JP2018535925A5 - - Google Patents
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- JP2018535925A5 JP2018535925A5 JP2018512411A JP2018512411A JP2018535925A5 JP 2018535925 A5 JP2018535925 A5 JP 2018535925A5 JP 2018512411 A JP2018512411 A JP 2018512411A JP 2018512411 A JP2018512411 A JP 2018512411A JP 2018535925 A5 JP2018535925 A5 JP 2018535925A5
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- amino acid
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- 210000004027 cell Anatomy 0.000 claims description 136
- 150000001875 compounds Chemical class 0.000 claims description 111
- 229910052739 hydrogen Inorganic materials 0.000 claims description 37
- -1 aromatic amino acid Chemical class 0.000 claims description 29
- 210000001519 tissue Anatomy 0.000 claims description 27
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 24
- 150000001413 amino acids Chemical class 0.000 claims description 22
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 19
- 239000001257 hydrogen Substances 0.000 claims description 19
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 15
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 15
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 15
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 15
- 229910052760 oxygen Inorganic materials 0.000 claims description 15
- 239000001301 oxygen Substances 0.000 claims description 15
- 229910052717 sulfur Inorganic materials 0.000 claims description 15
- 239000011593 sulfur Substances 0.000 claims description 15
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 150000002431 hydrogen Chemical class 0.000 claims description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims description 11
- 229920002873 Polyethylenimine Polymers 0.000 claims description 11
- 229920001223 polyethylene glycol Polymers 0.000 claims description 11
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 10
- 206010005003 Bladder cancer Diseases 0.000 claims description 9
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 9
- 206010006187 Breast cancer Diseases 0.000 claims description 9
- 208000026310 Breast neoplasm Diseases 0.000 claims description 9
- 206010009944 Colon cancer Diseases 0.000 claims description 9
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 9
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 9
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 9
- 206010060862 Prostate cancer Diseases 0.000 claims description 9
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 9
- 206010038389 Renal cancer Diseases 0.000 claims description 9
- 206010039491 Sarcoma Diseases 0.000 claims description 9
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 9
- 206010057644 Testis cancer Diseases 0.000 claims description 9
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 208000029742 colonic neoplasm Diseases 0.000 claims description 9
- 201000010982 kidney cancer Diseases 0.000 claims description 9
- 201000007270 liver cancer Diseases 0.000 claims description 9
- 208000014018 liver neoplasm Diseases 0.000 claims description 9
- 201000005202 lung cancer Diseases 0.000 claims description 9
- 208000020816 lung neoplasm Diseases 0.000 claims description 9
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 9
- 201000001441 melanoma Diseases 0.000 claims description 9
- 201000002528 pancreatic cancer Diseases 0.000 claims description 9
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 9
- 210000005267 prostate cell Anatomy 0.000 claims description 9
- 201000003120 testicular cancer Diseases 0.000 claims description 9
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 9
- 125000004429 atom Chemical group 0.000 claims description 8
- SOAPXKSPJAZNGO-WDSKDSINSA-N (2s)-2-[[(1s)-1,3-dicarboxypropyl]carbamoylamino]pentanedioic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)N[C@H](C(O)=O)CCC(O)=O SOAPXKSPJAZNGO-WDSKDSINSA-N 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 7
- BEJKOYIMCGMNRB-GRHHLOCNSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 BEJKOYIMCGMNRB-GRHHLOCNSA-N 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 6
