JP2021527137A5 - - Google Patents
Info
- Publication number
- JP2021527137A5 JP2021527137A5 JP2021518994A JP2021518994A JP2021527137A5 JP 2021527137 A5 JP2021527137 A5 JP 2021527137A5 JP 2021518994 A JP2021518994 A JP 2021518994A JP 2021518994 A JP2021518994 A JP 2021518994A JP 2021527137 A5 JP2021527137 A5 JP 2021527137A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- rpn11
- nhme
- sme
- ome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862684265P | 2018-06-13 | 2018-06-13 | |
| US62/684,265 | 2018-06-13 | ||
| US201962835953P | 2019-04-18 | 2019-04-18 | |
| US62/835,953 | 2019-04-18 | ||
| PCT/EP2019/065481 WO2019238817A1 (en) | 2018-06-13 | 2019-06-13 | Bifunctional molecules for targeting rpn11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021527137A JP2021527137A (ja) | 2021-10-11 |
| JP2021527137A5 true JP2021527137A5 (https=) | 2022-06-21 |
Family
ID=67105990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021518994A Pending JP2021527137A (ja) | 2018-06-13 | 2019-06-13 | Ｒｐｎ１１を標的化するための二機能性分子 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11925690B2 (https=) |
| EP (1) | EP3807272A1 (https=) |
| JP (1) | JP2021527137A (https=) |
| KR (1) | KR20210021016A (https=) |
| CN (1) | CN112533918A (https=) |
| CA (1) | CA3103185A1 (https=) |
| WO (1) | WO2019238817A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022129925A1 (en) | 2020-12-18 | 2022-06-23 | Amphista Therapeutics Limited | Novel bifunctional molecules for targeted protein degradation |
| IL312013A (en) * | 2021-10-14 | 2024-06-01 | Cullgen Shanghai Inc | Modified proteins and protein degraders |
| CN114959036A (zh) * | 2022-06-07 | 2022-08-30 | 北京大学 | Rpn11标记物在检测骨髓瘤及其患病风险、预后分析及治疗药物中的应用 |
| CN119384408A (zh) | 2022-06-16 | 2025-01-28 | 安菲斯塔治疗有限责任公司 | 用于靶向蛋白降解的双功能分子 |
| WO2023242598A1 (en) | 2022-06-16 | 2023-12-21 | Amphista Therapeutics Limited | Bifunctional molecules for targeted protein degradation |
| EP4587126A1 (en) | 2022-09-13 | 2025-07-23 | Amphista Therapeutics Ltd | Compounds for targeted protein degradation |
| KR20250075705A (ko) | 2022-10-07 | 2025-05-28 | 화이자 인코포레이티드 | Hsd17b13 억제제 및/또는 분해제 |
| EP4634169A1 (en) | 2022-12-16 | 2025-10-22 | Pfizer Inc. | 3-fluoro-4-hydroxybenzmide-containing inhibitors and/or degraders and uses thereof |
| WO2025120592A1 (en) | 2023-12-07 | 2025-06-12 | Pfizer Inc. | Biphenyl and phenylpyridine compounds as inhibitors of kat2a and/or kat2b |
| GB202319256D0 (en) | 2023-12-15 | 2024-01-31 | Amphista Therapeutics Ltd | Novel compounds for targeted protein degradation |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| AU3938893A (en) | 1992-03-27 | 1993-11-08 | Abbott Laboratories | Haptens, tracers, immunogens and antibodies for quinoline |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| EP1169038B9 (en) | 1999-04-15 | 2013-07-10 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| US7208157B2 (en) | 2000-09-08 | 2007-04-24 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
| WO2002020740A2 (en) * | 2000-09-08 | 2002-03-14 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
| EP1896040B1 (en) | 2005-06-29 | 2012-08-01 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| ES2884044T3 (es) | 2006-12-26 | 2021-12-10 | Immunogenesis Inc | Profármaco alquilante de fosforamidato para el tratamiento del cáncer |
