JP2021527137A - Ｒｐｎ１１を標的化するための二機能性分子 - Google Patents

Ｒｐｎ１１を標的化するための二機能性分子 Download PDF

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JP2021527137A
JP2021527137A JP2021518994A JP2021518994A JP2021527137A JP 2021527137 A JP2021527137 A JP 2021527137A JP 2021518994 A JP2021518994 A JP 2021518994A JP 2021518994 A JP2021518994 A JP 2021518994A JP 2021527137 A JP2021527137 A JP 2021527137A
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rpn11
nhme
sme
ome
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アレッシオ シウリー
アンドレア テスタ
スコット ヒューズ
スティーブン ピーター ブッチャー
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アンフィスタ セラピューティクス リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
JP2021518994A 2018-06-13 2019-06-13 Ｒｐｎ１１を標的化するための二機能性分子 Pending JP2021527137A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862684265P 2018-06-13 2018-06-13
US62/684,265 2018-06-13
US201962835953P 2019-04-18 2019-04-18
US62/835,953 2019-04-18
PCT/EP2019/065481 WO2019238817A1 (en) 2018-06-13 2019-06-13 Bifunctional molecules for targeting rpn11

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JP2021527137A true JP2021527137A (ja) 2021-10-11
JP2021527137A5 JP2021527137A5 (https=) 2022-06-21

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US (1) US11925690B2 (https=)
EP (1) EP3807272A1 (https=)
JP (1) JP2021527137A (https=)
KR (1) KR20210021016A (https=)
CN (1) CN112533918A (https=)
CA (1) CA3103185A1 (https=)
WO (1) WO2019238817A1 (https=)

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WO2022129925A1 (en) 2020-12-18 2022-06-23 Amphista Therapeutics Limited Novel bifunctional molecules for targeted protein degradation
IL312013A (en) * 2021-10-14 2024-06-01 Cullgen Shanghai Inc Modified proteins and protein degraders
CN114959036A (zh) * 2022-06-07 2022-08-30 北京大学 Rpn11标记物在检测骨髓瘤及其患病风险、预后分析及治疗药物中的应用
CN119384408A (zh) 2022-06-16 2025-01-28 安菲斯塔治疗有限责任公司 用于靶向蛋白降解的双功能分子
WO2023242598A1 (en) 2022-06-16 2023-12-21 Amphista Therapeutics Limited Bifunctional molecules for targeted protein degradation
EP4587126A1 (en) 2022-09-13 2025-07-23 Amphista Therapeutics Ltd Compounds for targeted protein degradation
KR20250075705A (ko) 2022-10-07 2025-05-28 화이자 인코포레이티드 Hsd17b13 억제제 및/또는 분해제
EP4634169A1 (en) 2022-12-16 2025-10-22 Pfizer Inc. 3-fluoro-4-hydroxybenzmide-containing inhibitors and/or degraders and uses thereof
WO2025120592A1 (en) 2023-12-07 2025-06-12 Pfizer Inc. Biphenyl and phenylpyridine compounds as inhibitors of kat2a and/or kat2b
GB202319256D0 (en) 2023-12-15 2024-01-31 Amphista Therapeutics Ltd Novel compounds for targeted protein degradation

Citations (1)

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US20170050931A1 (en) * 2015-08-17 2017-02-23 California Institute Of Technology Inhibitors of rpn11

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