MX2020011638A - Regimenes de dosificacion para una inhibicion dirigida del factor de crecimiento transformante beta (tgf-beta) en el tratamiento del cancer en sujetos no tratados previamente. - Google Patents

Regimenes de dosificacion para una inhibicion dirigida del factor de crecimiento transformante beta (tgf-beta) en el tratamiento del cancer en sujetos no tratados previamente.

Info

Publication number
MX2020011638A
MX2020011638A MX2020011638A MX2020011638A MX2020011638A MX 2020011638 A MX2020011638 A MX 2020011638A MX 2020011638 A MX2020011638 A MX 2020011638A MX 2020011638 A MX2020011638 A MX 2020011638A MX 2020011638 A MX2020011638 A MX 2020011638A
Authority
MX
Mexico
Prior art keywords
inhibition
treating cancer
treatment naive
dosing regimens
naive subjects
Prior art date
Application number
MX2020011638A
Other languages
English (en)
Inventor
Isabelle Dussault
Bawab Samer El
Yulia Vugmeyster
Akash Khandelwal
Laureen Ojalvo
Olaf Christensen
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2020011638A publication Critical patent/MX2020011638A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/86—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Regímenes de dosificación para una inhibición dirigida de TGF-ß con una proteína de fusión bifuncional para usarse en un método de tratamiento del cáncer o para inhibir el crecimiento tumoral en pacientes no tratados previamente (naïve).
MX2020011638A 2018-05-15 2019-05-14 Regimenes de dosificacion para una inhibicion dirigida del factor de crecimiento transformante beta (tgf-beta) en el tratamiento del cancer en sujetos no tratados previamente. MX2020011638A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862671963P 2018-05-15 2018-05-15
US201962804931P 2019-02-13 2019-02-13
PCT/US2019/032271 WO2019222252A1 (en) 2018-05-15 2019-05-14 Dosing regimens for targeted tgf-b inhibition for use in treating cancer in treatment naive subjects

Publications (1)

Publication Number Publication Date
MX2020011638A true MX2020011638A (es) 2022-02-10

Family

ID=68540945

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020011638A MX2020011638A (es) 2018-05-15 2019-05-14 Regimenes de dosificacion para una inhibicion dirigida del factor de crecimiento transformante beta (tgf-beta) en el tratamiento del cancer en sujetos no tratados previamente.

Country Status (12)

Country Link
US (1) US20210061899A1 (es)
EP (1) EP3813868A4 (es)
JP (1) JP2021523096A (es)
KR (1) KR20210009339A (es)
CN (1) CN112118858A (es)
AU (1) AU2019271065A1 (es)
BR (1) BR112020021082A2 (es)
CA (1) CA3096844A1 (es)
MX (1) MX2020011638A (es)
SG (1) SG11202011148VA (es)
TW (1) TW202003577A (es)
WO (1) WO2019222252A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230035169A1 (en) * 2019-12-11 2023-02-02 WuXi Biologics Ireland Limited BI-FUNCTIONAL ANTIBODY AGAINST PD-L1 AND TGF-Beta
US20230365653A1 (en) * 2020-07-24 2023-11-16 Mabwell (shanghai) Bioscience Co., Ltd. Tgf-beta rii mutant and fusion protein thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201216649D0 (en) * 2012-09-18 2012-10-31 Univ Birmingham Agents and methods
AU2014249405C1 (en) * 2013-03-12 2018-08-16 Biocon Ltd. Fusion immunomodulatory proteins and methods for making same
HUE054873T2 (hu) * 2014-02-10 2021-10-28 Merck Patent Gmbh Célzott TGF-béta-gátlás
CN116327924A (zh) * 2015-11-23 2023-06-27 戊瑞治疗有限公司 用于癌症治疗的单独fgfr2抑制剂或与免疫刺激剂的组合
RU2019106663A (ru) * 2016-08-12 2020-09-14 Мерк Патент Гмбх Комбинированная терапия рака

Also Published As

Publication number Publication date
AU2019271065A1 (en) 2020-11-05
CA3096844A1 (en) 2019-11-21
JP2021523096A (ja) 2021-09-02
US20210061899A1 (en) 2021-03-04
KR20210009339A (ko) 2021-01-26
CN112118858A (zh) 2020-12-22
BR112020021082A2 (pt) 2021-02-17
WO2019222252A1 (en) 2019-11-21
EP3813868A1 (en) 2021-05-05
EP3813868A4 (en) 2022-03-02
SG11202011148VA (en) 2020-12-30
TW202003577A (zh) 2020-01-16

Similar Documents

Publication Publication Date Title
MX2017005258A (es) Terapia combinada para tratamiento de enfermedad.
MX2020008977A (es) Formulaciones de anticuerpos de her2 subcutaneas.
MX2022010270A (es) Nuevo enfoque para tratar el cancer mediante el uso de la inmunomodulacion.
MX2023001527A (es) Compuestos con actividad inductora de ferroptosis y metodos de uso de estos.
MX2016013025A (es) Focalizacion de cancer de mama her2+ resistente a trastuzumab con una nanoparticula dirigida de her3.
MX2019015207A (es) Compuestos para tratar el cancer de ovario.
BR112018075660A2 (pt) métodos de tratamento de câncer de pâncreas
MA40364A (fr) Polythérapie pour le traitement du cancer
EA201790352A1 (ru) Терапевтическое лечение на основе анаморелина
MX2020011638A (es) Regimenes de dosificacion para una inhibicion dirigida del factor de crecimiento transformante beta (tgf-beta) en el tratamiento del cancer en sujetos no tratados previamente.
EP3991749A3 (en) A therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody
MX2019008233A (es) Nanoconjugados de doxorrubicina y oro dirigidos para terapia tumoral.
IL281920A (en) Methods for the treatment of peripheral T-cell lymphoma using anti-CD30 antibody drug conjugate therapy
MX2019003751A (es) Proteina terapeutica.
EA202193276A1 (ru) Способы лечения холангиокарциномы
MX2021003160A (es) Combinaciones de inhibidores de tgfbeta e inhibidores de cdk para el tratamiento de cancer de mama.
MX2020008881A (es) Métodos de tratamiento contra el cáncer que comprenden inhibidores de chk1.
BR112016023011A2 (pt) tratamento de câncer gástrico
MX2021011799A (es) Antagonistas de semaforina 4d para usarlos en la terapia contra el cancer.
MX2020014166A (es) Regímenes de dosis para la inhibición dirigida del factor de crecimiento transformante beta (tgf-b) para usarse en el tratamiento de cáncer del tracto biliar.
IL276068A (en) iort device for radiotherapy treatment in cancer patients
MX2021007402A (es) Metodos para la toma de imagenes y el tratamiento de tumores positivos para el receptor de somatostatina.
MX2017013666A (es) Terapia de combinacion de agente anti-fuctactico y agente de inmunoterapia y composiciones para el tratamiento de cancer.
EA201650085A1 (ru) Способ лечения опухолевого заболевания и способ селективного ингибирования роста опухолевых клеток с помощью производного хиноксалин-1,4-диоксида
AR115100A1 (es) REGÍMENES DE DOSIFICACIÓN PARA UNA INHIBICIÓN DIRIGIDA DE TGF-b EN EL TRATAMIENTO DEL CÁNCER EN SUJETOS NO TRATADOS PREVIAMENTE