JP2021525545A - 液体真菌胞子製剤用の新規担体流体 - Google Patents
液体真菌胞子製剤用の新規担体流体 Download PDFInfo
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- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- ZUHZGEOKBKGPSW-UHFFFAOYSA-N tetraglyme Chemical compound COCCOCCOCCOCCOC ZUHZGEOKBKGPSW-UHFFFAOYSA-N 0.000 description 1
- 238000003971 tillage Methods 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
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- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical class [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/30—Microbial fungi; Substances produced thereby or obtained therefrom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/30—Microbial fungi; Substances produced thereby or obtained therefrom
- A01N63/36—Penicillium
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
a) 3〜10エチレンオキシド単位を有するエトキシル化脂肪酸トリグリセリド、ここで、前記脂肪酸トリグリセリドはヒマシ油および植物油からなる群から選択される;
b) 一般式:
c) 一般式:
mは0〜10の間の平均数であり;
nは0〜40、好ましくは0〜30、より好ましくは0〜20、最も好ましくは0〜15、さらには0〜10の平均数であり、m+nはゼロではない)
からなる群から選択される少なくとも1つのエトキシル化および/またはプロポキシル化有機液体を含むか、
またはa)〜c)のいずれか1つの混合物を含み;
および真菌胞子
を含む液体調製物に関する。
0,1〜40%の、好ましくは2,5〜30%の、最も好ましい5〜25%の、例えば10〜20%の真菌胞子、
99,9%までの、好ましくは70〜97,5%の、最も好ましい75〜95%の、例えば80〜90%の上記定義のエトキシル化および/またはプロポキシル化有機液体、
0〜10%の;好ましい0〜8%の、最も好ましい0.1〜5%の界面活性剤(例えば、分散剤乳化剤);
0〜10%の、好ましくは0〜7%の、より好ましくは0.5〜5%のレオロジー調整剤、例えばヒュームドシリカ、アタパルジャイト;
0〜5%の、好ましくは0〜3%の、最も好ましくは0.1〜0.5%の各消泡剤、酸化防止剤、染料
を含む液体調製物を提供する。
他に定義されない限り、用語「アルケニル」は、少なくとも1つの二重結合を含む不飽和直鎖または分岐炭化水素基、例えば(C2−C18)−、(C2−C6)−または(C2−C4)−アルケニルを指す。例:エテニル、1−プロペニル、3−ブテニルなど。
例(しかしこれに限定されない):(C2−C6)−アルケニル、例えばエテニル、1−プロペニル、2−プロペニル、1−メチルエテニル、1−ブテニル、2−ブテニル、3−ブテニル、1−メチル−1−プロペニル、2−メチル−1−プロペニル、1−メチル−2−プロペニル、2−メチル−2−プロペニル、1−ペンテニル、2−ペンテニル、3−ペンテニル、4−ペンテニル、1−メチル−1−ブテニル、2−メチル−1−ブテニル、3−メチル−1−ブテニル、1−メチル−2−ブテニル、2−メチル−2−ブテニル、3−メチル−2−ブテニル、1−メチル−3−ブテニル、2−メチル−3−ブテニル、3−メチル−3−ブテニル、1,1−ジメチル−2−プロペニル,1,2−ジメチル−1−プロペニル、1,2−ジメチル−2−プロペニル、1−エチル−1−プロペニル、1−エチル−2−プロペニル、1−ヘキセニル、2−ヘキセニル、3−ヘキセニル、4−ヘキセニル、5−ヘキセニル、1−メチル−1−ペンテニル、2−メチル−1−ペンテニル、3−メチル−1−ペンテニル、4−メチル−1−ペンテニル、1−メチル−2−ペンテニル、2−メチル−2−ペンテニル、3−メチル−2−ペンテニル、4−メチル−2−ペンテニル、1−メチル−3−ペンテニル、2−メチル−3−ペンテニル、3−メチル−3−ペンテニル、4−メチル−3−ペンテニル、1−メチル−4−ペンテニル、2−メチル−4−ペンテニル、3−メチル−4−ペンテニル、4−メチル−4−ペンテニル、1,1−ジメチル−2−ブテニル、1,1−ジメチル−3−ブテニル、1,2−ジメチル−1−ブテニル、1,2−ジメチル−2−ブテニル、1,2−ジメチル−3−ブテニル、1,3−ジメチル−1−ブテニル、1,3−ジメチル−2−ブテニル、1,3−ジメチル−3−ブテニル、2,2−ジメチル−3−ブテニル、2,3−ジメチル−1−ブテニル、2,3−ジメチル−2−ブテニル、2,3−ジメチル−3−ブテニル、3,3−ジメチル−1−ブテニル、3,3−ジメチル−2−ブテニル、1−エチル−1−ブテニル、1−エチル−2−ブテニル、1−エチル−3−ブテニル、2−エチル−1−ブテニル、2−エチル−2−ブテニル、2−エチル−3−ブテニル、1,1,2−トリメチル−2−プロペニル、1−エチル−1−メチル−2−プロペニル、1−エチル−2−メチル−1−プロペニル、および1−エチル−2−メチル−2−プロペニル。
他に定義されない限り、用語「アルコキシ」(アルキル−O−)は、酸素原子(−O−)を介して足場に結合したアルキル基、例えば(C1−C18)−、(C1−C6)−または(C1−C4)−アルコキシを指す。例:メトキシ、エトキシ、プロポキシ、1−メチルエトキシなど。
例(しかしこれらに限定されない):(C1−C6)−アルコキシ、例えばメトキシ、エトキシ、1−メチルエトキシ、ブトキシ、1−メチルプロポキシ、2−メチルプロポキシ、1,1−ジメチルエトキシ、ペントキシ、1−メチルブトキシ、2−メチルブトキシ、3−メチルブトキシ、1,1−ジメチルプロポキシ、1,2−ジメチルプロポキシ、2,2−ジメチルプロポキシ、1−エチルプロポキシ、ヘキソキシ、1−メチルペントキシ、2−メチルペントキシ、3−メチルペントキシ、4−メチルペントキシ、1,1−ジメチルブトキシ、1,2−ジメチルブトキシ、1,3−ジメチルブトキシ、2,2−ジメチルブトキシ、2,3−ジメチルブトキシ、3,3−ジメチルブトキシ、1−エチルブトキシ、2−エチルブトキシ、1,1,2−トリメチルプロポキシ、1,2,2−トリメチルプロポキシ、1−エチル−1−メチルプロポキシ、および1−エチル−2−メチルプロポキシ。
同様に、他に定義されない限り、用語「アルケノキシ」および「アルキノキシ」は、それぞれ、−O−を介して足場に結合したアルケニル基またはアルキニル基、例えば(C2−C18)−、(C2−C6)−または(C2−C4)−アルケノキシ、またはそれぞれ、(C3−C10)−、(C3−C6)−または(C3−C4)−アルキノキシを指す。
同様に、別に定義されない限り、用語「アルケニルカルボニル」および「アルキニルカルボニル」は、それぞれ、−C(=O)を介して足場に結合したアルケニルまたはアルキニル基、例えば(C2−C18)−、(C2−C6)−もしくは(C2−C4)−アルケニルカルボニル、またはそれぞれ(C2−C10)−、(C2−C6)−もしくは(C2−C4)−アルキニルカルボニルを指す。従って、C原子の数は、アルケニルカルボニル基またはアルキニルカルボニル基内のアルケニル基またはアルキニル基をそれぞれ意味する。
同様に、別に定義されない限り、「アルケニルカルボニルオキシ」および「アルキニルカルボニルオキシ」という用語は、それぞれ−C(=O)−Oを介して足場に結合したアルケニル基またはアルキニル基、例えば(C2−C10)−、(C2−C6)−または(C2−C4)−アルケニルカルボニルオキシ、または、それぞれ(C2−C10)−、(C2−C6)−または(C2−C4)−アルキニルカルボニルオキシを指す。したがって、C原子の数は、アルケニルカルボニルオキシまたはアルキニルカルボニルオキシ基内のアルケニル基またはアルキニル基をそれぞれ意味する。
