JP2021521138A5 - - Google Patents
Info
- Publication number
- JP2021521138A5 JP2021521138A5 JP2020555218A JP2020555218A JP2021521138A5 JP 2021521138 A5 JP2021521138 A5 JP 2021521138A5 JP 2020555218 A JP2020555218 A JP 2020555218A JP 2020555218 A JP2020555218 A JP 2020555218A JP 2021521138 A5 JP2021521138 A5 JP 2021521138A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- tetrahydro
- oxy
- sulfonyl
- pyrrolo
- Prior art date
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024094048A JP7540113B1 (ja) | 2018-04-29 | 2024-06-11 | Bcl-2阻害剤 |
| JP2024135320A JP7688210B2 (ja) | 2018-04-29 | 2024-08-14 | Bcl-2阻害剤 |
| JP2025085498A JP2025119001A (ja) | 2018-04-29 | 2025-05-22 | Bcl-2阻害剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018085217 | 2018-04-29 | ||
| CNPCT/CN2018/085217 | 2018-04-29 | ||
| CN2018107134 | 2018-09-21 | ||
| CNPCT/CN2018/107134 | 2018-09-21 | ||
| PCT/CN2019/085001 WO2019210828A1 (en) | 2018-04-29 | 2019-04-29 | Bcl-2 INHIBITORS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094048A Division JP7540113B1 (ja) | 2018-04-29 | 2024-06-11 | Bcl-2阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021521138A JP2021521138A (ja) | 2021-08-26 |
| JP2021521138A5 true JP2021521138A5 (https=) | 2022-04-22 |
| JPWO2019210828A5 JPWO2019210828A5 (https=) | 2022-04-22 |
Family
ID=68386968
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020555218A Withdrawn JP2021521138A (ja) | 2018-04-29 | 2019-04-29 | Bcl−2阻害剤 |
| JP2024094048A Active JP7540113B1 (ja) | 2018-04-29 | 2024-06-11 | Bcl-2阻害剤 |
| JP2024135320A Active JP7688210B2 (ja) | 2018-04-29 | 2024-08-14 | Bcl-2阻害剤 |
| JP2025085498A Pending JP2025119001A (ja) | 2018-04-29 | 2025-05-22 | Bcl-2阻害剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094048A Active JP7540113B1 (ja) | 2018-04-29 | 2024-06-11 | Bcl-2阻害剤 |
| JP2024135320A Active JP7688210B2 (ja) | 2018-04-29 | 2024-08-14 | Bcl-2阻害剤 |
| JP2025085498A Pending JP2025119001A (ja) | 2018-04-29 | 2025-05-22 | Bcl-2阻害剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US11420968B2 (https=) |
| EP (2) | EP3788042B1 (https=) |
| JP (4) | JP2021521138A (https=) |
| KR (1) | KR102738032B1 (https=) |
| CN (3) | CN117683029A (https=) |
| AU (1) | AU2019264475C1 (https=) |
| BR (1) | BR112020022092A2 (https=) |
| CA (1) | CA3098348A1 (https=) |
| DK (1) | DK3788042T3 (https=) |
| ES (1) | ES3018793T3 (https=) |
| FI (1) | FI3788042T3 (https=) |
| HR (1) | HRP20250392T1 (https=) |
| HU (1) | HUE071493T2 (https=) |
| IL (1) | IL278366B2 (https=) |
| LT (1) | LT3788042T (https=) |
| MX (2) | MX2020011495A (https=) |
| PL (1) | PL3788042T3 (https=) |
| PT (1) | PT3788042T (https=) |
| SG (1) | SG11202009933WA (https=) |
| SI (1) | SI3788042T1 (https=) |
| TW (1) | TWI855062B (https=) |
| WO (1) | WO2019210828A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| HUE060310T2 (hu) | 2017-04-18 | 2023-02-28 | Shanghai Fochon Pharmaceutical Co Ltd | Apoptosis-indukáló szerek |
| EP3737681A4 (en) | 2018-01-10 | 2022-01-12 | Recurium IP Holdings, LLC | BENZAMIDE COMPOUNDS |
| SI3788042T1 (sl) * | 2018-04-29 | 2025-06-30 | Beigene Switzerland Gmbh | Zaviralci BCL-2 |
| WO2020140005A2 (en) | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| WO2021083135A1 (en) * | 2019-10-28 | 2021-05-06 | Beigene, Ltd. | Bcl-2 INHIBITORS |
