KR102738032B1 - Bcl-2 억제제 - Google Patents
Bcl-2 억제제 Download PDFInfo
- Publication number
- KR102738032B1 KR102738032B1 KR1020207033817A KR20207033817A KR102738032B1 KR 102738032 B1 KR102738032 B1 KR 102738032B1 KR 1020207033817 A KR1020207033817 A KR 1020207033817A KR 20207033817 A KR20207033817 A KR 20207033817A KR 102738032 B1 KR102738032 B1 KR 102738032B1
- Authority
- KR
- South Korea
- Prior art keywords
- pyrrolidin
- methyl
- oxy
- pyridin
- pyrrolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2018/085217 | 2018-04-29 | ||
| CN2018085217 | 2018-04-29 | ||
| CNPCT/CN2018/107134 | 2018-09-21 | ||
| CN2018107134 | 2018-09-21 | ||
| PCT/CN2019/085001 WO2019210828A1 (en) | 2018-04-29 | 2019-04-29 | Bcl-2 INHIBITORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20210005677A KR20210005677A (ko) | 2021-01-14 |
| KR102738032B1 true KR102738032B1 (ko) | 2024-12-05 |
Family
ID=68386968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207033817A Active KR102738032B1 (ko) | 2018-04-29 | 2019-04-29 | Bcl-2 억제제 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US11420968B2 (https=) |
| EP (2) | EP4545515A1 (https=) |
| JP (4) | JP2021521138A (https=) |
| KR (1) | KR102738032B1 (https=) |
| CN (3) | CN112437772B (https=) |
| AU (1) | AU2019264475C1 (https=) |
| BR (1) | BR112020022092A2 (https=) |
| CA (1) | CA3098348A1 (https=) |
| DK (1) | DK3788042T3 (https=) |
| ES (1) | ES3018793T3 (https=) |
| FI (1) | FI3788042T3 (https=) |
| HR (1) | HRP20250392T1 (https=) |
| HU (1) | HUE071493T2 (https=) |
| IL (1) | IL278366B2 (https=) |
| LT (1) | LT3788042T (https=) |
| MX (2) | MX2020011495A (https=) |
| PL (1) | PL3788042T3 (https=) |
| PT (1) | PT3788042T (https=) |
| SG (1) | SG11202009933WA (https=) |
| SI (1) | SI3788042T1 (https=) |
| TW (1) | TWI855062B (https=) |
| WO (1) | WO2019210828A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| EP3612531B1 (en) | 2017-04-18 | 2022-08-24 | Shanghai Fochon Pharmaceutical Co., Ltd. | Apoptosis-inducing agents |
| KR20200108301A (ko) | 2018-01-10 | 2020-09-17 | 리커리엄 아이피 홀딩스, 엘엘씨 | 벤즈아미드 화합물 |
| SG11202009933WA (en) * | 2018-04-29 | 2020-11-27 | Beigene Ltd | Bcl-2 INHIBITORS |
| WO2020140005A2 (en) | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| WO2021083135A1 (en) * | 2019-10-28 | 2021-05-06 | Beigene, Ltd. | Bcl-2 INHIBITORS |
| WO2021110102A1 (en) * | 2019-12-02 | 2021-06-10 | Beigene, Ltd. | Methods of cancer treatment using bcl-2 inhibitor |
| JP7142173B2 (ja) | 2019-12-06 | 2022-09-26 | ロクソ オンコロジー， インコーポレイテッド | ブルトン型チロシンキナーゼ阻害剤の投薬 |
| WO2021133817A1 (en) | 2019-12-27 | 2021-07-01 | Guangzhou Lupeng Pharmaceutical Company Ltd. | 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases |
| IL296582A (en) * | 2020-04-15 | 2022-11-01 | Beigene Ltd | bcl-2 inhibitor |
| US20230159527A1 (en) * | 2020-05-08 | 2023-05-25 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2 inhibitors |
| CN114478520B (zh) * | 2020-10-28 | 2025-01-10 | 杭州和正医药有限公司 | Bcl-2蛋白凋亡诱导剂及应用 |