- 125000000129 anionic group Chemical group 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 125000002091 cationic group Chemical group 0.000 claims description 6
- 230000005284 excitation Effects 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 6
- 229920002554 vinyl polymer Chemical group 0.000 claims description 6
- QDJIJLMECSQFMG-VWURTLBMSA-N (2s)-2-amino-3-phenylpropanoic acid;(2r)-2-amino-3-sulfanylpropanoic acid Chemical group SC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 QDJIJLMECSQFMG-VWURTLBMSA-N 0.000 claims description 5
- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims description 5
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims description 5
- 210000004412 neuroendocrine cell Anatomy 0.000 claims description 5
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 4
- 239000004472 Lysine Substances 0.000 claims description 3
- 239000003446 ligand Substances 0.000 claims description 3
- QYRPFJSPYKSYEK-VWURTLBMSA-N (2s)-2-amino-3-hydroxypropanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical group OC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 QYRPFJSPYKSYEK-VWURTLBMSA-N 0.000 claims description 2
- USIQKIIZGMXBHT-IPIKRLCPSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,5-diaminopentanoic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 USIQKIIZGMXBHT-IPIKRLCPSA-N 0.000 claims description 2
- GQYAUZAWKROOLF-IPIKRLCPSA-N (2s)-2-amino-4-methylsulfanylbutanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical group CSCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 GQYAUZAWKROOLF-IPIKRLCPSA-N 0.000 claims description 2
- CLUOUYPICNCYNF-IPIKRLCPSA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical compound OC(=O)[C@@H](N)CCCNC(N)=N.OC(=O)[C@@H](N)CC1=CC=CC=C1 CLUOUYPICNCYNF-IPIKRLCPSA-N 0.000 claims description 2
- SOAPXKSPJAZNGO-UHFFFAOYSA-N 2-(1,3-dicarboxypropylcarbamoylamino)pentanedioic acid Chemical group OC(=O)CCC(C(O)=O)NC(=O)NC(C(O)=O)CCC(O)=O SOAPXKSPJAZNGO-UHFFFAOYSA-N 0.000 claims description 2
- DNEGJYIOMMXZFJ-QRPNPIFTSA-N 4-(2-aminoethyl)phenol (2S)-2-amino-3-phenylpropanoic acid Chemical group NCCc1ccc(O)cc1.N[C@@H](Cc1ccccc1)C(O)=O DNEGJYIOMMXZFJ-QRPNPIFTSA-N 0.000 claims description 2
- ZRQQTQFBKAWJLZ-VWURTLBMSA-N N[C@@H](C[SeH])C(=O)O.N[C@@H](CC1=CC=CC=C1)C(=O)O Chemical group N[C@@H](C[SeH])C(=O)O.N[C@@H](CC1=CC=CC=C1)C(=O)O ZRQQTQFBKAWJLZ-VWURTLBMSA-N 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims description 2
- 150000003862 amino acid derivatives Chemical class 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 150000003668 tyrosines Chemical class 0.000 claims description 2
- 235000001014 amino acid Nutrition 0.000 description 27
- 238000000034 method Methods 0.000 description 25
- 239000012472 biological sample Substances 0.000 description 16
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 5
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 description 4
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
- 229940125758 compound 15 Drugs 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 230000001678 irradiating effect Effects 0.000 description 4
- 208000029559 malignant endocrine neoplasm Diseases 0.000 description 4
- 210000002569 neuron Anatomy 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 238000012634 optical imaging Methods 0.000 description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 0 *C(CC[C@](*(C(*([C@@](CCO)(N)I)=C)=O)=C)(O)I=C)=O Chemical compound *C(CC[C@](*(C(*([C@@](CCO)(N)I)=C)=O)=C)(O)I=C)=O 0.000 description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- FTDJMHFEPHDWJS-CWRCKCRTSA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical compound OC(=O)[C@@H](N)CCCNC(N)=N.OC(=O)[C@@H](N)CC1=CC=CC=C1.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FTDJMHFEPHDWJS-CWRCKCRTSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562216157P | 2015-09-09 | 2015-09-09 | |
| US62/216,157 | 2015-09-09 | ||
| PCT/US2016/050709 WO2017044584A1 (en) | 2015-09-09 | 2016-09-08 | Psma-targeted nir dyes and their uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535925A JP2018535925A (ja) | 2018-12-06 |