| WO2021110102A1 (en) * | 2019-12-02 | 2021-06-10 | Beigene, Ltd. | Methods of cancer treatment using bcl-2 inhibitor |
| KR20220100992A (ko) | 2019-12-06 | 2022-07-18 | 록쏘 온콜로지, 인코포레이티드 | 브루톤 티로신 키나제 억제제의 투여 |
| WO2021133817A1 (en) | 2019-12-27 | 2021-07-01 | Guangzhou Lupeng Pharmaceutical Company Ltd. | 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases |
| JP7839962B2 (ja) * | 2020-04-15 | 2026-04-03 | ビーワン メディシンズ ワン ゲーエムベーハー | Bcl-2阻害剤 |
| EP4146649A4 (en) * | 2020-05-08 | 2024-09-11 | Fochon Biosciences, Ltd. | COMPOUNDS AS BCL-2 INHIBITORS |
| CN114478520B (zh) * | 2020-10-28 | 2025-01-10 | 杭州和正医药有限公司 | Bcl-2蛋白凋亡诱导剂及应用 |
| CN117642157A (zh) * | 2021-03-19 | 2024-03-01 | 伊尔治疗学股份有限公司 | 具有((3-硝基苯基)磺酰基)乙酰胺作为bcl-2抑制剂的化合物 |
| CN117616023A (zh) * | 2021-04-13 | 2024-02-27 | 爱新医药科技(香港)有限公司 | Bcl-2或bcl-2/bcl-xl调节剂及其用途 |
| EP4351542A4 (en) * | 2021-06-02 | 2025-04-09 | BeiGene Switzerland GmbH | Method for treating B-cell malignancy with BCL-2 inhibitor |
| CN115490708B (zh) * | 2021-06-18 | 2025-01-24 | 苏州亚盛药业有限公司 | 磺酰胺类大环衍生物及其制备方法和用途 |
| CA3230314A1 (en) * | 2021-08-31 | 2023-03-09 | Beigene Switzerland Gmbh | Solid forms of bcl-2 inhibitors, method of preparation, and use thereof |
| WO2023078398A1 (en) * | 2021-11-05 | 2023-05-11 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2 inhibitors |
| US20250122191A1 (en) * | 2021-11-20 | 2025-04-17 | Fochon Biosciences, Ltd | Compounds as bcl-2 inhibitors |
| EP4442685A4 (en) * | 2021-12-06 | 2025-11-19 | Hangzhou Healzen Therapeutics Co Ltd | BCL-2 PROTEIN ANTI-APOPTOTIC INHIBITOR: PHARMACEUTICAL COMPOSITION AND USES |
| TW202400163A (zh) | 2022-05-12 | 2024-01-01 | 英屬開曼群島商百濟神州有限公司 | 使用bcl-2抑制劑治療髓性惡性腫瘤之方法 |
| CN119365456A (zh) * | 2022-06-01 | 2025-01-24 | 重庆复创医药研究有限公司 | 作为bcl-2抑制剂的化合物 |
| CN119584963A (zh) * | 2022-07-21 | 2025-03-07 | 百济神州(苏州)生物科技有限公司 | 使用bcl-2抑制剂治疗多发性骨髓瘤的方法 |
| WO2024140690A1 (en) * | 2022-12-27 | 2024-07-04 | Beigene (Suzhou) Co., Ltd. | Intermediates of sonrotoclax and the method of preparing the same |
| AU2023416871A1 (en) * | 2022-12-27 | 2025-08-14 | Beone Medicines I Gmbh | Salts and solid forms of sonrotoclax intermediate |
| WO2024140678A1 (en) * | 2022-12-27 | 2024-07-04 | Beigene (Suzhou) Co., Ltd. | A ketal protected intermediate for sonrotoclax and preparation method thereof |
| WO2026002056A1 (en) | 2024-06-26 | 2026-01-02 | Beone Pharmaceutical (Suzhou) Co., Ltd. | A pharmaceutical formulation comprising solid dispersion of sonrotoclax and a process of preparation thereof |
| WO2026019442A1 (en) * | 2024-07-14 | 2026-01-22 | Eil Therapeutics, Inc. | Compounds having (3-nitrophenyl)acetamide as bcl-2 inhibitors |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY26942A1 (es) | 2000-09-20 | 2002-04-26 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| US20020055631A1 (en) * | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
| WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| CA2577752A1 (en) | 2004-08-20 | 2006-03-02 | The Regents Of The University Of Michigan | Small molecule inhibitors of anti-apoptotic bcl-2 family members and the uses thereof |
| EP1888550B1 (en) | 2005-05-12 | 2014-06-25 | AbbVie Bahamas Ltd. | Apoptosis promoters |
