MX2021007402A - Metodos para la toma de imagenes y el tratamiento de tumores positivos para el receptor de somatostatina. - Google Patents
Metodos para la toma de imagenes y el tratamiento de tumores positivos para el receptor de somatostatina.Info
- Publication number
- MX2021007402A MX2021007402A MX2021007402A MX2021007402A MX2021007402A MX 2021007402 A MX2021007402 A MX 2021007402A MX 2021007402 A MX2021007402 A MX 2021007402A MX 2021007402 A MX2021007402 A MX 2021007402A MX 2021007402 A MX2021007402 A MX 2021007402A
- Authority
- MX
- Mexico
- Prior art keywords
- somatostatin
- methods
- imaging
- hkgrm
- enhancing
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se dan a conocer métodos para el tratamiento, la identificación y la localización de los tumores que expresan los receptores de somatostatina (SR, por sus siglas en inglés), los cuales incluyen los métodos para mejorar la eficacia de las técnicas de toma de imágenes por medio de la administración de un modulador del receptor de glucocorticoides de azadecalina fusionada con heteroaril-cetona (HKGRM, por sus siglas en inglés) eficaz para aumentar la expresión de los SR en los tumores. La administración del HKGRM para potenciar la toma de imágenes de los tumores basados en los SR, y para el tratamiento de los tumores neuroendocrinos. una terapia de combinación de un HKGRM y somatostatina o un análogo de somatostatina para el tratamiento y la mejora de la toma de imágenes de los tumores basados en los SR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862783015P | 2018-12-20 | 2018-12-20 | |
PCT/US2019/067341 WO2020132171A1 (en) | 2018-12-20 | 2019-12-19 | Methods for imaging and treatment of somatostatin-receptor positive tumors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021007402A true MX2021007402A (es) | 2021-07-15 |
Family
ID=71101898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007402A MX2021007402A (es) | 2018-12-20 | 2019-12-19 | Metodos para la toma de imagenes y el tratamiento de tumores positivos para el receptor de somatostatina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220062386A1 (es) |
EP (1) | EP3897629A4 (es) |
JP (1) | JP7444889B2 (es) |
KR (1) | KR20210107004A (es) |
CN (1) | CN113194944A (es) |
AU (1) | AU2019405771A1 (es) |
CA (1) | CA3122581A1 (es) |
IL (1) | IL284237A (es) |
MX (1) | MX2021007402A (es) |
SG (1) | SG11202105746TA (es) |
WO (1) | WO2020132171A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024054785A2 (en) * | 2022-09-06 | 2024-03-14 | Corcept Therapeutics Incorporated | Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to selective glucocorticoid receptor modulators |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2665338T3 (es) | 2012-05-25 | 2018-04-25 | Corcept Therapeutics, Inc. | Moduladores del receptor de glucocorticoides de azadecalina condensada con heteroaril-cetona |
US8859774B2 (en) * | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
AU2016226451B2 (en) * | 2015-03-02 | 2019-12-19 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonist and somatostatin analogues to treat ACTH-secreting tumors |
CA2989266A1 (en) * | 2015-06-25 | 2016-12-29 | Advanced Accelerator Applications | Method of treatment of neuroendocrine tumors that over-express somatostatatin receptors |
EP3592358A4 (en) | 2017-03-09 | 2020-12-16 | Corcept Therapeutics, Inc. | USE OF GLUCOCORTICOID RECEPTOR MODULATORS IN THE TREATMENT OF CATECHOLAMIN SECRETING TUMORS |
EP3876936A4 (en) * | 2018-11-09 | 2022-08-17 | Corcept Therapeutics Incorporated | PROCEDURE FOR SHRINKING PITITUNITIAL TUMORS |
-
2019
- 2019-12-19 EP EP19899701.7A patent/EP3897629A4/en active Pending
- 2019-12-19 US US17/418,120 patent/US20220062386A1/en active Pending
- 2019-12-19 KR KR1020217019034A patent/KR20210107004A/ko unknown
- 2019-12-19 AU AU2019405771A patent/AU2019405771A1/en active Pending
- 2019-12-19 CN CN201980084219.5A patent/CN113194944A/zh active Pending
- 2019-12-19 SG SG11202105746TA patent/SG11202105746TA/en unknown
- 2019-12-19 WO PCT/US2019/067341 patent/WO2020132171A1/en unknown
- 2019-12-19 CA CA3122581A patent/CA3122581A1/en active Pending
- 2019-12-19 MX MX2021007402A patent/MX2021007402A/es unknown
- 2019-12-19 JP JP2021536302A patent/JP7444889B2/ja active Active
-
2021
- 2021-06-20 IL IL284237A patent/IL284237A/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG11202105746TA (en) | 2021-07-29 |
JP7444889B2 (ja) | 2024-03-06 |
JP2022515233A (ja) | 2022-02-17 |
WO2020132171A1 (en) | 2020-06-25 |
EP3897629A4 (en) | 2022-12-07 |
US20220062386A1 (en) | 2022-03-03 |
EP3897629A1 (en) | 2021-10-27 |
IL284237A (en) | 2021-08-31 |
AU2019405771A1 (en) | 2021-06-17 |
CN113194944A (zh) | 2021-07-30 |
CA3122581A1 (en) | 2020-06-25 |
KR20210107004A (ko) | 2021-08-31 |
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