からのBoveMax(登録商標));C2.4 Hirsutella citriformis; C2.5 Hirsutella thompsonii (例えば、Agro Bio−tech Research Centre, INからのMycohit and ABTEC);C2.6 Lecanicillium lecanii株(以前はVerticillium lecaniiとして知られていた)、特にKV01株の分生子(Koppert/ArystaからのMycotal(登録商標)およびVertalec(登録商標))、DAOM198499株またはDAOM216596株;C2.9 Lecanicillium muscarium株(以前はVerticillium lecanii株)、特にVE 6/ CABI(=IMI)268317/ CBS102071/ ARSEF5128株(例えば、Koppert からのMycotal);C2.10 Metarhizium anisopliae var acridum、例えばGreenGuard by Becker Underwood, US からのARSEF324株または分離株IMI 330189 (ARSEF7486;例えば、Biological Control ProductsによるGreen Muscle);C2.11 Metarhizium brunneum、例えば、Cb 15株(例えば、BIOCAREからのATTRACAP(登録商標));C2.12 Metarhizium anisopliae、例えば、ESALQ 1037株(例えば、Metarril(登録商標) SP Organic由来)、E−9株(例えば、Metarril(登録商標)SP Organic由来)、M206077株、C4−B株(NRRL 30905)、ESC1株、15013−1株(NRRL 67073)、3213−1株(NRRL 67074)、C20091株、C20092株、F52株(DSM3884/ ATCC 90448;例えば、Bayer CropScience社によるBio 1020およびNovozymesによるMet52)またはICIPE 78;C2.15 Metarhizium robertsii 23013−3 (NRRL 67075);C2.13 Nomuraea rileyi;C2.14 Paecilomyces fumosoroseus(新:Isaria fumosorosea)、特にApopka 97株(Certis,USAからのPreFeRalとして入手可能)、Fe9901(Natural industries,USAからのNoFlyとして入手可能)、ARSEF 3581、ARSEF 3302、ARSEF 2679(ARS Collection of Entomopathogenic Fungal Cultures,Ithaca,USA)、IfB01(China Center for Type Culture Collection CCTCC M2012400)、ESALQ1296、ESALQ1364、ESALQ1409(ESALQ:University of Sao Paulo(Piracicaba,SP,Brazil))、CG1228(EMBRAPA Genetic Resources and Biotechnology(Brasilia,DF,Brazil))、KCH J2(Dymarska等、2017;PLoS one 12(10)):e0184885)、HIB−19、HIB−23、HIB−29、HIB−30(Gandarilla−Pacheco等、2018;Rev Argent Microbiol 50:81−89)、CHE−CNRCB 304、EH−511/3(Flores−Villegas等、2016;Parasites & Vectors 2016 9:176 doi:10.1186/s13071−016−1453−1)、CHE−CNRCB 303、CHE−CNRCB 305、CHE−CNRCB 307(Gallou等、2016;fungal biology 120(2016)414−423)、EH−506/3、EH−503/3、EH−520/3、PFCAM、MBP、PSMB1(National Center for Biololgical Control,Mexico;Castellanos−Moguel等、2013;Revista Mexicana De Micologia 38:23−33,2013),RCEF3304(Meng等、2015;Genet Mol Biol.2015 Jul−Sep; 38(3):381−389),PF01−N10(CCTCC No.M207088)、CCM 8367(Czech Collection of