| US20100222347A1 (en) * | 2007-09-27 | 2010-09-02 | Kowa Company, Ltd. | Prophylactic and/or therapeutic agent for anemia, comprising tetrahydroquinoline compound as active ingredient |
| GB0913775D0 (en) | 2009-08-06 | 2009-09-16 | Medical Res Council | Multispecific peptides |
| CA2823837A1 (en) | 2010-12-07 | 2012-06-14 | Yale University | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same |
| US20140235548A1 (en) | 2011-05-17 | 2014-08-21 | Cleave Biosciences, Inc. | Compositions and methods for jamm protein inhibition |
| KR102668696B1 (ko) | 2012-01-12 | 2024-05-29 | 예일 유니버시티 | E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법 |
| WO2014182744A1 (en) | 2013-05-08 | 2014-11-13 | The Johns Hopkins University | Novel bis-benzylidine piperidone proteasome inhibitor with anticancer activity |
| RU2738833C9 (ru) | 2014-04-14 | 2022-02-28 | Арвинас, Оперэйшнз, Инк. | Имидные модуляторы протеолиза и способы их применения |
| US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| GB201504314D0 (en) | 2015-03-13 | 2015-04-29 | Univ Dundee | Small molecules |
| CA2988414C (en) | 2015-06-04 | 2023-09-26 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| KR20180021080A (ko) | 2015-06-19 | 2018-02-28 | 에츠코 미야모토 | 단백질 분해 유도 태그 및 그 용도 |
| WO2017024317A2 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| WO2017024318A1 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses |
| US10005735B2 (en) * | 2015-08-17 | 2018-06-26 | California Institute Of Technology | Inhibitors of RPN11 |
| GB201516243D0 (en) * | 2015-09-14 | 2015-10-28 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| AU2017253560B2 (en) * | 2016-04-20 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | Conjugates comprising RIPK2 inhibitors |
| AU2017361155B2 (en) | 2016-11-15 | 2023-03-30 | Tokyo University Of Science Foundation | Ras protein degradation inducing molecule and pharmaceutical composition |
| EP3746135A4 (en) | 2018-01-30 | 2022-03-09 | Foghorn Therapeutics Inc. | METHODS AND COMPOUNDS FOR TREATMENT OF DISEASE |
| US11702402B2 (en) | 2018-02-23 | 2023-07-18 | Dana-Farber Cancer Institute, Inc. | Small molecules that block proteasome-associated ubiquitin receptor RPN13 function and uses thereof |
| CA3090417A1 (en) | 2018-02-23 | 2019-08-29 | Dana-Farber Cancer Institute, Inc. | Small molecules for inducing selective protein degradation and uses thereof |
| IL302595A (en) | 2018-04-13 | 2023-07-01 | Arvinas Operations Inc | Servalon ligands and bifunctional compounds containing them |
| EP3677693A1 (en) | 2019-01-03 | 2020-07-08 | Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO | Transpochimeric gene trancripts (tcgts) as cancer biomarkers |
| CA3126141A1 (en) | 2019-01-09 | 2020-07-16 | Dana-Farber Cancer Institute, Inc. | Dot1l degraders and uses thereof |
-
2019
- 2019-06-13 EP EP19733978.1A patent/EP3807272A1/en not_active Withdrawn
- 2019-06-13 US US17/251,615 patent/US11925690B2/en active Active
- 2019-06-13 WO PCT/EP2019/065481 patent/WO2019238817A1/en not_active Ceased
- 2019-06-13 JP JP2021518994A patent/JP2021527137A/ja active Pending
- 2019-06-13 KR KR1020217000928A patent/KR20210021016A/ko not_active Withdrawn
- 2019-06-13 CN CN201980039241.8A patent/CN112533918A/zh not_active Withdrawn
- 2019-06-13 CA CA3103185A patent/CA3103185A1/en active Pending
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