| MX2023011000A (es) * | 2021-03-19 | 2023-09-28 | Eil Therapeutics Inc | Compuestos que contienen ((3-nitrofenilo)sulfonilo)acetamida como inhibidores bcl-2. |
| WO2022218311A1 (en) * | 2021-04-13 | 2022-10-20 | Appicine Therapeutics (Hk) Limited | Modulators of bcl-2 or bcl-2/bcl-xl and uses thereof |
| EP4351542A4 (en) * | 2021-06-02 | 2025-04-09 | BeiGene Switzerland GmbH | Method for treating B-cell malignancy with BCL-2 inhibitor |
| CN115490708B (zh) * | 2021-06-18 | 2025-01-24 | 苏州亚盛药业有限公司 | 磺酰胺类大环衍生物及其制备方法和用途 |
| EP4396180A4 (en) * | 2021-08-31 | 2025-07-09 | Beigene Ltd | SOLID FORMS OF BCL-2 INHIBITORS, PROCESS FOR THEIR PREPARATION AND USE THEREOF |
| WO2023078398A1 (en) * | 2021-11-05 | 2023-05-11 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2 inhibitors |
| US20250122191A1 (en) * | 2021-11-20 | 2025-04-17 | Fochon Biosciences, Ltd | Compounds as bcl-2 inhibitors |
| CA3238433A1 (en) * | 2021-12-06 | 2023-06-15 | Xingguo LIU | Anti-apoptotic protein bcl-2 inhibitor, pharmaceutical composition and uses thereof |
| TW202400163A (zh) | 2022-05-12 | 2024-01-01 | 英屬開曼群島商百濟神州有限公司 | 使用ｂｃｌ－２抑制劑治療髓性惡性腫瘤之方法 |
| WO2023231777A1 (en) * | 2022-06-01 | 2023-12-07 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2 inhibitors |
| JP2025525609A (ja) * | 2022-07-21 | 2025-08-05 | ベイジーン スイッツァランド ゲーエムベーハー | Ｂｃｌ－２阻害剤を使用する多発性骨髄腫の治療方法 |
| AU2023417649A1 (en) * | 2022-12-27 | 2025-08-14 | Beone Medicines I Gmbh | Intermediates of sonrotoclax and the method of preparing the same |
| KR20250127311A (ko) * | 2022-12-27 | 2025-08-26 | 비원 메디슨즈 아이 게엠베하 | 손로토클락스를 위한 케탈 보호된 중간체 및 이의 제조 방법 |
| IL321700A (en) * | 2022-12-27 | 2025-08-01 | Beone Medicines I Gmbh | Salts and solid forms of sonrotoclax intermediate |
| WO2026002056A1 (en) | 2024-06-26 | 2026-01-02 | Beone Pharmaceutical (Suzhou) Co., Ltd. | A pharmaceutical formulation comprising solid dispersion of sonrotoclax and a process of preparation thereof |
| WO2026019442A1 (en) * | 2024-07-14 | 2026-01-22 | Eil Therapeutics, Inc. | Compounds having (3-nitrophenyl)acetamide as bcl-2 inhibitors |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR031130A1 (es) * | 2000-09-20 | 2003-09-10 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| US20020055631A1 (en) | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
| WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| AU2005277223C1 (en) | 2004-08-20 | 2009-05-21 | The Regents Of The University Of Michigan | Small molecule inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof |
| PL1888550T3 (pl) | 2005-05-12 | 2014-12-31 | Abbvie Bahamas Ltd | Promotory apoptozy |
| MX2007014783A (es) | 2005-05-24 | 2008-02-19 | Abbott Lab | Activadores de apoptosis. |
| JP5277168B2 (ja) | 2006-09-05 | 2013-08-28 | アボット・ラボラトリーズ | 血小板過剰を治療するｂｃｌインヒビター |
| WO2009036051A1 (en) | 2007-09-10 | 2009-03-19 | Curis, Inc. | Bcl-2 inhibitors containing a zinc binding moiety |
| US8501992B2 (en) | 2008-06-09 | 2013-08-06 | Bristol-Myers Squibb Company | Hydroxyphenyl sulfonamides as antiapoptotic bcl inhibitors |
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| UA108193C2 (uk) | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| DK2376480T3 (en) | 2008-12-05 | 2016-09-12 | Abbvie Inc | Sulfonamide derivatives AS BCL-2-selective apoptosis inducing agents for the treatment of cancer and immune diseases |
| US8759520B2 (en) | 2008-12-08 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Compounds for treating cancer |
| CA2747835A1 (en) | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2010083442A1 (en) | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) * | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2010138588A2 (en) | 2009-05-26 | 2010-12-02 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CA2772989A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Sulfonamides as inhibitors of bcl-2 family proteins for the treatment of cancer |
| RU2015141713A (ru) | 2010-03-25 | 2018-12-28 | Эббви Инк. | Средства, индуцирующие апоптоз, для лечения рака, иммунных и аутоиммунных заболеваний |
| TWI520960B (zh) | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑 |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| CA3152557A1 (en) | 2010-10-29 | 2012-05-03 | Abbvie Inc. | Solid dispersions containing an apoptosis-inducing agent |
| IT1403156B1 (it) | 2010-12-01 | 2013-10-04 | Università Degli Studi Di Torino | Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi. |
| EP2668180B1 (en) | 2011-01-25 | 2018-08-01 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors for use in the treatment of cancer |
| JP2014521595A (ja) | 2011-05-25 | 2014-08-28 | ブリストル−マイヤーズ スクイブ カンパニー | 抗アポトーシスＢｃｌ阻害剤として有用な置換スルホンアミド |
| US8946445B2 (en) | 2011-10-12 | 2015-02-03 | Nanjing Allgen Pharma Co., Ltd. | Heterocyclic molecules as apoptosis inducers |
| WO2013096051A1 (en) | 2011-12-23 | 2013-06-27 | Novartis Ag | Compounds for inhibiting the interaction of bcl2 with binding partners |
| EP2794592A1 (en) | 2011-12-23 | 2014-10-29 | Novartis AG | Compounds for inhibiting the interaction of bcl2 with binding partners |
| US9126980B2 (en) | 2011-12-23 | 2015-09-08 | Novartis Ag | Compounds for inhibiting the interaction of BCL2 with binding partners |
| EP2794591A1 (en) | 2011-12-23 | 2014-10-29 | Novartis AG | Compounds for inhibiting the interaction of bcl2 with binding partners |
| BR112014015308A8 (pt) | 2011-12-23 | 2017-06-13 | Novartis Ag | compostos para inibição da interação de bcl2 com contrapartes de ligação |
| WO2013185202A1 (en) | 2012-06-14 | 2013-12-19 | Beta Pharma Canada Inc | Apoptosis inducers |
| EP3689886A1 (en) | 2013-01-16 | 2020-08-05 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors and their use in the treatment of cancer |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2017132474A1 (en) | 2016-01-30 | 2017-08-03 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| EP3481397A1 (en) | 2016-07-06 | 2019-05-15 | Concert Pharmaceuticals Inc. | Deuterated venetoclax |
| US10829488B2 (en) | 2016-08-05 | 2020-11-10 | The Regents Of The University Of Michigan | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
| WO2018041248A1 (zh) | 2016-09-01 | 2018-03-08 | 北京赛林泰医药技术有限公司 | Bcl-2选择性抑制剂及其制备和用途 |
