JP2021522862A5 - - Google Patents
Info
- Publication number
- JP2021522862A5 JP2021522862A5 JP2021513004A JP2021513004A JP2021522862A5 JP 2021522862 A5 JP2021522862 A5 JP 2021522862A5 JP 2021513004 A JP2021513004 A JP 2021513004A JP 2021513004 A JP2021513004 A JP 2021513004A JP 2021522862 A5 JP2021522862 A5 JP 2021522862A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- lipid group
- group
- lipid
- conjugate according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862670319P | 2018-05-11 | 2018-05-11 | |
| US62/670,319 | 2018-05-11 | ||
| PCT/EP2019/062064 WO2019215333A1 (en) | 2018-05-11 | 2019-05-10 | Oligonucleotides conjugates comprising 7'-5'-alpha-anomeric-bicyclic sugar nucleosides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021522862A JP2021522862A (ja) | 2021-09-02 |
| JP2021522862A5 true JP2021522862A5 (enExample) | 2024-06-07 |
| JP7665509B2 JP7665509B2 (ja) | 2025-04-21 |
Family
ID=66530048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021513004A Active JP7665509B2 (ja) | 2018-05-11 | 2019-05-10 | ７’－５’－アルファ－アノマー二環式糖ヌクレオシドを含むオリゴヌクレオチドコンジュゲート |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20230132377A9 (enExample) |
| EP (1) | EP3790968A1 (enExample) |
| JP (1) | JP7665509B2 (enExample) |
| KR (1) | KR20210008369A (enExample) |
| CN (1) | CN112424352A (enExample) |
| AU (1) | AU2019266550A1 (enExample) |
| BR (1) | BR112020022620A2 (enExample) |
| CA (1) | CA3098266A1 (enExample) |
| SG (1) | SG11202010841QA (enExample) |
| WO (1) | WO2019215333A1 (enExample) |
| ZA (1) | ZA202007564B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3330276A1 (en) * | 2016-11-30 | 2018-06-06 | Universität Bern | Novel bicyclic nucleosides and oligomers prepared therefrom |
| MX2020011570A (es) | 2018-05-07 | 2020-11-24 | Alnylam Pharmaceuticals Inc | Administracion extrahepatica. |
| CA3108282A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| SG11202100928QA (en) | 2018-08-02 | 2021-02-25 | Dyne Therapeutics Inc | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| WO2021054370A1 (ja) * | 2019-09-18 | 2021-03-25 | 国立大学法人東京医科歯科大学 | 核酸複合体 |
| WO2022058386A1 (en) * | 2020-09-16 | 2022-03-24 | Astrazeneca Ab | Oligonucleotides conjugated to fatty acids |
| EP4247949A1 (en) | 2020-11-23 | 2023-09-27 | Alpha Anomeric SAS | Nucleic acid duplexes |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| JP2024525608A (ja) | 2021-07-09 | 2024-07-12 | ダイン セラピューティクス，インコーポレーテッド | ジストロフィン異常症を処置するための筋標的化複合体および製剤 |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| CR20250257A (es) | 2022-12-02 | 2025-08-28 | Shanghai Argo Biopharmaceutical Co Ltd | Análogos de ácidos nucleicos bicíclicos abásicos y compuestos oligoméricos preparados a partir de estos |
| WO2025217304A1 (en) * | 2024-04-09 | 2025-10-16 | Bio-Rad Laboratories, Inc. | Compositions and methods for detection of contaminant enzymes |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| ES2113371T3 (es) | 1989-11-16 | 1998-05-01 | Univ Duke | Transformacion de celulas epidermicas de tejidos animales con la ayuda de particulas. |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| ES2061416T3 (es) | 1990-10-12 | 1997-03-01 | Max Planck Gesellschaft | Ribozimas modificadas. |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| KR100283601B1 (ko) | 1993-02-19 | 2001-03-02 | 아만 히데아키 | 글리세롤 유도체, 디바이스 및 의약 조성물 |