| WO2006127364A1 (en) | 2005-05-24 | 2006-11-30 | Abbott Laboratories | Apoptosis promoters |
| CA2662320C (en) | 2006-09-05 | 2014-07-22 | Abbott Laboratories | Bcl inhibitors treating platelet excess |
| WO2009036051A1 (en) | 2007-09-10 | 2009-03-19 | Curis, Inc. | Bcl-2 inhibitors containing a zinc binding moiety |
| CN102112445B (zh) | 2008-06-09 | 2014-06-18 | 百时美施贵宝公司 | 作为抗细胞凋亡Bcl抑制剂的羟基苯基磺酰胺 |
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| UA108193C2 (uk) | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
| US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| HUE029289T2 (en) | 2008-12-05 | 2017-02-28 | Abbvie Inc | Sulfonamide derivatives as Bcl-2 selective apoptosis inducers for the treatment of cancer and immune diseases |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| AU2009326259A1 (en) | 2008-12-08 | 2011-07-28 | Boehringer Ingelheim International Gmbh | Compounds for treating cancer |
| CN102282129A (zh) | 2009-01-19 | 2011-12-14 | 雅培制药有限公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
| CN102282128B (zh) | 2009-01-19 | 2015-06-17 | Abbvie公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
| NZ595708A (en) * | 2009-05-26 | 2014-03-28 | Abbvie Bahamas Ltd | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) * | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2011029842A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Sulfonamides as inhibitors of bcl-2 family proteins for the treatment of cancer |
| WO2011119345A2 (en) | 2010-03-25 | 2011-09-29 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TWI520960B (zh) | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑 |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| CA3152557A1 (en) | 2010-10-29 | 2012-05-03 | Abbvie Inc. | Solid dispersions containing an apoptosis-inducing agent |
| IT1403156B1 (it) | 2010-12-01 | 2013-10-04 | Università Degli Studi Di Torino | Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi. |
| SG192126A1 (en) | 2011-01-25 | 2013-09-30 | Univ Michigan | Bcl-2/bcl-xl inhibitors and therapeutic methods using the same |
| CN103732589B (zh) | 2011-05-25 | 2016-03-30 | 百时美施贵宝公司 | 可用作抗细胞凋亡bcl抑制剂的取代的磺酰胺 |
| CN104039797B (zh) | 2011-10-12 | 2016-06-01 | 南京奥昭生物科技有限公司 | 作为细胞凋亡诱导剂的杂环分子 |
| EP2794592A1 (en) | 2011-12-23 | 2014-10-29 | Novartis AG | Compounds for inhibiting the interaction of bcl2 with binding partners |
| EP2794588A1 (en) | 2011-12-23 | 2014-10-29 | Novartis AG | Compounds for inhibiting the interaction of bcl2 with binding partners |
| MX2014007732A (es) | 2011-12-23 | 2015-01-12 | Novartis Ag | Compuestos para inhibir la interaccion de bcl2 con los mismos componentes de enlace. |
| JP2015503518A (ja) | 2011-12-23 | 2015-02-02 | ノバルティス アーゲー | Bcl2と結合相手の相互作用を阻害するための化合物 |
| BR112014015442A8 (pt) | 2011-12-23 | 2017-07-04 | Novartis Ag | compostos e composições para inibir a interação de bcl2 com parceiros de ligação |
| WO2013185202A1 (en) | 2012-06-14 | 2013-12-19 | Beta Pharma Canada Inc | Apoptosis inducers |
| KR102318204B1 (ko) | 2013-01-16 | 2021-10-26 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Bcl-2bcl-xl 억제제 및 그를 사용하는 치료 방법 |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2017132474A1 (en) | 2016-01-30 | 2017-08-03 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| EP3481397A1 (en) | 2016-07-06 | 2019-05-15 | Concert Pharmaceuticals Inc. | Deuterated venetoclax |
