JP7365059B2 - 縮合チオフェン化合物 - Google Patents

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Publication number

JP7365059B2

JP7365059B2 JP2020569169A JP2020569169A JP7365059B2 JP 7365059 B2 JP7365059 B2 JP 7365059B2 JP 2020569169 A JP2020569169 A JP 2020569169A JP 2020569169 A JP2020569169 A JP 2020569169A JP 7365059 B2 JP7365059 B2 JP 7365059B2

Authority

JP

Japan

Prior art keywords

alkyl

optionally substituted

mmol

amino

cells

Prior art date

2018-06-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 229930192474 thiophene Natural products 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims description 168
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• 125000001424 substituent group Chemical group 0.000 claims description 71
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• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 42
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 40
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 39
• 229910052739 hydrogen Inorganic materials 0.000 claims description 38
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• 229910052805 deuterium Inorganic materials 0.000 claims description 30
• 239000001257 hydrogen Substances 0.000 claims description 29
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• 101000851788 Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Proteins 0.000 claims description 25
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• 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 24
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• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
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• SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 6
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• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 3
• CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims description 3
• YQCIWBXEVYWRCW-UHFFFAOYSA-N methane;sulfane Chemical compound C.S YQCIWBXEVYWRCW-UHFFFAOYSA-N 0.000 claims description 3
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