Microorganisms,Brno)、SFP−198 (Kim等、2010;Wiley Online:DOI 10.1002/ps.2020)、K3(Yanagawa等、2015; J Chem Ecol. 2015; 41(12): 118−1126)、CLO 55(Ansari Ali等、2011;PLoS One.2011;6(1):e16108.DOI:10.1371/journal.pone.0016108)、IfTS01、IfTS02、IfTS07(Dong等、2016/PLoS ONE 11(5):e0156087.doi:10.1371/journal.pone.0156087)、P1(Sun Agro Biotech Research Centre, India)、If−02、If−2.3、If−03(Farooq and Freed,2016;DOI:10.1016/j.bjm.2016.06.002)、Ifr AsC(Meyer等、2008;J. Invertebr.Pathol.99:96−102.10.1016/j.jip.2008.03.007)、PC−013(DSMZ 26931)、P43A、PCC(Carrillo−Perez等、2012;DOI 10.1007/s11274−012−1184−1)、Pf04、Pf59、Pf109(KimJun等、2013;Mycobiology 2013 Dec;41(4):221−224)、FG340(Han等、2014;DOI:10.5941/MYCO.2014.42.4.385)、Pfr1、Pfr8、Pfr9、Pfr10、Pfr11、Pfr12(Angel−Sahagun等、2005;Journal of Insect Science)、Ifr531(Daniel and Wyss,2009;DOI 10.1111/j.1439−0418.2009.01410.x)、IF−1106(Insect Ecology and Biocontrol Laboratory,Shanxi Agricultural University)、I9602、I7284(Hussain等、2016,DOI:10.3390/ijms17091518)、I03011(Patent US 4618578)、CNRCB1(Centro Nacional de Referencia de Control Biologico (CNRCB),Colima,Mexico),SCAU−IFCF01(Nian等、2015;DOI:10.1002/ps.3977)、PF01−N4(Engineering Research Center of Biological Control,SCAU,Guangzhou,P.R.China) Pfr−612(Institute of Biotechnology(IB−FCB−UANL),Mexico)、Pf−Tim、Pf−Tiz、Pf−Hal、Pf−Tic(Chan−Cupul等、2013,DOI:10.5897/AJMR12.493);C2.15 Aschersonia aleyrodis;C2.16 Beauveria brongniartii(例えば、Andermatt Biocontrol AGからのBeaupro);C2.17 Conidiobolus obscurus;C2.18 Entomophthora virulenta(例えば、EcomicからのVektor);C2.19 Lagenidium giganteum;C2.20 Metarhizium flavoviride;C2.21 Mucor haemelis(例えば、BioAvard from Indore Biotech Inputs & Research);C2.22 Pandora delphacis;C2.23 Sporothrix insectorum(例えば、Biocerto,BRからのSporothrix Es);C2.24 Zoophtora radicansを含む。
Uおよび北米(米国およびカナダ)で登録されている。
3gのP.lilacinum株251純粋胞子粉末を、滅菌スプーンを用いて製剤容器(ウルトラターラックス(Ultra Turrax)のための分散ツールを有するIKA Type DT−20混合容器)に移した。12mLの流体をそれぞれの製剤容器に添加し、ウルトラターラックス管駆動制御を用いて3000rpmで1分間分散させ、30秒後に方向を変えた。この2.8mLを4つのサンプルボトル(Wheaton血清バイアル、タイプI)に移し、ヘッドスペースをほとんど残さず、クリンプネックキャップ(Macherey−Nagel N タイプ13)を用いて密閉した後、すべてのサンプルボトルを30℃に設定したインキュベーターに移し、所定の時間保存した。
