JP2021532742A - Ｎｅｆを含むｔ細胞及びその生成方法 - Google Patents

Ｎｅｆを含むｔ細胞及びその生成方法 Download PDF

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JP2021532742A
JP2021532742A JP2021504286A JP2021504286A JP2021532742A JP 2021532742 A JP2021532742 A JP 2021532742A JP 2021504286 A JP2021504286 A JP 2021504286A JP 2021504286 A JP2021504286 A JP 2021504286A JP 2021532742 A JP2021532742 A JP 2021532742A
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nef
tcr
cells
nucleic acid
domain
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JP2021532742A5 (https=
JPWO2020020359A5 (https=
Inventor
シャオフー ファン，
ユンチェン ジャオ，
ダウェイ ユー，
ウジナン ジー，
チェンチェン ワン，
チウチュアン ジュアン，
ピンヤン ワン，
シュアンシュアン グオ，
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2319/00—Fusion polypeptide
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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JP2021504286A 2018-07-26 2019-07-26 Ｎｅｆを含むｔ細胞及びその生成方法 Pending JP2021532742A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018097235 2018-07-26
CNPCT/CN2018/097235 2018-07-26
PCT/CN2019/097969 WO2020020359A1 (en) 2018-07-26 2019-07-26 Nef-containing t cells and methods of producing thereof

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JP2021532742A true JP2021532742A (ja) 2021-12-02
JP2021532742A5 JP2021532742A5 (https=) 2022-07-06
JPWO2020020359A5 JPWO2020020359A5 (https=) 2022-07-06

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US (1) US20220177524A1 (https=)
EP (1) EP3827075A4 (https=)
JP (1) JP2021532742A (https=)
KR (1) KR20210049806A (https=)
CN (2) CN112771154B (https=)
AU (1) AU2019312411A1 (https=)
CA (1) CA3103337A1 (https=)
IL (1) IL280240A (https=)
MX (1) MX2021000934A (https=)
SG (1) SG11202012253WA (https=)
TW (1) TW202020146A (https=)
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WO2021180665A1 (en) * 2020-03-09 2021-09-16 Janssen Pharmaceutica Nv Compositions and methods for quantifying integration of recombinant vector nucleic acid
WO2022116086A1 (en) * 2020-12-03 2022-06-09 Janssen Biotech, Inc. Bcma-targeted car-t cell therapy for multiple myeloma
IL304904A (en) * 2021-02-01 2023-10-01 St Phi Therapeutics Co Ltd Target protein degradation system and its use
WO2022198027A1 (en) * 2021-03-18 2022-09-22 The Wistar Institute Of Anatomy And Biology DNA-ENCODED BISPECIFIC ANTIBODIES TARGETING IL13Rα2 AND METHODS OF USE IN CANCER THERAPEUTICS
EP4378952A4 (en) * 2021-07-30 2025-09-24 St Phi Therapeutics Co Ltd UNIVERSAL T LYMPHOCYTE AND ITS USE
WO2023077343A1 (en) * 2021-11-04 2023-05-11 Janssen Biotech, Inc. Bcma-targeted car-t cell therapy for multiple myeloma
WO2023081752A1 (en) * 2021-11-04 2023-05-11 Janssen Biotech, Inc. Bcma-targeted car-t cell therapy for multiple myeloma
EP4561628A1 (en) * 2022-07-29 2025-06-04 Legend Biotech Ireland Limited Methods for promoting persistence of cell therapy
EP4612168A1 (en) * 2022-11-04 2025-09-10 Wugen, Inc. Generation of cd3 expressing immune cells for use in conjunction with cd3 binding bispecific targeting agents
WO2024153211A1 (en) * 2023-01-19 2024-07-25 Nanjing Legend Biotech Co., Ltd. Fusion polypeptides for targeted protein degradation and mehtods of use thereof

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