CN110573501A - Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 - Google Patents

Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 Download PDF

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CN110573501A
CN110573501A CN201780090148.0A CN201780090148A CN110573501A CN 110573501 A CN110573501 A CN 110573501A CN 201780090148 A CN201780090148 A CN 201780090148A CN 110573501 A CN110573501 A CN 110573501A
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compound
ring
reaction
cancer
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CN110573501B (zh
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赵焰平
王红军
李功
姜媛媛
李想
周丽莹
刘亚男
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Mitralign Inc
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Mitralign Inc
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
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    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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Abstract

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN201780090148.0A 2017-06-30 2017-09-29 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 Active CN110573501B (zh)

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WO2022242321A1 (zh) * 2021-05-19 2022-11-24 中国药科大学 一种PI3Kα选择性抑制剂及其制备方法和应用

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