| CN106565706B (zh) | 2016-10-27 | 2018-05-01 | 广东东阳光药业有限公司 | 一种磺酰胺衍生物及其在药学中的应用 |
| CN106749233B (zh) * | 2016-11-24 | 2020-04-21 | 中山大学 | 一类磺酰胺衍生物及其应用 |
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| EP3612531B1 (en) | 2017-04-18 | 2022-08-24 | Shanghai Fochon Pharmaceutical Co., Ltd. | Apoptosis-inducing agents |
| CN111511748B (zh) | 2017-08-23 | 2023-05-02 | 广州麓鹏制药有限公司 | Bcl-2抑制剂 |
| SG11202009933WA (en) * | 2018-04-29 | 2020-11-27 | Beigene Ltd | Bcl-2 INHIBITORS |
| WO2020140005A2 (en) | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| WO2021083135A1 (en) | 2019-10-28 | 2021-05-06 | Beigene, Ltd. | Bcl-2 INHIBITORS |
| WO2021110102A1 (en) | 2019-12-02 | 2021-06-10 | Beigene, Ltd. | Methods of cancer treatment using bcl-2 inhibitor |
-
2019
- 2019-04-29 SG SG11202009933WA patent/SG11202009933WA/en unknown
- 2019-04-29 JP JP2020555218A patent/JP2021521138A/ja not_active Withdrawn
- 2019-04-29 FI FIEP19797052.8T patent/FI3788042T3/fi active
- 2019-04-29 DK DK19797052.8T patent/DK3788042T3/da active
- 2019-04-29 KR KR1020207033817A patent/KR102738032B1/ko active Active
- 2019-04-29 BR BR112020022092-2A patent/BR112020022092A2/pt unknown
- 2019-04-29 SI SI201930922T patent/SI3788042T1/sl unknown
- 2019-04-29 CN CN201980029015.1A patent/CN112437772B/zh active Active
- 2019-04-29 PT PT197970528T patent/PT3788042T/pt unknown
- 2019-04-29 CN CN202311486964.7A patent/CN117683029A/zh active Pending
- 2019-04-29 HR HRP20250392TT patent/HRP20250392T1/hr unknown
- 2019-04-29 ES ES19797052T patent/ES3018793T3/es active Active
- 2019-04-29 CN CN202311185016.XA patent/CN117430601A/zh active Pending
- 2019-04-29 EP EP25150254.8A patent/EP4545515A1/en active Pending
- 2019-04-29 HU HUE19797052A patent/HUE071493T2/hu unknown
- 2019-04-29 AU AU2019264475A patent/AU2019264475C1/en active Active
- 2019-04-29 LT LTEPPCT/CN2019/085001T patent/LT3788042T/lt unknown
- 2019-04-29 WO PCT/CN2019/085001 patent/WO2019210828A1/en not_active Ceased
- 2019-04-29 PL PL19797052.8T patent/PL3788042T3/pl unknown
- 2019-04-29 CA CA3098348A patent/CA3098348A1/en active Pending
- 2019-04-29 MX MX2020011495A patent/MX2020011495A/es unknown
- 2019-04-29 US US17/050,581 patent/US11420968B2/en active Active
- 2019-04-29 EP EP19797052.8A patent/EP3788042B1/en active Active
- 2019-04-29 IL IL278366A patent/IL278366B2/en unknown
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2020
- 2020-04-28 TW TW109114185A patent/TWI855062B/zh active
- 2020-10-29 MX MX2023001689A patent/MX2023001689A/es unknown
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2022
- 2022-05-23 US US17/750,821 patent/US12077536B2/en active Active
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2024
- 2024-06-11 JP JP2024094048A patent/JP7540113B1/ja active Active
- 2024-06-17 US US18/745,423 patent/US20240376104A1/en active Pending
- 2024-08-14 JP JP2024135320A patent/JP7688210B2/ja active Active
-
2025
- 2025-05-22 JP JP2025085498A patent/JP2025119001A/ja active Pending
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