JP2021525771A5 - - Google Patents

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Publication number
JP2021525771A5
JP2021525771A5 JP2020567199A JP2020567199A JP2021525771A5 JP 2021525771 A5 JP2021525771 A5 JP 2021525771A5 JP 2020567199 A JP2020567199 A JP 2020567199A JP 2020567199 A JP2020567199 A JP 2020567199A JP 2021525771 A5 JP2021525771 A5 JP 2021525771A5
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
compound
pharmaceutically acceptable
group
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Application number
JP2020567199A
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English (en)
Japanese (ja)
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JP7351859B2 (ja
JP2021525771A (ja
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Priority claimed from PCT/US2019/035247 external-priority patent/WO2019236496A1/en
Publication of JP2021525771A publication Critical patent/JP2021525771A/ja
Publication of JP2021525771A5 publication Critical patent/JP2021525771A5/ja
Application granted granted Critical
Publication of JP7351859B2 publication Critical patent/JP7351859B2/ja
Active legal-status Critical Current
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JP2020567199A 2018-06-04 2019-06-03 Tlr7の調節に関係する疾患を処置するのに有用な酸性基を含むピリミジン化合物 Active JP7351859B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862680324P 2018-06-04 2018-06-04
US62/680,324 2018-06-04
PCT/US2019/035247 WO2019236496A1 (en) 2018-06-04 2019-06-03 Pyrimidine compounds containing acidic groups useful to treat diseases connected to the modulation of tlr7

Publications (3)

Publication Number Publication Date
JP2021525771A JP2021525771A (ja) 2021-09-27
JP2021525771A5 true JP2021525771A5 (enExample) 2022-06-06
JP7351859B2 JP7351859B2 (ja) 2023-09-27

Family

ID=66913097

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020567199A Active JP7351859B2 (ja) 2018-06-04 2019-06-03 Tlr7の調節に関係する疾患を処置するのに有用な酸性基を含むピリミジン化合物

Country Status (7)

Country Link
US (1) US10857153B2 (enExample)
EP (1) EP3802519A1 (enExample)
JP (1) JP7351859B2 (enExample)
CN (1) CN112513031A (enExample)
AR (1) AR114910A1 (enExample)
TW (1) TW202003475A (enExample)
WO (1) WO2019236496A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10786502B2 (en) 2016-12-05 2020-09-29 Apros Therapeutics, Inc. Substituted pyrimidines containing acidic groups as TLR7 modulators
TW202003475A (zh) 2018-06-04 2020-01-16 美商亞博創新醫藥有限公司 含酸性基團之嘧啶化合物

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IL73534A (en) 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
DE69720965T2 (de) 1996-02-13 2004-02-05 Astrazeneca Ab Chinazolinderivate und deren verwendung als vegf hemmer
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
ES2232871T3 (es) 1996-07-03 2005-06-01 Sumitomo Pharmaceuticals Company, Limited Nuevos derivados de purina.
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
CA2280930C (en) 1997-02-12 2010-04-06 The Regents Of The University Of Michigan Protein markers for lung cancer and use thereof
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
DE69817393T2 (de) 1997-11-28 2004-06-17 Sumitomo Pharmaceuticals Co., Ltd. Neue heterozyklische verbindungen
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
PT1154774E (pt) 1999-02-10 2005-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de angiogenese
KR100881105B1 (ko) 1999-11-05 2009-02-02 아스트라제네카 아베 Vegf 억제제로서의 퀴나졸린 유도체
JP3663382B2 (ja) 2000-02-15 2005-06-22 スージェン・インコーポレーテッド ピロール置換2−インドリノン蛋白質キナーゼ阻害剤
AU2001258628A1 (en) 2000-05-31 2001-12-11 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
MXPA02012903A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como inhibidores de angiogenesis.
MXPA02012905A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como agentes de dano vascular..
US8138172B2 (en) 2006-07-05 2012-03-20 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of TLR7
PE20091236A1 (es) 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
AU2010250923A1 (en) 2009-05-21 2011-11-17 Astrazeneca Ab Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
JO3257B1 (ar) 2009-09-02 2018-09-16 Novartis Ag مركبات وتركيبات كمعدلات لفاعلية tlr
AU2011295853A1 (en) 2010-09-01 2013-04-04 Irm Llc Adsorption of immunopotentiators to insoluble metal salts
WO2012066336A1 (en) 2010-11-19 2012-05-24 Astrazeneca Ab Benzylamine compounds as toll -like receptor 7 agonists
JP6184423B2 (ja) * 2012-05-18 2017-08-23 大日本住友製薬株式会社 カルボン酸化合物
SG11201506639XA (en) 2013-02-21 2015-09-29 Janssen Sciences Ireland Uc 2-aminopyrimidine derivatives for the treatment of viral infections
JP7071392B2 (ja) 2016-12-05 2022-05-18 アプロス セラピューティクス, インコーポレイテッド 酸性基を含有するピリミジン化合物
US10786502B2 (en) 2016-12-05 2020-09-29 Apros Therapeutics, Inc. Substituted pyrimidines containing acidic groups as TLR7 modulators
TW202003475A (zh) 2018-06-04 2020-01-16 美商亞博創新醫藥有限公司 含酸性基團之嘧啶化合物

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