JP2021532183A - フェノール性ｔｒｐｖ１アゴニストのｐｅｇ化プロドラッグ - Google Patents

フェノール性ｔｒｐｖ１アゴニストのｐｅｇ化プロドラッグ Download PDF

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JP2021532183A
JP2021532183A JP2021527017A JP2021527017A JP2021532183A JP 2021532183 A JP2021532183 A JP 2021532183A JP 2021527017 A JP2021527017 A JP 2021527017A JP 2021527017 A JP2021527017 A JP 2021527017A JP 2021532183 A JP2021532183 A JP 2021532183A
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JP2021532183A5 (https=
JPWO2020023794A5 (https=
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エフ． ドノヴァン，ジョン
フスフェルド，クレーグ
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コンセントリック アナルジェジクス，インク．
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Publication of JP2021532183A5 publication Critical patent/JP2021532183A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021527017A 2018-07-27 2019-07-25 フェノール性ｔｒｐｖ１アゴニストのｐｅｇ化プロドラッグ Pending JP2021532183A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862711361P 2018-07-27 2018-07-27
US62/711,361 2018-07-27
PCT/US2019/043518 WO2020023794A1 (en) 2018-07-27 2019-07-25 Pegylated prodrugs of phenolic trpv1 agonists

Publications (3)

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JP2021532183A true JP2021532183A (ja) 2021-11-25
JP2021532183A5 JP2021532183A5 (https=) 2022-07-29
JPWO2020023794A5 JPWO2020023794A5 (https=) 2022-07-29

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JP2021527017A Pending JP2021532183A (ja) 2018-07-27 2019-07-25 フェノール性ｔｒｐｖ１アゴニストのｐｅｇ化プロドラッグ

Country Status (10)

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US (5) US10717712B2 (https=)
EP (1) EP3830078A4 (https=)
JP (1) JP2021532183A (https=)
KR (1) KR20210073513A (https=)
CN (1) CN113166051A (https=)
AU (1) AU2019310118A1 (https=)
CA (1) CA3107433A1 (https=)
IL (1) IL280406A (https=)
TW (1) TW202019887A (https=)
WO (1) WO2020023794A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11634384B2 (en) 2014-11-25 2023-04-25 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
EP3463576A4 (en) * 2016-05-25 2020-01-15 Concentric Analgesics, Inc. PRODRUGS BY PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETIC AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA
US10717712B2 (en) 2018-07-27 2020-07-21 Concentric Analgesics, Inc. Pegylated prodrugs of phenolic TRPV1 agonists

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008539253A (ja) * 2005-04-25 2008-11-13 ニューロジェシックス， インコーポレイテッド Ｔｒｐｖ１アゴニスト化合物、ならびにｔｒｐｖ１アゴニスト化合物を製造および使用するための方法
JP2013503862A (ja) * 2009-09-08 2013-02-04 シグネーチャー セラピューティクス，インク． 酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物
US20150203517A1 (en) * 2014-01-17 2015-07-23 Methylgene Inc. Prodrugs of Compounds that Enhance Antifungal Activity and Compositions of Said Prodrugs
JP2017522296A (ja) * 2014-06-26 2017-08-10 エコール ノルマル シュペリウール ドゥ リヨン 活性化可能な水溶性の分子プローブ、その合成のための中間体、および関連する検出方法
WO2017205534A1 (en) * 2016-05-25 2017-11-30 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
JP2017536416A (ja) * 2014-11-25 2017-12-07 コンセントリック アナルジジックス，インク． フェノール酸ｔｒｐｖ１アゴニストのプロドラッグ

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US20200031780A1 (en) 2020-01-30
US20200299245A1 (en) 2020-09-24
US20220388970A1 (en) 2022-12-08
US10717712B2 (en) 2020-07-21
EP3830078A1 (en) 2021-06-09
US20220112165A1 (en) 2022-04-14
AU2019310118A1 (en) 2021-03-11
CN113166051A (zh) 2021-07-23
WO2020023794A1 (en) 2020-01-30
EP3830078A4 (en) 2022-03-30
US20230219901A1 (en) 2023-07-13
US11242325B2 (en) 2022-02-08
TW202019887A (zh) 2020-06-01
KR20210073513A (ko) 2021-06-18
IL280406A (en) 2021-03-25
CA3107433A1 (en) 2020-01-30

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