表Iに示される結果から、貯蔵後に良好な胞子生存率を提供するために、全ての流体が好適であるわけではないことが明らかになる。試料の製造直後(1日目)の胞子生存率は、一般に高く、多くの場合、80%以上、多くの場合、90%以上でさえある。本発明の範囲に属さない特定の流体はサンプルの調製後1日目であっても胞子生存率の急激な低下を示し、所定の条件下で貯蔵した後であってもさらに急激な低下を示す(表I、エントリー5、6、14、20、23)。BreakThru S240は、宿主真菌胞子への優れた流体として以前から記載されている。所与の試験条件下で、BreakThru S240(表I、エントリー33)は2月の貯蔵後に〜77%の胞子生存率を提供し、7月の貯蔵後に〜7%を提供する。本発明による実施例の中には、それぞれ2ヶ月または3ヶ月の貯蔵後に約53%以上の胞子生存率を示す流体が選択される。多くの場合、約80%以上の胞子生存率が検出された(表I、エントリー1、7、10、11、13、15、16、18、21、26、29)。選択された流体について、例外的な胞子生存率が、30℃で7ヶ月間の貯蔵後でさえ見出された(表I、エントリー25、27、32)。
方法1:1,5gのIsaria fumosorosea純粋胞子粉末を、滅菌スプーンを用いて製剤容器(ウルトラターラックス(Ultra Turrax)のための分散ツールを有するIKA Type DT−20混合容器)に移した。13,5mLの流体をそれぞれの製剤容器に加え、ウルトラターラックス管駆動制御を用いて3000rpmで1分間分散させ、30秒後に方向を変えた。この2.8mLを4つのサンプルボトル(Wheaton血清バイアル、タイプI)に移し、ヘッドスペースをほとんど残さず、クリンプネックキャップ(Macherey−Nagel N タイプ13)を用いて密閉した後、すべてのサンプルボトルを30℃に設定したインキュベーターに移し、所定の時間保存した。
試料の製造直後(1日目)の胞子生存率は一般に高く、多くの場合、ネガティブ標準として使用された(すなわち、本発明に従わない)ButylcarbitolおよびCarbitol(表II、エントリー1、2)を除いて90%以上である。いくつかの実施例(表2、エントリー6/6a、7/7a、13/13a、14/14a、16/16a)で実証されるように、胞子生存率の決定のための両方の方法は、同等の結果を提供する。本発明による実施例の中で、貯蔵後1か月(表II、エントリー3−7、9−12、14、16、−1−20)で約60%以上、または貯蔵後30℃で7か月(表2、エントリー6、7、14、16、19、20)で約50%以上の胞子の生存率を示す流体が選択される。
1,5gのBeauveria Bassiana純粋胞子粉末を、滅菌スプーンを用いて製剤容器(ウルトラターラックス(Ultra Turrax)のための分散ツールを有するIKA Type DT−20混合容器)に移した。13.5mLの流体をそれぞれの製剤容器に添加し、ウルトラターラックス管駆動制御を用いて3000rpmで1分間分散させ、30秒後に方向を変えた。この2.8mLを4つのサンプルボトル(Wheaton血清バイアル、タイプI)に移し、ヘッドスペースをほとんど残さず、クリンプネックキャップ(Macherey−Nagel N タイプ13)を用いて密閉した後、すべてのサンプルボトルを30℃に設定したインキュベーターに移し、所定の時間保存した。
試料の製造直後(1日目)の胞子生存率は、一般に高く、多くの場合、80%以上、多くの場合、90%以上でさえある。本発明の範囲内に入らない流体は、所与の条件下での貯蔵後に胞子生存率の急激な低下を示す(表III、エントリー4、12)。本発明による実施例の中には、30℃で3週以上貯蔵した後に約50%以上の胞子生存率を示す流体が選択されている(表III、エントリー1、2、3、5、9、10、14、17)
例IV:Penicillium Bilaii
