JP2021533181A5 - - Google Patents
Info
- Publication number
- JP2021533181A5 JP2021533181A5 JP2021518993A JP2021518993A JP2021533181A5 JP 2021533181 A5 JP2021533181 A5 JP 2021533181A5 JP 2021518993 A JP2021518993 A JP 2021518993A JP 2021518993 A JP2021518993 A JP 2021518993A JP 2021533181 A5 JP2021533181 A5 JP 2021533181A5
- Authority
- JP
- Japan
- Prior art keywords
- uchl5
- bifunctional molecule
- target protein
- binding partner
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862684268P | 2018-06-13 | 2018-06-13 | |
| US62/684,268 | 2018-06-13 | ||
| US201962835955P | 2019-04-18 | 2019-04-18 | |
| US62/835,955 | 2019-04-18 | ||
| PCT/EP2019/065479 WO2019238816A1 (en) | 2018-06-13 | 2019-06-13 | Bifunctional molecules for targeting uchl5 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021533181A JP2021533181A (ja) | 2021-12-02 |
| JP2021533181A5 true JP2021533181A5 (https=) | 2022-06-21 |
Family
ID=67105989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021518993A Pending JP2021533181A (ja) | 2018-06-13 | 2019-06-13 | ＵｃｈＬ５を標的化するための二機能性分子 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210283139A1 (https=) |
| EP (1) | EP3807263A1 (https=) |
| JP (1) | JP2021533181A (https=) |
| KR (1) | KR20210020107A (https=) |
| CN (1) | CN112585127A (https=) |
| CA (1) | CA3103205A1 (https=) |
| WO (1) | WO2019238816A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4090371A4 (en) * | 2020-01-14 | 2024-04-03 | The Trustees of Columbia University in the City of New York | Compositions and methods for targeted protein stabilization by redirecting endogenous deubiquitinases |
| GB202102494D0 (en) * | 2021-02-22 | 2021-04-07 | Amphista Therapeurics Ltd | Novel bifunctional molecules for targeted protein degredation |
| WO2022129925A1 (en) | 2020-12-18 | 2022-06-23 | Amphista Therapeutics Limited | Novel bifunctional molecules for targeted protein degradation |
| JP2024513566A (ja) * | 2021-04-09 | 2024-03-26 | ザ・ブロード・インスティテュート・インコーポレイテッド | 標的基質の選択的修飾のための二官能性分子 |
| KR20240004584A (ko) * | 2021-04-29 | 2024-01-11 | 노파르티스 아게 | 탈유비퀴티나아제-표적화 키메라 및 관련된 방법 |
| WO2023242598A1 (en) | 2022-06-16 | 2023-12-21 | Amphista Therapeutics Limited | Bifunctional molecules for targeted protein degradation |
| CN119384408A (zh) | 2022-06-16 | 2025-01-28 | 安菲斯塔治疗有限责任公司 | 用于靶向蛋白降解的双功能分子 |
| EP4587126A1 (en) | 2022-09-13 | 2025-07-23 | Amphista Therapeutics Ltd | Compounds for targeted protein degradation |
| KR20250075705A (ko) | 2022-10-07 | 2025-05-28 | 화이자 인코포레이티드 | Hsd17b13 억제제 및/또는 분해제 |
| EP4634169A1 (en) | 2022-12-16 | 2025-10-22 | Pfizer Inc. | 3-fluoro-4-hydroxybenzmide-containing inhibitors and/or degraders and uses thereof |
| WO2025021140A1 (zh) * | 2023-07-26 | 2025-01-30 | 海南先声再明医药股份有限公司 | 用于靶蛋白降解类的化合物 |
| WO2025120592A1 (en) | 2023-12-07 | 2025-06-12 | Pfizer Inc. | Biphenyl and phenylpyridine compounds as inhibitors of kat2a and/or kat2b |
| GB202319256D0 (en) | 2023-12-15 | 2024-01-31 | Amphista Therapeutics Ltd | Novel compounds for targeted protein degradation |
| WO2025221154A1 (en) | 2024-04-17 | 2025-10-23 | Captor Therapeutics S.A. | Klhdc2 (kelch domain-containing protein 2) ligase ligands |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| EP1169038B9 (en) * | 1999-04-15 | 2013-07-10 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| US7208157B2 (en) | 2000-09-08 | 2007-04-24 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
| EP1896040B1 (en) | 2005-06-29 | 2012-08-01 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| RU59063U1 (ru) | 2006-05-30 | 2006-12-10 | Государственное образовательное учреждение высшего профессионального образования "Ульяновский государственный технический университет" | Режущий инструмент с многослойным покрытием |
| ES2884044T3 (es) | 2006-12-26 | 2021-12-10 | Immunogenesis Inc | Profármaco alquilante de fosforamidato para el tratamiento del cáncer |
| GB0913775D0 (en) | 2009-08-06 | 2009-09-16 | Medical Res Council | Multispecific peptides |
| WO2012040527A2 (en) * | 2010-09-24 | 2012-03-29 | The Regents Of The University Of Michigan | Deubiquitinase inhibitors and methods for use of the same |
| CA2823837A1 (en) | 2010-12-07 | 2012-06-14 | Yale University | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same |
| KR102668696B1 (ko) | 2012-01-12 | 2024-05-29 | 예일 유니버시티 | E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법 |
| US20170095457A1 (en) * | 2014-05-27 | 2017-04-06 | David Lonergan | Compositions and methods of delivery of deubiquitinase inhibitors |
| US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| GB201504314D0 (en) | 2015-03-13 | 2015-04-29 | Univ Dundee | Small molecules |
| WO2017024318A1 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses |
| WO2017024317A2 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| BR112018008918A8 (pt) * | 2015-11-02 | 2019-02-26 | Univ Yale | compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos |
| GB2554071A (en) * | 2016-09-14 | 2018-03-28 | Univ Dundee | Small molecules |
-
2019
- 2019-06-13 US US17/251,621 patent/US20210283139A1/en not_active Abandoned
- 2019-06-13 WO PCT/EP2019/065479 patent/WO2019238816A1/en not_active Ceased
- 2019-06-13 CA CA3103205A patent/CA3103205A1/en active Pending
- 2019-06-13 KR KR1020217000976A patent/KR20210020107A/ko not_active Withdrawn
- 2019-06-13 EP EP19733977.3A patent/EP3807263A1/en not_active Withdrawn
- 2019-06-13 JP JP2021518993A patent/JP2021533181A/ja active Pending
- 2019-06-13 CN CN201980038871.3A patent/CN112585127A/zh active Pending
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