MX420366B - Compuestos antiproliferativos y anticuerpo biespecifico contra bcma y cd3 para uso combinado - Google Patents

Compuestos antiproliferativos y anticuerpo biespecifico contra bcma y cd3 para uso combinado

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Publication number
MX420366B
MX420366B MX2020012485A MX2020012485A MX420366B MX 420366 B MX420366 B MX 420366B MX 2020012485 A MX2020012485 A MX 2020012485A MX 2020012485 A MX2020012485 A MX 2020012485A MX 420366 B MX420366 B MX 420366B
Authority
MX
Mexico
Prior art keywords
bispecific antibody
antibody against
combined use
antiproliferative compounds
against bcma
Prior art date
Application number
MX2020012485A
Other languages
English (en)
Other versions
MX2020012485A (es
Inventor
Daniel W Pierce
Lilly L Wong
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2020012485A publication Critical patent/MX2020012485A/es
Publication of MX420366B publication Critical patent/MX420366B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a métodos de uso de 4-(4-(4-(((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-4-il)oxi)metil)bencil)piperazin-1-il)-3-fluorobenzonitrilo, o un enantiómero, una mezcla de enantiómeros, un tautómero o una sal farmacéuticamente aceptable de este, y un anticuerpo biespecífico que se une con especificidad al antígeno de maduración de linfocitos B (BCMA) humano y al CD3e (CD3) humano proporcionado en la presente, para tratar, prevenir o controlar el mieloma múltiple.
MX2020012485A 2018-05-23 2019-05-22 Compuestos antiproliferativos y anticuerpo biespecifico contra bcma y cd3 para uso combinado MX420366B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862675639P 2018-05-23 2018-05-23
PCT/US2019/033505 WO2019226761A1 (en) 2018-05-23 2019-05-22 Antiproliferative compounds and bispecific antibody against bcma and cd3 for combined use

Publications (2)

Publication Number Publication Date
MX2020012485A MX2020012485A (es) 2021-04-28
MX420366B true MX420366B (es) 2025-02-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012485A MX420366B (es) 2018-05-23 2019-05-22 Compuestos antiproliferativos y anticuerpo biespecifico contra bcma y cd3 para uso combinado

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US (3) US11439637B2 (es)
EP (2) EP4218762A3 (es)
JP (2) JP7293256B2 (es)
KR (1) KR102813281B1 (es)
CN (2) CN112399848B (es)
AU (1) AU2019274530B2 (es)
BR (1) BR112020023704A2 (es)
CA (1) CA3101050A1 (es)
CY (1) CY1126060T1 (es)
DK (1) DK3796912T5 (es)
EA (1) EA202092830A1 (es)
ES (1) ES2945214T3 (es)
FI (1) FI3796912T3 (es)
HR (1) HRP20230449T1 (es)
HU (1) HUE061792T2 (es)
IL (1) IL278853B2 (es)
LT (1) LT3796912T (es)
MX (1) MX420366B (es)
PL (1) PL3796912T3 (es)
PT (1) PT3796912T (es)
RS (1) RS64189B1 (es)
SG (1) SG11202011545YA (es)
SI (1) SI3796912T1 (es)
SM (1) SMT202300142T1 (es)
WO (1) WO2019226761A1 (es)

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EP3796912A1 (en) 2021-03-31
KR102813281B1 (ko) 2025-05-28
IL278853A (en) 2021-01-31
LT3796912T (lt) 2023-06-12
CN113713095A (zh) 2021-11-30
CN112399848A (zh) 2021-02-23
EP3796912B1 (en) 2023-02-15
US11439637B2 (en) 2022-09-13
JP7293256B2 (ja) 2023-06-19
CN112399848B (zh) 2024-09-06
CA3101050A1 (en) 2019-11-28
KR20210021996A (ko) 2021-03-02
HRP20230449T1 (hr) 2023-07-21
SMT202300142T1 (it) 2023-07-20
AU2019274530B2 (en) 2024-09-19
SI3796912T1 (sl) 2023-07-31
PL3796912T3 (pl) 2023-09-11
US12053466B2 (en) 2024-08-06
CY1126060T1 (el) 2023-11-15
IL278853B1 (en) 2025-02-01
DK3796912T3 (da) 2023-05-15
US20230181575A1 (en) 2023-06-15
MX2020012485A (es) 2021-04-28
JP2023116613A (ja) 2023-08-22
AU2019274530A1 (en) 2020-12-10
JP7550922B2 (ja) 2024-09-13
HUE061792T2 (hu) 2023-08-28
SG11202011545YA (en) 2020-12-30
JP2021525248A (ja) 2021-09-24
CN113713095B (zh) 2025-07-15
WO2019226761A1 (en) 2019-11-28
EP4218762A2 (en) 2023-08-02
ES2945214T3 (es) 2023-06-29
EA202092830A1 (ru) 2021-04-08
US20240366593A1 (en) 2024-11-07
RS64189B1 (sr) 2023-06-30
DK3796912T5 (da) 2024-08-19
FI3796912T3 (fi) 2023-05-11
IL278853B2 (en) 2025-06-01
BR112020023704A2 (pt) 2021-02-17
EP4218762A3 (en) 2023-08-16
US20190381035A1 (en) 2019-12-19
PT3796912T (pt) 2023-05-17

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