1,5gのPenicillium bilaii (ATCC 20851)純粋胞子粉末を、滅菌スプーンを用いて製剤容器(ウルトラターラックス(Ultra Turrax)用の分散ツールを有するIKA Type DT−20混合容器)に移した。それぞれ13,5mLの流体を製剤容器に加え、ウルトラターラックス管駆動制御を用いて3000rpmで1分間分散させ、30秒後に方向を変えた。この後、2.8mLを4つのサンプルボトル(Wheaton血清バイアル、タイプI)に移し、ヘッドスペースをほとんど残さず、クリンプネックキャップ(Macherey−Nagel タイプN 13)を用いて密閉した後、すべてのサンプルボトルを30℃に設定したインキュベーターに移し、所定の時間保存した。
サンプルの製造直後(1日目)の胞子生存率は非常に可変であり;ほとんどの場合、生存率は50%以上、選択された場合はさらには90%以上である。本発明による実施例の中には、30℃で約3ヶ月間貯蔵した後に約50%以上の胞子生存率を示す流体が選択される(表IV、エントリー1、10、11、15〜17)。多くの場合、選択された流体中の胞子生存率は、30℃で約3ヶ月間貯蔵した後、対照として使用したBreak−Thru S240の生存率、すなわち約20%を超える。ここに示した条件下では、一部の液体は胞子の生存性に劣る。
Claims (27)
- 以下の
a)3〜10エチレンオキシド単位を有するエトキシル化脂肪酸トリグリセリドであって、前記脂肪酸トリグリセリドがヒマシ油および植物油からなる群から選択される、前記エトキシル化脂肪酸トリグリセリド;
b)一般式:
のブロックコポリマー〔ここで、a1およびa2は互いに独立して、1〜20の間の平均値を有し、bは、15〜35の間の平均値を有する〕;
c)一般式:
のポリマー〔式中、XおよびYは独立して
水素、
1〜24個の炭素原子をもつ分岐または直鎖アルキル、および
2〜24個の炭素原子を有し、飽和または部分的に不飽和であり、ヒドロキシル官能基を有してもよい、分枝または直鎖カルボニル
から選択され;
ここで、mは0〜10の間の平均数であり;
ここで、nは0〜40の間の平均数であり;
ここで、m+nはゼロではない〕
または、a)〜c)のいずれか1つの混合物;
からなる群から選択される少なくとも一つのエトキシル化および/またはプロポキシル化有機液体
および、真菌胞子
を含む、本質的に水を含まない液体調製物。 - a)の前記エトキシル化脂肪酸トリグリセリドが、ヒマワリ油、菜種油、大豆油、トウモロコシ油、ヤシ油、およびパーム油からなる群から選択される植物油である、請求項1に記載の液体調製物。
- a)の前記エトキシル化脂肪酸トリグリセリドがヒマシ油である、請求項1に記載の液体調製物。
- b)の前記エトキシル化およびプロポキシル化有機液体が、約1000〜約3000g/molの平均モル重量を有し、a1およびa2が互いに独立して1〜20の平均値を有し、bが15〜35の平均値を有するブロックコポリマーからなる群から選択される、請求項1に記載の液体調製物。
- b)の前記エトキシル化およびプロポキシル化有機液体が、約1500〜約3000g/molの平均モル重量を有し、a1およびa2が互いに独立して10〜15の平均値を有し、bが20〜30の平均値を有するブロックコポリマーからなる群から選択される、請求項1および4に記載の液体調製物。
- b)の前記エトキシル化およびプロポキシル化有機液体が、約2000〜約3000g/molの平均分子量を有し、a1およびa2が互いに独立して3〜16の平均値を有し、bが25〜35の平均値を有するブロックコポリマー;および、約1400〜約2200g/molの平均分子量を有し、a1およびa2が互いに独立して2〜12の平均値を有し、bが15〜25の平均値を有するブロックコポリマーからなる群から選択される、請求項1、4および5のいずれか1項に記載の液体調製物。
- c)のポリマーにおいて、Xが1〜18個の炭素原子を有する分岐または直鎖アルキル、または2〜18個の炭素原子を有し、飽和または部分不飽和であり、ヒドロキシル官能基を有してもよい分岐または直鎖カルボニルであり、Yが、水素または1〜6個の炭素原子を有する分岐または直鎖アルキル、または2〜6個の炭素原子を有し、飽和または部分不飽和であり、ヒドロキシル官能基を有してもよい分岐または直鎖カルボニルである、請求項1に記載の液体調製物。
- c)のポリマーにおいて、Xが1〜6個の炭素原子を有する分岐または直鎖アルキル、または1〜6個の炭素原子を有し、飽和または部分不飽和であり、ヒドロキシル官能基を有してもよい分岐または直鎖カルボニル、yが1〜18個の炭素原子を有する分岐または直鎖アルキル、または2〜18個の炭素原子を有し、飽和または部分不飽和であり、ヒドロキシル官能基を有してもよい分岐または直鎖カルボニルである、請求項1に記載の液体調製物。
