JOP20200256A1 - طريقة لتحضير 1، 2، 4-تريازولون يحمل ثلاثة بدائل في المواقع 2، 4، 5 - Google Patents

طريقة لتحضير 1، 2، 4-تريازولون يحمل ثلاثة بدائل في المواقع 2، 4، 5

Info

Publication number
JOP20200256A1
JOP20200256A1 JOP/2020/0256A JOP20200256A JOP20200256A1 JO P20200256 A1 JOP20200256 A1 JO P20200256A1 JO P20200256 A JOP20200256 A JO P20200256A JO P20200256 A1 JOP20200256 A1 JO P20200256A1
Authority
JO
Jordan
Prior art keywords
preparation
triazolone
trisubstituted
compound
intermediates
Prior art date
Application number
JOP/2020/0256A
Other languages
English (en)
Inventor
Gerardus Gieling Reinerus
Hassfeld Jorma
Nikolaus Gradl Stefan
Nicolaas Sebastiaan Van Der Haas Henricus
Rubenbauer Philipp
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of JOP20200256A1 publication Critical patent/JOP20200256A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يزود الاختراع الحالي طرقاً لتحضير المركب (I): المركب (I)، استخدام المركبات الوسيطة في تحضير المركب المذكور والشكل المتبلور A منه.
JOP/2020/0256A 2018-04-10 2019-04-03 طريقة لتحضير 1، 2، 4-تريازولون يحمل ثلاثة بدائل في المواقع 2، 4، 5 JOP20200256A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18166552 2018-04-10
EP18212916 2018-12-17
PCT/EP2019/058389 WO2019197239A1 (en) 2018-04-10 2019-04-03 Method for the preparation of a 2,4,5-trisubstituted 1,2,4-triazolone

Publications (1)

Publication Number Publication Date
JOP20200256A1 true JOP20200256A1 (ar) 2020-10-08

Family

ID=66001239

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0256A JOP20200256A1 (ar) 2018-04-10 2019-04-03 طريقة لتحضير 1، 2، 4-تريازولون يحمل ثلاثة بدائل في المواقع 2، 4، 5

Country Status (17)

Country Link
US (1) US11365179B2 (ar)
EP (1) EP3774786A1 (ar)
JP (1) JP7476107B2 (ar)
KR (1) KR20200141066A (ar)
CN (1) CN112236426A (ar)
AU (1) AU2019251694A1 (ar)
BR (1) BR112020020596A2 (ar)
CA (1) CA3096477A1 (ar)
CL (1) CL2020002598A1 (ar)
CO (1) CO2020012574A2 (ar)
IL (1) IL277860A (ar)
JO (1) JOP20200256A1 (ar)
MX (1) MX2020010655A (ar)
PE (1) PE20210159A1 (ar)
SG (1) SG11202009943QA (ar)
TW (1) TW201945346A (ar)
WO (1) WO2019197239A1 (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114921391B (zh) * 2016-10-27 2024-01-02 拜耳股份有限公司 4,5-环状1,2,4-三唑酮
CN111773214B (zh) * 2020-07-17 2021-04-20 中国人民解放军军事科学院军事医学研究院 2,4,5-三取代的1,2,4-三唑酮在制备抗病毒药物中的用途
CN116444525A (zh) * 2023-03-27 2023-07-18 成都苑东生物制药股份有限公司 一种盐酸泊那替尼a晶型的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2156472A1 (de) 1970-11-23 1972-05-31 Ciba-Geigy Ag, Basel (Schweiz) Verfahren zur Herstellung von neuen Diazepinderivaten
US4089958A (en) 1976-12-20 1978-05-16 American Home Products Corporation 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof
EP0586513A1 (en) * 1991-05-10 1994-03-16 Merck & Co. Inc. Acidic aralkyl triazole derivatives active as angiotensin ii antagonists
DE19627901A1 (de) 1996-07-11 1998-01-15 Bayer Ag Substituierte aromatische Carbonylverbindungen und ihre Derivate
DE19816882A1 (de) 1998-04-17 1999-10-21 Boehringer Ingelheim Pharma Triazolone mit neuroprotektiver Wirkung
US6444613B1 (en) 1999-03-12 2002-09-03 Hoechst Schering Agrevo Gmbh Defoliant
AU2009213488A1 (en) 2008-02-13 2009-08-20 Eisai R & D Management Co., Ltd. Bicycloamine derivative
MX2011006084A (es) 2008-12-08 2011-09-06 Sirtris Pharmaceuticals Inc Isoindolinona y analogos relacionados como moduladores de sirtuina.
JP5868575B2 (ja) 2010-04-15 2016-02-24 浜松ホトニクス株式会社 接続基板
CN103006645A (zh) 2011-09-27 2013-04-03 华东理工大学 2-氨基苯并噻唑衍生物作为dhodh抑制剂的应用
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
BR112015012843B8 (pt) 2012-12-05 2023-04-25 Merck Sharp & Dohme Método para sintetizar o composto
US20160251341A1 (en) 2015-02-27 2016-09-01 Verseon Corporation Substituted triazole compounds as serine protease inhibitors
JOP20190094A1 (ar) * 2016-10-27 2019-04-25 Broad Inst Inc مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh)
CN114921391B (zh) 2016-10-27 2024-01-02 拜耳股份有限公司 4,5-环状1,2,4-三唑酮

Also Published As

Publication number Publication date
AU2019251694A1 (en) 2020-10-22
CL2020002598A1 (es) 2020-12-04
KR20200141066A (ko) 2020-12-17
US20210032212A1 (en) 2021-02-04
CN112236426A (zh) 2021-01-15
WO2019197239A1 (en) 2019-10-17
IL277860A (en) 2020-11-30
MX2020010655A (es) 2020-10-28
PE20210159A1 (es) 2021-01-26
SG11202009943QA (en) 2020-11-27
CA3096477A1 (en) 2019-10-17
JP2021521166A (ja) 2021-08-26
JP7476107B2 (ja) 2024-04-30
BR112020020596A2 (pt) 2021-01-12
CO2020012574A2 (es) 2020-10-30
TW201945346A (zh) 2019-12-01
EP3774786A1 (en) 2021-02-17
US11365179B2 (en) 2022-06-21

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