JP2021529559A - グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用 - Google Patents

グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用 Download PDF

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JP2021529559A
JP2021529559A JP2021522932A JP2021522932A JP2021529559A JP 2021529559 A JP2021529559 A JP 2021529559A JP 2021522932 A JP2021522932 A JP 2021522932A JP 2021522932 A JP2021522932 A JP 2021522932A JP 2021529559 A JP2021529559 A JP 2021529559A
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cells
polypeptide
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immune cell
glucose
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JPWO2020010110A5 (https=
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マクギネス キャスリーン
エッテンバーグ セス
バロン ルーク
フレイ マイケル
ウィルソン チャールズ
モッツ グレゴリー
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ソティオ，リミティド ライアビリティ カンパニー
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JP2021522932A 2018-07-03 2019-07-02 グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用 Pending JP2021529559A (ja)

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JP2024076738A JP2024102286A (ja) 2018-07-03 2024-05-09 グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用

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US201862693677P 2018-07-03 2018-07-03
US201862693668P 2018-07-03 2018-07-03
US62/693,677 2018-07-03
US62/693,668 2018-07-03
US201862713369P 2018-08-01 2018-08-01
US62/713,369 2018-08-01
US201862756698P 2018-11-07 2018-11-07
US201862756664P 2018-11-07 2018-11-07
US62/756,698 2018-11-07
US62/756,664 2018-11-07
PCT/US2019/040346 WO2020010110A1 (en) 2018-07-03 2019-07-02 Chimeric receptors in combination with trans metabolism molecules enhancing glucose import and therapeutic uses thereof

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JPWO2020010110A5 JPWO2020010110A5 (https=) 2022-07-12
JP2021529559A5 JP2021529559A5 (https=) 2022-07-12

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JP2024076738A Pending JP2024102286A (ja) 2018-07-03 2024-05-09 グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用

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JP7685726B1 (ja) * 2024-01-09 2025-05-30 国立研究開発法人国立がん研究センター サバイバーｔ細胞、サバイバーｔ細胞集団および医薬組成物
WO2025150522A1 (ja) * 2024-01-09 2025-07-17 国立研究開発法人国立がん研究センター サバイバーｔ細胞、サバイバーｔ細胞集団および医薬組成物
WO2025150523A1 (ja) * 2024-01-09 2025-07-17 国立研究開発法人国立がん研究センター オンデマンドにグルコース取り込み能が強化されたｔ細胞、細胞集団およびそれを含む医薬組成物

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KR20210045418A (ko) 2018-08-14 2021-04-26 소티오, 엘엘씨 크렙스 사이클을 조정하는 트랜스 대사 분자와 조합된 키메라 항원 수용체 폴리펩타이드 및 이의 치료적 용도
EP4097219A4 (en) * 2020-01-28 2023-10-11 ImmunityBio, Inc. Chimeric antigen receptor-modified nk-92 cells targeting egfr super-family receptors
US11230699B2 (en) 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors
US20230248824A1 (en) * 2020-07-09 2023-08-10 The Board of Trutees of the Leland Stanford Junior University Immune cells with increased glycolytic flux
WO2022140361A1 (en) * 2020-12-22 2022-06-30 Ludwig Institute For Cancer Research Ltd Genetically engineered lymphocytes for adoptive cell therapy
US20240108652A1 (en) * 2021-02-18 2024-04-04 University Of Florida Research Foundation, Incorporated Enhancing metabolic fitness of t cells to treat cancer
WO2022226364A2 (en) * 2021-04-23 2022-10-27 Sorrento Therapeutics, Inc. Dimeric antigen receptors (dars) that bind gd2
WO2023049933A1 (en) 2021-09-27 2023-03-30 Sotio Biotech Inc. Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof
WO2023081455A2 (en) * 2021-11-08 2023-05-11 Memorial Sloan-Kettering Cancer Center Immune cells expressing glucose transporter 5 (gluts) and compositions and methods including the same
US20250000906A1 (en) 2021-11-16 2025-01-02 Sotio Biotech Inc. Treatment of myxoid/round cell liposarcoma patients
GB202118201D0 (en) 2021-12-15 2022-01-26 King S College London Engineered immune cell
WO2023172916A2 (en) * 2022-03-08 2023-09-14 Synthekine, Inc. Orthogonal gpc3 chimeric antigen receptor t cells
CN115678856A (zh) * 2022-06-09 2023-02-03 郑州大学第一附属医院 一种肿瘤杀伤细胞及其应用
US20260053924A1 (en) 2022-08-19 2026-02-26 Sotio Biotech Inc. Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof
WO2024040207A1 (en) 2022-08-19 2024-02-22 Sotio Biotech Inc. Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof
EP4694916A1 (en) 2023-04-14 2026-02-18 SOTIO Biotech Inc. Engineered immune cells for treating cancer in combination with il-2/il-15 receptor ?? agonists
WO2024215987A1 (en) 2023-04-14 2024-10-17 Sotio Biotech Inc. IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES

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