JP2021525248A5 - - Google Patents
Info
- Publication number
- JP2021525248A5 JP2021525248A5 JP2020565359A JP2020565359A JP2021525248A5 JP 2021525248 A5 JP2021525248 A5 JP 2021525248A5 JP 2020565359 A JP2020565359 A JP 2020565359A JP 2020565359 A JP2020565359 A JP 2020565359A JP 2021525248 A5 JP2021525248 A5 JP 2021525248A5
- Authority
- JP
- Japan
- Prior art keywords
- region
- compound
- sequence number
- seq
- cdr1l
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023093659A JP7550922B2 (ja) | 2018-05-23 | 2023-06-07 | 併用のためのbcma及びcd3に対する抗増殖性化合物及び二重特異性抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862675639P | 2018-05-23 | 2018-05-23 | |
| US62/675,639 | 2018-05-23 | ||
| PCT/US2019/033505 WO2019226761A1 (en) | 2018-05-23 | 2019-05-22 | Antiproliferative compounds and bispecific antibody against bcma and cd3 for combined use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023093659A Division JP7550922B2 (ja) | 2018-05-23 | 2023-06-07 | 併用のためのbcma及びcd3に対する抗増殖性化合物及び二重特異性抗体 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021525248A JP2021525248A (ja) | 2021-09-24 |
| JP2021525248A5 true JP2021525248A5 (https=) | 2022-05-30 |
| JPWO2019226761A5 JPWO2019226761A5 (https=) | 2022-05-30 |
| JP7293256B2 JP7293256B2 (ja) | 2023-06-19 |
Family
ID=66999900
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020565359A Active JP7293256B2 (ja) | 2018-05-23 | 2019-05-22 | 併用のためのbcma及びcd3に対する抗増殖性化合物及び二重特異性抗体 |
| JP2023093659A Active JP7550922B2 (ja) | 2018-05-23 | 2023-06-07 | 併用のためのbcma及びcd3に対する抗増殖性化合物及び二重特異性抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023093659A Active JP7550922B2 (ja) | 2018-05-23 | 2023-06-07 | 併用のためのbcma及びcd3に対する抗増殖性化合物及び二重特異性抗体 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US11439637B2 (https=) |
| EP (2) | EP4218762A3 (https=) |
| JP (2) | JP7293256B2 (https=) |
| KR (1) | KR102813281B1 (https=) |
| CN (2) | CN112399848B (https=) |
| AU (1) | AU2019274530B2 (https=) |
| BR (1) | BR112020023704A2 (https=) |
| CA (1) | CA3101050A1 (https=) |
| CY (1) | CY1126060T1 (https=) |
| DK (1) | DK3796912T5 (https=) |
| EA (1) | EA202092830A1 (https=) |
| ES (1) | ES2945214T3 (https=) |
| FI (1) | FI3796912T3 (https=) |
| HR (1) | HRP20230449T1 (https=) |
| HU (1) | HUE061792T2 (https=) |
| IL (1) | IL278853B2 (https=) |
| LT (1) | LT3796912T (https=) |
| MX (1) | MX420366B (https=) |
| PL (1) | PL3796912T3 (https=) |
| PT (1) | PT3796912T (https=) |
| RS (1) | RS64189B1 (https=) |
| SG (1) | SG11202011545YA (https=) |
| SI (1) | SI3796912T1 (https=) |
| SM (1) | SMT202300142T1 (https=) |
| WO (1) | WO2019226761A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI791552B (zh) * | 2017-07-10 | 2023-02-11 | 美商西建公司 | 抗增生化合物及其使用方法 |
| BR112020023756A2 (pt) | 2018-05-23 | 2021-02-09 | Celgene Corporation | tratamento de mieloma múltiplo e uso de biomarcadores para 4-(4-(4-(((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-4-il)oxi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrila |
| WO2020097403A1 (en) | 2018-11-08 | 2020-05-14 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
| JP2020103414A (ja) * | 2018-12-26 | 2020-07-09 | 株式会社三洋物産 | 遊技機 |
| RS67646B1 (sr) * | 2019-01-09 | 2026-02-27 | Celgene Corp | Čvrsti oblici koji obuhvataju (s)-4-(4-(4-(((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-4-il)oksi)metil) benzil)piperazin-1-il)-3-fluorobenzonitril i soli istog, kao i kompozicije koje obuhvataju i metode korišćenja istih |
| WO2020146440A1 (en) * | 2019-01-09 | 2020-07-16 | Celgene Corporation | Antiproliferative compounds and second active agents for use in treating multiple myeloma |