| JP2018535925A5 true JP2018535925A5 (https=) | 2019-07-25 |
| JP6937037B2 JP6937037B2 (ja) | 2021-09-22 |
Family
ID=58189184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018512411A Active JP6937037B2 (ja) | 2015-09-09 | 2016-09-08 | Ｐｓｍａ標的化ｎｉｒ色素およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9808538B2 (https=) |
| EP (1) | EP3347019B1 (https=) |
| JP (1) | JP6937037B2 (https=) |
| KR (1) | KR102862158B1 (https=) |
| CN (2) | CN108135903A (https=) |
| AU (1) | AU2016318949B2 (https=) |
| BR (1) | BR112018004726B1 (https=) |
| CA (1) | CA2996309A1 (https=) |
| ES (1) | ES2861528T3 (https=) |
| IL (1) | IL257669B (https=) |
| MX (1) | MX381760B (https=) |
| WO (1) | WO2017044584A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2187965T3 (pl) * | 2007-08-17 | 2020-05-18 | Purdue Research Foundation | Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania |
| US9951324B2 (en) * | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| US20170232119A1 (en) * | 2013-03-15 | 2017-08-17 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| EP3456700A1 (en) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EP3533473A3 (en) | 2013-11-14 | 2019-12-18 | Endocyte, Inc. | Compounds for positron emission tomography |
| US9808538B2 (en) | 2015-09-09 | 2017-11-07 | On Target Laboratories, LLC | PSMA-targeted NIR dyes and their uses |
| US10842887B2 (en) * | 2015-09-09 | 2020-11-24 | On Target Laboratories, LLC | PSMA-targeted NIR dyes and their uses |
| US10913071B2 (en) | 2016-03-09 | 2021-02-09 | Pearson Incorporated | Scalper apparatus and processing system |
| US11555821B2 (en) | 2016-03-16 | 2023-01-17 | On Target Laboratories, Inc. | CA IX-NIR dyes and their uses |
| EP3430383B1 (en) * | 2016-03-16 | 2024-06-26 | On Target Laboratories, LLC | Ca ix-target nir dyes and their uses |
| US10322487B1 (en) | 2016-07-15 | 2019-06-18 | Pearson Incorporated | Roller mill grinding apparatus with regenerative capability |
| ES2944610T3 (es) * | 2016-09-09 | 2023-06-22 | On Target Laboratories Llc | Colorantes NIR dirigidos a PSMA y sus usos |
| CN107266929B (zh) * | 2017-06-21 | 2019-10-29 | 四川大学 | 一类以菁染料荧光基团为母体骨架结构的近红外荧光染料及其制备方法与应用 |
| US10807098B1 (en) | 2017-07-26 | 2020-10-20 | Pearson Incorporated | Systems and methods for step grinding |
| CN108362671B (zh) * | 2018-02-23 | 2020-11-13 | 银川高新区广煜科技有限公司 | 检测半胱氨酸的方法 |
| WO2019173483A1 (en) * | 2018-03-07 | 2019-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Drug fragment imaging agent conjugates |
| CN112368024A (zh) | 2018-04-17 | 2021-02-12 | 恩多塞特公司 | 治疗癌症的方法 |
| US11325133B1 (en) | 2018-07-26 | 2022-05-10 | Pearson Incorporated | Systems and methods for monitoring the roll diameter and shock loads in a milling apparatus |
| WO2020030954A1 (en) | 2018-08-09 | 2020-02-13 | Integrative Medicine Clinic, Sia | Theranostics-like protein sanps conjugated to integrin and pmsa targeting peptides and therapy of prostate cancer |
| US10751722B1 (en) | 2018-10-24 | 2020-08-25 | Pearson Incorporated | System for processing cannabis crop materials |
| US10785906B2 (en) | 2019-02-19 | 2020-09-29 | Pearson Incorporated | Plant processing system |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
| RU2713151C1 (ru) * | 2019-07-02 | 2020-02-04 | Общество с ограниченной ответственностью "Изварино Фарма" | Конъюгат флуоресцентного красителя с веществом пептидной природы, включающим псма-связывающий лиганд на основе производного мочевины для визуализации клеток, экспрессирующих псма, способ его получения и применения |
| US10757860B1 (en) | 2019-10-31 | 2020-09-01 | Hemp Processing Solutions, LLC | Stripper apparatus crop harvesting system |
| US10933424B1 (en) | 2019-12-11 | 2021-03-02 | Pearson Incorporated | Grinding roll improvements |
| CN113117100B (zh) * | 2019-12-31 | 2024-03-01 | 广东精观生物医药科技有限公司 | 一种靶向psma的荧光分子探针及其制备方法和应用 |
| US11964965B2 (en) | 2020-05-08 | 2024-04-23 | On Target Laboratories, LLC | Methods of manufacture and synthesis of fluorescent dye compounds and uses thereof |
