

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JP2021533134A true JP2021533134A (ja) 2021-12-02
JP2021533134A5 JP2021533134A5 (https=) 2022-09-22
JPWO2020028532A5 JPWO2020028532A5 (https=) 2022-09-22

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US (1) US20210315992A1 (https=)
EP (1) EP3829571B1 (https=)
JP (1) JP2021533134A (https=)
KR (1) KR20210029280A (https=)
CN (1) CN113164445A (https=)
AU (2) AU2019315952A1 (https=)
BR (1) BR112021001992A2 (https=)
CA (1) CA3108515A1 (https=)
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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11938182B2 (en) 2020-03-26 2024-03-26 Provectus Pharmatech, Inc. Halogenated xanthenes as vaccine adjuvants
MX2022011765A (es) 2020-03-26 2022-11-09 Provectus Pharmatech Inc Usos novedosos de xantenos halogenados en oncologia y virologia.
JP2023527792A (ja) 2020-05-27 2023-06-30 アキシャル セラピューティクス，インク． Ｔｌｒ２調節剤化合物、医薬組成物、及びそれらの使用
CN115697363A (zh) * 2020-07-14 2023-02-03 Dic株式会社 细胞杀伤性t细胞(ctl)活化用组合物
US20250367166A1 (en) * 2022-04-29 2025-12-04 The Scripps Research Institute Next generation diprovocims that activate the innate and adaptive immune response

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018005812A1 (en) * 2016-06-29 2018-01-04 The Scripps Research Institute Diprovocims: a new and potent class of tlr agonists

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599231A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US5180806A (en) 1988-05-16 1993-01-19 The Scripps Research Institute Polypeptides and compositions of human papillomavirus latent proteins, diagnostic systems and methods
US6489354B1 (en) 1999-03-02 2002-12-03 Merck & Co., Inc. 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
US6942866B2 (en) 2000-08-16 2005-09-13 Apovia, Inc. Malaria immunogen and vaccine
DK1418905T3 (da) * 2001-08-08 2007-09-10 Pentraxin Therapeutics Ltd Terapeutisk middel til depletering af en uönsket proteinpopulation fra plasma
US7361352B2 (en) 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
CA2636424A1 (en) * 2006-01-09 2007-10-25 The Regents Of The University Of California Immunostimulatory combinations of tnfrsf, tlr, nlr, rhr, purinergic receptor, and cytokine receptor agonists for vaccines and tumor immunotherapy
EP2981281B1 (en) * 2013-04-03 2020-07-15 IBC Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
US9918959B2 (en) * 2014-08-06 2018-03-20 The Board Of Regents Of The University Of Texas System TLR-independent small molecule adjuvants
CA2974956A1 (en) * 2015-01-29 2016-08-04 The Trustees Of The University Of Pennsylvania Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
MX2017012939A (es) * 2015-04-08 2018-05-22 Novartis Ag Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
FI3436048T3 (fi) * 2016-03-31 2025-09-15 Biontech Us Inc Neoantigeeneja ja niiden käyttömenetelmiä
US20180088749A1 (en) 2016-09-26 2018-03-29 Uber Technologies, Inc. Customized content generation for a user interface for a network service
US20180169224A1 (en) 2016-12-12 2018-06-21 Wisconsin Alumni Research Foundation Tlr agonists for reducing activation-induced pd-1 expression on t cells and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018005812A1 (en) * 2016-06-29 2018-01-04 The Scripps Research Institute Diprovocims: a new and potent class of tlr agonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BINDER, D. C. ET AL.: "Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells", CANCER IMMUNOLOGY RESEARCH, vol. 1, no. 2, JPN6023041085, 2013, pages 123 - 133, XP002769331, ISSN: 0005168349, DOI: 10.1158/2326-6066.CIR-13-0058 *
STARK, F. C. ET AL.: "An Archaeosome-Adjuvanted Vaccine and Checkpoint Inhibitor Therapy Combination Significantly Enhance", VACCINES, vol. 5, no. 4, JPN6023041084, 2017, pages 38, ISSN: 0005168350 *

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WO2020028532A1 (en) 2020-02-06
US20210315992A1 (en) 2021-10-14
AU2019315952A1 (en) 2021-03-04
IL280584B1 (en) 2025-02-01
AU2025204146A1 (en) 2025-07-17
KR20210029280A (ko) 2021-03-15
AU2025204146A9 (en) 2026-03-19
EP3829571C0 (en) 2025-04-09
BR112021001992A2 (pt) 2021-05-04
EP3829571A1 (en) 2021-06-09
CA3108515A1 (en) 2020-02-06
EP3829571B1 (en) 2025-04-09
IL280584B2 (en) 2025-06-01
CN113164445A (zh) 2021-07-23
IL280584A (en) 2021-03-25
EP3829571A4 (en) 2022-04-27

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