| AU2020206692B2 (en) | 2019-01-09 | 2025-03-27 | Celgene Corporation | Pharmaceutical compositions comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same |
| EP3819007B1 (en) | 2019-11-11 | 2024-07-10 | Amgen Research (Munich) GmbH | Dosing regimen for anti-bcma agents |
| US20230114674A1 (en) * | 2020-01-20 | 2023-04-13 | Kangpu Biopharmaceuticals, Ltd. | Isoindoline derivative, and pharmaceutical composition and use thereof |
| JP2021133198A (ja) * | 2020-02-28 | 2021-09-13 | 株式会社三洋物産 | 遊技機 |
| JP2021133200A (ja) * | 2020-02-28 | 2021-09-13 | 株式会社三洋物産 | 遊技機 |
| JP2021133199A (ja) * | 2020-02-28 | 2021-09-13 | 株式会社三洋物産 | 遊技機 |
| CN116157125A (zh) * | 2020-04-28 | 2023-05-23 | 朱诺治疗学股份有限公司 | 针对bcma的t细胞疗法与免疫调节化合物的组合 |
| JP2023524068A (ja) | 2020-04-30 | 2023-06-08 | ブリストル-マイヤーズ スクイブ カンパニー | サイトカイン関連有害事象を治療する方法 |
| JP2021186294A (ja) * | 2020-05-29 | 2021-12-13 | 株式会社三洋物産 | 遊技機 |
| JP2022012088A (ja) * | 2020-06-30 | 2022-01-17 | 株式会社三洋物産 | 遊技機 |
| JP2022012090A (ja) * | 2020-06-30 | 2022-01-17 | 株式会社三洋物産 | 遊技機 |
| JP2022012089A (ja) * | 2020-06-30 | 2022-01-17 | 株式会社三洋物産 | 遊技機 |
| US12472176B2 (en) | 2020-07-07 | 2025-11-18 | Celgene Corporation | Pharmaceutical compositions comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same |
| FI4284512T3 (fi) | 2021-01-28 | 2025-05-22 | Regeneron Pharma | Koostumuksia ja menetelmiä sytokiinien vapautumisoireyhtymän hoitamiseksi |
| CN119546329A (zh) | 2022-04-11 | 2025-02-28 | 瑞泽恩制药公司 | 用于通用肿瘤细胞杀伤的组合物和方法 |
| KR20250151441A (ko) | 2023-02-17 | 2025-10-21 | 리제너론 파마슈티칼스 인코포레이티드 | Cd3/taa 이중특이적 항체에 대해 반응성인 유도된 nk 세포 |
| WO2026059921A1 (en) * | 2024-09-10 | 2026-03-19 | Regeneron Pharmaceuticals, Inc. | Methods of treating multiple myeloma with bcma inhibitors in combination with lag3 inhibitors |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5948893A (en) | 1996-01-17 | 1999-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody |
| US6207157B1 (en) | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| IL148079A0 (en) | 1999-08-24 | 2002-09-12 | Medarex Inc | Human ctla-4 antibodies and compositions containing the same |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| WO2003042402A2 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| HRP20131167T1 (hr) | 2007-06-18 | 2014-01-03 | Merck Sharp & Dohme B.V. | Antitijela za humani receptor programirane smrti pd-1 |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| KR101814408B1 (ko) | 2008-09-26 | 2018-01-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-pd-1, pd-l1, 및 pd-l2 항체 및 그의 용도 |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| WO2010089411A2 (en) | 2009-02-09 | 2010-08-12 | Universite De La Mediterranee | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| TWI409079B (zh) | 2009-08-14 | 2013-09-21 | Roche Glycart Ag | 非典型岩藻醣化cd20抗體與苯達莫斯汀(bendamustine)之組合療法 |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| WO2011082400A2 (en) | 2010-01-04 | 2011-07-07 | President And Fellows Of Harvard College | Modulators of immunoinhibitory receptor pd-1, and methods of use thereof |
| JP2013532153A (ja) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体 |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| PL3988117T3 (pl) * | 2015-04-13 | 2025-03-10 | Pfizer Inc. | Przeciwciała terapeutyczne i ich zastosowania |
| US10683369B2 (en) * | 2015-08-03 | 2020-06-16 | Engmab Sàrl | Monoclonal antibodies against BCMA |
| US10238225B2 (en) * | 2016-06-08 | 2019-03-26 | Windor Enterprises, LLC | Compression garment donning aid device, method, and kit |
