WO2015111085A8 - Processes for the preparation of eltrombopag and pharmaceutically acceptable salts, solvates and intermediates thereof - Google Patents
Processes for the preparation of eltrombopag and pharmaceutically acceptable salts, solvates and intermediates thereof Download PDFInfo
- Publication number
- WO2015111085A8 WO2015111085A8 PCT/IN2015/000052 IN2015000052W WO2015111085A8 WO 2015111085 A8 WO2015111085 A8 WO 2015111085A8 IN 2015000052 W IN2015000052 W IN 2015000052W WO 2015111085 A8 WO2015111085 A8 WO 2015111085A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- eltrombopag
- processes
- preparation
- pharmaceutically acceptable
- acceptable salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides the processes for the preparation of eltrombopag of Formula (I) or its pharmaceutically acceptable salts. The invention also provides crystalline forms of eltrombopag.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN293MU2014 | 2014-01-27 | ||
IN293/MUM/2014 | 2014-01-27 | ||
IN1946MU2014 | 2014-06-17 | ||
IN1946/MUM/2014 | 2014-06-17 | ||
IN3073/MUM/2014 | 2014-09-25 | ||
IN3073MU2014 | 2014-09-25 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2015111085A2 WO2015111085A2 (en) | 2015-07-30 |
WO2015111085A8 true WO2015111085A8 (en) | 2015-09-03 |
WO2015111085A3 WO2015111085A3 (en) | 2015-11-12 |
Family
ID=53059376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2015/000052 WO2015111085A2 (en) | 2014-01-27 | 2015-01-27 | Processes for the preparation of eltrombopag and pharmaceutically acceptable salts, solvates and intermediates thereof |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2015111085A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3188737A4 (en) * | 2014-09-05 | 2018-05-02 | Hetero Research Foundation | Crystalline form of eltrombopag free acid |
CN106146330B (en) * | 2015-04-21 | 2018-04-06 | 江苏威凯尔医药科技有限公司 | A kind of method for preparing eltrombopag olamine intermediate |
EP3802651A4 (en) * | 2018-06-01 | 2022-05-04 | Aurobindo Pharma Limited | An improved process for the preparation of eltrombopag olamine and its intermediates |
EP3994126A1 (en) * | 2019-07-04 | 2022-05-11 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of key intermediates for the synthesis of eltrombopag or salt thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CY2010012I2 (en) | 2000-05-25 | 2020-05-29 | Novartis Ag | THROMBOPOIETIN MIMETICS |
MY142390A (en) | 2002-05-22 | 2010-11-30 | Glaxosmithkline Llc | 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
JP4562523B2 (en) | 2002-06-06 | 2010-10-13 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Thrombopoietin mimetic |
CN101481352A (en) * | 2008-01-10 | 2009-07-15 | 上海恒瑞医药有限公司 | Bicycle substituted pyrazolone azo derivative, preparation thereof and use in medicine |
JP2012522792A (en) | 2009-04-01 | 2012-09-27 | プリバ フルバトゥスカ ドゥ.オ.オ. | Eltrombopag and polymorphs of eltrombopag salt and method for preparing the same |
EP2799425A1 (en) * | 2013-04-29 | 2014-11-05 | Esteve Química, S.A. | Preparation process of an agonist of the thrombopoietin receptor |
-
2015
- 2015-01-27 WO PCT/IN2015/000052 patent/WO2015111085A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2015111085A3 (en) | 2015-11-12 |
WO2015111085A2 (en) | 2015-07-30 |
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