JP2021527098A5 - - Google Patents
Info
- Publication number
- JP2021527098A5 JP2021527098A5 JP2020569169A JP2020569169A JP2021527098A5 JP 2021527098 A5 JP2021527098 A5 JP 2021527098A5 JP 2020569169 A JP2020569169 A JP 2020569169A JP 2020569169 A JP2020569169 A JP 2020569169A JP 2021527098 A5 JP2021527098 A5 JP 2021527098A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- cells
- cancer
- alkyls
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862684495P | 2018-06-13 | 2018-06-13 | |
| US62/684,495 | 2018-06-13 | ||
| PCT/US2019/036581 WO2019241271A1 (en) | 2018-06-13 | 2019-06-11 | Fused thiophene compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021527098A JP2021527098A (ja) | 2021-10-11 |
| JP2021527098A5 true JP2021527098A5 (https=) | 2022-06-10 |
| JP7365059B2 JP7365059B2 (ja) | 2023-10-19 |
Family
ID=67263033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569169A Active JP7365059B2 (ja) | 2018-06-13 | 2019-06-11 | 縮合チオフェン化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11191769B2 (https=) |
| EP (1) | EP3807283A1 (https=) |
| JP (1) | JP7365059B2 (https=) |
| CN (1) | CN112601751B (https=) |
| AU (1) | AU2019284605A1 (https=) |
| CA (1) | CA3101335C (https=) |
| TW (1) | TWI826463B (https=) |
| WO (1) | WO2019241271A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10513515B2 (en) * | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| JP7629459B2 (ja) | 2019-11-19 | 2025-02-13 | ブリストル－マイヤーズ スクイブ カンパニー | Ｈｅｌｉｏｓタンパク質の阻害剤として有用な化合物 |
| WO2021155050A1 (en) * | 2020-01-29 | 2021-08-05 | Biotheryx, Inc. | Kinase modulators, pharmaceutical compositions, and therapeutic applications |
| TW202140441A (zh) | 2020-03-23 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 經取代之側氧基異吲哚啉化合物 |
| US20240025863A1 (en) | 2020-09-16 | 2024-01-25 | Biotheryx, Inc. | Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications |
| JP2023545274A (ja) * | 2020-10-07 | 2023-10-27 | クルゲン（シャンハイ），インク． | 癌を処置する化合物および方法 |
| WO2022087335A1 (en) | 2020-10-23 | 2022-04-28 | Biotheryx, Inc. | Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications |
| CN117203196A (zh) | 2020-12-14 | 2023-12-08 | 拜欧斯瑞克斯公司 | Pde4降解剂、药物组合物和治疗应用 |
| AU2022207648A1 (en) | 2021-01-13 | 2023-07-27 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
| EP4320112B1 (en) | 2021-04-06 | 2025-05-14 | Bristol-Myers Squibb Company | Pyridinyl substituted oxoisoindoline compounds |
| WO2023069731A1 (en) * | 2021-10-22 | 2023-04-27 | Monte Rosa Therapeutics, Inc. | Compounds that mediate protein degradation and methods of use thereof |
| US12419962B2 (en) | 2022-03-16 | 2025-09-23 | Biotheryx, Inc. | Quinazolines, pharmaceutical compositions, and therapeutic applications |
| WO2024015855A1 (en) | 2022-07-13 | 2024-01-18 | Monte Rosa Therapeutics, Inc. | COMBINATION THERAPY COMPRISING GSPT1-DIRECTED MOLECULAR GLUE DEGRADERS AND PI3K/AKT/mTOR PATHWAY INHIBITORS |
| EP4584259A1 (en) | 2022-09-09 | 2025-07-16 | Innovo Therapeutics, Inc. | Ck1alpha and dual ck1alpha / gspt1 degrading compounds |
| WO2024222918A1 (zh) * | 2023-04-28 | 2024-10-31 | 中国药科大学 | 一种苯并六元杂环类gspt1蛋白降解剂及其应用 |
| CN119371398A (zh) * | 2023-07-25 | 2025-01-28 | 安道麦阿甘有限公司 | 用于制备噻吩酮的新路线 |
| WO2025179161A1 (en) | 2024-02-21 | 2025-08-28 | Innovo Therapeutics, Inc. | Protein degrading compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939922B (zh) * | 2005-09-27 | 2010-10-13 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物 |
| CN101186611B (zh) * | 2006-11-15 | 2011-05-18 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的吡咯啉-2-酮衍生物及其制备和应用 |
| AU2015305449B2 (en) * | 2014-08-22 | 2021-05-06 | Celgene Corporation | Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies |
| SG11201708303XA (en) * | 2015-05-22 | 2017-11-29 | Biotheryx Inc | Compounds targeting proteins, compositions, methods, and uses thereof |
| US10040804B2 (en) * | 2016-12-21 | 2018-08-07 | Biotheryx, Inc. | Compounds targeting proteins, compositions, methods, and uses thereof |
-
2019
- 2019-06-11 WO PCT/US2019/036581 patent/WO2019241271A1/en not_active Ceased
- 2019-06-11 CN CN201980039027.2A patent/CN112601751B/zh active Active
- 2019-06-11 EP EP19739747.4A patent/EP3807283A1/en not_active Withdrawn
- 2019-06-11 JP JP2020569169A patent/JP7365059B2/ja active Active
- 2019-06-11 CA CA3101335A patent/CA3101335C/en active Active
- 2019-06-11 AU AU2019284605A patent/AU2019284605A1/en not_active Abandoned
- 2019-06-11 US US16/438,244 patent/US11191769B2/en active Active
- 2019-06-13 TW TW108120511A patent/TWI826463B/zh not_active IP Right Cessation
-
2021
- 2021-12-06 US US17/457,733 patent/US20220088025A1/en not_active Abandoned
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