| TW360548B (en) | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
| US5994316A (en) | 1996-02-21 | 1999-11-30 | The Immune Response Corporation | Method of preparing polynucleotide-carrier complexes for delivery to cells |
| US6218108B1 (en) | 1997-05-16 | 2001-04-17 | Research Corporation Technologies, Inc. | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor |
| US6042820A (en) | 1996-12-20 | 2000-03-28 | Connaught Laboratories Limited | Biodegradable copolymer containing α-hydroxy acid and α-amino acid units |
| US6248878B1 (en) | 1996-12-24 | 2001-06-19 | Ribozyme Pharmaceuticals, Inc. | Nucleoside analogs |
| US6472375B1 (en) | 1998-04-16 | 2002-10-29 | John Wayne Cancer Institute | DNA vaccine and methods for its use |
| JP2000325085A (ja) * | 1999-05-21 | 2000-11-28 | Masafumi Matsuo | デュシェンヌ型筋ジストロフィー治療剤 |
| US6653467B1 (en) * | 2000-04-26 | 2003-11-25 | Jcr Pharmaceutical Co., Ltd. | Medicament for treatment of Duchenne muscular dystrophy |
| AU2003225410A1 (en) * | 2003-03-21 | 2004-10-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| US20080213891A1 (en) | 2004-07-21 | 2008-09-04 | Alnylam Pharmaceuticals, Inc. | RNAi Agents Comprising Universal Nucleobases |
| WO2007030167A1 (en) | 2005-09-02 | 2007-03-15 | Nastech Pharmaceutical Company Inc. | Modification of double-stranded ribonucleic acid molecules |
| SG10201406016SA (en) * | 2006-04-03 | 2014-11-27 | Stella Aps | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| DK2356129T3 (da) * | 2008-09-24 | 2013-05-13 | Isis Pharmaceuticals Inc | Substituerede alpha-L-bicykliske nukleosider |
| KR20200133284A (ko) | 2010-05-28 | 2020-11-26 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체 |
| CN104837996A (zh) * | 2012-11-15 | 2015-08-12 | 罗氏创新中心哥本哈根有限公司 | 抗apob反义缀合物化合物 |
| AU2014211406B2 (en) * | 2013-01-30 | 2019-07-18 | Roche Innovation Center Copenhagen A/S | LNA oligonucleotide carbohydrate conjugates |
| CN106581043A (zh) * | 2016-10-24 | 2017-04-26 | 佳木斯大学 | 一种适用于杜氏肌营养不良症的药物制剂及其制备方法 |
| EP3330276A1 (en) | 2016-11-30 | 2018-06-06 | Universität Bern | Novel bicyclic nucleosides and oligomers prepared therefrom |
-
2019
- 2019-05-10 JP JP2021513004A patent/JP7665509B2/ja active Active
- 2019-05-10 SG SG11202010841QA patent/SG11202010841QA/en unknown
- 2019-05-10 AU AU2019266550A patent/AU2019266550A1/en not_active Abandoned
- 2019-05-10 BR BR112020022620-3A patent/BR112020022620A2/pt not_active IP Right Cessation
- 2019-05-10 CN CN201980046260.3A patent/CN112424352A/zh active Pending
- 2019-05-10 EP EP19723781.1A patent/EP3790968A1/en active Pending
- 2019-05-10 WO PCT/EP2019/062064 patent/WO2019215333A1/en not_active Ceased
- 2019-05-10 KR KR1020207034385A patent/KR20210008369A/ko not_active Ceased
- 2019-05-10 US US17/054,724 patent/US20230132377A9/en not_active Abandoned
- 2019-05-10 CA CA3098266A patent/CA3098266A1/en active Pending
-
2020
- 2020-12-04 ZA ZA2020/07564A patent/ZA202007564B/en unknown
-
2024
- 2024-09-10 US US18/830,182 patent/US20250250565A1/en active Pending