| WO2018075820A2 (en) | 2016-10-20 | 2018-04-26 | Celgene Corporation | Cereblon-based heterodimerizable chimeric antigen receptors |
| EP4295918A3 (en) | 2016-11-02 | 2024-03-20 | Bristol-Myers Squibb Company | Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma |
| TWI791552B (zh) * | 2017-07-10 | 2023-02-11 | 美商西建公司 | 抗增生化合物及其使用方法 |
-
2019
- 2019-05-22 EA EA202092830A patent/EA202092830A1/ru unknown
- 2019-05-22 HR HRP20230449TT patent/HRP20230449T1/hr unknown
- 2019-05-22 CN CN201980046500.XA patent/CN112399848B/zh active Active
- 2019-05-22 ES ES19732494T patent/ES2945214T3/es active Active
- 2019-05-22 RS RS20230351A patent/RS64189B1/sr unknown
- 2019-05-22 MX MX2020012485A patent/MX420366B/es unknown
- 2019-05-22 KR KR1020207036733A patent/KR102813281B1/ko active Active
- 2019-05-22 IL IL278853A patent/IL278853B2/en unknown
- 2019-05-22 JP JP2020565359A patent/JP7293256B2/ja active Active
- 2019-05-22 US US16/419,971 patent/US11439637B2/en active Active
- 2019-05-22 SM SM20230142T patent/SMT202300142T1/it unknown
- 2019-05-22 CA CA3101050A patent/CA3101050A1/en active Pending
- 2019-05-22 FI FIEP19732494.0T patent/FI3796912T3/fi active
- 2019-05-22 HU HUE19732494A patent/HUE061792T2/hu unknown
- 2019-05-22 CN CN202110586843.4A patent/CN113713095B/zh active Active
- 2019-05-22 LT LTEPPCT/US2019/033505T patent/LT3796912T/lt unknown
- 2019-05-22 PT PT197324940T patent/PT3796912T/pt unknown
- 2019-05-22 SI SI201930535T patent/SI3796912T1/sl unknown
- 2019-05-22 AU AU2019274530A patent/AU2019274530B2/en active Active
- 2019-05-22 EP EP23156579.7A patent/EP4218762A3/en active Pending
- 2019-05-22 EP EP19732494.0A patent/EP3796912B1/en active Active
- 2019-05-22 PL PL19732494.0T patent/PL3796912T3/pl unknown
- 2019-05-22 BR BR112020023704-3A patent/BR112020023704A2/pt unknown
- 2019-05-22 SG SG11202011545YA patent/SG11202011545YA/en unknown
- 2019-05-22 WO PCT/US2019/033505 patent/WO2019226761A1/en not_active Ceased
- 2019-05-22 DK DK19732494.0T patent/DK3796912T5/da active
-
2022
- 2022-08-17 US US17/820,534 patent/US12053466B2/en active Active
-
2023
- 2023-05-15 CY CY20231100227T patent/CY1126060T1/el unknown
- 2023-06-07 JP JP2023093659A patent/JP7550922B2/ja active Active
-
2024
- 2024-06-25 US US18/753,467 patent/US20240366593A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021525248A5 (https=) | ||
| FI3796912T3 (fi) | Antiproliferatiivisia yhdisteitä ja bcma:n ja cd3:n vastainen bispesifinen vasta-aine yhdistelmäkäyttöön | |
| JPWO2019226761A5 (https=) | ||
| TWI786044B (zh) | 藉由投予pd-1抑制劑治療皮膚癌之方法 | |
| JP7126941B2 (ja) | がんを治療するための抗pd-1抗体と二重特異性抗cd20/抗cd3抗体の組合せ | |
| JP2020500181A5 (https=) | ||
| JP2021513540A5 (https=) | ||
| JP2018506550A5 (https=) | ||
| JP2014533279A5 (https=) | ||
| JP2017522307A5 (https=) | ||
| JP2020502271A5 (https=) | ||
| JP2015534579A5 (https=) | ||
| JP7160533B2 (ja) | 多発性骨髄腫(mm)の処置 | |
| JP2009519257A5 (https=) | ||
| US20200002428A1 (en) | Treatment of c1013g/cxcr4-associated waldenstrom's macroglobulinemia with an anti-cxcr4 antibody | |
| RU2020112490A (ru) | Антитела из тяжелых цепей, связывающиеся с эктоферментами | |
| CA2939464A1 (en) | Use of anti-ccr5 antibodies in graft versus host disease | |
| JP2022189827A (ja) | 癌を治療するための免疫調節剤と組み合わせた低酸素活性化型プロドラッグの投与 | |
| JP2020533362A5 (https=) | ||
| JP2018529661A5 (https=) | ||
| JP2013504603A5 (https=) | ||
| JP2018533569A5 (https=) | ||
| EP3630177B1 (en) | Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment | |
| JP2011505371A5 (https=) | ||
| JP2021511344A5 (https=) |