- c)のポリマーにおいて、m+nが1〜30である、請求項1、7および8のいずれか1項に記載の液体調製物。
- c)のポリマーにおいて、m+nが、好ましくは1〜20である、請求項1および7〜9のいずれか1項に記載の液体調製物。
- c)のポリマーにおいて、m+nが、好ましくは1〜15である、請求項1および7〜10のいずれか1項に記載の液体調製物。
- c)のポリマーにおいて、mがゼロに等しい場合、前記少なくとも1つのエトキシル化有機液体の分子量(MW)が190質量単位以上である、請求項1および7〜11のいずれか1項に記載の液体調製物。
- mがゼロに等しい場合、前記少なくとも1つのエトキシル化有機液体の分子量(MW)が205質量単位以上である、請求項12に記載の液体調製物。
- 前記c)のエトキシル化および/またはプロポキシル化有機液体が、ポリエチレンオキシド、エトキシル化アルコール、モノ−/ポリエチレンオキシドジエーテル、モノ−/ポリエチレンオキシドエーテルエステル、エトキシル化カルボン酸、モノ−/ポリエチレンオキシドジエステル、ポリプロピレンオキシド、プロポキシル化アルコール、モノ−/ポリプロピレンオキシドジエーテル、モノ−/ポリプロピレンオキシドエーテルエステル、プロポキシル化カルボン酸、モノ−/ポリプロピレンオキシドジエステル、アルコールプロポキシレート−エトキシレート、カルボン酸プロポキシレート−エトキシレートおよびカルボン酸プロポキシレート−エトキシレートエーテルからなる群より選択される、請求項1および7〜13のいずれか1項に記載の液体調製物。
- 前記エトキシル化および/またはプロポキシル化有機液体が、少なくとも40重量%、好ましくは少なくとも50重量%の量で存在する、請求項1〜14のいずれか1項に記載の液体調製物。
- 水混和性である、請求項1〜15のいずれか1項に記載の液体調製物。
- 前記真菌胞子が、植物保護における生物的防除剤または植物健康増進剤として有効な真菌種に由来する、請求項1〜16のいずれか1項に記載の液体調製物。
- 前記真菌種が昆虫病原性真菌である、請求項1〜17のいずれか1項に記載の液体製剤。
- 前記真菌種が殺線虫活性真菌である、請求項1〜17のいずれか1項に記載の液体製剤。
- 前記真菌種が、Isaria fumosorosea、Penicillium bilaii、Metarhizium anisopliae、Purpureocillium lilacinum、Coniothyrium minitans、Beauveria bassianaおよびClonostachys roseaからなる群より選択される、請求項1〜19のいずれか1項に記載の液体調製物。
- 界面活性剤、レオロジー調整剤、消泡剤、酸化防止剤および染料の群から選択される少なくとも1つの物質をさらに含む、請求項1〜20のいずれか1項に記載の液体調製物。
- 前記レオロジー調整剤が、ヒュームド(疎水性/親水性)または沈降シリカ、天然起源のシリカ、アタパルジャイトベースのレオロジー調整剤、有機改質粘土、およびそれらの混合物からなる群より選択される、請求項21に記載の液体調製物。
- 前記レオロジー調整剤がヒュームドシリカである、請求項22に記載の液体調製物。
- 0.1〜40重量%の真菌胞子、99.9%までの請求項1〜16のいずれか1項に記載の少なくとも1つのエトキシル化および/またはプロポキシル化有機液体および0〜10重量%の少なくとも1つの界面活性剤および/またはレオロジー調整剤を含む、先行する請求項のいずれか1項に記載の液体調製物。
- 請求項1〜24のいずれか1項に記載の液体調製物を含む液体組成物。
- 植物内または植物上の植物病原性真菌、昆虫および/または線虫を防除するための方法、植物の成長を増強するための方法、または植物の収量もしくは根の健康を増加させるための方法であって、先行する請求項のいずれかに記載の液体調製物または液体組成物の有効量を前記植物または植物が成長しているかまたは成長することが意図されている場所へ施用することを含む、前記方法。
- 植物保護剤としての、または植物の活力および/または植物の健康を促進するための、先行する請求項のいずれかに記載の液体調製物または液体組成物の使用。
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