JP2021523096A - 未治療対象において癌を治療する際に使用するための標的ｔｇｆ−β阻害のための投与計画 - Google Patents

未治療対象において癌を治療する際に使用するための標的ｔｇｆ−β阻害のための投与計画 Download PDF

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JP2021523096A
JP2021523096A JP2020556807A JP2020556807A JP2021523096A JP 2021523096 A JP2021523096 A JP 2021523096A JP 2020556807 A JP2020556807 A JP 2020556807A JP 2020556807 A JP2020556807 A JP 2020556807A JP 2021523096 A JP2021523096 A JP 2021523096A
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seq
protein
polypeptide
sequence
tgfβ
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JP2021523096A5 (enExample
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オジャルボ，ローリーン
バワブ，サメール エル
バワブ，サメール エル
デュサール，イザベル
ヴァグマイスター，ユリア
カーンデルワル，アカシュ
クリステンセン，オラフ
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メルク パテント ゲーエムベーハー
メルク パテント ゲーエムベーハー
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2020556807A 2018-05-15 2019-05-14 未治療対象において癌を治療する際に使用するための標的ｔｇｆ−β阻害のための投与計画 Pending JP2021523096A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862671963P 2018-05-15 2018-05-15
US62/671,963 2018-05-15
US201962804931P 2019-02-13 2019-02-13
US62/804,931 2019-02-13
PCT/US2019/032271 WO2019222252A1 (en) 2018-05-15 2019-05-14 Dosing regimens for targeted tgf-b inhibition for use in treating cancer in treatment naive subjects

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JP2021523096A true JP2021523096A (ja) 2021-09-02
JP2021523096A5 JP2021523096A5 (enExample) 2022-05-18

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JP2020556807A Pending JP2021523096A (ja) 2018-05-15 2019-05-14 未治療対象において癌を治療する際に使用するための標的ｔｇｆ−β阻害のための投与計画

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US (1) US20210061899A1 (enExample)
EP (1) EP3813868A4 (enExample)
JP (1) JP2021523096A (enExample)
KR (1) KR20210009339A (enExample)
CN (1) CN112118858A (enExample)
AU (1) AU2019271065A1 (enExample)
BR (1) BR112020021082A2 (enExample)
CA (1) CA3096844A1 (enExample)
MX (1) MX2020011638A (enExample)
SG (1) SG11202011148VA (enExample)
TW (1) TW202003577A (enExample)
WO (1) WO2019222252A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3158047A1 (en) * 2019-12-11 2021-06-17 Yunying CHEN Bi-functional antibody against pd-l1 and tgf?
WO2021218883A1 (zh) * 2020-04-28 2021-11-04 神州细胞工程有限公司 一种TGFβR2胞外区截短分子、其与抗EGFR抗体的融合蛋白及其抗肿瘤用途
EP4194002A4 (en) * 2020-07-24 2024-08-14 Mabwell (Shanghai) Bioscience Co., Ltd. TGF-BETA RII MUTANT AND ASSOCIATED FUSION PROTEIN

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017506217A (ja) * 2014-02-10 2017-03-02 メルク パテント ゲーエムベーハー 標的ＴＧＦβ阻害
US20180118832A1 (en) * 2016-08-12 2018-05-03 Merck Patent Gmbh Combination therapy for cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201216649D0 (en) * 2012-09-18 2012-10-31 Univ Birmingham Agents and methods
MY186864A (en) * 2013-03-12 2021-08-26 Biocon Ltd Fusion immunomodulatory proteins and methods for making same
SG10201913538VA (en) * 2015-11-23 2020-02-27 Five Prime Therapeutics Inc Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017506217A (ja) * 2014-02-10 2017-03-02 メルク パテント ゲーエムベーハー 標的ＴＧＦβ阻害
US20180118832A1 (en) * 2016-08-12 2018-05-03 Merck Patent Gmbh Combination therapy for cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANCER RES. (2017) VOL.77, ISSUE 13 SUPPL., ABSTRACT 611, <HTTPS://AACRJOURNALS.ORG/CANCERRES/ARTICL, JPN6023009221, ISSN: 0005165105 *
J. IMMUNOTHER. CANCER (2017) VOL.5, SUPPL.2, 86, P.7-8, JPN6023009219, ISSN: 0005165107 *
ONCOIMMUNOLOGY (2017) VOL.6, NO.10, E1349589, P.1-16, JPN6023009220, ISSN: 0005165106 *

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AU2019271065A1 (en) 2020-11-05
MX2020011638A (es) 2022-02-10
EP3813868A4 (en) 2022-03-02
BR112020021082A2 (pt) 2021-02-17
US20210061899A1 (en) 2021-03-04
KR20210009339A (ko) 2021-01-26
CA3096844A1 (en) 2019-11-21
WO2019222252A1 (en) 2019-11-21
TW202003577A (zh) 2020-01-16
SG11202011148VA (en) 2020-12-30
EP3813868A1 (en) 2021-05-05
CN112118858A (zh) 2020-12-22

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