JP2021529174A5 - - Google Patents

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Publication number
JP2021529174A5
JP2021529174A5 JP2020571383A JP2020571383A JP2021529174A5 JP 2021529174 A5 JP2021529174 A5 JP 2021529174A5 JP 2020571383 A JP2020571383 A JP 2020571383A JP 2020571383 A JP2020571383 A JP 2020571383A JP 2021529174 A5 JP2021529174 A5 JP 2021529174A5
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JP
Japan
Prior art keywords
hydrogen
alkyl
optionally substituted
unsubstituted
independently
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JP2020571383A
Other languages
English (en)
Japanese (ja)
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JP2021529174A (ja
JP7821573B2 (ja
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Application filed filed Critical
Priority claimed from PCT/US2019/039368 external-priority patent/WO2020006157A1/en
Publication of JP2021529174A publication Critical patent/JP2021529174A/ja
Publication of JP2021529174A5 publication Critical patent/JP2021529174A5/ja
Application granted granted Critical
Publication of JP7821573B2 publication Critical patent/JP7821573B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2020571383A 2018-06-27 2019-06-27 Ｄｏｔ１ｌディグレーダーおよびその使用 Active JP7821573B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690791P 2018-06-27 2018-06-27
US62/690,791 2018-06-27
PCT/US2019/039368 WO2020006157A1 (en) 2018-06-27 2019-06-27 Dot1l degrader and uses thereof

Publications (3)

Publication Number Publication Date
JP2021529174A JP2021529174A (ja) 2021-10-28
JP2021529174A5 true JP2021529174A5 (enExample) 2022-07-05
JP7821573B2 JP7821573B2 (ja) 2026-02-27

Family

ID=67263119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020571383A Active JP7821573B2 (ja) 2018-06-27 2019-06-27 Ｄｏｔ１ｌディグレーダーおよびその使用

Country Status (6)

Country Link
US (1) US11634450B2 (enExample)
EP (1) EP3814365B1 (enExample)
JP (1) JP7821573B2 (enExample)
AU (1) AU2019294723B2 (enExample)
CA (1) CA3102856A1 (enExample)
WO (1) WO2020006157A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3126141A1 (en) * 2019-01-09 2020-07-16 Dana-Farber Cancer Institute, Inc. Dot1l degraders and uses thereof
US20240245787A1 (en) 2021-04-13 2024-07-25 President And Fellows Of Harvard College E3 ligase binders and uses thereof
EP4419518A1 (en) * 2021-10-18 2024-08-28 Dana-Farber Cancer Institute, Inc. Small molecules for dot1l degradation and uses thereof
WO2023215354A1 (en) * 2022-05-03 2023-11-09 Board Of Regents, The University Of Texas System Menin proteolysis targeting chimeras (protacs)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3027195B1 (en) * 2013-07-29 2019-02-06 Dana-Farber Cancer Institute, Inc. Dot1l probes
US9458165B2 (en) * 2014-08-27 2016-10-04 Dana-Farber Cancer Institute, Inc. DOT1L inhibitors

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