JP2021525534A - Ｍｕｃ１６特異的キメラ抗原受容体およびそれらの使用 - Google Patents

Ｍｕｃ１６特異的キメラ抗原受容体およびそれらの使用 Download PDF

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JP2021525534A
JP2021525534A JP2020567215A JP2020567215A JP2021525534A JP 2021525534 A JP2021525534 A JP 2021525534A JP 2020567215 A JP2020567215 A JP 2020567215A JP 2020567215 A JP2020567215 A JP 2020567215A JP 2021525534 A JP2021525534 A JP 2021525534A
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car
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JPWO2019236577A5 (cg-RX-API-DMAC7.html
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サブゼヴァリ，ヘレン
アール． シャー，ルトゥル
アール． シャー，ルトゥル
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プレシゲン，インコーポレイテッド
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JP2020567215A 2018-06-04 2019-06-04 Ｍｕｃ１６特異的キメラ抗原受容体およびそれらの使用 Pending JP2021525534A (ja)

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JP2023189072A JP2024023232A (ja) 2018-06-04 2023-11-06 Ｍｕｃ１６特異的キメラ抗原受容体およびそれらの使用

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US201862680297P 2018-06-04 2018-06-04
US62/680,297 2018-06-04
PCT/US2019/035384 WO2019236577A2 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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JPWO2019236577A5 JPWO2019236577A5 (cg-RX-API-DMAC7.html) 2022-05-30

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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
JP2021500882A (ja) * 2017-10-18 2021-01-14 プレシゲン，インコーポレイテッド スペーサーを含むポリペプチド組成物
SG11202104524YA (en) * 2018-11-01 2021-05-28 Gracell Biotechnologies Shanghai Co Ltd Compositions and methods for t cell engineering
CN114651003A (zh) 2019-09-10 2022-06-21 黑曜石疗法公司 用于可调调节的ca2-il15融合蛋白
CN115885038A (zh) * 2020-06-17 2023-03-31 国立大学法人京都大学 表达嵌合抗原受体的免疫活性细胞
KR20230122618A (ko) * 2020-12-21 2023-08-22 알로젠 테라퓨틱스 인코포레이티드 프로테아제 활성화 cd45-게이트 car
WO2022143928A1 (zh) * 2020-12-31 2022-07-07 亘喜生物科技（上海）有限公司 膜融合蛋白及其在免疫细胞中的应用
US20240108722A1 (en) * 2021-01-19 2024-04-04 Obsidian Therapeutics, Inc. Tumor-infiltrating lymphocytes with membrane bound interleukin 15 and uses thereof
US20250145950A1 (en) * 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
CN115819613B (zh) * 2022-05-10 2023-10-20 四川大学华西医院 基于msln前体蛋白构建的嵌合抗原受体免疫细胞制备及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013529061A (ja) * 2010-03-26 2013-07-18 メモリアル スローン−ケタリング キャンサー センター Ｍｕｃ１６に対する抗体およびその使用方法
US20180002397A1 (en) * 2016-06-08 2018-01-04 Intrexon Corporation Cd33 specific chimeric antigen receptors
CN107557336A (zh) * 2017-09-15 2018-01-09 山东兴瑞生物科技有限公司 一种抗muc16安全型嵌合抗原受体修饰的免疫细胞及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202346B2 (en) 2002-07-03 2007-04-10 Immunogen Inc. Antibodies to non-shed Muc1 and Muc16, and uses thereof
DK2135881T3 (da) 2005-06-20 2011-12-05 Genentech Inc Antistoffer, som binder til det tumor-associerede antigen TAT10772, til diagnose og behandling af tumor
WO2008141044A2 (en) 2007-05-08 2008-11-20 Genentech, Inc. Cysteine engineered anti-muc16 antibodies and antibody drug conjugates
JP2011509650A (ja) 2008-01-11 2011-03-31 株式会社ジーンテクノサイエンス ヒト化抗−α９インテグリン抗体及びその使用
DK2496698T3 (en) * 2009-11-03 2019-04-15 Hope City TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION
ES2831315T3 (es) 2013-04-03 2021-06-08 Memorial Sloan Kettering Cancer Center Generación efectiva de células T dirigidas al tumor derivadas de células madre pluripotentes
WO2014186469A2 (en) * 2013-05-14 2014-11-20 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
EP3126390B2 (en) * 2014-04-03 2026-01-07 Cellectis Cd33 specific chimeric antigen receptors for cancer immunotherapy
KR102612313B1 (ko) * 2014-07-21 2023-12-12 노파르티스 아게 인간화 항-bcma 키메라 항원 수용체를 사용한 암의 치료
EP3273994B1 (en) 2015-03-27 2021-12-01 University of Southern California Car t-cell therapy directed to lhr for the treatment of solid tumors
WO2016205176A1 (en) 2015-06-15 2016-12-22 Genentech, Inc. Antibodies and immunoconjugates
CA2997551A1 (en) 2015-09-04 2017-03-09 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use
CN109715207B (zh) * 2016-03-29 2023-03-31 南加利福尼亚大学 靶向癌症的嵌合抗原受体
EP3482205A1 (en) * 2016-07-08 2019-05-15 H. Hoffnabb-La Roche Ag Use of human epididymis protein 4 (he4) for assessing responsiveness of muc 16-positive cancer treatment
WO2018023093A1 (en) 2016-07-29 2018-02-01 Juno Therapeutics, Inc. Immunomodulatory polypeptides and related compositions and methods
CN110139674B (zh) * 2016-10-05 2023-05-16 豪夫迈·罗氏有限公司 制备抗体药物缀合物的方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013529061A (ja) * 2010-03-26 2013-07-18 メモリアル スローン−ケタリング キャンサー センター Ｍｕｃ１６に対する抗体およびその使用方法
US20180002397A1 (en) * 2016-06-08 2018-01-04 Intrexon Corporation Cd33 specific chimeric antigen receptors
CN107557336A (zh) * 2017-09-15 2018-01-09 山东兴瑞生物科技有限公司 一种抗muc16安全型嵌合抗原受体修饰的免疫细胞及其应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MYTHILI KONERU, ET AL., ONCOIMMUNOLOGY, vol. Vol.4, Issue 3, e994446, JPN6023022899, 2015, pages 994446 - 1, ISSN: 0005227383 *

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