| EP4214513A4 (en) * | 2020-09-16 | 2024-12-11 | On Target Laboratories, LLC | Detection of circulating tumor cells using tumor-targeted nir agents |
| EP4247436A4 (en) * | 2020-11-18 | 2024-10-16 | On Target Laboratories, LLC | NEAR-INFRARED II PROBES AS HIGH-AFFINE TARGETING IMAGING AGENTS AND USES THEREOF |
| WO2022167681A1 (en) * | 2021-02-08 | 2022-08-11 | Stichting Radboud Universitair Medisch Centrum | Psma-targeting ligands for multimodal applications |
| CN115872950B (zh) * | 2021-09-25 | 2024-04-16 | 上海交通大学医学院附属第九人民医院 | 荧光化合物及在检测尿素酶中的应用和体外诊断试剂 |
| CN113979912B (zh) * | 2021-11-16 | 2023-04-07 | 中国医学科学院肿瘤医院 | 两种前列腺特异性膜抗原靶向荧光探针及其制备方法与应用 |
| CN114014843B (zh) * | 2021-11-17 | 2022-09-20 | 北京大学第一医院 | 一种psma靶向核素/荧光双模态配体和分子探针与应用 |
| CN114214061B (zh) * | 2022-02-22 | 2022-05-17 | 北京大学 | 一种聚乙二醇修饰的两性离子化荧光探针、制剂及其应用 |
| AU2023283882A1 (en) * | 2022-06-10 | 2025-01-30 | Peking University | Trifunctional compound and use thereof |
| CN114835723B (zh) * | 2022-07-01 | 2022-09-16 | 戴格普瑞生物科技(苏州)有限公司 | Psma荧光分子探针、制备方法及试剂盒 |
| CN115490672B (zh) * | 2022-09-30 | 2023-11-17 | 南华大学 | 一种兼具光热和光动力效应的光敏剂及其制备方法和应用 |
| CN118978470B (zh) * | 2023-05-10 | 2025-04-22 | 新斗生物科技(苏州)有限公司 | 化合物及其制备方法、组合物、试剂盒及应用 |
| CN116621820B (zh) * | 2023-05-23 | 2025-05-23 | 中山大学 | 一种两性离子荧光化合物及其制备方法和应用 |
| KR20260009883A (ko) * | 2023-05-24 | 2026-01-20 | 베이징 창핑 래보러토리 | 신규 삼관능 화합물 및 이의 용도 |
| WO2025038752A1 (en) * | 2023-08-14 | 2025-02-20 | Cancer Targeted Technology Llc | Psma binding ligand-linker conjugates and methods for use thereof |
| WO2025119908A1 (en) | 2023-12-06 | 2025-06-12 | Bracco Imaging Spa | Psma-targeting fluorescent probes |
| US20250275943A1 (en) * | 2024-01-30 | 2025-09-04 | Korea University Research And Business Foundation | Composition for cancer diagnosis targeting tumor and/or tumor microenvironment and use thereof |
| CN118048050B (zh) * | 2024-04-16 | 2024-06-25 | 南京诺源医疗器械有限公司 | 一种七甲川菁近红外荧光染料及其制备方法和应用 |
| CN118078219B (zh) * | 2024-04-24 | 2024-08-02 | 新斗生物科技(苏州)有限公司 | 近红外荧光捕获系统、装置及应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19649971A1 (de) * | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
| US6326531B1 (en) | 2000-08-01 | 2001-12-04 | Neil Bremner | Instrument case support system and method |
| US20100022449A1 (en) * | 2006-03-09 | 2010-01-28 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| CA2645809C (en) * | 2006-03-14 | 2015-05-26 | Cancer Targeted Technology Llc | Peptidomimetic inhibitors of psma, compounds comprising them, and methods of use |
| JP2010509570A (ja) * | 2006-11-03 | 2010-03-25 | パーデュー・リサーチ・ファウンデーション | エクスビボフローサイトメトリーの方法および装置 |
| PL2187965T3 (pl) * | 2007-08-17 | 2020-05-18 | Purdue Research Foundation | Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania |
| JP5798043B2 (ja) * | 2009-02-06 | 2015-10-21 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | 電荷均衡造影剤 |
| US9056841B2 (en) * | 2009-03-19 | 2015-06-16 | The Johns Hopkins University | PSMA-targeting compounds and uses thereof |
| CA2790577A1 (en) * | 2010-02-25 | 2011-09-01 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| WO2014127365A1 (en) * | 2013-02-15 | 2014-08-21 | Case Western Reserve University | Psma ligands and uses thereof |
| WO2014149069A1 (en) | 2013-03-15 | 2014-09-25 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| US10406246B2 (en) * | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| US9808538B2 (en) | 2015-09-09 | 2017-11-07 | On Target Laboratories, LLC | PSMA-targeted NIR dyes and their uses |
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2015
- 2015-11-10 US US14/937,169 patent/US9808538B2/en active Active
- 2015-11-12 US US14/939,915 patent/US9801956B2/en active Active
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2016
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- 2016-09-08 ES ES16845024T patent/ES2861528T3/es active Active
- 2016-09-08 CN CN201680059695.8A patent/CN108135903A/zh active Pending
- 2016-09-08 CN CN202511843740.6A patent/CN121824666A/zh active Pending
- 2016-09-08 WO PCT/US2016/050709 patent/WO2017044584A1/en not_active Ceased
- 2016-09-08 MX MX2018002933A patent/MX381760B/es unknown
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