| KR102376764B1 (ko) | 2016-08-05 | 2022-03-18 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | Bcl-2 억제제로서의 n-(페닐설포닐)벤즈아미드 및 관련 화합물 |
| WO2018041248A1 (zh) | 2016-09-01 | 2018-03-08 | 北京赛林泰医药技术有限公司 | Bcl-2选择性抑制剂及其制备和用途 |
| CN106565706B (zh) | 2016-10-27 | 2018-05-01 | 广东东阳光药业有限公司 | 一种磺酰胺衍生物及其在药学中的应用 |
| CN106749233B (zh) * | 2016-11-24 | 2020-04-21 | 中山大学 | 一类磺酰胺衍生物及其应用 |
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| HUE060310T2 (hu) | 2017-04-18 | 2023-02-28 | Shanghai Fochon Pharmaceutical Co Ltd | Apoptosis-indukáló szerek |
| AU2018322059C1 (en) | 2017-08-23 | 2024-09-12 | Guangzhou Lupeng Pharmaceutical Company Ltd. | BCL-2 inhibitors |
| SI3788042T1 (sl) | 2018-04-29 | 2025-06-30 | Beigene Switzerland Gmbh | Zaviralci BCL-2 |
| WO2020140005A2 (en) | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| WO2021083135A1 (en) | 2019-10-28 | 2021-05-06 | Beigene, Ltd. | Bcl-2 INHIBITORS |
| WO2021110102A1 (en) | 2019-12-02 | 2021-06-10 | Beigene, Ltd. | Methods of cancer treatment using bcl-2 inhibitor |
-
2019
- 2019-04-29 SI SI201930922T patent/SI3788042T1/sl unknown
- 2019-04-29 JP JP2020555218A patent/JP2021521138A/ja not_active Withdrawn
- 2019-04-29 AU AU2019264475A patent/AU2019264475C1/en active Active
- 2019-04-29 IL IL278366A patent/IL278366B2/en unknown
- 2019-04-29 EP EP19797052.8A patent/EP3788042B1/en active Active
- 2019-04-29 BR BR112020022092-2A patent/BR112020022092A2/pt unknown
- 2019-04-29 WO PCT/CN2019/085001 patent/WO2019210828A1/en not_active Ceased
- 2019-04-29 MX MX2020011495A patent/MX2020011495A/es unknown
- 2019-04-29 HU HUE19797052A patent/HUE071493T2/hu unknown
- 2019-04-29 EP EP25150254.8A patent/EP4545515A1/en active Pending
- 2019-04-29 CA CA3098348A patent/CA3098348A1/en active Pending
- 2019-04-29 US US17/050,581 patent/US11420968B2/en active Active
- 2019-04-29 SG SG11202009933WA patent/SG11202009933WA/en unknown
- 2019-04-29 HR HRP20250392TT patent/HRP20250392T1/hr unknown
- 2019-04-29 PT PT197970528T patent/PT3788042T/pt unknown
- 2019-04-29 CN CN202311486964.7A patent/CN117683029A/zh active Pending
- 2019-04-29 KR KR1020207033817A patent/KR102738032B1/ko active Active
- 2019-04-29 DK DK19797052.8T patent/DK3788042T3/da active
- 2019-04-29 LT LTEPPCT/CN2019/085001T patent/LT3788042T/lt unknown
- 2019-04-29 CN CN201980029015.1A patent/CN112437772B/zh active Active
- 2019-04-29 ES ES19797052T patent/ES3018793T3/es active Active
- 2019-04-29 CN CN202311185016.XA patent/CN117430601A/zh active Pending
- 2019-04-29 PL PL19797052.8T patent/PL3788042T3/pl unknown
- 2019-04-29 FI FIEP19797052.8T patent/FI3788042T3/fi active
-
2020
- 2020-04-28 TW TW109114185A patent/TWI855062B/zh active
- 2020-10-29 MX MX2023001689A patent/MX2023001689A/es unknown
-
2022
- 2022-05-23 US US17/750,821 patent/US12077536B2/en active Active
-
2024
- 2024-06-11 JP JP2024094048A patent/JP7540113B1/ja active Active
- 2024-06-17 US US18/745,423 patent/US20240376104A1/en active Pending
- 2024-08-14 JP JP2024135320A patent/JP7688210B2/ja active Active
-
2025
- 2025-05-22 JP JP2025085498A patent/JP2025119001A/ja active Pending
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