CN112533918A - 用于靶向Rpn11的双功能分子 - Google Patents

用于靶向Rpn11的双功能分子 Download PDF

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CN112533918A
CN112533918A CN201980039241.8A CN201980039241A CN112533918A CN 112533918 A CN112533918 A CN 112533918A CN 201980039241 A CN201980039241 A CN 201980039241A CN 112533918 A CN112533918 A CN 112533918A
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rpn11
nhme
sme
ome
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Chinese (zh)
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阿莱西奥·丘利
安德烈亚·泰斯塔
斯科特·休斯
史蒂文·彼得·布彻
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Anfista Treatment Co ltd
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Anfista Treatment Co ltd
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  • Molecular Biology (AREA)
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  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
CN201980039241.8A 2018-06-13 2019-06-13 用于靶向Rpn11的双功能分子 Withdrawn CN112533918A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862684265P 2018-06-13 2018-06-13
US62/684,265 2018-06-13
US201962835953P 2019-04-18 2019-04-18
US62/835,953 2019-04-18
PCT/EP2019/065481 WO2019238817A1 (en) 2018-06-13 2019-06-13 Bifunctional molecules for targeting rpn11

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US (1) US11925690B2 (https=)
EP (1) EP3807272A1 (https=)
JP (1) JP2021527137A (https=)
KR (1) KR20210021016A (https=)
CN (1) CN112533918A (https=)
CA (1) CA3103185A1 (https=)
WO (1) WO2019238817A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023061440A1 (en) * 2021-10-14 2023-04-20 Cullgen (Shanghai), Inc. Modified proteins and protein degraders
WO2023236583A1 (zh) * 2022-06-07 2023-12-14 北京大学 Rpn11标记物在检测骨髓瘤及其患病风险、预后分析及治疗药物中的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022129925A1 (en) 2020-12-18 2022-06-23 Amphista Therapeutics Limited Novel bifunctional molecules for targeted protein degradation
CN119384408A (zh) 2022-06-16 2025-01-28 安菲斯塔治疗有限责任公司 用于靶向蛋白降解的双功能分子
WO2023242598A1 (en) 2022-06-16 2023-12-21 Amphista Therapeutics Limited Bifunctional molecules for targeted protein degradation
EP4587126A1 (en) 2022-09-13 2025-07-23 Amphista Therapeutics Ltd Compounds for targeted protein degradation
KR20250075705A (ko) 2022-10-07 2025-05-28 화이자 인코포레이티드 Hsd17b13 억제제 및/또는 분해제
EP4634169A1 (en) 2022-12-16 2025-10-22 Pfizer Inc. 3-fluoro-4-hydroxybenzmide-containing inhibitors and/or degraders and uses thereof
WO2025120592A1 (en) 2023-12-07 2025-06-12 Pfizer Inc. Biphenyl and phenylpyridine compounds as inhibitors of kat2a and/or kat2b
GB202319256D0 (en) 2023-12-15 2024-01-31 Amphista Therapeutics Ltd Novel compounds for targeted protein degradation

Citations (5)

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WO1993020094A1 (en) * 1992-03-27 1993-10-14 Abbott Laboratories Haptens, tracers, immunogens and antibodies for quinoline
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